LOCUS       NM_020995               1242 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens haptoglobin-related protein (HPR), transcript variant
            1, mRNA.
ACCESSION   NM_020995
VERSION     NM_020995.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Maesaka,J.K., Imbriano,L.J., Grant,C. and Miyawaki,N.
  TITLE     Haptoglobin-Related Protein without Signal Peptide as Biomarker of
            Renal Salt Wasting in Hyponatremia, Hyponatremia-Related Diseases
            and as New Syndrome in Alzheimer's Disease
  JOURNAL   Biomolecules 13 (4), 638 (2023)
   PUBMED   37189385
  REMARK    GeneRIF: Haptoglobin-Related Protein without Signal Peptide as
            Biomarker of Renal Salt Wasting in Hyponatremia,
            Hyponatremia-Related Diseases and as New Syndrome in Alzheimer's
            Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1242)
  AUTHORS   Skytthe,M.K., Sorensen,A.L., Hennig,D., Sandberg,M.B.,
            Rasmussen,L.M., Hojrup,P., Moller,H.J., Skjodt,K., Moestrup,S.K.
            and Graversen,J.H.
  TITLE     Haptoglobin-related protein in human plasma correlates to
            haptoglobin concentrations and phenotypes
  JOURNAL   Scand J Clin Lab Invest 82 (6), 461-466 (2022)
   PUBMED   36129375
  REMARK    GeneRIF: Haptoglobin-related protein in human plasma correlates to
            haptoglobin concentrations and phenotypes.
REFERENCE   3  (bases 1 to 1242)
  AUTHORS   Soejima,M. and Koda,Y.
  TITLE     Haptoglobin polymorphisms in Latin American populations
  JOURNAL   Sci Rep 10 (1), 13780 (2020)
   PUBMED   32792581
  REMARK    GeneRIF: Haptoglobin polymorphisms in Latin American populations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1242)
  AUTHORS   Yang,L., Yang,Z., Cheng,L., Cheng,J., Cheng,L., Sun,Y., Li,W.,
            Song,K., Huang,W., Yin,Y., Tao,S. and Zhang,Q.
  TITLE     Lectin Microarray Combined with Mass Spectrometry Identifies
            Haptoglobin-Related Protein (HPR) as a Potential Serologic
            Biomarker for Separating Nonbacterial Pneumonia from Bacterial
            Pneumonia in Childhood
  JOURNAL   Proteomics Clin Appl 12 (6), e1800030 (2018)
   PUBMED   29785832
  REMARK    GeneRIF: These results indicate that HPR is a potential serologic
            biomarker which can differentiate between bacterial pneumonia and
            nonbacterial pneumonia. Detection of serum HPR might be useful for
            clinical diagnosis.
REFERENCE   5  (bases 1 to 1242)
  AUTHORS   Ofon,E., Noyes,H., Mulindwa,J., Ilboudo,H., Simuunza,M., Ebo'o,V.,
            Njiokou,F., Koffi,M., Bucheton,B., Fogue,P., Hertz-Fowler,C.,
            MacLeod,A. and Simo,G.
  CONSRTM   TrypanoGEN Research Group, as members of The H3Africa Consortium
  TITLE     A polymorphism in the haptoglobin, haptoglobin related protein
            locus is associated with risk of human sleeping sickness within
            Cameroonian populations
  JOURNAL   PLoS Negl Trop Dis 11 (10), e0005979 (2017)
   PUBMED   29077717
  REMARK    GeneRIF: the haptoglobin (HP) rs8062041 appeared to be protective
            against African Trypanosomiasis; HPR is adjacent to HP and is a
            component of the Trypanolytic factor; the HP and HPR locus is
            duplicated in some people; the rs8062041 variant may be associated
            with this duplication and it is possible that increased production
            of HPR is the cause of protection associated with rs806204
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1242)
  AUTHORS   Smith,A.B., Esko,J.D. and Hajduk,S.L.
  TITLE     Killing of trypanosomes by the human haptoglobin-related protein
  JOURNAL   Science 268 (5208), 284-286 (1995)
   PUBMED   7716520
REFERENCE   7  (bases 1 to 1242)
  AUTHORS   Erickson,L.M., Kim,H.S. and Maeda,N.
  TITLE     Junctions between genes in the haptoglobin gene cluster of primates
  JOURNAL   Genomics 14 (4), 948-958 (1992)
   PUBMED   1478675
REFERENCE   8  (bases 1 to 1242)
  AUTHORS   Maeda,N., McEvoy,S.M., Harris,H.F., Huisman,T.H. and Smithies,O.
  TITLE     Polymorphisms in the human haptoglobin gene cluster: chromosomes
            with multiple haptoglobin-related (Hpr) genes
  JOURNAL   Proc Natl Acad Sci U S A 83 (19), 7395-7399 (1986)
   PUBMED   2876426
REFERENCE   9  (bases 1 to 1242)
  AUTHORS   Maeda,N.
  TITLE     Nucleotide sequence of the haptoglobin and haptoglobin-related gene
            pair. The haptoglobin-related gene contains a retrovirus-like
            element
  JOURNAL   J Biol Chem 260 (11), 6698-6709 (1985)
   PUBMED   2987228
REFERENCE   10 (bases 1 to 1242)
  AUTHORS   Bensi,G., Raugei,G., Klefenz,H. and Cortese,R.
  TITLE     Structure and expression of the human haptoglobin locus
  JOURNAL   EMBO J 4 (1), 119-126 (1985)
   PUBMED   4018023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB147217.1, T71114.1,
            AV698541.1, CB115435.1, BM547990.1, N55255.1 and H93376.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 17, 2020 this sequence version replaced NM_020995.3.
            
            Summary: This gene encodes a haptoglobin-related protein that binds
            hemoglobin as efficiently as haptoglobin. Unlike haptoglobin,
            plasma concentration of this protein is unaffected in patients with
            sickle cell anemia and extensive intravascular hemolysis,
            suggesting a difference in binding between haptoglobin-hemoglobin
            and haptoglobin-related protein-hemoglobin complexes to CD163, the
            hemoglobin scavenger receptor. This protein may also be a
            clinically important predictor of recurrence of breast cancer.
            [provided by RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.745901.1,
                                           SRR14038194.2784129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000540303.7/ ENSP00000441828.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CB147217.1         1-26
            27-33               T71114.1           12-18
            34-363              AV698541.1         19-348
            364-548             CB115435.1         363-547
            549-991             BM547990.1         436-878
            992-1241            N55255.1           2-251               c
            1242-1242           H93376.1           4-4                 c
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..1242
                     /gene="HPR"
                     /gene_synonym="A-259H10.2; HP"
                     /note="haptoglobin-related protein"
                     /db_xref="GeneID:3250"
                     /db_xref="HGNC:HGNC:5156"
                     /db_xref="MIM:140210"
     exon            1..35
                     /gene="HPR"
                     /gene_synonym="A-259H10.2; HP"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1077
                     /gene="HPR"
                     /gene_synonym="A-259H10.2; HP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Haptoglobin-related locus"
                     /codon_start=1
                     /product="haptoglobin-related protein isoform 1 precursor"
                     /protein_id="NP_066275.3"
                     /db_xref="CCDS:CCDS42193.1"
                     /db_xref="GeneID:3250"
                     /db_xref="HGNC:HGNC:5156"
                     /db_xref="MIM:140210"
                     /translation="MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGY
                     VEHLFRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQ
                     RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIA
                     PTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVG
                     RVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPIL
                     NEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKV
                     TSIQHWVQKTIAEN"
     exon            36..121
                     /gene="HPR"
                     /gene_synonym="A-259H10.2; HP"
                     /inference="alignment:Splign:2.1.0"
     exon            122..223
                     /gene="HPR"
                     /gene_synonym="A-259H10.2; HP"
                     /inference="alignment:Splign:2.1.0"
     exon            224..298
                     /gene="HPR"
                     /gene_synonym="A-259H10.2; HP"
                     /inference="alignment:Splign:2.1.0"
     exon            299..1242
                     /gene="HPR"
                     /gene_synonym="A-259H10.2; HP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgctcttc cagaggcaag accaaccaag atgagtgacc tgggagctgt catttccctc
       61 ctgctctggg gacgacagct ttttgcactg tactcaggca atgatgtcac ggatatttca
      121 gatgaccgct tcccgaagcc ccctgagatt gcaaatggct atgtggagca cttgtttcgc
      181 taccagtgta agaactacta cagactgcgc acagaaggag atggagtata caccttaaat
      241 gataagaagc agtggataaa taaggctgtt ggagataaac ttcctgaatg tgaagcagta
      301 tgtgggaagc ccaagaatcc ggcaaaccca gtgcagcgga tcctgggtgg acacctggat
      361 gccaaaggca gctttccctg gcaggctaag atggtttccc accataatct caccacaggg
      421 gccacgctga tcaatgaaca atggctgctg accacggcta aaaatctctt cctgaaccat
      481 tcagaaaatg caacagcgaa agacattgcc cctactttaa cactctatgt ggggaaaaag
      541 cagcttgtag agattgagaa ggtggttcta caccctaact accaccaggt agatattggg
      601 ctcatcaaac tcaaacagaa ggtgcttgtt aatgagagag tgatgcccat ctgcctacct
      661 tcaaagaatt atgcagaagt agggcgtgtg ggttacgtgt ctggctgggg acaaagtgac
      721 aactttaaac ttactgacca tctgaagtat gtcatgctgc ctgtggctga ccaatacgat
      781 tgcataacgc attatgaagg cagcacatgc cccaaatgga aggcaccgaa gagccctgta
      841 ggggtgcagc ccatactgaa cgaacacacc ttctgtgtcg gcatgtctaa gtaccaggaa
      901 gacacctgct atggcgatgc gggcagtgcc tttgccgttc acgacctgga ggaggacacc
      961 tggtacgcgg ctgggatcct aagctttgat aagagctgtg ctgtggctga gtatggtgtg
     1021 tatgtgaagg tgacttccat ccagcactgg gttcagaaga ccatagctga gaactaatgc
     1081 aaggctggcc ggaagccctt gcctgaaagc aagatttcag cctggaagag ggcaaagtgg
     1141 acgggagtgg acaggagtgg atgcgataag atgtggtttg aagctgatgg gtgccagccc
     1201 tgcattgctg agtcaatcaa taaagagctt tcttttgacc ca
//
