LOCUS       NM_181507               4840 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens HPS5 biogenesis of lysosomal organelles complex 2
            subunit 2 (HPS5), transcript variant 1, mRNA.
ACCESSION   NM_181507
VERSION     NM_181507.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4840)
  AUTHORS   D'Costa,V.M., Coyaud,E., Boddy,K.C., Laurent,E.M.N., St-Germain,J.,
            Li,T., Grinstein,S., Raught,B. and Brumell,J.H.
  TITLE     BioID screen of Salmonella type 3 secreted effectors reveals host
            factors involved in vacuole positioning and stability during
            infection
  JOURNAL   Nat Microbiol 4 (12), 2511-2522 (2019)
   PUBMED   31611645
REFERENCE   2  (bases 1 to 4840)
  AUTHORS   Botero,J.P., Chen,D., Majerus,J.A., Coon,L.M., He,R., Warad,D.M.,
            Pruthi,R.K. and Nichols,W.L.
  TITLE     Hermansky-Pudlak syndrome subtype 5 (HPS-5) novel mutation in a 65
            year-old with oculocutaneous hypopigmentation and mild bleeding
            diathesis: The importance of recognizing a subtle phenotype
  JOURNAL   Platelets 29 (1), 91-94 (2018)
   PUBMED   29090612
  REMARK    GeneRIF: This case underscores the importance of recognizing the
            mild clinical phenotype of HPS-5 and utilization of both laboratory
            and molecular testing for diagnosis, prognostication, and
            surveillance for end organ damage in patients affected with HPS.
            Review article
REFERENCE   3  (bases 1 to 4840)
  AUTHORS   Wei,A., Yuan,Y., Bai,D., Ma,J., Hao,Z., Zhang,Y., Yu,J., Zhou,Z.,
            Yang,L., Yang,X., Li,L. and Li,W.
  TITLE     NGS-based 100-gene panel of hypopigmentation identifies mutations
            in Chinese Hermansky-Pudlak syndrome patients
  JOURNAL   Pigment Cell Melanoma Res 29 (6), 702-706 (2016)
   PUBMED   27593200
  REMARK    GeneRIF: HPS5 mutation is associated with high hypopigmentation in
            Hermansky-Pudlak syndrome.
REFERENCE   4  (bases 1 to 4840)
  AUTHORS   Li,K., Yang,L., Zhang,C., Niu,Y., Li,W. and Liu,J.J.
  TITLE     HPS6 interacts with dynactin p150Glued to mediate retrograde
            trafficking and maturation of lysosomes
  JOURNAL   J Cell Sci 127 (Pt 21), 4574-4588 (2014)
   PUBMED   25189619
REFERENCE   5  (bases 1 to 4840)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 4840)
  AUTHORS   Huizing,M., Hess,R., Dorward,H., Claassen,D.A., Helip-Wooley,A.,
            Kleta,R., Kaiser-Kupfer,M.I., White,J.G. and Gahl,W.A.
  TITLE     Cellular, molecular and clinical characterization of patients with
            Hermansky-Pudlak syndrome type 5
  JOURNAL   Traffic 5 (9), 711-722 (2004)
   PUBMED   15296495
  REMARK    GeneRIF: LAMP-3 distribution was restricted to the perinuclear
            region in HPS-5 fibroblasts, instead of extending to the periphery
REFERENCE   7  (bases 1 to 4840)
  AUTHORS   Di Pietro,S.M., Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Characterization of BLOC-2, a complex containing the
            Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6
  JOURNAL   Traffic 5 (4), 276-283 (2004)
   PUBMED   15030569
  REMARK    GeneRIF: Component of BLOC-2.  Results suggest a common biological
            basis underlying the pathogenesis of HPS-3, -5 and -6 disease.
REFERENCE   8  (bases 1 to 4840)
  AUTHORS   Zhang,Q., Zhao,B., Li,W., Oiso,N., Novak,E.K., Rusiniak,M.E.,
            Gautam,R., Chintala,S., O'Brien,E.P., Zhang,Y., Roe,B.A.,
            Elliott,R.W., Eicher,E.M., Liang,P., Kratz,C., Legius,E.,
            Spritz,R.A., O'Sullivan,T.N., Copeland,N.G., Jenkins,N.A. and
            Swank,R.T.
  TITLE     Ru2 and Ru encode mouse orthologs of the genes mutated in human
            Hermansky-Pudlak syndrome types 5 and 6
  JOURNAL   Nat Genet 33 (2), 145-153 (2003)
   PUBMED   12548288
REFERENCE   9  (bases 1 to 4840)
  AUTHORS   Wixler,V., Laplantine,E., Geerts,D., Sonnenberg,A., Petersohn,D.,
            Eckes,B., Paulsson,M. and Aumailley,M.
  TITLE     Identification of novel interaction partners for the conserved
            membrane proximal region of alpha-integrin cytoplasmic domains
  JOURNAL   FEBS Lett 445 (2-3), 351-355 (1999)
   PUBMED   10094488
REFERENCE   10 (bases 1 to 4840)
  AUTHORS   Introne,W.J., Huizing,M., Malicdan,M.C.V., O'Brien,K.J. and
            Gahl,W.A.
  TITLE     Hermansky-Pudlak Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084117.6 and AC107948.7.
            
            On Aug 31, 2019 this sequence version replaced NM_181507.1.
            
            Summary: This gene encodes a protein that may play a role in
            organelle biogenesis associated with melanosomes, platelet dense
            granules, and lysosomes. This protein interacts with
            Hermansky-Pudlak syndrome 6 protein and may interact with the
            cytoplasmic domain of integrin, alpha-3. Mutations in this gene are
            associated with Hermansky-Pudlak syndrome type 5. Multiple
            transcript variants encoding two distinct isoforms have been
            identified for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291663.1, AF534401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349215.8/ ENSP00000265967.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC084117.6         30320-30514         c
            196-352             AC084117.6         26125-26281         c
            353-463             AC084117.6         20288-20398         c
            464-528             AC084117.6         19761-19825         c
            529-721             AC084117.6         19115-19307         c
            722-855             AC084117.6         17320-17453         c
            856-1068            AC084117.6         14509-14721         c
            1069-1140           AC084117.6         13796-13867         c
            1141-1229           AC084117.6         9202-9290           c
            1230-1408           AC084117.6         7166-7344           c
            1409-1567           AC084117.6         5933-6091           c
            1568-1754           AC084117.6         5172-5358           c
            1755-1878           AC084117.6         4373-4496           c
            1879-2028           AC084117.6         3394-3543           c
            2029-2106           AC084117.6         1273-1350           c
            2107-2499           AC084117.6         1-393               c
            2500-2684           AC107948.7         37697-37881
            2685-2805           AC107948.7         41310-41430
            2806-2961           AC107948.7         41633-41788
            2962-3081           AC107948.7         42613-42732
            3082-3195           AC107948.7         43864-43977
            3196-3302           AC107948.7         45422-45528
            3303-3573           AC107948.7         47103-47373
            3574-4840           AC107948.7         49381-50647
FEATURES             Location/Qualifiers
     source          1..4840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..4840
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /note="HPS5 biogenesis of lysosomal organelles complex 2
                     subunit 2"
                     /db_xref="GeneID:11234"
                     /db_xref="HGNC:HGNC:17022"
                     /db_xref="MIM:607521"
     exon            1..195
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            196..352
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..3634
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /note="isoform a is encoded by transcript variant 1; alpha
                     integrin binding protein 63; ruby-eye protein 2 homolog;
                     Hermansky-Pudlak syndrome 5 protein; BLOC-2 complex member
                     HPS5"
                     /codon_start=1
                     /product="BLOC-2 complex member HPS5 isoform a"
                     /protein_id="NP_852608.1"
                     /db_xref="CCDS:CCDS7836.1"
                     /db_xref="GeneID:11234"
                     /db_xref="HGNC:HGNC:17022"
                     /db_xref="MIM:607521"
                     /translation="MAFVPVIPESYSHVLAEFESLDPLLSALRLDSSRLKCTSIAVSR
                     KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVACCLHDDDYVAVATSQGLVVVW
                     ELNQERRGKPEQMYVSSEHKGRRVTALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKA
                     AAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTEREKFWKIGNKERDGE
                     YGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLLSLPPLPVITLRS
                     EPQYDHTAGSSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVA
                     VCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNSVIASRARKT
                     LTADKLEHLKSQLDHGTYNDLISQLEELILKFEPLDSACSSRRSSISSHESFSILDSG
                     IYRIISSRRGSQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSH
                     APVMFETDKNETFLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDL
                     KVRPELRGDEQSCEEDVSSDTCPKEEDTEEEKEVTSPPPEEDRFQELKVATAEAMTKL
                     QDPLVLFESESLRMVLQEWLSHLEKTFAMKDFSGVSDTDNSSMKLNQDVLLVNESKKG
                     ILDEDNEKEKRDSLGNEESVDKTACECVRSPRESLDDLFQICSPCAIASGLRNDLAEL
                     TTLCLELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKKYFFLLNLKRAKESIKLSY
                     SNSPSVWDTFIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEVPFDSPLLVVYATRLY
                     EKFGESALRSLIKFFPSILPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRSSFLESLL
                     QPESLRLDWLLLAVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLILHLIKLPADFIT
                     KEKMTDICRSCGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWK
                     LLLHLIQSKSTRPAPQESLNGSLSDGPSPINVENVALLLAKAMGPDRAWSLLQECGLA
                     LELSEKFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA"
     exon            353..463
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..528
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..721
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..855
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1068
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1140
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1229
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1408
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1567
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1754
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1878
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2028
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2106
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2684
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2805
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2961
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3081
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3195
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3302
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3573
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..4840
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4746..4751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /note="hexamer: ACTAAA"
     polyA_site      4764
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
     regulatory      4818..4823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /note="hexamer: AGTAAA"
     polyA_site      4840
                     /gene="HPS5"
                     /gene_synonym="AIBP63; BLOC2S2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcggt gagttccccg gcgctaagcc gggagacaag atccgatcta ctgagagctg
       61 cgaggtactg ccctggatgt ggtggagctg ggctgggacc tccgggctgc tggtctgtga
      121 gcctggcttt gaaaattggt tactgggtct cctctcaaga aatctcaaga tattaaagtt
      181 actgctgtta aaaaggtgag gaatactgta tctatcattc aacaagtttc agctttctgg
      241 ctaaatggct tttgtgccag tgataccaga gtcctacagc catgttcttg cagagtttga
      301 atctctggat ccattactct cagccctgcg gctggactcc agtcgtctaa agtgcacgag
      361 catagctgtg tctcggaaat ggttggcttt gggcagttca ggaggaggac tccatctcat
      421 tcagaaagaa ggctggaagc acaggctttt tctttcacac agggaaggtg caatttctca
      481 agtcgcctgt tgtttacatg atgatgatta tgttgctgta gctaccagtc aaggtcttgt
      541 ggttgtttgg gaattaaatc aagagcgtcg tgggaaaccg gaacaaatgt atgtgtcttc
      601 agaacacaaa ggccgaagag tcacagctct ctgctgggat acagctattc ttagagtttt
      661 tgtaggtgat catgctggga aggtttctgc tatcaaactc aatacttcta aacaagcaaa
      721 ggcagctgct gcttttgtga tgtttcctgt tcagacaatc acaactgttg actcctgtgt
      781 tgtacagtta gattatttgg atggaaggct acttatatct tcacttactc gatccttctt
      841 gtgtgacact gagagagaaa agttttggaa aattggaaac aaggaaagag atggagaata
      901 tggagcttgt ttctttcctg gaagatgttc tgggggccag caacctctga tatattgtgc
      961 tcgcccaggc tctaggatgt gggaagtgaa ctttgatgga gaagttataa gtacacatca
     1021 gttcaagaaa ctcctctcgt tgccacctct ccctgtgatt actctcagat cagaacctca
     1081 gtatgatcat acagctggat cctcccagtc tttgtctttc cccaaactct tacatcttag
     1141 tgagcattgt gtgctgactt ggacagaaag aggaatttat attttcattc ctcagaatgt
     1201 tcaagttctt ctttggagtg aagtcaaaga tattcaggat gtggctgtct gtaggaatga
     1261 attgttctgt ttgcacctaa atgggaaagt ctcacatctc tccctgatat ctgtggagcg
     1321 ctgtgtggaa cgcctgctaa gaagaggcct atggaacttg gctgctcgta catgctgtct
     1381 tttccaaaat tctgtcattg ccagcagagc aagaaaaact ttgactgcag ataaattgga
     1441 gcatttgaaa tctcagctgg accatggcac ctacaatgat ctaatttctc aactggaaga
     1501 attgatctta aaatttgaac ctttggattc agcttgtagc agtagaagaa gctccatttc
     1561 atcacatgaa agtttcagca tcttggactc tggtatttat cgtatcatta gtagtagaag
     1621 aggcagtcag tcagatgaag actcttgctc ccttcacagc caaaccctct cagaagatga
     1681 gagatttaaa gaattcacct cacagcagga agaggacctg ccagatcagt gttgtggctc
     1741 acacggaaat gaagacaatg tttctcatgc tccagtgatg tttgagacag ataagaatga
     1801 aacttttctc ccgttcggca ttccattacc atttcgttct ccatctcctc ttgtgtctct
     1861 tcaggctgtc aaagaaagtg tttctagctt tgtgcgtaaa actactgaga agattggcac
     1921 ccttcacacg agccctgatc tgaaagtgag accagagctc aggggtgatg agcaatcatg
     1981 tgaagaggat gtgagttcag atacctgccc aaaggaggaa gacactgagg aggaaaaaga
     2041 ggtaactagt ccacctccag aagaagacag gttccaggag cttaaagtag caacagcaga
     2101 agcaatgacc aagctacagg accctctggt tttatttgaa tccgagtctc tgagaatggt
     2161 tttacaggag tggctttcac atttagaaaa aacatttgcc atgaaggact tttcaggtgt
     2221 ttcagatact gacaactcat ccatgaaatt gaaccaggat gtgctattag ttaatgaatc
     2281 aaaaaaggga atattagatg aagataatga aaaagaaaaa agggactctt taggcaatga
     2341 agaatctgtt gataaaacag catgtgaatg tgtaaggagt ccaagggagt ctttggatga
     2401 cctgtttcaa atatgttctc catgcgccat tgcaagtggt cttcggaacg acctggctga
     2461 attgacaaca ttatgtttgg agttgaatgt attgaattct aagatcaaaa gcaccagtgg
     2521 acatgtggac cacactttgc aacagtactc tcctgaaatt ctggcttgcc agttcctgaa
     2581 gaagtacttt tttctcctga acttgaaaag agcgaaggag agtatcaagc ttagttacag
     2641 taatagccct tctgtttggg atacttttat tgaaggattg aaagaaatgg caagttccaa
     2701 tcctgtgtat atggagatgg aaaaaggaga tctaccaaca aggttaaagt tactagatga
     2761 cgaggttcct tttgatagtc cgttgttggt tgtttatgct acccggttgt atgaaaagtt
     2821 tggggagtct gctcttcgat ccttaatcaa gttctttcca tccattttgc catcggatat
     2881 catacaactt tgtcatcatc atcctgctga gtttttggcc tatttagaca gtctggtgaa
     2941 atcaaggcct gaagatcagc ggtcatcttt tcttgagtcc cttctgcaac cagagtcttt
     3001 aaggttggat tggctgcttt tggcagtgtc ccttgatgct ccaccaagca ccagcacaat
     3061 ggatgatgaa ggttatccca ggcctcattc acacttgctt tcctggggtt acagtcagct
     3121 gatccttcat ctaattaaac ttcctgcaga ttttataacc aaagagaaaa tgacagacat
     3181 ctgcaggtct tgtggtttct ggcctggata tctaattctc tgtttggagc tggagagaag
     3241 aagagaggcc ttcaccaata ttgtgtatct gaatgatatg agcctgatgg aaggggacaa
     3301 tggttggatc ccagagaccg tggaggaatg gaagcttctc cttcatctca tacagagcaa
     3361 gagcacgagg ccagcccccc aggagtcact aaatgggagc ctcagtgatg ggccttcccc
     3421 catcaatgtg gagaatgtgg cacttctgtt agctaaggcc atgggcccag atcgggcttg
     3481 gtcactgcta caggaatgtg gtctggccct tgagttgtca gagaagttta ccagaacctg
     3541 cgatatcctg aggattgctg agaaaaggca gagggccttg atacaaagca tgcttgaaaa
     3601 atgcgatcgg tttctctggt cccagcaggc ctagtgggag aagattcagc aggatgtcat
     3661 gacattttga gaaaaactaa atcatgctcc tgaaccttct gaacgcattt gttattgaag
     3721 gaaagacacc acccccaaat cctgccatct tattggggct acttttgtca gtgtctgtac
     3781 ccttggcatc ggcatctgtg actctttatc catgacctca gtgtttctta accaaagttg
     3841 tactcagcat ttcttaacca aagttgaatt ttgaaaagag tcagtccttg tttgctggaa
     3901 ttagaatgtt aatgtcctag tattattccg aactacagta ttaactgctt gttgctagtg
     3961 gattagacag attcttttct tactgtggct tccatgttgg gagcagaagc ttttcatcct
     4021 ggtcacatga agacagatgg tattattgac tggagttgaa ttatttttat atcttgtctg
     4081 gcacaatatg gaaattactg aaataagacg gtgtataatg gaattaacac ccaaaataag
     4141 tagaacactg aagatttgaa tttgatattt aagtaaaatg ggactgggtg cagtggctca
     4201 ggcctgtaat cccaaccctt tggaaggtaa agacgggagg atcacttgag gccaggagtt
     4261 caagaccagc ctgggcaaca tagtgagaat gcatctctac aaaaaataaa aaaaattagc
     4321 taggcatagt acctgaggcc aggaggtcca ggccgcaatg agatgtgttt gtgccattgc
     4381 acaccagtct gggtgacaga gaaagaccct gtctcaaaaa caaattaaat aaaatatctt
     4441 catatataaa ttaagctaat taaaaatatt tttccctgta tttatttaat attttctaat
     4501 ctgaacccat atacagctga ctaattcatt cttagaaatg tgttatctgt aatctttcct
     4561 aaacagagta gcccacaaga atcatgcact ttttaaaatt atttctaaga agccataaca
     4621 aagctgtgta ctaataaaga ctgcagcaag cacttgtgtt atttaaatta tgtaagtaga
     4681 ttgtcatttg tcaggctcct gtacatttac atagcatgtt atattaataa taaatgtaaa
     4741 atatgactaa agttttcatt ggaacacaat gtagacagga ggtttattat gagcattttg
     4801 cagaaaggtg tggagtaagt aaagtgttgg atgcactgaa
//
