LOCUS       NM_006042               4186 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens heparan sulfate-glucosamine 3-sulfotransferase 3A1
            (HS3ST3A1), mRNA.
ACCESSION   NM_006042
VERSION     NM_006042.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Kassim,S.K., Shehata,H.H., Abou-Alhussein,M.M., Sallam,M.M. and
            Amin,I.I.
  TITLE     Laboratory validation of formal concept analysis of the methylation
            status of microarray-detected genes in primary breast cancer
  JOURNAL   Tumour Biol 39 (6), 1010428317698390 (2017)
   PUBMED   28618938
  REMARK    GeneRIF: Detection of MUC1 and HS3ST2 promoter methylation status
            appears to be useful molecular markers for assessing the
            progressive state of the disease and could be helpful in
            discriminating breast cancer molecular subtypes. These results
            validate the methylation-based microarray analysis, thus trust
            their output in the future.
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Mao,X., Gauche,C., Coughtrie,M.W., Bui,C., Gulberti,S.,
            Merhi-Soussi,F., Ramalanjaona,N., Bertin-Jung,I., Diot,A.,
            Dumas,D., De Freitas Caires,N., Thompson,A.M., Bourdon,J.C.,
            Ouzzine,M. and Fournel-Gigleux,S.
  TITLE     The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel
            tumor regulator and a prognostic marker in breast cancer
  JOURNAL   Oncogene 35 (38), 5043-5055 (2016)
   PUBMED   27041583
  REMARK    GeneRIF: Our findings define 3-OST3A as a novel regulator of breast
            cancer pathogenicity, displaying tumor-suppressive or oncogenic
            activities in a cell- and tumor-dependent context, and demonstrate
            the clinical value of the HS-O-sulfotransferase 3-OST3A as a
            prognostic marker in HER2+ patients.
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Amraoui,F., Hassani Lahsinoui,H., Boussata,S., Keijser,R.,
            Veenboer,G.J., Middeldorp,S., van der Post,J.A., Ris-Stalpers,C.,
            Afink,G.B. and van den Born,B.J.
  TITLE     Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 in
            normotensive and pre-eclamptic pregnancies
  JOURNAL   Placenta 36 (11), 1218-1224 (2015)
   PUBMED   26410339
  REMARK    GeneRIF: decreased in pre-eclamptic placental tissue
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Nakano,T., Shimizu,K., Kawashima,O., Kamiyoshihara,M., Kakegawa,S.,
            Sugano,M., Ibe,T., Nagashima,T., Kaira,K., Sunaga,N., Ohtaki,Y.,
            Atsumi,J. and Takeyoshi,I.
  TITLE     Establishment of a human lung cancer cell line with high metastatic
            potential to multiple organs: gene expression associated with
            metastatic potential in human lung cancer
  JOURNAL   Oncol Rep 28 (5), 1727-1735 (2012)
   PUBMED   22922681
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Atkinson,A., Garnier,S., Afridi,S., Fumoux,F. and Rihet,P.
  TITLE     Genetic variations in genes involved in heparan sulphate
            biosynthesis are associated with Plasmodium falciparum
            parasitaemia: a familial study in Burkina Faso
  JOURNAL   Malar J 11, 108 (2012)
   PUBMED   22475533
  REMARK    GeneRIF: Genetic variants of HS3ST3A1 and HS3ST3B1 are associated
            with Plasmodium falciparum parasitaemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Liu,J., Shriver,Z., Blaiklock,P., Yoshida,K., Sasisekharan,R. and
            Rosenberg,R.D.
  TITLE     Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates
            N-unsubstituted glucosamine residues
  JOURNAL   J Biol Chem 274 (53), 38155-38162 (1999)
   PUBMED   10608887
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Shukla,D., Liu,J., Blaiklock,P., Shworak,N.W., Bai,X., Esko,J.D.,
            Cohen,G.H., Eisenberg,R.J., Rosenberg,R.D. and Spear,P.G.
  TITLE     A novel role for 3-O-sulfated heparan sulfate in herpes simplex
            virus 1 entry
  JOURNAL   Cell 99 (1), 13-22 (1999)
   PUBMED   10520990
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Liu,J., Shworak,N.W., Sinay,P., Schwartz,J.J., Zhang,L.,
            Fritze,L.M. and Rosenberg,R.D.
  TITLE     Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase
            isoforms reveals novel substrate specificities
  JOURNAL   J Biol Chem 274 (8), 5185-5192 (1999)
   PUBMED   9988768
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Razi,N. and Lindahl,U.
  TITLE     Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl
            3-O-sulfotransferase reaction: target and inhibitor saccharides
  JOURNAL   J Biol Chem 270 (19), 11267-11275 (1995)
   PUBMED   7744762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292047.1, AC005411.1,
            AY358838.1, AF105376.1, BU619124.1, AC005375.4, BU161930.1 and
            AA746890.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006042.2.
            
            Summary: Heparan sulfate biosynthetic enzymes are key components in
            generating a myriad of distinct heparan sulfate fine structures
            that carry out multiple biologic activities. The enzyme encoded by
            this gene is a member of the heparan sulfate biosynthetic enzyme
            family. It is a type II integral membrane protein and possesses
            heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The
            sulfotransferase domain of this enzyme is highly similar to the
            same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase
            3B1, and these two enzymes sulfate an identical disaccharide. This
            gene is widely expressed, with the most abundant expression in
            liver and placenta. [provided by RefSeq, Dec 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF105376.1, AK292047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284110.2/ ENSP00000284110.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK292047.1         14-15
            3-3                 AC005411.1         72174-72174         c
            4-28                AK292047.1         16-40
            29-2037             AY358838.1         1-2009
            2038-2529           AF105376.1         2036-2527
            2530-3074           BU619124.1         7-551               c
            3075-3332           AC005375.4         112163-112420       c
            3333-3578           BU161930.1         1-246
            3579-3579           AC005375.4         111916-111916       c
            3580-4020           BU161930.1         248-688
            4021-4163           AA746890.1         16-158              c
            4164-4186           AC005375.4         111309-111331       c
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..4186
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /note="heparan sulfate-glucosamine 3-sulfotransferase 3A1"
                     /db_xref="GeneID:9955"
                     /db_xref="HGNC:HGNC:5196"
                     /db_xref="MIM:604057"
     exon            1..1399
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             801..2021
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /EC_number="2.8.2.30"
                     /note="heparin-glucosamine 3-O-sulfotransferase; heparan
                     sulfate 3-O-sulfotransferase 3A1; heparan sulfate
                     D-glucosaminyl 3-O-sulfotransferase 3A1; heparan sulfate
                     (glucosamine) 3-O-sulfotransferase 3A1"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     3A1"
                     /protein_id="NP_006033.1"
                     /db_xref="CCDS:CCDS11165.1"
                     /db_xref="GeneID:9955"
                     /db_xref="HGNC:HGNC:5196"
                     /db_xref="MIM:604057"
                     /translation="MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAE
                     RCQTLSGPVVGLSGGGEEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPP
                     APRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGV
                     KKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPS
                     YFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTA
                     GLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKR
                     IITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNL
                     KFYQMTGHDFGWDG"
     exon            1400..4186
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /note="hexamer: ATTAAA"
     polyA_site      2333
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /note="major polyA site"
     regulatory      3423..3428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /note="hexamer: AATAAA"
     polyA_site      3448
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /note="major polyA site"
     regulatory      4158..4163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
                     /note="hexamer: AATAAA"
     polyA_site      4186
                     /gene="HS3ST3A1"
                     /gene_synonym="3-OST-3A; 3OST3A1"
ORIGIN      
        1 gccagcggcg gcccaggagg cagccggtga gcgcctgcga gcagagtggc gggggccgct
       61 gacaggtccc gcgcagccca gcccagccca gccacgcggc tcacaggtgg ggtccaagag
      121 cagtttggag caacccggcg ctacggagag gggtggacgg ctctgcacgg gcctcctgtc
      181 tcccgctcgg gcagagggac tcggggggac ctcgctcctt ggctgagaga acctgaactc
      241 gggcggagag aacgcgccca ggcgggcaag gggaccagag aaagccgggg ctggaagtca
      301 ctgtcgctcg ccactgtctg gagcgcacgg agcgcagagg cccggcagcc gcgcgtgccc
      361 tcacggggac cgagccagtg atgcaggatc gctgagcgga gatccgcgcc gagaagtctc
      421 tcggggccgg ggctgagacg cacgccttcg acaccgctgc caagaccccg attccggcga
      481 ctcttgcggg gaaccgaggg gccaaggctg ccccaagctc aggacttggg cgagtctaag
      541 acgatggttt cttaagcacg gacccgcgtt ccccttcccg ctccctcgac tggaggcagg
      601 gatcctgcgc ggggcccccg ggattccgtt tccccgcgga gccccggccg ctgcctcccg
      661 ggacagttcg cacggccaca ggggcgcacg gcgatgtggc ctccgtccag cgcgctggcc
      721 cgccgggggg atgctctggc acctgtcggg gtccaggcct agcatggccg gcgcgttgcc
      781 cgacgtcgcc tccggctagg atggcccctc cgggcccggc cagtgccctc tccacctcgg
      841 ccgagccgct gtcccgcagc atcttccgga agttcttgct gatgctctgc tccctgctca
      901 cgtcccttta cgtcttctac tgcctggccg agcgctgcca gaccctgtcc ggccccgtcg
      961 tggggctgtc cggcggcggc gaggaggcgg gggcccctgg tggcggcgtc ctggccggag
     1021 gcccgaggga gctggcggtg tggccggcgg cggcacagag aaagcgcctc ctgcaactgc
     1081 cgcagtggcg gaggcgccgg ccgcccgcgc cccgcgacga cggcgaggag gcggcctggg
     1141 aagaagagtc ccctggcctg tcagggggtc cgggcggctc cggggccgga agcaccgtgg
     1201 ccgaggcccc gccggggacc ctggcgctgc tcctggacga aggcagcaag cagctgccgc
     1261 aggccatcat catcggagtg aagaagggcg gcacgcgggc gctgctggag ttcctgcgcg
     1321 tgcaccccga cgtgcgcgcc gtgggcgccg agccccactt cttcgaccgc agctacgaca
     1381 agggcctcgc ctggtaccgg gacctgatgc ccagaaccct ggacgggcag atcaccatgg
     1441 agaagacgcc cagttacttc gtcacgcggg aggcccccgc gcgcatctcg gccatgtcca
     1501 aggacaccaa gctcatcgtg gtggtgcggg acccggtgac cagggccatc tcggactaca
     1561 cgcagacgct gtccaagcgg cccgacatcc ccaccttcga gagcttgacg ttcaaaaaca
     1621 ggacagcggg cctcatcgac acgtcgtgga gcgccatcca gatcggcatc tacgccaagc
     1681 acctggagca ctggctgcgc cacttcccca tccgccagat gctcttcgtg agcggcgagc
     1741 ggctcatcag cgacccggcc ggggagctgg gccgcgtgca agacttcctg ggcctcaaga
     1801 ggatcatcac ggacaagcac ttctacttca acaagaccaa gggcttcccc tgcctgaaga
     1861 aggcggaggg cagcagccgg ccccattgcc tgggcaagac caagggcagg acccatcctg
     1921 agatcgaccg cgaggtggtg cgcaggctgc gcgagttcta ccggcctttc aacctcaagt
     1981 tctaccagat gaccgggcac gactttggct gggatggata accatataat ttaaaaagaa
     2041 aaaaaaaatc aaaatataat atattttttt accaatcggt agagaagaga cagtttaata
     2101 tttgtgctga aaatatgttt cagtattttt ttcaatgaat gttaagagat tgttctcact
     2161 cccgccccat cttaatgtat aaccaacacc aaacacgtgg atcaacagaa aaggaaaatt
     2221 tcactcgtct aaacactttc aattttcagt ttttatttta tgttctatat acccagtcat
     2281 aaagtataag catcagttgt cattaaaagt tttcagaaaa tcttgaggtt aaacatctct
     2341 ctctcttttt ttaaaataca aggccctgat aaaattgata tctatcctta tatttttctc
     2401 cctttttccc gtgccacttt ttcttaaatt atttcccagt tagtattatc atatgtttgt
     2461 acccgtcaca gttttcatag tgctttcaaa tacacctttt tgatcattaa aataaaaaaa
     2521 taaatcttgc tctgttgtat aagatcacaa taggtaaata ttattatccc cattttacag
     2581 aaaggaaaac tgagtctttg ggaggtgaaa taatgtatct aaaggtcaaa tgttggatgg
     2641 accctggaca aaattccatc ttccacttgt tccctatttc atgtcacttt ttccagggag
     2701 aatggaaaag aagacatctg cacctttaga aatggttagg tagttttcag atgatatgaa
     2761 aagggaaaga gagccccttg ttttctaaat tcccaggcta cccctcatgg cacccagtct
     2821 cattacatag ttgtgtccaa gaaaaccact gagacctgga cacaacctct cttaagagcc
     2881 agtcttgcct cttggctatt taaagtacac tgagatatgg aaatcttgac tgatgaatgc
     2941 ttgattgaat tggagaggaa ttattggatt cttgcatgga ggacaaggtg gccagccaca
     3001 ctaggggtag cacaagatgt gttaggaacg taacttaccc atttgttgat ttaattgact
     3061 ttaaaaaaaa aaaagaaaca gatttcaatt agcacttaca ggtatgagtc tcatttgttt
     3121 tttagtttac ctctttttaa agagagaaaa cctacctttc tttgtaatat ctcacttcta
     3181 actttggagc tagtactctg aaagaattaa ttagcagttc gtttaaaatg tttttatttt
     3241 tcatggatgg aggactatca ttttgtcact ttattccccc ctcccacttc ctatttatac
     3301 catttataac ctaatgttca gtaatatttg gaaaaatatt ctaggaaatg catttgtggg
     3361 taaaatggtg gcttttcctc ttctctcgtc tgtttctgcc catcccccat ttaaatcact
     3421 caaataaatc aatagtttat taacagtatt cctttcctct ctgagtgggt attaacaaga
     3481 ttagcattaa tgggaattaa attggtttag agaggaacac atatgcacga aatatataaa
     3541 acatttataa ttagcctgtc agcaacattt tattagaaat ttaaacccaa gaggaaaaat
     3601 gtcttctatt tcatggaagt tttctttatc tgccaaaatt taaacgacca gacactctaa
     3661 aataatattc tttttcttct ttaatgttgt caatcaaaag aaactaaagt tgttttaaaa
     3721 tatgcagtac aattgtacat ttaccatagc tgctgcatta ggtgatgtaa atatttcttg
     3781 agaagcttaa cacaggatta aaatgaagga aaaaatattt taagtgttag atattttgtc
     3841 attgctccaa atctttggat ttatctgtta atatcccatt tatagaagtt aagtaaaccc
     3901 caaatccagg tcaccttttt tcagttgatt tccttcatgt ctatgctctc aatttcccag
     3961 tgccacagac tgtttttatt ctacttgaat cactagctgc aacaagatac tcattttaaa
     4021 ctcttgtcat catttctctt agctcatttt gtttgtacaa ctgattcttt tgtaagtgtt
     4081 tgcttggcat tatgcaaaag tggcttgcac aaagaaacaa ttgcattctg caaccttcat
     4141 ttttttaatg tgaaagaaat aaaagaacag aattgaatgc aaagga
//
