LOCUS       NM_000613               1575 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens hemopexin (HPX), mRNA.
ACCESSION   NM_000613
VERSION     NM_000613.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Greite,R., Schott,S., Wang,L., Gohlke,L., Kreimann,K., Derlin,K.,
            Gutberlet,M., Schmidbauer,M., Leffler,A., Tudorache,I., Salman,J.,
            Ius,F., Natanov,R., Fegbeutel,C., Haverich,A., Lichtinghagen,R.,
            Husing,A.M., von Vietinghoff,S., Schmitt,R., Shushakova,N.,
            Rong,S., Haller,H., Schmidt-Ott,K.M., Gram,M., Vijayan,V.,
            Scheffner,I., Gwinner,W. and Immenschuh,S.
  TITLE     Free heme and hemopexin in acute kidney injury after
            cardiopulmonary bypass and transient renal ischemia
  JOURNAL   Clin Transl Sci 16 (12), 2729-2743 (2023)
   PUBMED   37899696
  REMARK    GeneRIF: Free heme and hemopexin in acute kidney injury after
            cardiopulmonary bypass and transient renal ischemia.
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Liu,W., Lu,L., Pan,H., He,X., Zhang,M., Wang,N., Zhu,J., Yi,H. and
            Tang,S.
  TITLE     Heme oxygenase-1 and hemopexin gene polymorphisms and the risk of
            anti-tuberculosis drug-induced hepatotoxicity in China
  JOURNAL   Pharmacogenomics 23 (7), 431-441 (2022)
   PUBMED   35470713
  REMARK    GeneRIF: Heme oxygenase-1 and hemopexin gene polymorphisms and the
            risk of anti-tuberculosis drug-induced hepatotoxicity in China.
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Yildirim,N., Unal,S., Yalcinkaya,A., Karahan,F. and Oztas,Y.
  TITLE     Evaluation of the relationship between intravascular hemolysis and
            clinical manifestations in sickle cell disease: decreased hemopexin
            during vaso-occlusive crises and increased inflammation in acute
            chest syndrome
  JOURNAL   Ann Hematol 101 (1), 35-41 (2022)
   PUBMED   34564750
  REMARK    GeneRIF: Evaluation of the relationship between intravascular
            hemolysis and clinical manifestations in sickle cell disease:
            decreased hemopexin during vaso-occlusive crises and increased
            inflammation in acute chest syndrome.
REFERENCE   4  (bases 1 to 1575)
  AUTHORS   Law,M.L., Cai,G.Y., Hartz,J.A., Jones,C. and Kao,F.T.
  TITLE     The hemopexin gene maps to the same location as the beta-globin
            gene cluster on human chromosome 11
  JOURNAL   Genomics 3 (1), 48-52 (1988)
   PUBMED   3220477
REFERENCE   5  (bases 1 to 1575)
  AUTHORS   Morgan,W.T., Alam,J., Deaciuc,V., Muster,P., Tatum,F.M. and
            Smith,A.
  TITLE     Interaction of hemopexin with Sn-protoporphyrin IX, an inhibitor of
            heme oxygenase. Role for hemopexin in hepatic uptake of
            Sn-protoporphyrin IX and induction of mRNA for heme oxygenase
  JOURNAL   J Biol Chem 263 (17), 8226-8231 (1988)
   PUBMED   3372522
REFERENCE   6  (bases 1 to 1575)
  AUTHORS   Smith,A., Tatum,F.M., Muster,P., Burch,M.K. and Morgan,W.T.
  TITLE     Importance of ligand-induced conformational changes in hemopexin
            for receptor-mediated heme transport
  JOURNAL   J Biol Chem 263 (11), 5224-5229 (1988)
   PUBMED   2833500
REFERENCE   7  (bases 1 to 1575)
  AUTHORS   Altruda,F., Poli,V., Restagno,G. and Silengo,L.
  TITLE     Structure of the human hemopexin gene and evidence for
            intron-mediated evolution
  JOURNAL   J Mol Evol 27 (2), 102-108 (1988)
   PUBMED   2842511
REFERENCE   8  (bases 1 to 1575)
  AUTHORS   Taketani,S., Kohno,H., Naitoh,Y. and Tokunaga,R.
  TITLE     Isolation of the hemopexin receptor from human placenta
  JOURNAL   J Biol Chem 262 (18), 8668-8671 (1987)
   PUBMED   3036819
REFERENCE   9  (bases 1 to 1575)
  AUTHORS   Altruda,F., Poli,V., Restagno,G., Argos,P., Cortese,R. and
            Silengo,L.
  TITLE     The primary structure of human hemopexin deduced from cDNA
            sequence: evidence for internal, repeating homology
  JOURNAL   Nucleic Acids Res 13 (11), 3841-3859 (1985)
   PUBMED   2989777
REFERENCE   10 (bases 1 to 1575)
  AUTHORS   Takahashi,N., Takahashi,Y. and Putnam,F.W.
  TITLE     Complete amino acid sequence of human hemopexin, the heme-binding
            protein of serum
  JOURNAL   Proc Natl Acad Sci U S A 82 (1), 73-77 (1985)
   PUBMED   3855550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005395.1, AK313648.1 and
            AV655383.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000613.2.
            
            Summary: This gene encodes a plasma glycoprotein that binds heme
            with high affinity. The encoded protein is an acute phase protein
            that transports heme from the plasma to the liver and may be
            involved in protecting cells from oxidative stress. [provided by
            RefSeq, Apr 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.81928.1,
                                           SRR5189658.89065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265983.8/ ENSP00000265983.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-766               BC005395.1         38-803
            767-786             AK313648.1         767-786
            787-1572            BC005395.1         805-1590
            1573-1575           AV655383.1         408-410
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1575
                     /gene="HPX"
                     /gene_synonym="HX"
                     /note="hemopexin"
                     /db_xref="GeneID:3263"
                     /db_xref="HGNC:HGNC:5171"
                     /db_xref="MIM:142290"
     exon            1..107
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1413
                     /gene="HPX"
                     /gene_synonym="HX"
                     /EC_number="3.2.1.35"
                     /note="beta-1B-glycoprotein; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="hemopexin precursor"
                     /protein_id="NP_000604.1"
                     /db_xref="CCDS:CCDS7763.1"
                     /db_xref="GeneID:3263"
                     /db_xref="HGNC:HGNC:5171"
                     /db_xref="MIM:142290"
                     /translation="MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDP
                     DVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFR
                     QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVL
                     FFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPP
                     RYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYA
                     FSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGG
                     YTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQAT
                     WTELPWPHEKVDGALCMEKSLGPNSCSANGPGLYLIHGPNLYCYSDVEKLNAAKALPQ
                     PQNVTSLLGCTH"
     exon            108..166
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            167..238
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            239..360
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            361..514
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            515..727
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            728..859
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            860..990
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1153
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1575
                     /gene="HPX"
                     /gene_synonym="HX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPX"
                     /gene_synonym="HX"
                     /note="hexamer: AATAAA"
     polyA_site      1575
                     /gene="HPX"
                     /gene_synonym="HX"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgtggc ctctgcagct cagcatggct agggtactgg gagcacccgt tgcactgggg
       61 ttgtggagcc tatgctggtc tctggccatt gccacccctc ttcctccgac tagtgcccat
      121 gggaatgttg ctgaaggcga gaccaagcca gacccagacg tgactgaacg ctgctcagat
      181 ggctggagct ttgatgctac caccctggat gacaatggaa ccatgctgtt ttttaaaggg
      241 gagtttgtgt ggaagagtca caaatgggac cgggagttaa tctcagagag atggaagaat
      301 ttccccagcc ctgtggatgc tgcattccgt caaggtcaca acagtgtctt tctgatcaag
      361 ggggacaaag tctgggtata ccctcctgaa aagaaggaga aaggataccc aaagttgctc
      421 caagatgaat ttcctggaat cccatcccca ctggatgcag ctgtggaatg tcaccgtgga
      481 gaatgtcaag ctgaaggcgt cctcttcttc caaggtgacc gcgagtggtt ctgggacttg
      541 gctacgggaa ccatgaagga gcgttcctgg ccagctgttg ggaactgctc ctctgccctg
      601 agatggctgg gccgctacta ctgcttccag ggtaaccaat tcctgcgctt cgaccctgtc
      661 aggggagagg tgcctcccag gtacccgcgg gatgtccgag actacttcat gccctgccct
      721 ggcagaggcc atggacacag gaatgggact ggccatggga acagtaccca ccatggccct
      781 gagtatatgc gctgtagccc acatctagtc ttgtctgcac tgacgtctga caaccatggt
      841 gccacctatg ccttcagtgg gacccactac tggcgtctgg acaccagccg ggatggctgg
      901 catagctggc ccattgctca tcagtggccc cagggtcctt cagcagtgga tgctgccttt
      961 tcctgggaag aaaaactcta tctggtccag ggcacccagg tatatgtctt cctgacaaag
     1021 ggaggctata ccctagtaag cggttatccg aagcggctgg agaaggaagt cgggacccct
     1081 catgggatta tcctggactc tgtggatgcg gcctttatct gccctgggtc ttctcggctc
     1141 catatcatgg caggacggcg gctgtggtgg ctggacctga agtcaggagc ccaagccacg
     1201 tggacagagc ttccttggcc ccatgagaag gtagacggag ccttgtgtat ggaaaagtcc
     1261 cttggcccta actcatgttc cgccaatggt cccggcttgt acctcatcca tggtcccaat
     1321 ttgtactgct acagtgatgt ggagaaactg aatgcagcca aggcccttcc gcaaccccag
     1381 aatgtgacca gtctcctggg ctgcactcac tgaggggcct tctgacatga gtctggcctg
     1441 gccccacctc ctagttcctc ataataaaga cagattgctt cttcgcttct cactgagggg
     1501 ccttctgaca tgagtctggc ctggccccac ctccccagtt tctcataata aagacagatt
     1561 gcttcttcac ttgaa
//
