LOCUS       NM_001039792             935 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens histidine rich carboxyl terminus 1 (HRCT1), mRNA.
ACCESSION   NM_001039792 XM_929930
VERSION     NM_001039792.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Hou,F., Shi,D.B., Guo,X.Y., Zhao,R.N., Zhang,H., Ma,R.R., He,J.Y.
            and Gao,P.
  TITLE     HRCT1, negatively regulated by miR-124-3p, promotes tumor
            metastasis and the growth of gastric cancer by activating the
            ERBB2-MAPK pathway
  JOURNAL   Gastric Cancer 26 (2), 250-263 (2023)
   PUBMED   36602696
  REMARK    GeneRIF: HRCT1, negatively regulated by miR-124-3p, promotes tumor
            metastasis and the growth of gastric cancer by activating the
            ERBB2-MAPK pathway.
REFERENCE   2  (bases 1 to 935)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358408.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039792.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY358408.1, ERR279842.1349.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354323.3/ ENSP00000346283.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-935               AY358408.1         11-945
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..935
                     /gene="HRCT1"
                     /gene_synonym="LGLL338; PRO537; UNQ338"
                     /note="histidine rich carboxyl terminus 1"
                     /db_xref="GeneID:646962"
                     /db_xref="HGNC:HGNC:33872"
     exon            1..935
                     /gene="HRCT1"
                     /gene_synonym="LGLL338; PRO537; UNQ338"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..434
                     /gene="HRCT1"
                     /gene_synonym="LGLL338; PRO537; UNQ338"
                     /codon_start=1
                     /product="histidine-rich carboxyl terminus protein 1"
                     /protein_id="NP_001034881.1"
                     /db_xref="CCDS:CCDS35012.1"
                     /db_xref="GeneID:646962"
                     /db_xref="HGNC:HGNC:33872"
                     /translation="MLGLLGSTALVGWITGAAVAVLLLLLLLATCLFHGRQDCDVERN
                     RTAAGGNRVRRAQPWPFRRRGHLGIFHHHRHPGHVSHVPNVGLHHHHHPRHTPHHLHH
                     HHHPHRHHPRHAR"
     regulatory      918..923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HRCT1"
                     /gene_synonym="LGLL338; PRO537; UNQ338"
                     /note="hexamer: AATAAA"
     polyA_site      935
                     /gene="HRCT1"
                     /gene_synonym="LGLL338; PRO537; UNQ338"
                     /note="major polyA site"
ORIGIN      
        1 agtgactgag agggctgagc ggaggctgct gaaggggaga aaggagtgag gagctgctgg
       61 gcagagaggg actgtccggc tcccagatgc tgggcctcct ggggagcaca gccctcgtgg
      121 gatggatcac aggtgctgct gtggcggtcc tgctgctgct gctgctgctg gccacctgcc
      181 ttttccacgg acggcaggac tgtgacgtgg agaggaaccg tacagctgca gggggaaacc
      241 gagtccgccg ggcccagcct tggcccttcc ggcggcgggg ccacctggga atctttcacc
      301 atcaccgtca tcctggccac gtatctcatg tgccgaatgt gggcctccac caccaccacc
      361 acccccgcca cacccctcac cacctccacc accaccacca cccccaccgc caccatcccc
      421 gccacgctcg ctgaggctgc tgtcgccggt gcctgtggac agcagctgcc cctgccctcc
      481 catctgttcc caggacaagt ggaccccatg tttccatgtg gaaggatgca tctctggggt
      541 gaacgagggg aacaatagac tggggcttgc tccagctgca tttgcatggc atgccccagt
      601 gtactatggc agcagagaat ggaggaacac tgggtctgca gtgctgaagg gtttggggag
      661 tggagagcaa gggtgctctt tcggggctgg acagcccgtc ttgtgacagt gactcccagt
      721 gagccccaga aatgacaagc gtgtcttggc agagccagca cacaagtgga tgtgaagtgc
      781 ccgtcttgac ctcctcatca ggctgctgca ggcctctggc gggcagggca ctgggagagg
      841 ccctgagaat gtccttttgg tttggagaag gcagtgtgag gctgcacagt caattcatcg
      901 gtgccttagt ccaagaaaat aaaaaccact aagaa
//
