LOCUS       NM_005144               5474 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens HR lysine demethylase and nuclear receptor corepressor
            (HR), transcript variant 1, mRNA.
ACCESSION   NM_005144
VERSION     NM_005144.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5474)
  AUTHORS   Saldanha,C., Vieira-Baptista,P., Costa,M., Silva,A.R., Picao,M. and
            Sousa,C.
  TITLE     Impact of a High Coverage Vaccination Rate on Human Papillomavirus
            Infection Prevalence in Young Women: A Cross-sectional Study
  JOURNAL   J Low Genit Tract Dis 24 (4), 363-366 (2020)
   PUBMED   32796265
  REMARK    GeneRIF: Impact of a High Coverage Vaccination Rate on Human
            Papillomavirus Infection Prevalence in Young Women: A
            Cross-sectional Study.
REFERENCE   2  (bases 1 to 5474)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5474)
  AUTHORS   Huang,Y., Cai,C., Ren,L., Cui,C., Zhang,X. and Liu,W.
  TITLE     Marie Unna hereditary hypotrichosis accompanied by multiple
            familial trichoepithelioma in a Chinese family
  JOURNAL   J Dermatol 46 (5), 413-417 (2019)
   PUBMED   30809827
  REMARK    GeneRIF: Study in a large, five-generation Han Chinese family with
            several patients presenting with Marie Unna hereditary
            hypotrichosis (MUHH) and multiple familial trichoepithelioma (MFT)
            revealed that the c.1A>G mutation in HR (U2HR) was present in all
            MUHH patients. No pathogenic variants were found in EPS8L3 or CYLD
            in any family members but FABP12 (rs536105592 G>A) was identified
            in the patients with both MUHH and MFT.
REFERENCE   4  (bases 1 to 5474)
  AUTHORS   Brook,L., Palade,P., Maatough,A., Whitfield,G.K., Emeterio,L.S.,
            Hsieh,D. and Hsieh,J.C.
  TITLE     Hairless regulates p53 target genes to exert tumor suppressive
            functions in glioblastoma
  JOURNAL   J Cell Biochem 120 (1), 533-543 (2019)
   PUBMED   30191601
  REMARK    GeneRIF: These results suggest that transcriptional repression or
            mutation of HR may contribute to glioblastoma pathogenesis, which
            uncovers a role of HR in brain and suggests that modulating HR
            activity in glioblastoma may be a therapeutic strategy.
REFERENCE   5  (bases 1 to 5474)
  AUTHORS   Duzenli,S., Redler,S., Muller,M., Polat,M., Dogruer,D.,
            Pasternack,S.M. and Betz,R.C.
  TITLE     Identification of a U2HR gene mutation in Turkish families with
            Marie Unna hereditary hypotrichosis
  JOURNAL   Clin Exp Dermatol 34 (8), e953-e956 (2009)
   PUBMED   20055871
  REMARK    GeneRIF: the first time that a mutation in U2HR has been identified
            in families from the Middle East
REFERENCE   6  (bases 1 to 5474)
  AUTHORS   Wen,Y., Liu,Y., Xu,Y., Zhao,Y., Hua,R., Wang,K., Sun,M., Li,Y.,
            Yang,S., Zhang,X.J., Kruse,R., Cichon,S., Betz,R.C., Nothen,M.M.,
            van Steensel,M.A., van Geel,M., Steijlen,P.M., Hohl,D., Huber,M.,
            Dunnill,G.S., Kennedy,C., Messenger,A., Munro,C.S., Terrinoni,A.,
            Hovnanian,A., Bodemer,C., de Prost,Y., Paller,A.S., Irvine,A.D.,
            Sinclair,R., Green,J., Shang,D., Liu,Q., Luo,Y., Jiang,L.,
            Chen,H.D., Lo,W.H., McLean,W.H., He,C.D. and Zhang,X.
  TITLE     Loss-of-function mutations of an inhibitory upstream ORF in the
            human hairless transcript cause Marie Unna hereditary hypotrichosis
  JOURNAL   Nat Genet 41 (2), 228-233 (2009)
   PUBMED   19122663
  REMARK    GeneRIF: A pathogenic initiation codon mutation in U2HR, an
            inhibitory upstream ORF in the 5' UTR of the gene encoding the
            human hairless homolog (HR).
            Erratum:[Nat Genet. 2009 Jun;41(6):762]
REFERENCE   7  (bases 1 to 5474)
  AUTHORS   Ahmad,W., Irvine,A.D., Lam,H., Buckley,C., Bingham,E.A.,
            Panteleyev,A.A., Ahmad,M., McGrath,J.A. and Christiano,A.M.
  TITLE     A missense mutation in the zinc-finger domain of the human hairless
            gene underlies congenital atrichia in a family of Irish travellers
  JOURNAL   Am J Hum Genet 63 (4), 984-991 (1998)
   PUBMED   9758627
REFERENCE   8  (bases 1 to 5474)
  AUTHORS   Cichon,S., Anker,M., Vogt,I.R., Rohleder,H., Putzstuck,M.,
            Hillmer,A., Farooq,S.A., Al-Dhafri,K.S., Ahmad,M., Haque,S.,
            Rietschel,M., Propping,P., Kruse,R. and Nothen,M.M.
  TITLE     Cloning, genomic organization, alternative transcripts and
            mutational analysis of the gene responsible for autosomal recessive
            universal congenital alopecia
  JOURNAL   Hum Mol Genet 7 (11), 1671-1679 (1998)
   PUBMED   9736769
  REMARK    Erratum:[Hum Mol Genet 1998 Nov;7(12):1987-8]
REFERENCE   9  (bases 1 to 5474)
  AUTHORS   Nothen,M.M., Cichon,S., Vogt,I.R., Hemmer,S., Kruse,R., Knapp,M.,
            Holler,T., Faiyaz ul Haque,M., Haque,S., Propping,P., Ahmad,M. and
            Rietschel,M.
  TITLE     A gene for universal congenital alopecia maps to chromosome 8p21-22
  JOURNAL   Am J Hum Genet 62 (2), 386-390 (1998)
   PUBMED   9463324
REFERENCE   10 (bases 1 to 5474)
  AUTHORS   Ahmad,W., Faiyaz ul Haque,M., Brancolini,V., Tsou,H.C., ul
            Haque,S., Lam,H., Aita,V.M., Owen,J., deBlaquiere,M., Frank,J.,
            Cserhalmi-Friedman,P.B., Leask,A., McGrath,J.A., Peacocke,M.,
            Ahmad,M., Ott,J. and Christiano,A.M.
  TITLE     Alopecia universalis associated with a mutation in the human
            hairless gene
  JOURNAL   Science 279 (5351), 720-724 (1998)
   PUBMED   9445480
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA114279.1, DA326731.1,
            AJ277165.2, AF039196.3, BM982749.1 and BX109092.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_005144.4.
            
            Summary: This gene encodes a protein that is involved in hair
            growth. This protein functions as a transcriptional corepressor of
            multiple nuclear receptors, including thyroid hormone receptor, the
            retinoic acid receptor-related orphan receptors and the vitamin D
            receptors, and it interacts with histone deacetylases. The
            translation of this protein is modulated by a regulatory open
            reading frame (ORF) that exists upstream of the primary ORF.
            Mutations in this upstream ORF cause Marie Unna hereditary
            hypotrichosis (MUHH), an autosomal dominant form of genetic hair
            loss. Mutations in this gene also cause autosomal recessive
            congenital alopecia and atrichia with papular lesions, other
            diseases resulting in hair loss. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record represents the hairless protein
            encoded by the primary ORF. Four upstream ORFs (U1HR-U4HR), which
            may regulate translation of the primary ORF as described in
            PMID:19122663, are also annotated on this sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039196.3, BC067128.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381418.9/ ENSP00000370826.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            regulatory uORF        :: PMID: 19122663
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               DA114279.1         165-306
            143-591             DA326731.1         144-592
            592-4245            AJ277165.2         9-3662
            4246-4762           AF039196.3         5107-5623
            4763-5125           BM982749.1         369-731             c
            5126-5474           BX109092.1         13-361              c
FEATURES             Location/Qualifiers
     source          1..5474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..5474
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /note="HR lysine demethylase and nuclear receptor
                     corepressor"
                     /db_xref="GeneID:55806"
                     /db_xref="HGNC:HGNC:5172"
                     /db_xref="MIM:602302"
     exon            1..583
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      303..407
                     /regulatory_class="uORF"
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19122663]"
                     /note="this uORF is known as U2HR and is predicted to
                     encode a 34 aa peptide. Mutations in this uORF cause Marie
                     Unna hereditary hypotrichosis (PMID:19122663)"
     exon            584..1235
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             624..4193
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /EC_number="1.14.11.65"
                     /note="isoform a is encoded by transcript variant 1;
                     protein hairless; hairless homolog; hair growth
                     associated; lysine-specific demethylase hairless; [histone
                     H3]-dimethyl-L-lysine(9) demethylase hairless"
                     /codon_start=1
                     /product="lysine-specific demethylase hairless isoform a"
                     /protein_id="NP_005135.2"
                     /db_xref="CCDS:CCDS6022.1"
                     /db_xref="GeneID:55806"
                     /db_xref="HGNC:HGNC:5172"
                     /db_xref="MIM:602302"
                     /translation="MESTPSFLKGTPTWEKTAPENGIVRQEPGSPPRDGLHHGPLCLG
                     EPAPFWRGVLSTPDSWLPPGFPQGPKDMLPLVEGEGPQNGERKVNWLGSKEGLRWKEA
                     MLTHPLAFCGPACPPRCGPLMPEHSGGHLKSDPVAFRPWHCPFLLETKILERAPFWVP
                     TCLPPYLVSGLPPEHPCDWPLTPHPWVYSGGQPKVPSAFSLGSKGFYYKDPSIPRLAK
                     EPLAAAEPGLFGLNSGGHLQRAGEAERPSLHQRDGEMGAGRQQNPCPLFLGQPDTVPW
                     TSWPACPPGLVHTLGNVWAGPGDGNLGYQLGPPATPRCPSPEPPVTQRGCCSSYPPTK
                     GGGLGPCGKCQEGLEGGASGASEPSEEVNKASGPRACPPSHHTKLKKTWLTRHSEQFE
                     CPRGCPEVEERPVARLRALKRAGSPEVQGAMGSPAPKRPPDPFPGTAEQGAGGWQEVR
                     DTSIGNKDVDSGQHDEQKGPQDGQASLQDPGLQDIPCLALPAKLAQCQSCAQAAGEGG
                     GHACHSQQVRRSPLGGELQQEEDTATNSSSEEGPGSGPDSRLSTGLAKHLLSGLGDRL
                     CRLLRREREALAWAQREGQGPAVTEDSPGIPRCCSRCHHGLFNTHWRCPRCSHRLCVA
                     CGRVAGTGRAREKAGFQEQSAEECTQEAGHAACSLMLTQFVSSQALAELSTAMHQVWV
                     KFDIRGHCPCQADARVWAPGDAGQQKESTQKTPPTPQPSCNGDTHRTKSIKEETPDSA
                     ETPAEDRAGRGPLPCPSLCELLASTAVKLCLGHERIHMAFAPVTPALPSDDRITNILD
                     SIIAQVVERKIQEKALGPGLRAGPGLRKGLGLPLSPVRPRLPPPGALLWLQEPQPCPR
                     RGFHLFQEHWRQGQPVLVSGIQRTLQGNLWGTEALGALGGQVQALSPLGPPQPSSLGS
                     TTFWEGFSWPELRPKSDEGSVLLLHRALGDEDTSRVENLAASLPLPEYCALHGKLNLA
                     SYLPPGLALRPLEPQLWAAYGVSPHRGHLGTKNLCVEVADLVSILVHADTPLPAWHRA
                     QKDFLSGLDGEGLWSPGSQVSTVWHVFRAQDAQRIRRFLQMVCPAGAGALEPGAPGSC
                     YLDAGLRRRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTVSVTQHFLSPETS
                     ALSAQLCHQGPSLPPDCHLLYAQMDWAVFQAVKVAVGTLQEAK"
     exon            1236..2028
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2179
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2373
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2538
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2628
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2744
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2826
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2990
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3233
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3399
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3469
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3600
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..3720
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3836
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..4001
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4130
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..5474
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4804..4809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /note="hexamer: ATTAAA"
     polyA_site      4825
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /note="major polyA site"
     regulatory      5449..5454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
                     /note="hexamer: AATAAA"
     polyA_site      5474
                     /gene="HR"
                     /gene_synonym="ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1"
ORIGIN      
        1 agttgcgctt ctggcgatgg cgatcagagg tcctgctgcg ctctccgccg cgctctacct
       61 ccattagccg cgctgcgcgg tgctgcgccc tcgccggtgc ctctctcctg ggtcccagga
      121 tcggccccca ccatccaggc acgaccccct tccccggccc ctcggccttt cccccaactc
      181 ggccatctcc gacccggggc gcgtgttccc cccggcccgg cgccttctct ccctccgggg
      241 gcacccgctc cctagccccg gcccggccct ccccgcggcg cagcacggag tctcggcgtc
      301 ccatggcgca acctacggcc tcggcccaga agctggtgcg gccgatccgc gccgtgtgcc
      361 gcatcctgca gatcccggag tccgacccct ccaacctgcg gccctagagc gcccccgccg
      421 ccccggggga aggagagcgc gagcgcgctg agcagacaga gcgggagaac gcgtcctcgc
      481 ccgccggccg ggaggccccg gagctggccc atggggagca ggcgcccggt gccggccacg
      541 acgaccgcca ccgcccgcgc cgcgaccggc cggtgaagcc cagggacccc cctctgggag
      601 agccccatga gggcaggaga gtgatggaga gtacgcccag cttcctgaag ggcaccccaa
      661 cctgggagaa gacggcccca gagaacggca tcgtgagaca ggagcccggc agcccgcctc
      721 gagatggact gcaccatggg ccgctgtgcc tgggagagcc tgctcccttt tggaggggcg
      781 tcctgagcac cccagactcc tggcttcccc ctggcttccc ccagggcccc aaggacatgc
      841 tcccacttgt ggagggcgag ggcccccaga atggggagag gaaggtcaac tggctgggca
      901 gcaaagaggg actgcgctgg aaggaggcca tgcttaccca tccgctggca ttctgcgggc
      961 cagcgtgccc acctcgctgt ggccccctga tgcctgagca tagtggtggc catctcaaga
     1021 gtgaccctgt ggccttccgg ccctggcact gccctttcct tctggagacc aagatcctgg
     1081 agcgagctcc cttctgggtg cccacctgct tgccacccta cctagtgtct ggcctgcccc
     1141 cagagcatcc atgtgactgg cccctgaccc cgcacccctg ggtatactcc gggggccagc
     1201 ccaaagtgcc ctctgccttc agcttaggca gcaagggctt ttactacaag gatccgagca
     1261 ttcccaggtt ggcaaaggag cccttggcag ctgcggaacc tgggttgttt ggcttaaact
     1321 ctggtgggca cctgcagaga gccggggagg ccgaacgccc ttcactgcac cagagggatg
     1381 gagagatggg agctggccgg cagcagaatc cttgcccgct cttcctgggg cagccagaca
     1441 ctgtgccctg gacctcctgg cccgcttgtc ccccaggcct tgttcatact cttggcaacg
     1501 tctgggctgg gccaggcgat gggaaccttg ggtaccagct ggggccacca gcaacaccaa
     1561 ggtgcccctc tcctgagccg cctgtcaccc agcggggctg ctgttcatcc tacccaccca
     1621 ctaaaggtgg gggtcttggc ccttgtggga agtgccagga gggcctggag gggggtgcca
     1681 gtggagccag cgaacccagc gaggaagtga acaaggcctc tggccccagg gcctgtcccc
     1741 ccagccacca caccaagctg aagaagacat ggctcacacg gcactcggag cagtttgaat
     1801 gtccacgcgg ctgccctgag gtcgaggaga ggccggttgc tcggctccgg gccctcaaaa
     1861 gggcaggcag ccccgaggtc cagggagcaa tgggcagtcc agcccccaag cggccaccgg
     1921 acccttttcc aggcactgca gaacaggggg ctgggggttg gcaggaggtg cgggacacat
     1981 cgatagggaa caaggatgtg gactcgggac agcatgatga gcagaaagga ccccaagatg
     2041 gccaggccag tctccaggac ccgggacttc aggacatacc atgcctggct ctccctgcaa
     2101 aactggctca atgccaaagt tgtgcccagg cagctggaga gggaggaggg cacgcctgcc
     2161 actctcagca agtgcggaga tcgcctctgg gaggggagct gcagcaggag gaagacacag
     2221 ccaccaactc cagctctgag gaaggcccag ggtccggccc tgacagccgg ctcagcacag
     2281 gcctcgccaa gcacctgctc agtggtttgg gggaccgact gtgccgcctg ctgcggaggg
     2341 agcgggaggc cctggcttgg gcccagcggg aaggccaagg gccagccgtg acagaggaca
     2401 gcccaggcat tccacgctgc tgcagccgtt gccaccatgg actcttcaac acccactggc
     2461 gatgtccccg ctgcagccac cggctgtgtg tggcctgtgg tcgtgtggca ggcactgggc
     2521 gggccaggga gaaagcaggc tttcaggagc agtccgcgga ggagtgcacg caggaggccg
     2581 ggcacgctgc ctgttccctg atgctgaccc agtttgtctc cagccaggct ttggcagagc
     2641 tgagcactgc aatgcaccag gtctgggtca agtttgatat ccgggggcac tgcccctgcc
     2701 aagctgatgc ccgggtatgg gcccccgggg atgcaggcca gcagaaggaa tcaacacaga
     2761 aaacgccccc aactccacaa ccttcctgca atggcgacac ccacaggacc aagagcatca
     2821 aagaggagac ccccgattcc gctgagaccc cagcagagga ccgtgctggc cgagggcccc
     2881 tgccttgtcc ttctctctgc gaactgctgg cttctaccgc ggtcaaactc tgcttgggcc
     2941 atgagcgaat acacatggcc ttcgcccccg tcactccggc cctgcccagt gatgaccgca
     3001 tcaccaacat cctggacagc attatcgcac aggtggtgga acggaagatc caggagaaag
     3061 ccctggggcc ggggcttcga gctggcccgg gtctgcgcaa gggcctgggc ctgcccctct
     3121 ctccagtgcg gccccggctg cctcccccag gggctttgct gtggctgcag gagccccagc
     3181 cttgccctcg gcgtggcttc cacctcttcc aggagcactg gaggcagggc cagcctgtgt
     3241 tggtgtcagg gatccaaagg acattgcagg gcaacctgtg ggggacagaa gctcttgggg
     3301 cacttggagg ccaggtgcag gcgctgagcc ccctcggacc tccccagccc agcagcctgg
     3361 gcagcacaac attctgggag ggcttctcct ggcctgagct tcgcccaaag tcagacgagg
     3421 gctctgtcct cctgctgcac cgagctttgg gggatgagga caccagcagg gtggagaacc
     3481 tagctgccag tctgccactt ccggagtact gcgccctcca tggaaaactc aacctggctt
     3541 cctacctccc accgggcctt gccctgcgtc cactggagcc ccagctctgg gcagcctatg
     3601 gtgtgagccc gcaccgggga cacctgggga ccaagaacct ctgtgtggag gtggccgacc
     3661 tggtcagcat cctggtgcat gccgacacac cactgcctgc ctggcaccgg gcacagaaag
     3721 acttcctttc aggcctggac ggggaggggc tctggtctcc gggcagccag gtcagcactg
     3781 tgtggcacgt gttccgggca caggacgccc agcgcatccg ccgctttctc cagatggtgt
     3841 gcccggccgg ggcaggcgcc ctggagcctg gcgccccagg cagctgctac ctggatgcag
     3901 ggctgcggcg gcgcctgcgg gaggagtggg gcgtgagctg ctggaccctg ctccaggccc
     3961 ccggagaggc cgtgctggtg cctgcagggg ctccccacca ggtgcagggc ctggtgagca
     4021 cagtcagcgt cactcagcac ttcctctccc ctgagacctc tgccctctct gctcagctct
     4081 gccaccaggg acccagcctt ccccctgact gccacctgct ttatgcccag atggactggg
     4141 ctgtgttcca agcagtgaag gtggccgtgg ggacattaca ggaggccaaa tagagggatg
     4201 ctaggtgtct gggatcgggg tggggacagg tagaccaggt gctcagccca ggcacaactt
     4261 cagcagggga tggcgctagg ggacttgggg atttctggtc aaccccacaa gcaccactct
     4321 gggcacaagc agggcactct gttcccctcc cccttaagcc aacaaccaca gtgccaccaa
     4381 gctcacacct gtccttctca ggctggcatc tcccccaccc tgtgcccctt ttcatggtac
     4441 caggcccgca ctgggggcaa ttgacttcct ccaatcccca ctcctccgag acccaggaga
     4501 caaacagccc ttccttgggg aaacttggga atcattctgg cttaaacaac acctcctcct
     4561 gctgctcact cccgctgagc ccactctact gccccagctc cgtttctacc accgcatcct
     4621 cactgggctc actgcaggca tgctgaacaa ggggcctcca accttctgcc ctcctgccaa
     4681 aagatctggg gagtgtgagg agagggtggc atcaggagct gctcaggctt ggcggaggga
     4741 gcggcatggg cgatgtcact cagccccttc ccggtccgcc cgcttccctc cttcatgatt
     4801 tccattaaag tctgttgttt tgtgactgct gccagtgtgg ttggccctgc ccctgcaggc
     4861 cacatggtcc agggagggag ggggacatgg aaatctgcct tagagacaaa tggagtaggg
     4921 cagcccggag ctggggccca agggacagga caccactgcc tgctcttcgt ctggggcctg
     4981 gggccttgcc tcccactgag gagactttgg gtggggtggg gggctgtccc ccaaagatgc
     5041 tcctgagtgc aagagcaggc aaggcagagt cctggggcac agccacgagg tgacctccct
     5101 gtgcagagac tcccgagccc tactccaccc agcaagctcc agtccgcccc atctctcccg
     5161 tctaccctga cctggagatc cagaagtatg gcccagaaga gcccttgccc cgcctgtctg
     5221 cccttggtgg cagtggccat ggccgacgcc aggcccagcc accctgggac tgagcctgac
     5281 tgcttcagac agccgacccc tccttgtccc cgctccacgc ccgcagcctc ctggtggcgc
     5341 tccgccctct cccgcttcct ttgtgtatct cagccctaca aagaaaaaca ctcccactct
     5401 tgtcatacct aattgttcct gctgtggttt ggggaatttt ttttattaaa taaagttttt
     5461 tattataagg gtaa
//
