LOCUS       NM_001098212            4617 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens histamine receptor H1 (HRH1), transcript variant 2,
            mRNA.
ACCESSION   NM_001098212
VERSION     NM_001098212.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4617)
  AUTHORS   Yu,F., Liu,X., Ou,H., Li,X., Liu,R., Lv,X., Xiao,S., Hu,M.,
            Liang,T., Chen,T., Wei,X., Zhang,Z., Liu,S., Liu,H., Zhu,Y.,
            Liu,G., Tu,T., Li,P., Zhang,H., Pan,T. and Ma,X.
  TITLE     The histamine receptor H1 acts as an alternative receptor for
            SARS-CoV-2
  JOURNAL   mBio 15 (8), e0108824 (2024)
   PUBMED   38953634
  REMARK    GeneRIF: The histamine receptor H1 acts as an alternative receptor
            for SARS-CoV-2.
REFERENCE   2  (bases 1 to 4617)
  AUTHORS   Michinaga,S., Nagata,A., Ogami,R., Ogawa,Y. and Hishinuma,S.
  TITLE     Histamine H1 Receptor-Mediated JNK Phosphorylation Is Regulated by
            Gq Protein-Dependent but Arrestin-Independent Pathways
  JOURNAL   Int J Mol Sci 25 (6), 3395 (2024)
   PUBMED   38542369
  REMARK    GeneRIF: Histamine H1 Receptor-Mediated JNK Phosphorylation Is
            Regulated by Gq Protein-Dependent but Arrestin-Independent
            Pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4617)
  AUTHORS   McNaught-Flores,D.A., Kooistra,A.J., Chen,Y.C., Arias-Montano,J.A.,
            Panula,P. and Leurs,R.
  TITLE     Pharmacological Characterization of the Zebrafish (Danio Rerio)
            Histamine H1 Receptor Reveals the Involvement of the Second
            Extracellular Loop in the Binding of Histamine
  JOURNAL   Mol Pharmacol 105 (2), 84-96 (2024)
   PUBMED   37977823
  REMARK    GeneRIF: Pharmacological Characterization of the Zebrafish (Danio
            Rerio) Histamine H1 Receptor Reveals the Involvement of the Second
            Extracellular Loop in the Binding of Histamine.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4617)
  AUTHORS   Schrammel,J.C., Konig,M., Frommer,M., Andersen,K.S., Kirsten,M.,
            Seifert,R., Neumann,D. and Schirmer,B.
  TITLE     Histamine H1- and H4-receptor expression in human colon-derived
            cell lines
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (12), 3683-3693 (2023)
   PUBMED   37300703
  REMARK    GeneRIF: Histamine H1- and H4-receptor expression in human
            colon-derived cell lines.
REFERENCE   5  (bases 1 to 4617)
  AUTHORS   Michinaga,S., Nagata,A., Ogami,R., Ogawa,Y. and Hishinuma,S.
  TITLE     Differential regulation of histamine H1 receptor-mediated ERK
            phosphorylation by Gq proteins and arrestins
  JOURNAL   Biochem Pharmacol 213, 115595 (2023)
   PUBMED   37201878
  REMARK    GeneRIF: Differential regulation of histamine H1 receptor-mediated
            ERK phosphorylation by Gq proteins and arrestins.
REFERENCE   6  (bases 1 to 4617)
  AUTHORS   Moguilevsky,N., Varsalona,F., Noyer,M., Gillard,M., Guillaume,J.P.,
            Garcia,L., Szpirer,C., Szpirer,J. and Bollen,A.
  TITLE     Stable expression of human H1-histamine-receptor cDNA in Chinese
            hamster ovary cells. Pharmacological characterisation of the
            protein, tissue distribution of messenger RNA and chromosomal
            localisation of the gene
  JOURNAL   Eur J Biochem 224 (2), 489-495 (1994)
   PUBMED   7925364
REFERENCE   7  (bases 1 to 4617)
  AUTHORS   Fukui,H., Fujimoto,K., Mizuguchi,H., Sakamoto,K., Horio,Y.,
            Takai,S., Yamada,K. and Ito,S.
  TITLE     Molecular cloning of the human histamine H1 receptor gene
  JOURNAL   Biochem Biophys Res Commun 201 (2), 894-901 (1994)
   PUBMED   8003029
REFERENCE   8  (bases 1 to 4617)
  AUTHORS   Mitsuchashi,M. and Payan,D.G.
  TITLE     Molecular and cellular analysis of histamine H1 receptors on
            cultured smooth muscle cells
  JOURNAL   J Cell Biochem 40 (2), 183-192 (1989)
   PUBMED   2670975
  REMARK    Review article
REFERENCE   9  (bases 1 to 4617)
  AUTHORS   Holden,C.A., Chan,S.C., Norris,S. and Hanifin,J.M.
  TITLE     Histamine induced elevation of cyclic AMP phosphodiesterase
            activity in human monocytes
  JOURNAL   Agents Actions 22 (1-2), 36-42 (1987)
   PUBMED   2891264
REFERENCE   10 (bases 1 to 4617)
  AUTHORS   Braman,S.S.
  TITLE     Histamine receptors in the lung
  JOURNAL   N Engl Reg Allergy Proc 8 (2), 116-120 (1987)
   PUBMED   2886904
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083855.3, BP366267.1,
            D28481.1 and BM905371.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001098212.1.
            
            Summary: Histamine is a ubiquitous messenger molecule released from
            mast cells, enterochromaffin-like cells, and neurons. Its various
            actions are mediated by histamine receptors H1, H2, H3 and H4. The
            protein encoded by this gene is an integral membrane protein and
            belongs to the G protein-coupled receptor superfamily. It mediates
            the contraction of smooth muscles, the increase in capillary
            permeability due to contraction of terminal venules, the release of
            catecholamine from adrenal medulla, and neurotransmission in the
            central nervous system. It has been associated with multiple
            processes, including memory and learning, circadian rhythm, and
            thermoregulation. It is also known to contribute to the
            pathophysiology of allergic diseases such as atopic dermatitis,
            asthma, anaphylaxis and allergic rhinitis. Multiple alternatively
            spliced variants, encoding the same protein, have been identified.
            [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2), also known as B/K, differs in
            the 5' UTR compared to variant 1. Variants 1-4 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.132494.1,
                                           SRR1803616.143254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431010.3/ ENSP00000397028.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC083855.3         52704-52738
            36-548              BP366267.1         1-513
            549-1748            D28481.1           455-1654
            1749-4048           AC083855.3         158900-161199
            4049-4313           BM905371.1         12-276
            4314-4617           AC083855.3         161465-161768
FEATURES             Location/Qualifiers
     source          1..4617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..4617
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
                     /note="histamine receptor H1"
                     /db_xref="GeneID:3269"
                     /db_xref="HGNC:HGNC:5182"
                     /db_xref="MIM:600167"
     exon            1..62
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..4617
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1561
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
                     /note="histamine receptor, subclass H1"
                     /codon_start=1
                     /product="histamine H1 receptor"
                     /protein_id="NP_001091682.1"
                     /db_xref="CCDS:CCDS2604.1"
                     /db_xref="GeneID:3269"
                     /db_xref="HGNC:HGNC:5182"
                     /db_xref="MIM:600167"
                     /translation="MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGL
                     NLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLF
                     WLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVI
                     PILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVR
                     QHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSP
                     SQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTD
                     EQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWK
                     RLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLH
                     MFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS"
     regulatory      3850..3855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
                     /note="hexamer: TATAAA"
     polyA_site      3873
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
                     /note="major polyA site"
     regulatory      4293..4298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
                     /note="hexamer: AATAAA"
     polyA_site      4313
                     /gene="HRH1"
                     /gene_synonym="H1-R; H1R; HH1R; hisH1"
ORIGIN      
        1 acacccagca gcctggccgc cgcggccaac gcgccaccaa actttccccg gagccggcgc
       61 cgggagtgag ccataactgg tggctgctct tgcgccaatg agcctcccca attcctcctg
      121 cctcttagaa gacaagatgt gtgagggcaa caagaccact atggccagcc cccagctgat
      181 gcccctggtg gtggtcctga gcactatctg cttggtcaca gtagggctca acctgctggt
      241 gctgtatgcc gtacggagtg agcggaagct ccacactgtg gggaacctgt acatcgtcag
      301 cctctcggtg gcggacttga tcgtgggtgc cgtcgtcatg cctatgaaca tcctctacct
      361 gctcatgtcc aagtggtcac tgggccgtcc tctctgcctc ttttggcttt ccatggacta
      421 tgtggccagc acagcgtcca ttttcagtgt cttcatcctg tgcattgatc gctaccgctc
      481 tgtccagcag cccctcaggt accttaagta tcgtaccaag acccgagcct cggccaccat
      541 tctgggggcc tggtttctct cttttctgtg ggttattccc attctaggct ggaatcactt
      601 catgcagcag acctcggtgc gccgagagga caagtgtgag acagacttct atgatgtcac
      661 ctggttcaag gtcatgactg ccatcatcaa cttctacctg cccaccttgc tcatgctctg
      721 gttctatgcc aagatctaca aggccgtacg acaacactgc cagcaccggg agctcatcaa
      781 taggtccctc ccttccttct cagaaattaa gctgaggcca gagaacccca agggggatgc
      841 caagaaacca gggaaggagt ctccctggga ggttctgaaa aggaagccaa aagatgctgg
      901 tggtggatct gtcttgaagt caccatccca aacccccaag gagatgaaat ccccagttgt
      961 cttcagccaa gaggatgata gagaagtaga caaactctac tgctttccac ttgatattgt
     1021 gcacatgcag gctgcggcag aggggagtag cagggactat gtagccgtca accggagcca
     1081 tggccagctc aagacagatg agcagggcct gaacacacat ggggccagcg agatatcaga
     1141 ggatcagatg ttaggtgata gccaatcctt ctctcgaacg gactcagata ccaccacaga
     1201 gacagcacca ggcaaaggca aattgaggag tgggtctaac acaggcctgg attacatcaa
     1261 gtttacttgg aagaggctcc gctcgcattc aagacagtat gtatctgggt tgcacatgaa
     1321 ccgcgaaagg aaggccgcca aacagttggg ttttatcatg gcagccttca tcctctgctg
     1381 gatcccttat ttcatcttct tcatggtcat tgccttctgc aagaactgtt gcaatgaaca
     1441 tttgcacatg ttcaccatct ggctgggcta catcaactcc acactgaacc ccctcatcta
     1501 ccccttgtgc aatgagaact tcaagaagac attcaagaga attctgcata ttcgctccta
     1561 agggaggctc tgaggggatg caacaaaatg atccttatga tgtccaacaa ggaaatagag
     1621 gacgaaggcc tgtgtgttgc caggcaggca cctgggcttt ctggaatcca aaccacagtc
     1681 ttaggggctt ggtagtttgg aaagttctta ggcaccatag aagaacagca gatggcggtg
     1741 atcagcagag agattgaact ttgaggagga agcagaatct ttgcaagaaa gtcagacctg
     1801 tttcttgtaa ctgggttcaa aaagaaaaaa ataataaaaa taaaagagag agagaatcag
     1861 acctgggtgg aactctcctg ctcctcagga actatgggag cctcagactc attgtaattc
     1921 aagctttccg agtcaagtga ttgacaactg aagagacacg tggctagggt tccactggag
     1981 aattgaaaag gactcttgag ccctcctgga atggagctgt ataactgtgc agagacttta
     2041 tccatgccaa tagttgctgt ccccttccag gggtcacctt gagaggcatg acagctgttc
     2101 cacaggggct atcccttctc agaaaacttc tcttctgagc ctctttaaca gctttctcca
     2161 gaaccagtgt ctgaaccacc ctggaaattc tgccttatta tttcttactc aaacatgttt
     2221 agagtggata gaaaattatg cagcttgcac acccatcgtc tttaacccca aatttccttt
     2281 ggctattaaa aaagtggtgg caaaagacat cctcaaaaga aagagaaatg aaatattttt
     2341 gaatggttgc acgttaaaaa ttaaaagaag gaatgggggc agaatgccat atttttgagg
     2401 gctgtactag gtttatctca tttaagcccc acaacacccc acaggagggt aattttctaa
     2461 ctctagtttg cagaggagca aattgaggtt cagcaaggtg agagaggtac ccaaggtcac
     2521 atagctagtt atgtgagaaa gttagagtac agatcctctg gggtttcagc ttattgtagc
     2581 atattttctc cgaaaggcaa aaatgtgccc ttttggccgg gcatggtagc tcaagcctat
     2641 aatcccagca tgttgagagg ctgaggtggg cagatcattt gaggccagga gttcaagacc
     2701 agtctggcca atatggagaa accttgtctc tactaaaaac acaaaaatta tctgggcatg
     2761 gtggggcatg cctgtagtcc cacttacttg ggaggccgag gcacgagaat tgcttgaacc
     2821 cgggaggtgg aggttgccgt gagccaagat cacgccactg cactccagcc tgggcaacag
     2881 agcaagactc tgtctcaaaa aaaaaaatac aatattttaa caatgtgccc tcttaagtgt
     2941 gcacagatac acatacacgg tattcccaag agtggtggca gctcaaaatg atatgtttga
     3001 gtagacgaac agctgacatg gagttcccgt gcacctacgg aaggggacgc tttgaaggaa
     3061 ccaagtgcat ttttatctgt gagttctgtt gtgtttgtca aaaagtcatt gtaatctttc
     3121 atagccatac ctggtaagca aaaactagta aagacatagg aacatgtagt tttacttggt
     3181 gtttatgttg caatctggtt gtgatttata ttttaaagct tggtgctaaa ccacaatatg
     3241 tatagcatat ggagtgcctg tacaagctga tgttttgtat tttgtgttcc tctttgcatg
     3301 atctgtcaaa gtgagatatt tttacctgcc taaaatatga tgtttaaaag catactctat
     3361 gtgatttatt tatttctacc tttctgagtc tcttggacta agaagatgtt ttgaaatgta
     3421 ccatcaaatg ttaacagagt ttgatatggg ctttctcttt ggtttctcat cacatttgta
     3481 aatgtctttt caaaaggatt tactttttgt aaaaagcttc attctcactc tgctttgcat
     3541 cccccaaact tcttgttcaa aacgggggga gtttaggaga ctttaatccc ggtttcagaa
     3601 gctgcagctg gtctgtttcc aggtcagaaa ccattgttca gaagacctcc ctgtgagaga
     3661 gttgctcctc agggtccctc aggaccaaag aacactcgaa aagagcactt cacacagaca
     3721 agtggctaag tgtccattat ttaccttgaa caatcaaggc aactagtgga gagaactgat
     3781 tgtgagctct gcctctgggt cagagagacc tggatttgag tctgacaaga acaagaaatg
     3841 gtcaataaat ataaattacc agcgtctaag gaacaaggtc tatgcattat tgtatacagt
     3901 gtctctagtg cttgtatagt gtctggtata cagagggcac tcctatgcat ttttaaaaca
     3961 tgctgagcac ataccatgtg ccaggctttg tgttttatct aatgttatct aatggtattg
     4021 gtgccattat gtaatgttgc ctttacaaca acctcatgag ggagatttcc atctttacaa
     4081 ataggcaaac tgaggcccag agagattgag gaactgctcc gaggtctgat tctggaatgt
     4141 gcttcctttc cactttatca atctgctctt cgtactcctg tctgaacgat ggaaattaat
     4201 ttttgaatgt ataaaagaca acagactatg atacagaaat gtcagcccca gcccactaag
     4261 aaagccccag cccatcagtg gctaatggct ttaataaatt ggtcatttgg ctacttggct
     4321 tgtggacaat ctctgacctc ttttgaagat gggcactgca tggacttcca ggaggtggat
     4381 ttaatagtct taactcagca tgaaaaagat gctgggatgc tcctggctat ttatgcaccc
     4441 taagtgccat agagacatgc tgttggcaag gcatggtggc tcatgcctgt aatcccagca
     4501 cactgggagg ctgacgcggg cagatggctg gagtccagga gttcgagaca agcctgggca
     4561 ccatggtgaa atcctgtctc tactaaaaat aaaaaattag ccaggggctg tgacgca
//
