LOCUS       NM_021624               3664 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens histamine receptor H4 (HRH4), transcript variant 1,
            mRNA.
ACCESSION   NM_021624
VERSION     NM_021624.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Schrammel,J.C., Konig,M., Frommer,M., Andersen,K.S., Kirsten,M.,
            Seifert,R., Neumann,D. and Schirmer,B.
  TITLE     Histamine H1- and H4-receptor expression in human colon-derived
            cell lines
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (12), 3683-3693 (2023)
   PUBMED   37300703
  REMARK    GeneRIF: Histamine H1- and H4-receptor expression in human
            colon-derived cell lines.
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Seldeslachts,A., Peigneur,S., Mebs,D. and Tytgat,J.
  TITLE     Unraveling the venom chemistry with evidence for histamine as key
            regulator in the envenomation by caterpillar Automeris zaruma
  JOURNAL   Front Immunol 13, 972442 (2022)
   PUBMED   36091066
  REMARK    GeneRIF: Unraveling the venom chemistry with evidence for histamine
            as key regulator in the envenomation by caterpillar Automeris
            zaruma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Speisky,D., Taquez Delgado,M.A., Iotti,A., Nicoud,M.B.,
            Ospital,I.A., Vigovich,F., Dezanzo,P., Ernst,G., Uriburu,J.L. and
            Medina,V.A.
  TITLE     Histamine H4 Receptor Expression in Triple-negative Breast Cancer:
            An Exploratory Study
  JOURNAL   J Histochem Cytochem 70 (4), 311-322 (2022)
   PUBMED   35227109
  REMARK    GeneRIF: Histamine H4 Receptor Expression in Triple-negative Breast
            Cancer: An Exploratory Study.
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Clauzure,M., Taquez Delgado,M.A., Phillip,J.M., Revuelta,M.V.,
            Cerchietti,L. and Medina,V.A.
  TITLE     Histamine H4 Receptor Agonism Induces Antitumor Effects in Human
            T-Cell Lymphoma
  JOURNAL   Int J Mol Sci 23 (3), 1378 (2022)
   PUBMED   35163302
  REMARK    GeneRIF: Histamine H4 Receptor Agonism Induces Antitumor Effects in
            Human T-Cell Lymphoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Ma,X., Verweij,E.W.E., Siderius,M., Leurs,R. and Vischer,H.F.
  TITLE     Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor
  JOURNAL   Biomolecules 11 (8), 1127 (2021)
   PUBMED   34439793
  REMARK    GeneRIF: Identification of TSPAN4 as Novel Histamine H4 Receptor
            Interactor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   van Rijn,R.M., van Marle,A., Chazot,P.L., Langemeijer,E., Qin,Y.,
            Shenton,F.C., Lim,H.D., Zuiderveld,O.P., Sansuk,K., Dy,M.,
            Smit,M.J., Tensen,C.P., Bakker,R.A. and Leurs,R.
  TITLE     Cloning and characterization of dominant negative splice variants
            of the human histamine H4 receptor
  JOURNAL   Biochem J 414 (1), 121-131 (2008)
   PUBMED   18452403
  REMARK    GeneRIF: Recombinant histamine 4 receptor (H4R) splice variants
            derived from cord blood cells have a dominant negative effect on
            functionality, as these H4R are retained intracellularly and
            inactivate a population of H4R, presumably via
            hetero-oligomerization.
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Nguyen,T., Shapiro,D.A., George,S.R., Setola,V., Lee,D.K.,
            Cheng,R., Rauser,L., Lee,S.P., Lynch,K.R., Roth,B.L. and
            O'Dowd,B.F.
  TITLE     Discovery of a novel member of the histamine receptor family
  JOURNAL   Mol Pharmacol 59 (3), 427-433 (2001)
   PUBMED   11179435
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Liu,C., Ma,X., Jiang,X., Wilson,S.J., Hofstra,C.L., Blevitt,J.,
            Pyati,J., Li,X., Chai,W., Carruthers,N. and Lovenberg,T.W.
  TITLE     Cloning and pharmacological characterization of a fourth histamine
            receptor (H(4)) expressed in bone marrow
  JOURNAL   Mol Pharmacol 59 (3), 420-426 (2001)
   PUBMED   11179434
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Nakamura,T., Itadani,H., Hidaka,Y., Ohta,M. and Tanaka,K.
  TITLE     Molecular cloning and characterization of a new human histamine
            receptor, HH4R
  JOURNAL   Biochem Biophys Res Commun 279 (2), 615-620 (2000)
   PUBMED   11118334
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Oda,T., Morikawa,N., Saito,Y., Masuho,Y. and Matsumoto,S.
  TITLE     Molecular cloning and characterization of a novel type of histamine
            receptor preferentially expressed in leukocytes
  JOURNAL   J Biol Chem 275 (47), 36781-36786 (2000)
   PUBMED   10973974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF312230.1 and AC007922.13.
            
            On Nov 23, 2018 this sequence version replaced NM_021624.3.
            
            Summary: Histamine is a ubiquitous messenger molecule released from
            mast cells, enterochromaffin-like cells, and neurons. Its various
            actions are mediated by a family of histamine receptors, which are
            a subset of the G-protein coupled receptor superfamily. This gene
            encodes a histamine receptor that is predominantly expressed in
            haematopoietic cells. The protein is thought to play a role in
            inflammation and allergy reponses. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312230.1, BC112348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256906.5/ ENSP00000256906.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2336              AF312230.1         9-2344
            2337-3059           AC007922.13        57932-58654         c
            3060-3660           AF312230.1         3071-3671
            3661-3664           AC007922.13        57327-57330         c
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..3664
                     /gene="HRH4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /note="histamine receptor H4"
                     /db_xref="GeneID:59340"
                     /db_xref="HGNC:HGNC:17383"
                     /db_xref="MIM:606792"
     exon            1..285
                     /gene="HRH4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1265
                     /gene="HRH4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histamine H4 receptor; SP9144; pfi-013; G-protein coupled
                     receptor 105"
                     /codon_start=1
                     /product="histamine H4 receptor isoform 1"
                     /protein_id="NP_067637.2"
                     /db_xref="CCDS:CCDS11887.1"
                     /db_xref="GeneID:59340"
                     /db_xref="HGNC:HGNC:17383"
                     /db_xref="MIM:606792"
                     /translation="MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDK
                     NLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASV
                     YNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDE
                     GSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTA
                     VSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKM
                     GSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATG
                     PKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS"
     exon            286..449
                     /gene="HRH4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /inference="alignment:Splign:2.1.0"
     exon            450..3664
                     /gene="HRH4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3641..3646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HRH4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /note="hexamer: AATAAA"
     polyA_site      3664
                     /gene="HRH4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /note="major polyA site"
ORIGIN      
        1 acacatttta ggtatgtgat tagaaaacat acttgtcaga attgtctggc tggattaatt
       61 tgctaatttg accttcttca tcatttgatg tgatgccaga tactaatagc acaatcaatt
      121 tatcactaag cactcgtgtt actttagcat tttttatgtc cttagtagct tttgctataa
      181 tgctaggaaa tgctttggtc attttagctt ttgtggtgga caaaaacctt agacatcgaa
      241 gtagttattt ttttcttaac ttggccatct ctgacttctt tgtgggtgtg atctccattc
      301 ctttgtacat ccctcacacg ctgttcgaat gggattttgg aaaggaaatc tgtgtatttt
      361 ggctcactac tgactatctg ttatgtacag catctgtata taacattgtc ctcatcagct
      421 atgatcgata cctgtcagtc tcaaatgctg tgtcttatag aactcaacat actggggtct
      481 tgaagattgt tactctgatg gtggccgttt gggtgctggc cttcttagtg aatgggccaa
      541 tgattctagt ttcagagtct tggaaggatg aaggtagtga atgtgaacct ggattttttt
      601 cggaatggta catccttgcc atcacatcat tcttggaatt cgtgatccca gtcatcttag
      661 tcgcttattt caacatgaat atttattgga gcctgtggaa gcgtgatcat ctcagtaggt
      721 gccaaagcca tcctggactg actgctgtct cttccaacat ctgtggacac tcattcagag
      781 gtagactatc ttcaaggaga tctctttctg catcgacaga agttcctgca tcctttcatt
      841 cagagagaca gaggagaaag agtagtctca tgttttcctc aagaaccaag atgaatagca
      901 atacaattgc ttccaaaatg ggttccttct cccaatcaga ttctgtagct cttcaccaaa
      961 gggaacatgt tgaactgctt agagccagga gattagccaa gtcactggcc attctcttag
     1021 gggtttttgc tgtttgctgg gctccatatt ctctgttcac aattgtcctt tcattttatt
     1081 cctcagcaac aggtcctaaa tcagtttggt atagaattgc attttggctt cagtggttca
     1141 attcctttgt caatcctctt ttgtatccat tgtgtcacaa gcgctttcaa aaggctttct
     1201 tgaaaatatt ttgtataaaa aagcaacctc taccatcaca acacagtcgg tcagtatctt
     1261 cttaaagaca attttctcac ctctgtaaat tttagtctca atctcaccta aatgaatcag
     1321 gtctgccctt tatcttgccc ttttcattct accaacagat ctgcactttg aagtcaatgg
     1381 taaattactc cagtgaataa tagcagtata atatgacttg ataatatttt tgtaaacttg
     1441 tagtcataat agtactatat tcttcttagt cctcacctct tccttgtctt ttagatctta
     1501 atttcatgct gattacaaaa atccagtttt gttttctttc tatgttccat gcataataca
     1561 gtcttaagtg aatttctctt ttttaatttt atcgtaatag aaacttatcc agtttgaaaa
     1621 tcattcccta aagcatgcaa taggaaaaag aacctcctgg ctgggactgc ccaactctgt
     1681 tctgatcagt gggtgggtga ggtagggttt gagttggcaa gagcagggaa cgggcatgtg
     1741 cccaggtgag ctcctgtgtg tgtccagatt ttatattcct aatcccagta aggaagaaag
     1801 cgtagtgtgg gagaggagag agctgatgac tgcagttctc aaaggtcctc agtgaagtta
     1861 ttttggaggc cctggtggtc acaggatcag aaggcaaggg ataggcagtg gtcaccaatg
     1921 gttgaaagta tggcttgtcc catttcttcc tgttctcttt ttctagcttc cacatcagct
     1981 tccttttttg agaacatata gaagaagaag gctaagagat ggtgaagaga ctgcatgatt
     2041 aaactagata gacctggtat acagtcactg aactagtaga tgtcaataat tattattttt
     2101 aaaaattttt atttgttggc cgggcatggt ggctcacgcc tgaaatccca gcactttggg
     2161 aggccaaggt gggcggatca tgaggtcagg agatcgagac catcctggcc aacatggtga
     2221 aaccccatct gtactaaaat acaaacaagt agctggttgt ggcgccgcat gcctgtagtc
     2281 ccagctactc gggaggctga ggcaggggaa ttgcttgaac ccgggaggcg gagtttgcca
     2341 gcctggcaac agaacaagac tctgtctaaa aagaaaaaaa aatttttttg tttaagacag
     2401 catcttgctc tgtctcccag gctggagcgt agtaatgcaa tcatagctca ctgcagcctg
     2461 gaactccttg gctcaagcaa tcctgctgcc ttggcctccc aagtatgtag gactacaggt
     2521 actcgccacc acacctggat aattaaaaaa ttatttctgt agagatgaag tctcactgtg
     2581 ttgcccagcc tgggtgtcaa taattatttt ttaaaaaaaa tttttaaaaa ggttttttga
     2641 gacagattct tgctctgtca cccaggctgg agtgcagtag catgatcagg gatcactgca
     2701 acctctgcct cctgggttca agcgattctt gtgcctaagc cacctgagca gctgggatta
     2761 caggtgcatg ccaccatgcc tggctaattt tggtattttt agtagagatg aggttttgcc
     2821 attttggtca ggctggaatt tttttttttt taattttgat aagacagggt attgccgtgt
     2881 tggccagact ggtctcaaac tcctgggctg aaacaatcct cccgccttgg cctcccaaag
     2941 tgctgggatt ataggcacaa gacaccacaa taattattgc ctgtatgtca attattattt
     3001 taaaatattg ttgtatttac ttaatgtctt taatgcattt gcccaatatt ttacattgta
     3061 ctgctcagag gtattccttt attatgtggt tagcataggt tatactttgc tgacgattca
     3121 cattttatta gtttggttat gttttgtcct tttaaaacat tttcttttga gatgggggtc
     3181 ttgctctgtt gcccacgcag gagtgcagtg gcatgctctc agctcactgc agccctgact
     3241 gcctaggctc cagcaatctt cttacgtcag cctccagagt agctgggacc gcaggcactt
     3301 gccaccacgc cccactaaaa attttttaaa ttgttgcctt tcttgaagtg ttctctgcct
     3361 gtctttgtca caaaatttca tttttctcat agttaatttc atctctccgg taagatttta
     3421 ttggtgtttc ttttataact ttgcagttct tacaccgttt ggtgattttc atgtttctta
     3481 gaaactttaa acctttaact tcaaacatta aaatacaagt cttttaagta catgagtgct
     3541 tagaaatgta cataatgttt atatacactt atgccttaca ttaaagtcca atatgagaaa
     3601 tacatgttta acattcaata ataattttaa aaatttgaga aataaactct cataaatgca
     3661 caca
//
