LOCUS       NM_001009931            9629 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens hornerin (HRNR), mRNA.
ACCESSION   NM_001009931 XM_373868
VERSION     NM_001009931.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9629)
  AUTHORS   Makino,T., Mizawa,M., Takemoto,K. and Shimizu,T.
  TITLE     Expression of hornerin in skin lesions of atopic dermatitis and
            skin diseases
  JOURNAL   Clin Exp Dermatol 49 (3), 255-258 (2024)
   PUBMED   38123340
  REMARK    GeneRIF: Expression of hornerin in skin lesions of atopic
            dermatitis and skin diseases.
REFERENCE   2  (bases 1 to 9629)
  AUTHORS   Xiang,Q., Wang,Z., Mu,G., Xie,Q., Liu,Z., Zhou,S., Zhang,H.,
            Wang,Z., Hu,K., Song,H., Yuan,D., Xia,Q., Huang,Y. and Cui,Y.
  TITLE     PROK2, HRNR, and FIG4 as potential genetic biomarkers of high
            bleeding propensity in East Asian patients with acute coronary
            syndrome using ticagrelor
  JOURNAL   Pharmacotherapy 42 (12), 872-879 (2022)
   PUBMED   36263704
  REMARK    GeneRIF: PROK2, HRNR, and FIG4 as potential genetic biomarkers of
            high bleeding propensity in East Asian patients with acute coronary
            syndrome using ticagrelor.
REFERENCE   3  (bases 1 to 9629)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 9629)
  AUTHORS   Romero,V., Nakaoka,H., Hosomichi,K. and Inoue,I.
  TITLE     High Order Formation and Evolution of Hornerin in Primates
  JOURNAL   Genome Biol Evol 10 (12), 3167-3175 (2018)
   PUBMED   30256937
  REMARK    GeneRIF: high order repeat formation conserved in apes
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9629)
  AUTHORS   Fu,S.J., Shen,S.L., Li,S.Q., Hua,Y.P., Hu,W.J., Guo,B. and
            Peng,B.G.
  TITLE     Hornerin promotes tumor progression and is associated with poor
            prognosis in hepatocellular carcinoma
  JOURNAL   BMC Cancer 18 (1), 815 (2018)
   PUBMED   30103712
  REMARK    GeneRIF: HRNR promotes tumor progression and is correlated with a
            poor hepatocellular carcinoma (HCC)prognosis. HRNR may contribute
            to HCC progression via the regulation of the AKT pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9629)
  AUTHORS   Stamer,W.D., Hoffman,E.A., Luther,J.M., Hachey,D.L. and Schey,K.L.
  TITLE     Protein profile of exosomes from trabecular meshwork cells
  JOURNAL   J Proteomics 74 (6), 796-804 (2011)
   PUBMED   21362503
REFERENCE   7  (bases 1 to 9629)
  AUTHORS   Henry,J., Hsu,C.Y., Haftek,M., Nachat,R., de Koning,H.D.,
            Gardinal-Galera,I., Hitomi,K., Balica,S., Jean-Decoster,C.,
            Schmitt,A.M., Paul,C., Serre,G. and Simon,M.
  TITLE     Hornerin is a component of the epidermal cornified cell envelopes
  JOURNAL   FASEB J 25 (5), 1567-1576 (2011)
   PUBMED   21282207
  REMARK    GeneRIF: The data demonstrate that HRNR is a component of cornified
            cell envelopes of human epidermis. Its reduced expression in AD may
            contribute to the epidermal barrier defect observed in the disease.
REFERENCE   8  (bases 1 to 9629)
  AUTHORS   Stemmler,S., Nothnagel,M., Parwez,Q., Petrasch-Parwez,E.,
            Epplen,J.T. and Hoffjan,S.
  TITLE     Variation in genes of the epidermal differentiation complex in
            German atopic dermatitis patients
  JOURNAL   Int J Immunogenet 36 (4), 217-222 (2009)
   PUBMED   19601998
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 9629)
  AUTHORS   Wu,Z., Meyer-Hoffert,U., Reithmayer,K., Paus,R., Hansmann,B.,
            He,Y., Bartels,J., Glaser,R., Harder,J. and Schroder,J.M.
  TITLE     Highly complex peptide aggregates of the S100 fused-type protein
            hornerin are present in human skin
  JOURNAL   J Invest Dermatol 129 (6), 1446-1458 (2009)
   PUBMED   19020553
  REMARK    GeneRIF: HRNR is expressed in healthy skin and contributes to its
            barrier function
REFERENCE   10 (bases 1 to 9629)
  AUTHORS   Takaishi,M., Makino,T., Morohashi,M. and Huh,N.H.
  TITLE     Identification of human hornerin and its expression in regenerating
            and psoriatic skin
  JOURNAL   J Biol Chem 280 (6), 4696-4703 (2005)
   PUBMED   15507446
  REMARK    GeneRIF: hornerin is expressed in regenerating and psoriatic skin
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589986.15.
            
            On Nov 27, 2019 this sequence version replaced NM_001009931.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY396741.1, BR000036.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368801.4/ ENSP00000357791.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL589986.15        128401-128451       c
            52-214              AL589986.15        127374-127536       c
            215-9629            AL589986.15        116334-125748       c
FEATURES             Location/Qualifiers
     source          1..9629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..9629
                     /gene="HRNR"
                     /gene_synonym="FLG3; S100A16; S100a18"
                     /note="hornerin"
                     /db_xref="GeneID:388697"
                     /db_xref="HGNC:HGNC:20846"
                     /db_xref="MIM:616293"
     exon            1..51
                     /gene="HRNR"
                     /gene_synonym="FLG3; S100A16; S100a18"
                     /inference="alignment:Splign:2.1.0"
     exon            52..214
                     /gene="HRNR"
                     /gene_synonym="FLG3; S100A16; S100a18"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..8629
                     /gene="HRNR"
                     /gene_synonym="FLG3; S100A16; S100a18"
                     /note="intermediate filament-associated protein; filaggrin
                     family member 3"
                     /codon_start=1
                     /product="hornerin"
                     /protein_id="NP_001009931.1"
                     /db_xref="CCDS:CCDS30859.1"
                     /db_xref="GeneID:388697"
                     /db_xref="HGNC:HGNC:20846"
                     /db_xref="MIM:616293"
                     /translation="MPKLLQGVITVIDVFYQYATQHGEYDTLNKAELKELLENEFHQI
                     LKNPNDPDTVDIILQSLDRDHNKKVDFTEYLLMIFKLVQARNKIIGKDYCQVSGSKLR
                     DDTHQHQEEQEETEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRLS
                     FQRDFSGQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGSGQSSSN
                     DTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSS
                     SGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYS
                     RGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGS
                     SSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSS
                     SSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQG
                     SSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSG
                     RSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCG
                     QHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGS
                     GWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSE
                     QHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSGT
                     SCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQ
                     HDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSG
                     RSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQ
                     HGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSG
                     SGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSS
                     CGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGS
                     GSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSS
                     RGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHG
                     SGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQS
                     STFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQH
                     GSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQ
                     SSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSY
                     SPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGST
                     SGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPS
                     YGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGS
                     RSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSS
                     SHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHG
                     STSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHS
                     SSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQH
                     GSRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGS
                     GQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTH
                     GQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSG
                     SRQSPSYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG
                     YGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGS
                     GSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFC
                     SQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHG
                     SGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHS
                     SSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG
                     RHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSS
                     GHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH
                     GQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSG
                     SGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPS
                     RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGS
                     GSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSL
                     SHGRHGSGSGQSSSYGQHGSGSGQSSGYSQHGSGSGQDGYSYCKGGSNHDGGSSGSYF
                     LSFPSSTSPYEYVQEQRCYFYQ"
     exon            215..9629
                     /gene="HRNR"
                     /gene_synonym="FLG3; S100A16; S100a18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctgaaag ctgtttctgt ctctacccta cttgttcctc tggtgagcta ggttactcaa
       61 acttgcaaaa aaaaaaatgc ctaaactcct acaaggcgtc atcactgtca tcgatgtttt
      121 ctaccaatat gccacccagc atggggagta tgatacgttg aacaaggcag agctgaaaga
      181 acttctggaa aatgagtttc atcaaattct gaagaatcca aacgatccag atactgtgga
      241 tatcatcttg caaagtctgg atcgagacca taacaagaaa gtggatttta ctgagtatct
      301 tctgatgata ttcaagctgg ttcaggctcg taataaaatc attggcaaag attactgcca
      361 agtttcaggg tcaaagctga gagatgacac tcaccagcac caagaggaac aagaagaaac
      421 tgaaaaagag gagaacaaac ggcaagaatc ctcttttagt cattcaagtt ggagtgcagg
      481 agagaatgat tcctattcca gaaacgtcag aggaagtctt aaacctggga ctgaatccat
      541 atccagaaga ctgagttttc aaagagactt ttctggccaa cataactcct actcaggtca
      601 gtcttccagc tatggtgagc aaaactccga ctcccatcag tcttcaggcc gcggccaatg
      661 tgggtctggg tcagggcagt ctcccaacta tggccaacac ggctctggct ccggacagtc
      721 ttccagcaat gacacacatg ggtctggctc aggccagtct tctggcttta gtcaacacaa
      781 gtctagctca gggcagtcct ctggttacag tcagcatgga tctggctcag gtcactcctc
      841 tggctacgga caacacggct ctaggtcagg acagtcatct aggggtgaac gacacagatc
      901 tagctcaggt tcgtcttcca gctatggtca gcatgggtct ggttcccgtc agtctttggg
      961 ccacggccga caagggtctg gatctcgcca gtctcctagc cacgtccgac atgggtccgg
     1021 ttcggggcac tcctccagcc acggccaaca cgggtctggc tcaagttact cttacagccg
     1081 tggccattat gagtctggct caggccagac ttctggcttt gggcaacatg agtctggctc
     1141 aggacagtcc tctggctata gtaagcatgg ttctggctca ggtcactcct ctagccaggg
     1201 acaacatgga tctacgtcag ggcaggcatc aagctctggc caacatggct ccagctcacg
     1261 tcagtcttcc agctatggtc agcatgagtc tgcctcccgt cactcttcag gccgcggcca
     1321 acacagctct ggatctggcc agtctccagg ccacggccag cgtgggtctg ggtcagggca
     1381 gtctcccagc tccggccaac atgggactgg ctttggtcga tcttccagca gtggcccata
     1441 tgtgtctggt tcaggctact cttctggctt tggtcaccac gagtctagct cagagcattc
     1501 ctctggttac actcagcatg gatctggctc aggtcactcc tccggccacg gacaacacgg
     1561 ctctaggtca ggacagtcat ctaggggtga acgacaagga tctagtgcag gttcatcttc
     1621 cagctatggt cagcatgggt ctggctcccg tcaatctttg ggacacagcc gacatgggtc
     1681 tggatctggc cagtctccta gccctagccg tggccgacat gagtctggtt ccaggcagtc
     1741 ttccagctat ggcccacatg ggtatggctc agggaggtct tcaagccgtg gcccatatga
     1801 gtctggctcc ggtcactctt ctggcttagg tcaccaagag tctcgctcag gacagtcctc
     1861 tggctacggt caacacggat ctagctcggg tcattcctct acccatgggc aacatggttc
     1921 tacatcagga cagtcatcga gctgtggcca acatggagct acctcaggtc agtcttccag
     1981 ccacggtcag catggctctg gctcaagtca gtcttctcgc tatggccaac agggctctgg
     2041 atctggccag tctcctagtc gcggccgaca tgggtccgat tttgggcact cttccagcta
     2101 cggccaacat gggtctggct ccggttggtc ttcaagcaat ggcccacatg ggtctgtctc
     2161 aggccagtct tccggctttg gtcacaagtc tggctcaggg cagtcctctg gttacagtca
     2221 gcatggatct ggctcaagtc actcctccgg ctacagaaaa cacggctcta ggtcaggaca
     2281 gtcatctagg agtgaacaac acggatctag ctcaggtttg tcttccagct atggtcagca
     2341 tgggtcgggc tcccatcaat cttcgggcca cggccgacaa gggtctggat ctggccactc
     2401 tcctagccgt gtccgacatg ggtccagttc agggcactcc tccagccacg gccaacacgg
     2461 gtctggcaca agttgttctt ccagctgtgg ccattatgag tctggctcag gccaggcttc
     2521 tggttttggg caacacgagt ctggctcagg acagggctat agtcagcatg gttctgcctc
     2581 aggtcacttc tctagccagg gacgacatgg atctacgtca gggcagtcat caagctccgg
     2641 ccaacatgac tctagctcag gtcaatcttc cagctatggt cagcatgagt ctgcctccca
     2701 tcacgcttcg ggccgcggcc gacatggctc tggatctggc cagtctccag gccacggcca
     2761 gcgtgggtct gggtcagggc agtctcccag ctatggccga catgggtctg gctccggtcg
     2821 gtcttccagc agtggccgac atgggtctgg ctcaggccag tcttctggct ttggtcacaa
     2881 gtctagctca gggcagtcct ctggttacac tcagcatgga tctggctcag gtcactcctc
     2941 cagctacgaa caacacggct ctaggtcagg acagtcatct aggagcgaac aacatggatc
     3001 tagctcaggt tcgtcttcca gctatggtca gcatgggtct ggctcccgtc agtctttggg
     3061 ccacggccaa catgggtctg gatctggcca gtctcctagc cctagccgtg gccgacatgg
     3121 gtctggttcc gggcagtctt ccagctatgg cccatatagg tctggctcag ggtggtcttc
     3181 aagccgtggc ccatatgagt ctggctccgg tcactcttct ggcttaggtc accgagagtc
     3241 tcgctcagga cagtcctctg gctacggtca acatggatct agctcaggtc attcctctac
     3301 ccatgggcaa cacggttcta catcaggaca gtcatcgagc tgtggccaac atggagctag
     3361 ctcaggtcag tcttccagcc acggtcagca tggctctggc tcaagtcagt cttctggcta
     3421 tggccgacag ggctctggat ctggccagtc tccaggccac ggccagcgtg ggtctgggtc
     3481 aaggcagtct cccagctacg gccgacatgg gtctggctcc ggtcggtctt ccagcagtgg
     3541 ccaacatggg tctggcttag gcgagtcttc tggctttggt caccacgagt ctagctcagg
     3601 gcagtcctct agttacagtc agcatgggtc tggctcaggt cactcctctg gctacggaca
     3661 acacggctct agatcaggac agtcatctag gggtgaacga cacggatcta gctcaggttc
     3721 gtcttcccac tatggtcagc atgggtctgg ctcccgtcag tcttcgggcc acggccgaca
     3781 agggtctgga tctggccatt cccctagccg cggccgacat gggtccggtt tggggcactc
     3841 ctccagccac ggccaacatg ggtctggctc aggtcgttct tccagccgtg gcccatatga
     3901 gtctcgctcg ggtcactctt ctgtctttgg tcaacatgag tctggctcag gacattcctc
     3961 tgcttacagt cagcatggta gtggctcagg gcacttctgt agccaaggac agcatggttc
     4021 tacatcagga cagtcatcaa cctttgacca ggagggatct agcacaggcc agtcttccag
     4081 ctatggccac cgtggctctg gctccagtca gtcttctggc tatggccgac atggggctgg
     4141 atctggccag tctcctagtc gcggccgaca tgggtccggt tctgggcact cttccagcta
     4201 cggccaacat gggtctggct ccggttggtc ttccagcagt ggccgacatg ggtctggctc
     4261 aggtcagtct tctggatttg gtcaccacga gtctagctca tggcagtcct ctggttgcac
     4321 tcagcatgga tctggctcag gtcactcctc cagctacgaa caacacggct ctaggtcagg
     4381 acagtcatct aggggtgaac gacacggatc tagctcaggt tcatcttcca gctatggtca
     4441 gcatgggtct ggctcccgtc agtctttggg ccacggccaa catgggtctg gatctggcca
     4501 gtctcctagc cctagccgtg gccgacatgg gtctggttct gggcagtctt ccagctacag
     4561 cccatatggg tctggctcag ggtggtcttc cagccgtggc ccatatgagt ctggctccag
     4621 tcactcttct ggcttaggtc accgagagtc tcgctcagga cagtcctctg gctacggtca
     4681 acatggatct agctcaggtc attcctctac ccatgggcaa catggttcta catcaggaca
     4741 gtcatcgagc tgtggccaac atggagctag ctcaggtcag tcttccagcc acggtcagca
     4801 tggctctggc tcaagtcagt cttctggcta tggccgacag ggctctggat ctggccagtc
     4861 tccaggccac ggccagcgtg ggtctgggtc aaggcagtct cccagctacg gccgacatgg
     4921 gtctggctcc ggtcggtctt ccagcagtgg ccaacatggg tctggcttag gcgagtcttc
     4981 tggctttggt caccacgagt ctagctcagg gcagtcctct agttacagtc agcatgggtc
     5041 tggctcaggt cactcctctg gctacggaca acacggctct agatcaggac agtcatctag
     5101 gggtgaacga cacggatcta gctcacgttc gtcttcccgc tatggtcagc atgggtctgg
     5161 ctcccgtcag tcttcgggcc acggccgaca agggtctgga tctggccagt cccctagccg
     5221 cggccgacat gggtccggtt tggggcactc ctccagccac ggccaacatg ggtctggctc
     5281 aggtcgttct tccagccgtg gcccatatga gtctcgctcg ggtcactctt ctgtctttgg
     5341 tcaacatgag tctggctcag gacattcctc tgcttacagt cagcatggta gtggctcagg
     5401 gcacttctgt agccaaggac agcatggttc tacatcagga cagtcatcaa cctttgacca
     5461 ggagggatct agcacaggtc agtcttccag ccacggtcag catggctctg gctcaagtca
     5521 gtcttctagc tatggccaac agggctctgg atctggccag tctcctagtc gcggccgaca
     5581 tgggtccggt tccgggcact cttccagcta cggccaacat gggtctggct ccggttggtc
     5641 ttccagcagt ggccgacatg ggtctggctc aggtcagtct tctggatttg gtcaccatga
     5701 gtctagctca tggcagtcct ctggttacac tcagcatgga tctggctcag gtcactcctc
     5761 cagctacgaa caacacggct ctaggtcagg acagtcatct aggggtgaac aacacggatc
     5821 tagctcaggt tcatcttcca gctatggtca gcatgggtct ggctcccgtc agtctttggg
     5881 ccacggccaa catgggtctg gatctggcca gtctcctagc cctagccgtg gccgacatgg
     5941 gtctggttct gggcagtctt ccagctacgg cccatatggg tctggctcag ggtggtcttc
     6001 cagccgtggc ccatatgagt ctggctccgg tcactcttct ggcttaggtc accgagagtc
     6061 tcgctcagga cagtcctctg gctacggtca acatggatct agctcaggtc attcctctac
     6121 ccatgggcaa catggttctg catcaggaca gtcatcgagc tgtggccaac atggagctag
     6181 ctcaggtcag tcttccagcc acggtcagca tggctctggc tcaagtcagt cttctggcta
     6241 tggccgacag ggctctggat ctggccagtc tccaggccac ggccagcgtg ggtctgggtc
     6301 aaggcagtct cccagctatg gccgacatgg gtctggctcc ggtcggtctt ccagcagtgg
     6361 ccaacatggg cctggcttag gcgagtcttc tggctttggt caccacgagt ctagctcagg
     6421 gcagtcctct agttacagtc agcatgggtc tggctcaggt cactcctctg gctacggaca
     6481 acacggctct agatcaggac agtcatctag gggtgaacga cacggatcta gctcaggttc
     6541 gtcttcccgc tatggtcagc atgggtctgg ctcccgtcag tcttcgggcc acggccgaca
     6601 agggtctgga tctggccatt cccctagccg cggccgacat gggtccggtt cggggcactc
     6661 ctccagccac ggccaacatg ggtctggctc aggtcgttct tccagccgtg gcccatatga
     6721 gtctcgctcg ggtcactctt ctgtctttgg tcaacatgag tctggctcag gacattcctc
     6781 tgcttacagt cagcatggta gtggctcagg gcacttctgt agccaaggac agcatggttc
     6841 tacatcagga cagtcatcaa cctttgacca ggagggatct agcacaggtc agtcttccag
     6901 ccacggtcag catggctctg gctcaagtca gtcttctagc tatggccaac agggctctgg
     6961 atctggccag tctcctagtc gcggccgaca tgggtccggt tccgggcact cttccagcta
     7021 cggccaacat gggtctggct ccggttggtc ttccagcagt ggccgacatg ggtctggctc
     7081 aggtcagtct tctggatttg gtcaccacga gtctagctca tggcagtcct ctggttacac
     7141 tcagcatgga tctggctcag gtcactcctc cagctacgaa caacacggct ctaggtcagg
     7201 acagtcatct aggggtgaac gacacggatc tagctcaggt tcatcttcca gctatggtca
     7261 gcatgggtct ggctcccgtc agtctttggg ccacggccaa catgggtctg gatctggcca
     7321 gtctcctagc cctagccgtg gccgacatgg gtctggttct gggcagtctt ccagctacag
     7381 cccatatggg tctggctcag ggtggtcttc cagccgtggc ccatatgagt ctggctccgg
     7441 tcactcttct ggcttaggtc accgagagtc tcgctcagga cagtcctctg gctacggtca
     7501 acatggatct agctcaggtc attcctctac ccatgggcaa catggttcta catcaggaca
     7561 gtcatcgagc tgtggccaac atggagctag ctcaggtcag tcttccagcc acggtcagca
     7621 tggctctggc tcaagtcagt cttctggcta tggccgacag ggctctggat ctggccagtc
     7681 tccaggccac ggccagcgtg ggtctgggtc aaggcagtct cccagctacg gccgacatgg
     7741 gtctggctcc ggtcggtctt ccagcagtgg ccaacatggg tctggcttag gcgagtcttc
     7801 tggctttggt caccacgagt ctagctcagg gcagtcctct agttacagtc agcatgggtc
     7861 tggctcaggt cactcctctg gctacggaca acacggctct agatcaggac agtcatctag
     7921 gggtgaacga cacggatcta gctcaggttc gtcttcccac tatggtcagc atgggtctgg
     7981 ctcccgtcag tcttcgggcc acggccgaca agggtctgga tctggccagt cccctagccg
     8041 cggccgacat gggtccggtt tggggcactc ctccagccac ggccaacatg ggtctggctc
     8101 aggtcgttct tccagccgtg gcccatatga gtctcgcttg ggtcactctt ctgtctttgg
     8161 tcaacatgag tctggctcag gacattcctc tgcttacagt cagcatggta gtggctcagg
     8221 gcacttctgt agccaaggac agcatggttc tacatcagga cagtcatcaa cctttgacca
     8281 ggagggatct agcacaggcc agtcttccag ctatggccac cgtggctctg gctccagtca
     8341 gtcttctggc tatggccgac atggggctgg atctggccag tctcttagcc acggccgaca
     8401 cgggtctggt tcagggcagt cttccagcta cggccaacat gggtctggct caggacagtc
     8461 ctctggttat agtcagcatg gaagtggctc agggcaagat gggtattctt attgcaaagg
     8521 aggaagtaac catgatgggg gaagttctgg ctcatatttt ctcagttttc ctagtagcac
     8581 ttcaccctat gaatatgtcc aagagcagag gtgctacttt tatcagtgaa taataaacat
     8641 aaatgcaatt tactcaagta gcaatttaag aaataggaaa gtcatctatg aattcatcat
     8701 gaaagacaag caatccatca tgaaattcgt tctaaaagtg aatcaatgca tttctgtctc
     8761 tttctttaga gcctaaaact gtagcatata tcttgttatg gggttccttc caaagactgt
     8821 taggcatttg tgctactttg ttagaaaata ctgagtggaa taacttgtta gaatgagggt
     8881 taaactttga ggaataatga aaagctttta aagagctttg ggtttagttg gagttgtctt
     8941 tttgagagct catcattcat ttatagatgg tgccaaagct aaccttacat ttcttagaag
     9001 caaaatatta caaatgcatt accagtccta gatacaaagc tttgttttac agcaattagt
     9061 gtaccctaat ttttagtgtg ccccaagttt ggtgtgtccc aatttttggt attgtggcag
     9121 aaggtgaagg ctctgaaagc aaagatgcag cagcggtagt gtctttactt atcaaaacca
     9181 tcaagtcctt tttcttgggt atatatttaa tcagtaagtt aattagtggc ataaaaaagt
     9241 agcatcaggg tcttttccca agccagtgag caagagcatt atttcataaa gaatagggat
     9301 ttatcatttc aggaaaaaaa aaaacattca aatgtgggct ttagcttgtt ttcagcagaa
     9361 agatcttgct ccctatttct aagaggctgc tcaatattgg gaaatatatt gaggagttat
     9421 tccatggaaa tacaatgctt tccacctact actgtagttc aataacgttt ccacctgaaa
     9481 aaatatcatc catgcccaga tgaaaaggaa gagtatctgt cactgctaca tagttcctta
     9541 atttgactgt aacacatttg tttcaagtct ttggattcaa acaaccggat tgtattaaaa
     9601 ttgacaataa ataaatgttg attaaatac
//
