LOCUS       NM_007232               2692 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens histamine receptor H3 (HRH3), mRNA.
ACCESSION   NM_007232
VERSION     NM_007232.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2692)
  AUTHORS   Watanabe,A., Nakajima,A. and Shiroishi,M.
  TITLE     Recovery of the histamine H3 receptor activity lost in yeast cells
            through error-prone PCR and in vivo selection
  JOURNAL   Sci Rep 13 (1), 16127 (2023)
   PUBMED   37752220
  REMARK    GeneRIF: Recovery of the histamine H3 receptor activity lost in
            yeast cells through error-prone PCR and in vivo selection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2692)
  AUTHORS   Seldeslachts,A., Peigneur,S., Mebs,D. and Tytgat,J.
  TITLE     Unraveling the venom chemistry with evidence for histamine as key
            regulator in the envenomation by caterpillar Automeris zaruma
  JOURNAL   Front Immunol 13, 972442 (2022)
   PUBMED   36091066
  REMARK    GeneRIF: Unraveling the venom chemistry with evidence for histamine
            as key regulator in the envenomation by caterpillar Automeris
            zaruma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2692)
  AUTHORS   Pallardo-Fernandez,I., Munoz-Rodriguez,J.R., Gonzalez-Martin,C. and
            Alguacil,L.F.
  TITLE     Histamine H3 receptor gene variants associated with drug abuse in
            patients with cocaine use disorder
  JOURNAL   J Psychopharmacol 34 (11), 1326-1330 (2020)
   PUBMED   33063610
  REMARK    GeneRIF: Histamine H3 receptor gene variants associated with drug
            abuse in patients with cocaine use disorder.
REFERENCE   4  (bases 1 to 2692)
  AUTHORS   Yu,D., Zhao,J., Wang,Y., Hu,J., Zhao,Q., Li,J. and Zhu,J.
  TITLE     Upregulated histamine receptor H3 promotes tumor growth and
            metastasis in hepatocellular carcinoma
  JOURNAL   Oncol Rep 41 (6), 3347-3354 (2019)
   PUBMED   31002350
  REMARK    GeneRIF: These findings revealed that HRH3 serves an important role
            in the growth and metastasis of hepatocellular carcinomacells,
            which provides experimental evidence supporting the application of
            HRH3 as a potential therapeutic target in hepatocellular carcinoma
            treatment
REFERENCE   5  (bases 1 to 2692)
  AUTHORS   Bakker,R.A.
  TITLE     Histamine H3-receptor isoforms
  JOURNAL   Inflamm Res 53 (10), 509-516 (2004)
   PUBMED   15597144
  REMARK    Review article
REFERENCE   6  (bases 1 to 2692)
  AUTHORS   Wellendorph,P., Goodman,M.W., Burstein,E.S., Nash,N.R., Brann,M.R.
            and Weiner,D.M.
  TITLE     Molecular cloning and pharmacology of functionally distinct
            isoforms of the human histamine H(3) receptor
  JOURNAL   Neuropharmacology 42 (7), 929-940 (2002)
   PUBMED   12069903
  REMARK    GeneRIF: Molecular cloning of functionally distinct isoforms of the
            human histamine H(3) receptor
REFERENCE   7  (bases 1 to 2692)
  AUTHORS   Nakamura,T., Itadani,H., Hidaka,Y., Ohta,M. and Tanaka,K.
  TITLE     Molecular cloning and characterization of a new human histamine
            receptor, HH4R
  JOURNAL   Biochem Biophys Res Commun 279 (2), 615-620 (2000)
   PUBMED   11118334
REFERENCE   8  (bases 1 to 2692)
  AUTHORS   Lovenberg,T.W., Roland,B.L., Wilson,S.J., Jiang,X., Pyati,J.,
            Huvar,A., Jackson,M.R. and Erlander,M.G.
  TITLE     Cloning and functional expression of the human histamine H3
            receptor
  JOURNAL   Mol Pharmacol 55 (6), 1101-1107 (1999)
   PUBMED   10347254
REFERENCE   9  (bases 1 to 2692)
  AUTHORS   Malinowska,B., Godlewski,G. and Schlicker,E.
  TITLE     Histamine H3 receptors--general characterization and their function
            in the cardiovascular system
  JOURNAL   J Physiol Pharmacol 49 (2), 191-211 (1998)
   PUBMED   9670104
  REMARK    Review article
REFERENCE   10 (bases 1 to 2692)
  AUTHORS   Hill,S.J., Ganellin,C.R., Timmerman,H., Schwartz,J.C.,
            Shankley,N.P., Young,J.M., Schunack,W., Levi,R. and Haas,H.L.
  TITLE     International Union of Pharmacology. XIII. Classification of
            histamine receptors
  JOURNAL   Pharmacol Rev 49 (3), 253-278 (1997)
   PUBMED   9311023
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL078633.32.
            
            On Nov 23, 2018 this sequence version replaced NM_007232.2.
            
            Summary: Histamine is a ubiquitous messenger molecule released from
            mast cells, enterochromaffin-like cells, and neurons. Its various
            actions are mediated by histamine receptors H1, H2, H3 and H4. This
            gene encodes one of the histamine receptors (H3) which belongs to
            the family 1 of G protein-coupled receptors. It is an integral
            membrane protein and can regulate neurotransmitter release. This
            receptor can also increase voltage-dependent calcium current in
            smooth muscles and innervates the blood vessels and the heart in
            cardiovascular system. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF140538.1, SRR3476690.923662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340177.10/ ENSP00000342560.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL078633.32        15398-15408
            12-558              AL078633.32        15409-15955
            559-725             AL078633.32        17019-17185
            726-2691            AL078633.32        18750-20715
            2692-2692           AL078633.32        20716-20716
FEATURES             Location/Qualifiers
     source          1..2692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2692
                     /gene="HRH3"
                     /gene_synonym="GPCR97; HH3R"
                     /note="histamine receptor H3"
                     /db_xref="GeneID:11255"
                     /db_xref="HGNC:HGNC:5184"
                     /db_xref="MIM:604525"
     exon            1..558
                     /gene="HRH3"
                     /gene_synonym="GPCR97; HH3R"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1646
                     /gene="HRH3"
                     /gene_synonym="GPCR97; HH3R"
                     /note="G protein-coupled receptor 97; H3R"
                     /codon_start=1
                     /product="histamine H3 receptor"
                     /protein_id="NP_009163.2"
                     /db_xref="CCDS:CCDS13493.1"
                     /db_xref="GeneID:11255"
                     /db_xref="HGNC:HGNC:5184"
                     /db_xref="MIM:604525"
                     /translation="MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALL
                     IVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTF
                     GRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVW
                     VLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFN
                     LSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYG
                     VGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLE
                     KRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDY
                     WYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK"
     exon            559..725
                     /gene="HRH3"
                     /gene_synonym="GPCR97; HH3R"
                     /inference="alignment:Splign:2.1.0"
     exon            726..2692
                     /gene="HRH3"
                     /gene_synonym="GPCR97; HH3R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2664..2669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HRH3"
                     /gene_synonym="GPCR97; HH3R"
                     /note="hexamer: AATAAA"
     polyA_site      2692
                     /gene="HRH3"
                     /gene_synonym="GPCR97; HH3R"
                     /note="major polyA site"
ORIGIN      
        1 gcactcggct gcgcgttgcg ctccggctgc acggtcgcac cggcagcggc tcaggctccg
       61 gctcctctcc cgctgcagca gccgcgctgc cggccccact gggctcggat ccggccccgg
      121 ccccctcggc accgcctgct ctggccccgg ccccggcccc gcggaccatg cgctgggcgc
      181 ccccagggga acccgacccg gccaagggcc cgcaaagacg aggctcccgg gccggggccc
      241 ctcccggccg cccagctctc ggccggcgcc ctgccccgcg tcccggagcc gcgtgagcct
      301 gcggggccat ggagcgcgcg ccgcccgacg ggccgctgaa cgcttcgggg gcgctggcgg
      361 gcgaggcggc ggcggcgggc ggggcgcgcg gcttctcggc agcctggacc gcggtgctgg
      421 ccgcgctcat ggcgctgctc atcgtggcca cggtgctggg caacgcgctg gtcatgctcg
      481 ccttcgtggc cgactcgagc ctccgcaccc agaacaactt cttcctgctc aacctcgcca
      541 tctccgactt cctcgtcggc gccttctgca tcccactgta tgtaccctac gtgctgacag
      601 gccgctggac cttcggccgg ggcctctgca agctgtggct ggtagtggac tacctgctgt
      661 gcacctcctc tgccttcaac atcgtgctca tcagctacga ccgcttcctg tcggtcaccc
      721 gagcggtctc ataccgggcc cagcagggtg acacgcggcg ggcagtgcgg aagatgctgc
      781 tggtgtgggt gctggccttc ctgctgtacg gaccagccat cctgagctgg gagtacctgt
      841 ccgggggcag ctccatcccc gagggccact gctatgccga gttcttctac aactggtact
      901 tcctcatcac ggcttccacc ctggagttct ttacgccctt cctcagcgtc accttcttta
      961 acctcagcat ctacctgaac atccagaggc gcacccgcct ccggctggat ggggctcgag
     1021 aggcagccgg ccccgagccc cctcccgagg cccagccctc accaccccca ccgcctggct
     1081 gctggggctg ctggcagaag gggcacgggg aggccatgcc gctgcacagg tatggggtgg
     1141 gtgaggcggc cgtaggcgct gaggccgggg aggcgaccct cgggggtggc ggtgggggcg
     1201 gctccgtggc ttcacccacc tccagctccg gcagctcctc gaggggcact gagaggccgc
     1261 gctcactcaa gaggggctcc aagccgtcgg cgtcctcggc ctcgctggag aagcgcatga
     1321 agatggtgtc ccagagcttc acccagcgct ttcggctgtc tcgggacagg aaagtggcca
     1381 agtcgctggc cgtcatcgtg agcatctttg ggctctgctg ggccccatac acgctgctga
     1441 tgatcatccg ggccgcctgc catggccact gcgtccctga ctactggtac gaaacctcct
     1501 tctggctcct gtgggccaac tcggctgtca accctgtcct ctaccctctg tgccaccaca
     1561 gcttccgccg ggccttcacc aagctgctct gcccccagaa gctcaaaatc cagccccaca
     1621 gctccctgga gcactgctgg aagtgagtgg cccaccagag cctccctcag ccacgcctct
     1681 ctcagcccag gtctcctggg catctggccc tgctgccccc tacccggctc gttcccccag
     1741 gggtgagccc cgccgtgtct gtggccctct cttaatgcca cggcagccac cctgccatgg
     1801 aggcgccttc ctgggttggc cagagggccc ctcactggct ggactggagg ctgggtggcc
     1861 ggccctgccc cccacattct ggctccaccg ggagggacag tctggaggtc ccagacatgc
     1921 tgcccacccc ctgctggtgc ccacccttcg cagttactgg ttggtgttct tcccaaagca
     1981 agcacctggg tgtgctccag gcttcctgcc ctagcagttt gcctctgcac gtgcacacac
     2041 ctgcacaccc ctgcacacac ctgcacaccg tccctctccc cggacaagcc caggacactg
     2101 cctttgctgc cttctgtctc ttgcataagc ctcaggcctg gccctttcac ccctcttccc
     2161 accaactctc tctgccccca aaagtgtcaa ggggccctag gaacctcgaa gctgttctct
     2221 gcttttccat tctgggtgtt ttcagaaaga tgaagaagaa aacatgtctg tgaacttgat
     2281 gttcctggga tgtttaatca agagagacaa aattgctgag gagctcaggg ctggattggc
     2341 aggtgtgggc tcccacgccc tcctccctcc gctaaggctt ccggctgagc tgtgccagct
     2401 gcttctgccc accccgcctc tgggctcaca ccagccctgg tggccaagcc tgccccggcc
     2461 actctgtttg ctcacccagg acctctgggg gttgttggga ggagggggcc cggctgggcc
     2521 cgagggtccc aaggcgtgca ggggcggtcc agaggaggtg cccgggcagg ggccgcttcg
     2581 ccatgtgctg tgcacccgtg ccacgcgctc tgcatgctcc tctgcctgtg cccgctgcgc
     2641 tgccctgcaa accgtgaggt cacaataaag tgtatttttt tattggtgct ga
//
