LOCUS       NM_001367711            4664 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens histamine receptor H2 (HRH2), transcript variant 2,
            mRNA.
ACCESSION   NM_001367711 XM_005265904
VERSION     NM_001367711.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4664)
  AUTHORS   Kock,Z., Schnelle,K., Persechino,M., Umbach,S., Schihada,H.,
            Januliene,D., Parey,K., Pockes,S., Kolb,P., Dotsch,V., Moller,A.,
            Hilger,D. and Bernhard,F.
  TITLE     Cryo-EM structure of cell-free synthesized human histamine 2
            receptor/Gs complex in nanodisc environment
  JOURNAL   Nat Commun 15 (1), 1831 (2024)
   PUBMED   38418462
  REMARK    GeneRIF: Cryo-EM structure of cell-free synthesized human histamine
            2 receptor/Gs complex in nanodisc environment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4664)
  AUTHORS   Dawodu,D., Sand,S., Nikolouli,E., Werfel,T. and Mommert,S.
  TITLE     The mRNA expression and secretion of granzyme B are up-regulated
            via the histamine H2 receptor in human CD4+ T cells
  JOURNAL   Inflamm Res 72 (8), 1525-1538 (2023)
   PUBMED   37470818
  REMARK    GeneRIF: The mRNA expression and secretion of granzyme B are
            up-regulated via the histamine H2 receptor in human CD4[+] T cells.
REFERENCE   3  (bases 1 to 4664)
  AUTHORS   Pal,S., Gashev,A. and Roy,D.
  TITLE     Nuclear localization of histamine receptor 2 in primary human
            lymphatic endothelial cells
  JOURNAL   Biol Open 11 (7) (2022)
   PUBMED   35776777
  REMARK    GeneRIF: Nuclear localization of histamine receptor 2 in primary
            human lymphatic endothelial cells.
REFERENCE   4  (bases 1 to 4664)
  AUTHORS   Potnuri,A.G., Allakonda,L. and Saheera,S.
  TITLE     Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor
            Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio
            Myoblasts
  JOURNAL   J Cardiovasc Transl Res 14 (1), 184-194 (2021)
   PUBMED   32385805
  REMARK    GeneRIF: Involvement of Histamine 2 Receptor in Alpha 1
            Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in
            H9c2 Cardio Myoblasts.
REFERENCE   5  (bases 1 to 4664)
  AUTHORS   Leary,P.J., Kronmal,R.A., Bluemke,D.A., Buttrick,P.M., Jones,K.L.,
            Kao,D.P., Kawut,S.M., Krieger,E.V., Lima,J.A., Minobe,W.,
            Ralph,D.D., Tedford,R.J., Weiss,N.S. and Bristow,M.R.
  TITLE     Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and
            Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and
            Beta-Blocker Effect on Remodeling and Gene Expression Trial)
  JOURNAL   Am J Cardiol 121 (2), 256-261 (2018)
   PUBMED   29191567
  REMARK    GeneRIF: The presence of a minor allele at rs2241562 was associated
            with increased HF incidence in Chinese participants. Differences in
            myocardial HRH2 transcript abundance were seen in participants with
            dilated cardiomyopathy who responded to beta blockade compared to
            those who did not.
REFERENCE   6  (bases 1 to 4664)
  AUTHORS   Smit,M.J., Timmerman,H., Alewijnse,A.E., Punin,M., van den
            Nieuwenhof,I., Blauw,J., van Minnen,J. and Leurs,R.
  TITLE     Visualization of agonist-induced internalization of histamine H2
            receptors
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1138-1145 (1995)
   PUBMED   7575521
REFERENCE   7  (bases 1 to 4664)
  AUTHORS   Traiffort,E., Vizuete,M.L., Tardivel-Lacombe,J., Souil,E.,
            Schwartz,J.C. and Ruat,M.
  TITLE     The guinea pig histamine H2 receptor: gene cloning, tissue
            expression and chromosomal localization of its human counterpart
  JOURNAL   Biochem Biophys Res Commun 211 (2), 570-577 (1995)
   PUBMED   7794271
REFERENCE   8  (bases 1 to 4664)
  AUTHORS   Nishi,T., Koike,T., Oka,T., Maeda,M. and Futai,M.
  TITLE     Identification of the promoter region of the human histamine
            H2-receptor gene
  JOURNAL   Biochem Biophys Res Commun 210 (2), 616-623 (1995)
   PUBMED   7755641
REFERENCE   9  (bases 1 to 4664)
  AUTHORS   Vannier,E. and Dinarello,C.A.
  TITLE     Histamine enhances interleukin (IL)-1-induced IL-6 gene expression
            and protein synthesis via H2 receptors in peripheral blood
            mononuclear cells
  JOURNAL   J Biol Chem 269 (13), 9952-9956 (1994)
   PUBMED   7511596
REFERENCE   10 (bases 1 to 4664)
  AUTHORS   Gantz,I., Munzert,G., Tashiro,T., Schaffer,M., Wang,L., DelValle,J.
            and Yamada,T.
  TITLE     Molecular cloning of the human histamine H2 receptor
  JOURNAL   Biochem Biophys Res Commun 178 (3), 1386-1392 (1991)
   PUBMED   1714721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010219.4.
            
            On Dec 13, 2018 this sequence version replaced XM_005265904.3.
            
            Summary: Histamine is a ubiquitous messenger molecule released from
            mast cells, enterochromaffin-like cells, and neurons. Its various
            actions are mediated by histamine receptors H1, H2, H3 and H4.
            Histamine receptor H2 belongs to the family 1 of G protein-coupled
            receptors. It is an integral membrane protein and stimulates
            gastric acid secretion. It also regulates gastrointestinal motility
            and intestinal secretion and is thought to be involved in
            regulating cell growth and differentiation. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660807.100522.1, SRR1660803.102749.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000636584.2/ ENSP00000489742.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC010219.4         62516-62600         c
            86-1686             AC010219.4         36362-37962         c
            1687-4664           AC010219.4         9915-12892          c
FEATURES             Location/Qualifiers
     source          1..4664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4664
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /note="histamine receptor H2"
                     /db_xref="GeneID:3274"
                     /db_xref="HGNC:HGNC:5183"
                     /db_xref="MIM:142703"
     exon            1..85
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     exon            86..1686
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..1879
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /note="isoform 2 is encoded by transcript variant 2;
                     gastric receptor 1; gastric receptor I"
                     /codon_start=1
                     /product="histamine H2 receptor isoform 2"
                     /protein_id="NP_001354640.1"
                     /db_xref="CCDS:CCDS93828.1"
                     /db_xref="GeneID:3274"
                     /db_xref="HGNC:HGNC:5183"
                     /db_xref="MIM:142703"
                     /translation="MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVG
                     LNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLC
                     TASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNS
                     RNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINH
                     ISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWL
                     GYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQ
                     QEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHMGGP
                     SEELSGEPLSEEPQKRPPQKAVRTLPSEAV"
     exon            1687..4664
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4645..4650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /note="hexamer: AATAAA"
     polyA_site      4664
                     /gene="HRH2"
                     /gene_synonym="H2R; HH2R"
                     /note="major polyA site"
ORIGIN      
        1 gcatccctgc ccggagcgca gccggcgcgg gcgcgggacc gaggcgaacc gggtgcggag
       61 ccaatacccg cggcagcagc accagctcct gccctccact gactccagag agggagatcc
      121 ccagtacttg actccatcac gcagatggga gcaggcacca gctatggaga gggatacagc
      181 tgcgtctcca catgacccat cctgcatgac accaaagcca ccgccagaca gtgcctcgga
      241 ttctatgcaa aacctgggaa gcggagacct accccagccc cgggaggaag ctagctcttc
      301 aggggaccgt ctgaggactg gagtttgatc catgaacctg gcttcgaggc cttgcttttc
      361 tctcttcttc attcatattc attcccaaca ccttagaagg tgttgcttaa tttatttcta
      421 gaaaagcagc ccagagtcag tcattgaagc cttccccacc ccctggccaa aaaaaaaaaa
      481 aaaaaaaaac tggacacatt ttggatctgt tgggagcttg gagtccagtg gttggcatag
      541 ttgtcacatt gggagcagag aagaagcaac caggggccct gatcagggga ctgagccgta
      601 gagtcccagg atggcaccca atggcacagc ctcttccttt tgcctggact ctaccgcatg
      661 caagatcacc atcaccgtgg tccttgcggt cctcatcctc atcaccgttg ctggcaatgt
      721 ggtcgtctgt ctggccgtgg gcttgaaccg ccggctccgc aacctgacca attgtttcat
      781 cgtgtccttg gctatcactg acctgctcct cggcctcctg gtgctgccct tctctgccat
      841 ctaccagctg tcctgcaagt ggagctttgg caaggtcttc tgcaatatct acaccagcct
      901 ggatgtgatg ctctgcacag cctccattct taacctcttc atgatcagcc tcgaccggta
      961 ctgcgctgtc atggacccac tgcggtaccc tgtgctggtc accccagttc gggtcgccat
     1021 ctctctggtc ttaatttggg tcatctccat taccctgtcc tttctgtcta tccacctggg
     1081 gtggaacagc aggaacgaga ccagcaaggg caatcatacc acctctaagt gcaaagtcca
     1141 ggtcaatgaa gtgtacgggc tggtggatgg gctggtcacc ttctacctcc cgctactgat
     1201 catgtgcatc acctactacc gcatcttcaa ggtcgcccgg gatcaggcca agaggatcaa
     1261 tcacattagc tcctggaagg cagccaccat cagggagcac aaagccacag tgacactggc
     1321 cgccgtcatg ggggccttca tcatctgctg gtttccctac ttcaccgcgt ttgtgtaccg
     1381 tgggctgaga ggggatgatg ccatcaatga ggtgttagaa gccatcgttc tgtggctggg
     1441 ctatgccaac tcagccctga accccatcct gtatgctgcg ctgaacagag acttccgcac
     1501 cgggtaccaa cagctcttct gctgcaggct ggccaaccgc aactcccaca aaacttctct
     1561 gaggtccaac gcctctcagc tgtccaggac ccaaagccga gaacccaggc aacaggaaga
     1621 gaaacccctg aagctccagg tgtggagtgg gacagaagtc acggcccccc agggagccac
     1681 agacaggaag ccagcactgt cctgcactac gtgctccagc aacctcctga gctgctgcaa
     1741 gagcctgtgg gggctcaggt tccttcagag acacatggga ggcccctcgg aggagctatc
     1801 gggggagcca ctgtctgagg agccacagaa gagacctccc cagaaagcgg tgaggacgct
     1861 gccctctgag gctgtctaga cctagcccca ggacactgaa gataccgctc ccggtcccca
     1921 agatgtgact cctggagctc ctaaggaccc agtctccaaa gccaccaagg actcaccctg
     1981 gactgaatct gggggctccc agaacacaca gctgggtgtg gggtcctcag gcctagggcg
     2041 gaacagccta ttctgtgctc agcattccca gacaggcacg caagactcct ctgggcccga
     2101 gtgggctgaa tcccatgggt tcaaagctca cgttggtgct ggccctggga gtcatgagca
     2161 gagacggtgg gacagacggg gatgcgtgca catgtgtgtg catgggtgca tacgtgtagg
     2221 gacgtgcatg acctctgagc aaggcagagg gtattgaaga aagcattggc ctctcactcc
     2281 ctcatgggtt ctgcaggatg aaggaaagga aaggaaaaga cagagaaagg aaggaaatag
     2341 cttttcatga gcacctactg tgtaccaggt gcttccctgg catgagctct cgtaaccctt
     2401 atagcaacat gagtttagag caagaatcac accccgactt tacagagatg gaaactgagg
     2461 ctcagagaag taagggacct gcccaaggcc actcagcacc tagaaagtgt gcctagcaca
     2521 taggaggcac acaaaaatat gtgttgaatg ggtgaatgaa tgagagaacg ggtgaaaagc
     2581 caggcctcaa gcccacacta ctgacactgc actacaccac ctctcaggag agaaggcaaa
     2641 tatttccttg actcagccac cttcctccta gcaaggctta gacccccagg ctctgggggt
     2701 cccttcctgc tacagtatga ccctctctgg tgcttgtcat caagaagtgg tatgcggtgg
     2761 acttgctgga gagagtgtct gcagccaggc atcatggagg gagggatgga tcttgaggga
     2821 ctgtaatggt tgtgaatggg ggagttggcc cccagcactc tctggtggcc gtatgacctt
     2881 gggcacgtct cctgaccact ctaagcagct tttgattccc ctgtccaaga gggtaggccc
     2941 cctgttccta tttacaggat ccataaagag actcaaagag atagggtagt gccagcccca
     3001 gagagagggg gctgtggagg gacttctacc cccagggctt ctcagtggca tctcctggct
     3061 ggcccctgac actcaatctt ccttggtttc caagatgctt catgatcttc cccctccctg
     3121 acatccccga cctccctttt ctgtcccttt tgcaactcat tgtcctctac ctgccatcag
     3181 atgtggctgt tcctcagtct cagtccagag tcctctcttc tcactcagca tctctcctcc
     3241 tgtgacctcg tctgcaccca caactccagt tacaaggcac gaggtttggt tatgaaatca
     3301 ctcacagatt tataactgca ggcttggctc cttccgggag cttgagaccc actgccgcct
     3361 ccgcaacacc tccacctggg agtttcagag gcgctctccc tcagcgtgtc tgcagctgcg
     3421 tgcctgcagc tgcgtgcctg ccttctccct gcacctgctc tgctccccag gtccctttct
     3481 cagaccaaag cctgcccggg cttcacaggc tgagggtcca ccttgccacc tccgtttgcc
     3541 tcagtcctca tggagccctg gctccactgt ctgctggctt ctccccatct actctgtgtc
     3601 actccatccg accaccattg tctccatcag gacagttgga acacctcttc tcagcactct
     3661 cgcccccacc cagtccaccc cctacctgac agccagagtg ggccatgcca gatgcaaccc
     3721 aggtcatgcc acacaggtag ataaaaccat cttcagccca gccctcaggc cctgtgtgct
     3781 gggaccctgc tgggccctct ccagcctccc cctgcgccag gcctcctccg tcacttcact
     3841 ctggccctgc tgttcttttc cttttagttt gattaactca ctctgcccat tccatgctca
     3901 aagctgtttc cgtgaggaaa ggctcctcct gctcatttta gtgccctgaa atgtcacttc
     3961 cttgaggaag tcttccttga ccctccacac caaaccaggc cccctgccac acccctcaga
     4021 gctctccttg gaaggcactg gcatggctgt ttgcgtgatt ccttgaacgt tgtctgtctc
     4081 tcctcctcac caggctgtgg gtcctgtctg tttctggtga ccgttgtctg tctaacccct
     4141 agaggagagt ttgtcacatg gtaggagctt aataaatatg tgttggatga atgatcagag
     4201 aaaagagagt gcagagagtg gccaaaacag atgctttcag cagtgtatct gccaataaac
     4261 ctaaaggcat gatttgccct ggtgatcccc ccagaggtgc ttagtctctt ggctgaattc
     4321 cttctggaat ccccagaatc cccctccttg gaagttttcc caggagtctg aggcaggcag
     4381 gtctctcagt cacggccaca tgacctcaag tgaaaacaaa ccagtctggc tgttcacaga
     4441 ctcagctggt cagagctctg gcccgagggg cccacgcacc acccgccact gcagaagacg
     4501 cctccacgtc tgtctctggg ctgcctccac cttctgcagg cctcctggag cctctgctgg
     4561 ctgcagaagt ggggtgcatg ctgcctggag gaggaacatc tgtggtggga ccccaaatcc
     4621 atgtttgtgt taccatcgtg ttccaataaa actatcgaaa caga
//
