LOCUS       NM_006043               2329 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens heparan sulfate-glucosamine 3-sulfotransferase 2
            (HS3ST2), mRNA.
ACCESSION   NM_006043
VERSION     NM_006043.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2329)
  AUTHORS   Huynh,M.B., Rebergue,N., Merrick,H., Gomez-Henao,W., Jospin,E.,
            Biard,D.S.F. and Papy-Garcia,D.
  TITLE     HS3ST2 expression induces the cell autonomous aggregation of tau
  JOURNAL   Sci Rep 12 (1), 10850 (2022)
   PUBMED   35760982
  REMARK    GeneRIF: HS3ST2 expression induces the cell autonomous aggregation
            of tau.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2329)
  AUTHORS   Eyvazi,S., Khamaneh,A.M., Tarhriz,V., Bandehpour,M., Hejazi,M.S.,
            Sadat,A.T.E. and Sepehri,B.
  TITLE     CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes
            in Gastric Adenocarcinoma Patients
  JOURNAL   J Gastrointest Cancer 51 (2), 579-583 (2020)
   PUBMED   31407253
  REMARK    GeneRIF: CpG Islands Methylation Analysis of CDH11, EphA5, and
            HS3ST2 Genes in Gastric Adenocarcinoma Patients.
REFERENCE   3  (bases 1 to 2329)
  AUTHORS   Meng,L., Li,M., Gao,Z., Ren,H., Chen,J., Liu,X., Cai,Q., Jiang,L.,
            Ren,X., Yu,Q., Chen,J. and Yang,L.
  TITLE     Possible role of hsa-miR-194-5p, via regulation of HS3ST2, in the
            pathogenesis of atopic dermatitis in children
  JOURNAL   Eur J Dermatol 29 (6), 603-613 (2019)
   PUBMED   31903950
  REMARK    GeneRIF: Hsa-miR-194-5p might be involved in the pathogenesis of
            atopic dermatitis by regulating HS3ST2 expression.
REFERENCE   4  (bases 1 to 2329)
  AUTHORS   Dankova,Z., Brany,D., Dvorska,D., Nachajova,M., Fiolka,R.,
            Grendar,M., Hatok,J., Kubatka,P., Holubekova,V., Halasova,E.,
            Bielik,T. and Zubor,P.
  TITLE     Methylation status of KLF4 and HS3ST2 genes as predictors of
            endometrial cancer and hyperplastic endometrial lesions
  JOURNAL   Int J Mol Med 42 (6), 3318-3328 (2018)
   PUBMED   30221668
  REMARK    GeneRIF: Methylation status of KLF4 and HS3ST2 genes as predictors
            of endometrial cancer and hyperplastic endometrial lesio
REFERENCE   5  (bases 1 to 2329)
  AUTHORS   Delos,M., Foulquier,F., Hellec,C., Vicogne,D., Fifre,A.,
            Carpentier,M., Papy-Garcia,D., Allain,F. and Denys,A.
  TITLE     Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an
            unexpected subcellular localization in the plasma membrane
  JOURNAL   Biochim Biophys Acta Gen Subj 1862 (7), 1644-1655 (2018)
   PUBMED   29660372
  REMARK    GeneRIF: In primary macrophages, HS3ST2 was clearly visualized at
            the plasma membrane. Its truncated form remained in the Golgi
            apparatus, meaning that the catalytic domain might support correct
            addressing of HS3ST2 to cell surface. HS3ST2 partly co-localized
            with syndecan-2 in HeLa cells and primary macrophages suggesting
            that this enzyme may participate in discrete processes that occur
            at the cell surface.
REFERENCE   6  (bases 1 to 2329)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 2329)
  AUTHORS   Miyamoto,K., Asada,K., Fukutomi,T., Okochi,E., Yagi,Y.,
            Hasegawa,T., Asahara,T., Sugimura,T. and Ushijima,T.
  TITLE     Methylation-associated silencing of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and
            pancreatic cancers
  JOURNAL   Oncogene 22 (2), 274-280 (2003)
   PUBMED   12527896
  REMARK    GeneRIF: These results showed that silencing of 3-OST-2 was present
            in a wide range of human cancersFrom the high incidence, silencing
            of the 3-OST-2 gene is expected to have high diagnostic, and
            potentially therapeutic, values.
REFERENCE   8  (bases 1 to 2329)
  AUTHORS   Liu,J., Shworak,N.W., Sinay,P., Schwartz,J.J., Zhang,L.,
            Fritze,L.M. and Rosenberg,R.D.
  TITLE     Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase
            isoforms reveals novel substrate specificities
  JOURNAL   J Biol Chem 274 (8), 5185-5192 (1999)
   PUBMED   9988768
REFERENCE   9  (bases 1 to 2329)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
REFERENCE   10 (bases 1 to 2329)
  AUTHORS   Razi,N. and Lindahl,U.
  TITLE     Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl
            3-O-sulfotransferase reaction: target and inhibitor saccharides
  JOURNAL   J Biol Chem 270 (19), 11267-11275 (1995)
   PUBMED   7744762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130466.2 and AF105375.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006043.1.
            
            Summary: Heparan sulfate biosynthetic enzymes are key components in
            generating a myriad of distinct heparan sulfate fine structures
            that carry out multiple biologic activities. The enzyme encoded by
            this gene is a member of the heparan sulfate biosynthetic enzyme
            family. It is a type II integral membrane protein and possesses
            heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This
            gene is expressed predominantly in brain and may play a role in the
            nervous system. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.99338.1, AY359095.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261374.4/ ENSP00000261374.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               AC130466.2         48558-48934         c
            378-2329            AF105375.1         1-1952
FEATURES             Location/Qualifiers
     source          1..2329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..2329
                     /gene="HS3ST2"
                     /gene_synonym="30ST2; 3OST2"
                     /note="heparan sulfate-glucosamine 3-sulfotransferase 2"
                     /db_xref="GeneID:9956"
                     /db_xref="HGNC:HGNC:5195"
                     /db_xref="MIM:604056"
     exon            1..934
                     /gene="HS3ST2"
                     /gene_synonym="30ST2; 3OST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..1553
                     /gene="HS3ST2"
                     /gene_synonym="30ST2; 3OST2"
                     /EC_number="2.8.2.29"
                     /note="heparin-glucosamine 3-O-sulfotransferase; 3-OST-2;
                     h3-OST-2; heparan sulfate 3-O-sulfotransferase 2; heparan
                     sulfate (glucosamine) 3-O-sulfotransferase 2; heparan
                     sulfate D-glucosaminyl 3-O-sulfotransferase 2"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     2"
                     /protein_id="NP_006034.1"
                     /db_xref="CCDS:CCDS10606.1"
                     /db_xref="GeneID:9956"
                     /db_xref="HGNC:HGNC:5195"
                     /db_xref="MIM:604056"
                     /translation="MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDDL
                     GRSRLLGAPRCLRGPSAGGQKLLQKSRPCDPSGPTPSEPSAPSAPAAAVPAPRLSGSN
                     HSGSPKLGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDW
                     YRSLMPRTLESQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQT
                     LSKKPDIPTFEGLSFRNRTLGLVDVSWNAIRIGMYVLHLESWLQYFPLAQIHFVSGER
                     LITDPAGEMGRVQDFLGIKRFITDKHFYFNKTKGFPCLKKTESSLLPRCLGKSKGRTH
                     VQIDPEVIDQLREFYRPYNIKFYETVGQDFRWE"
     exon            935..2329
                     /gene="HS3ST2"
                     /gene_synonym="30ST2; 3OST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HS3ST2"
                     /gene_synonym="30ST2; 3OST2"
                     /note="hexamer: AATAAA"
     polyA_site      2329
                     /gene="HS3ST2"
                     /gene_synonym="30ST2; 3OST2"
                     /note="major polyA site"
ORIGIN      
        1 ggcatttccc gaagagccag atcgcggccg gcgccagcgc caccgtccgg tccacccgcc
       61 agcccgcaca gccgcgccgc cgccgagcgt ttcgtgagcg gcgctccgag gatcaggaat
      121 ggggcttcgg gcgctgggcg cgctccgaac ccggcgcacg taagagcctg ggagcgcccg
      181 agccgcccgg ctgcccggag ccccatcgcc taggaccggg agatgctgga aatgcaaccg
      241 cctgttcccc gaggagccgc tgcccccggg accccctggc actgtgcgca ccctggtcag
      301 cagcccccgg agaagacggc gcccccaacg cccgacccgc gtggccgtgg cagcgccacg
      361 cgagccctct aggcgaccgc agggccacag cagctcagcc gccggtgccc cctcggaaac
      421 catgaccccc ggcgcgggcc catggagcca tggcctatag ggtcctgggc cgcgcggggc
      481 cacctcagcc gcggagggcg cgcaggctgc tcttcgcctt cacgctctcg ctctcctgca
      541 cttacctgtg ttacagcttc ctgtgctgct gcgacgacct gggtcggagc cgcctcctcg
      601 gcgcgcctcg ctgcctccgc ggccccagcg cgggcggcca gaaacttctc cagaagtccc
      661 gcccctgtga tccctccggg ccgacgccca gcgagcccag cgctcccagc gcgcccgccg
      721 ccgccgtgcc cgcccctcgc ctctccggtt ccaaccactc cggctcaccc aagctgggta
      781 ccaagcggtt gccccaagcc ctcattgtgg gcgtgaagaa ggggggcacc cgggccgtgc
      841 tggagtttat ccgagtacac ccggacgtgc gggccttggg cacggaaccc cacttctttg
      901 acaggaacta cggccgcggg ctggattggt acaggagcct gatgcccagg accctcgaga
      961 gccagatcac gctggagaag acgcccagct actttgtcac tcaagaggct cctcgacgca
     1021 tcttcaacat gtcccgagac accaagctga tcgtggttgt gcggaaccct gtgacccgtg
     1081 ccatctctga ttacacgcag acactctcca agaagcccga catcccgacc tttgagggcc
     1141 tctccttccg caaccgcacc ctgggcctgg tggacgtgtc atggaacgcc atccgcatcg
     1201 gcatgtacgt gctgcacctg gagagctggc tgcagtactt cccgctagct cagattcact
     1261 tcgtcagtgg cgagcgactc atcactgacc cggccggcga gatggggcga gtccaggact
     1321 tcctgggcat taagagattc atcacggaca agcacttcta tttcaacaag accaaaggat
     1381 tcccttgctt gaaaaaaaca gaatcgagcc tcctgcctcg atgcttgggc aaatcaaaag
     1441 ggagaactca tgtacagatt gatcctgaag tgatagacca gctccgagaa ttttatagac
     1501 cgtataatat caaattttat gaaaccgttg ggcaggactt caggtgggaa taagcccacg
     1561 aaaggaaagg gctctcaagg gctcttctgc tcatctcttc cgtgagattt gctcccagac
     1621 cctctgatct ccctccaaca aaccctggct ccagccccct ttcccaactt gagttgcatc
     1681 atcttggaac caggaagccc agctaaagcc aagagaccag agagtccctg ccactagttt
     1741 tcatcagtct gttcaagcaa agttgatctg ctcctggcac gtccagtaaa ttccagaatc
     1801 attctccttt ctgcccataa agggccttgg agaattgctt taagaagagt gaatgttcca
     1861 atgatgatag atattataag cgatgatggt tctgttgcta tgaacacagc agtcggtccc
     1921 tgtcattgtc cacccaggag tggccttgtt aattccaagt ggcatgtatc ttccctctga
     1981 gcttcatttc ttcaagatgc tctgggtggt gggatgggag accatcctca gccctcctca
     2041 gaccttatca attcattgag agattgcaaa gctgaaagca cctccggcca ctcctgggag
     2101 acagaccctt tggtgatgaa ataaaccagt gacttcagag cctatggtct caactgtgct
     2161 tgaaaaacac tgtctctgaa aacaactttg tgattctccc tgctccctgt ggacaaaagc
     2221 acataattct gctgttacgg gtactttgct catacgagct ttcatgttca gcatgcaatg
     2281 gaatcatgct tgtccatgtg aaataaatat ggctctctcg tgtccttaa
//
