LOCUS       XM_011534549            4843 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens histamine receptor H2 (HRH2), transcript
            variant X1, mRNA.
ACCESSION   XM_011534549
VERSION     XM_011534549.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011534549.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..4843
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /note="histamine receptor H2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 5 ESTs, 102 long SRA reads, 3 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:3274"
                     /db_xref="HGNC:HGNC:5183"
                     /db_xref="MIM:142703"
     CDS             790..2058
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /codon_start=1
                     /product="histamine H2 receptor isoform X1"
                     /protein_id="XP_011532851.1"
                     /db_xref="GeneID:3274"
                     /db_xref="HGNC:HGNC:5183"
                     /db_xref="MIM:142703"
                     /translation="MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVG
                     LNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLC
                     TASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNS
                     RNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINH
                     ISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWL
                     GYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQ
                     QEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHMGGP
                     SEELSGEPLSEEPQKRPPQKAVRTLPSEAV"
ORIGIN      
        1 gcatccctgc ccggagcgca gccggcgcgg gcgcgggacc gaggcgaacc gggtgcggag
       61 ccaatacccg cggcagcagc accaggctga tgattaacta ctgaccctcc caggcgatgc
      121 gtccgtggga aaaacaagac cagctgtggt ccatctctgc caacacccca aaattttatg
      181 caatgagcat gttctttaat aattagtgga ctacctggct tcgagttctg agagcaggga
      241 ggagggtgcc tgattgaaaa aaagctcctg ccctccactg actccagaga gggagatccc
      301 cagtacttga ctccatcacg cagatgggag caggcaccag ctatggagag ggatacagct
      361 gcgtctccac atgacccatc ctgcatgaca ccaaagccac cgccagacag tgcctcggat
      421 tctatgcaaa acctgggaag cggagaccta ccccagcccc gggaggaagc tagctcttca
      481 ggggaccgtc tgaggactgg agtttgatcc atgaacctgg cttcgaggcc ttgcttttct
      541 ctcttcttca ttcatattca ttcccaacac cttagaaggt gttgcttaat ttatttctag
      601 aaaagcagcc cagagtcagt cattgaagcc ttccccaccc cctggccaaa aaaaaaaaaa
      661 aaaaaaaact ggacacattt tggatctgtt gggagcttgg agtccagtgg ttggcatagt
      721 tgtcacattg ggagcagaga agaagcaacc aggggccctg atcaggggac tgagccgtag
      781 agtcccagga tggcacccaa tggcacagcc tcttcctttt gcctggactc taccgcatgc
      841 aagatcacca tcaccgtggt ccttgcggtc ctcatcctca tcaccgttgc tggcaatgtg
      901 gtcgtctgtc tggccgtggg cttgaaccgc cggctccgca acctgaccaa ttgtttcatc
      961 gtgtccttgg ctatcactga cctgctcctc ggcctcctgg tgctgccctt ctctgccatc
     1021 taccagctgt cctgcaagtg gagctttggc aaggtcttct gcaatatcta caccagcctg
     1081 gatgtgatgc tctgcacagc ctccattctt aacctcttca tgatcagcct cgaccggtac
     1141 tgcgctgtca tggacccact gcggtaccct gtgctggtca ccccagttcg ggtcgccatc
     1201 tctctggtct taatttgggt catctccatt accctgtcct ttctgtctat ccacctgggg
     1261 tggaacagca ggaacgagac cagcaagggc aatcatacca cctctaagtg caaagtccag
     1321 gtcaatgaag tgtacgggct ggtggatggg ctggtcacct tctacctccc gctactgatc
     1381 atgtgcatca cctactaccg catcttcaag gtcgcccggg atcaggccaa gaggatcaat
     1441 cacattagct cctggaaggc agccaccatc agggagcaca aagccacagt gacactggcc
     1501 gccgtcatgg gggccttcat catctgctgg tttccctact tcaccgcgtt tgtgtaccgt
     1561 gggctgagag gggatgatgc catcaatgag gtgttagaag ccatcgttct gtggctgggc
     1621 tatgccaact cagccctgaa ccccatcctg tatgctgcgc tgaacagaga cttccgcacc
     1681 gggtaccaac agctcttctg ctgcaggctg gccaaccgca actcccacaa aacttctctg
     1741 aggtccaacg cctctcagct gtccaggacc caaagccgag aacccaggca acaggaagag
     1801 aaacccctga agctccaggt gtggagtggg acagaagtca cggcccccca gggagccaca
     1861 gacaggaagc cagcactgtc ctgcactacg tgctccagca acctcctgag ctgctgcaag
     1921 agcctgtggg ggctcaggtt ccttcagaga cacatgggag gcccctcgga ggagctatcg
     1981 ggggagccac tgtctgagga gccacagaag agacctcccc agaaagcggt gaggacgctg
     2041 ccctctgagg ctgtctagac ctagccccag gacactgaag ataccgctcc cggtccccaa
     2101 gatgtgactc ctggagctcc taaggaccca gtctccaaag ccaccaagga ctcaccctgg
     2161 actgaatctg ggggctccca gaacacacag ctgggtgtgg ggtcctcagg cctagggcgg
     2221 aacagcctat tctgtgctca gcattcccag acaggcacgc aagactcctc tgggcccgag
     2281 tgggctgaat cccatgggtt caaagctcac gttggtgctg gccctgggag tcatgagcag
     2341 agacggtggg acagacgggg atgcgtgcac atgtgtgtgc atgggtgcat acgtgtaggg
     2401 acgtgcatga cctctgagca aggcagaggg tattgaagaa agcattggcc tctcactccc
     2461 tcatgggttc tgcaggatga aggaaaggaa aggaaaagac agagaaagga aggaaatagc
     2521 ttttcatgag cacctactgt gtaccaggtg cttccctggc atgagctctc gtaaccctta
     2581 tagcaacatg agtttagagc aagaatcaca ccccgacttt acagagatgg aaactgaggc
     2641 tcagagaagt aagggacctg cccaaggcca ctcagcacct agaaagtgtg cctagcacat
     2701 aggaggcaca caaaaatatg tgttgaatgg gtgaatgaat gagagaacgg gtgaaaagcc
     2761 aggcctcaag cccacactac tgacactgca ctacaccacc tctcaggaga gaaggcaaat
     2821 atttccttga ctcagccacc ttcctcctag caaggcttag acccccaggc tctgggggtc
     2881 ccttcctgct acagtatgac cctctctggt gcttgtcatc aagaagtggt atgcggtgga
     2941 cttgctggag agagtgtctg cagccaggca tcatggaggg agggatggat cttgagggac
     3001 tgtaatggtt gtgaatgggg gagttggccc ccagcactct ctggtggccg tatgaccttg
     3061 ggcacgtctc ctgaccactc taagcagctt ttgattcccc tgtccaagag ggtaggcccc
     3121 ctgttcctat ttacaggatc cataaagaga ctcaaagaga tagggtagtg ccagccccag
     3181 agagaggggg ctgtggaggg acttctaccc ccagggcttc tcagtggcat ctcctggctg
     3241 gcccctgaca ctcaatcttc cttggtttcc aagatgcttc atgatcttcc ccctccctga
     3301 catccccgac ctcccttttc tgtccctttt gcaactcatt gtcctctacc tgccatcaga
     3361 tgtggctgtt cctcagtctc agtccagagt cctctcttct cactcagcat ctctcctcct
     3421 gtgacctcgt ctgcacccac aactccagtt acaaggcacg aggtttggtt atgaaatcac
     3481 tcacagattt ataactgcag gcttggctcc ttccgggagc ttgagaccca ctgccgcctc
     3541 cgcaacacct ccacctggga gtttcagagg cgctctccct cagcgtgtct gcagctgcgt
     3601 gcctgcagct gcgtgcctgc cttctccctg cacctgctct gctccccagg tccctttctc
     3661 agaccaaagc ctgcccgggc ttcacaggct gagggtccac cttgccacct ccgtttgcct
     3721 cagtcctcat ggagccctgg ctccactgtc tgctggcttc tccccatcta ctctgtgtca
     3781 ctccatccga ccaccattgt ctccatcagg acagttggaa cacctcttct cagcactctc
     3841 gcccccaccc agtccacccc ctacctgaca gccagagtgg gccatgccag atgcaaccca
     3901 ggtcatgcca cacaggtaga taaaaccatc ttcagcccag ccctcaggcc ctgtgtgctg
     3961 ggaccctgct gggccctctc cagcctcccc ctgcgccagg cctcctccgt cacttcactc
     4021 tggccctgct gttcttttcc ttttagtttg attaactcac tctgcccatt ccatgctcaa
     4081 agctgtttcc gtgaggaaag gctcctcctg ctcattttag tgccctgaaa tgtcacttcc
     4141 ttgaggaagt cttccttgac cctccacacc aaaccaggcc ccctgccaca cccctcagag
     4201 ctctccttgg aaggcactgg catggctgtt tgcgtgattc cttgaacgtt gtctgtctct
     4261 cctcctcacc aggctgtggg tcctgtctgt ttctggtgac cgttgtctgt ctaaccccta
     4321 gaggagagtt tgtcacatgg taggagctta ataaatatgt gttggatgaa tgatcagaga
     4381 aaagagagtg cagagagtgg ccaaaacaga tgctttcagc agtgtatctg ccaataaacc
     4441 taaaggcatg atttgccctg gtgatccccc cagaggtgct tagtctcttg gctgaattcc
     4501 ttctggaatc cccagaatcc ccctccttgg aagttttccc aggagtctga ggcaggcagg
     4561 tctctcagtc acggccacat gacctcaagt gaaaacaaac cagtctggct gttcacagac
     4621 tcagctggtc agagctctgg cccgaggggc ccacgcacca cccgccactg cagaagacgc
     4681 ctccacgtct gtctctgggc tgcctccacc ttctgcaggc ctcctggagc ctctgctggc
     4741 tgcagaagtg gggtgcatgc tgcctggagg aggaacatct gtggtgggac cccaaatcca
     4801 tgtttgtgtt accatcgtgt tccaataaaa ctatcgaaac aga
//
