LOCUS       NM_014485               1596 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), mRNA.
ACCESSION   NM_014485
VERSION     NM_014485.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Hamamura,K., Yoshida,Y., Oyama,K., Li,J., Kawano,S., Inoue,K.,
            Toyooka,K., Yamadera,M., Matsunaga,N., Matsumura,T. and Aritake,K.
  TITLE     Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells
            and Pericytes in Autopsy Myocardial Specimens from Patients with
            Duchenne Muscular Dystrophy
  JOURNAL   Int J Mol Sci 25 (3), 1846 (2024)
   PUBMED   38339125
  REMARK    GeneRIF: Hematopoietic Prostaglandin D Synthase Is Increased in
            Mast Cells and Pericytes in Autopsy Myocardial Specimens from
            Patients with Duchenne Muscular Dystrophy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Meleza,C., Thomasson,B., Ramachandran,C., O'Neill,J.W.,
            Michelsen,K. and Lo,M.C.
  TITLE     Development of a scintillation proximity binding assay for
            high-throughput screening of hematopoietic prostaglandin D2
            synthase
  JOURNAL   Anal Biochem 511, 17-23 (2016)
   PUBMED   27485270
  REMARK    GeneRIF: the development of a competition binding assay amenable to
            high-throughput screening (HTS) in a scintillation proximity assay
            (SPA) format. This assay was used to screen an in-house compound
            library of approximately 280,000 compounds for novel H-PGDS
            inhibitors.
REFERENCE   5  (bases 1 to 1596)
  AUTHORS   Hamsten,C., Haggmark,A., Grundstrom,J., Mikus,M., Lindskog,C.,
            Konradsen,J.R., Eklund,A., Pershagen,G., Wickman,M., Grunewald,J.,
            Melen,E., Hedlin,G., Nilsson,P. and van Hage,M.
  TITLE     Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal
            association with childhood asthma
  JOURNAL   Allergy 71 (9), 1357-1361 (2016)
   PUBMED   27145233
  REMARK    GeneRIF: we have utilized a broad-scaled affinity proteomics
            approach to identify three proteins (CCL5, HPGDS, and NPSR1) with
            altered plasma levels in asthmatic children compared to healthy
            controls, representing the first evaluation of HPGDS and NPSR1 in
            plasma.
REFERENCE   6  (bases 1 to 1596)
  AUTHORS   Kanaoka,Y., Fujimori,K., Kikuno,R., Sakaguchi,Y., Urade,Y. and
            Hayaishi,O.
  TITLE     Structure and chromosomal localization of human and mouse genes for
            hematopoietic prostaglandin D synthase. Conservation of the
            ancestral genomic structure of sigma-class glutathione
            S-transferase
  JOURNAL   Eur J Biochem 267 (11), 3315-3322 (2000)
   PUBMED   10824118
REFERENCE   7  (bases 1 to 1596)
  AUTHORS   Pinzar,E., Kanaoka,Y., Inui,T., Eguchi,N., Urade,Y. and Hayaishi,O.
  TITLE     Prostaglandin D synthase gene is involved in the regulation of
            non-rapid eye movement sleep
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4903-4907 (2000)
   PUBMED   10781097
REFERENCE   8  (bases 1 to 1596)
  AUTHORS   Tokugawa,Y., Kunishige,I., Kubota,Y., Shimoya,K., Nobunaga,T.,
            Kimura,T., Saji,F., Murata,Y., Eguchi,N., Oda,H., Urade,Y. and
            Hayaishi,O.
  TITLE     Lipocalin-type prostaglandin D synthase in human male reproductive
            organs and seminal plasma
  JOURNAL   Biol Reprod 58 (2), 600-607 (1998)
   PUBMED   9475419
REFERENCE   9  (bases 1 to 1596)
  AUTHORS   Suzuki,T., Watanabe,K., Kanaoka,Y., Sato,T. and Hayaishi,O.
  TITLE     Induction of hematopoietic prostaglandin D synthase in human
            megakaryocytic cells by phorbol ester
  JOURNAL   Biochem Biophys Res Commun 241 (2), 288-293 (1997)
   PUBMED   9425264
REFERENCE   10 (bases 1 to 1596)
  AUTHORS   Mahmud,I., Ueda,N., Yamaguchi,H., Yamashita,R., Yamamoto,S.,
            Kanaoka,Y., Urade,Y. and Hayaishi,O.
  TITLE     Prostaglandin D synthase in human megakaryoblastic cells
  JOURNAL   J Biol Chem 272 (45), 28263-28266 (1997)
   PUBMED   9353279
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020734.1 and AC096746.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014485.2.
            
            Summary: Prostaglandin-D synthase is a sigma class
            glutathione-S-transferase family member. The enzyme catalyzes the
            conversion of PGH2 to PGD2 and plays a role in the production of
            prostanoids in the immune system and mast cells. The presence of
            this enzyme can be used to identify the differentiation stage of
            human megakaryocytes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891393.1, SRR1803617.205606.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295256.10/ ENSP00000295256.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-827               BC020734.1         18-844
            828-1596            AC096746.3         141660-142428       c
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.3"
     gene            1..1596
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /note="hematopoietic prostaglandin D synthase"
                     /db_xref="GeneID:27306"
                     /db_xref="HGNC:HGNC:17890"
                     /db_xref="MIM:602598"
     exon            1..42
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /inference="alignment:Splign:2.1.0"
     exon            43..184
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..651
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /EC_number="2.5.1.18"
                     /EC_number="5.3.99.2"
                     /note="hematopoietic prostaglandin D2 synthase;
                     glutathione S-transferase sigma; glutathione-requiring
                     prostaglandin D synthase; glutathione-dependent PGD
                     synthetase; prostaglandin-H2 D-isomerase; GST class-sigma;
                     glutathione-dependent PGD synthase; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="hematopoietic prostaglandin D synthase"
                     /protein_id="NP_055300.1"
                     /db_xref="CCDS:CCDS3640.1"
                     /db_xref="GeneID:27306"
                     /db_xref="HGNC:HGNC:17890"
                     /db_xref="MIM:602598"
                     /translation="MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKS
                     TLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCF
                     PWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTL
                     LVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL"
     exon            185..277
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /inference="alignment:Splign:2.1.0"
     exon            278..387
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /inference="alignment:Splign:2.1.0"
     exon            388..486
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /inference="alignment:Splign:2.1.0"
     exon            487..1596
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      803..808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /note="hexamer: AATAAA"
     polyA_site      827
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /note="major polyA site"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
                     /note="hexamer: AATAAA"
     polyA_site      1439
                     /gene="HPGDS"
                     /gene_synonym="GSTS; GSTS1; GSTS1-1; PGD2; PGDS"
ORIGIN      
        1 agggatacaa gacactgcag actcccgaga gacataacac agaattgcac catgccaaac
       61 tacaaactca cttattttaa tatgaggggg agagcagaaa ttattcgtta catatttgct
      121 tatttggaca tacagtatga agaccacaga atagaacaag ctgactggcc tgaaatcaaa
      181 tcaactctcc catttggaaa aatccccatt ttggaagttg atggacttac tcttcaccag
      241 agcctagcaa tagcaagata tttgaccaaa aacacagatt tggctggaaa cacagaaatg
      301 gaacaatgtc atgttgatgc tattgtggac actctggatg atttcatgtc atgttttcct
      361 tgggcagaga aaaagcaaga tgtgaaagag cagatgttca atgagctgct cacgtataat
      421 gcgcctcatc ttatgcaaga cttggacaca tatttagggg ggagagaatg gcttattggt
      481 aactctgtaa cttgggcaga cttctactgg gagatttgca gtaccacact tttggtcttt
      541 aagcctgacc tgttagacaa ccatccaagg ctggtgactt tacggaagaa agtccaagcc
      601 attcctgccg tcgctaactg gataaaacga aggccccaaa ccaaactcta gctgatccat
      661 gttgccttca agtttgtttt tctcgggggc atctctctca tcagataaga cagctacatc
      721 agcctgccag ataatccaca tgctccctcc ccagctccac taagattttc actttagcca
      781 tattctgatt tttaaaaagg aaaataaaaa caaatctttc ttcagtatct ttttctttca
      841 gaatagcttc tcatcattta caattacaga aaaatagtat gtaatacagg cagaccttgc
      901 tttgcacagg ttctaacatg cacgaattgc agtcataatg gtttagcaac accattcttc
      961 ccctccccca aaatgttttg gacttcagct accacaatta cctgtaattg cataaaacac
     1021 aaactttgct agtagctctc cagttcacat atcgctgtgt aaataaccta tgtacatcat
     1081 gaccaatgac cagtcacttc tatcaaagac tgccagaggt cactgcacat ctgttattcc
     1141 tgcatagata gcaaagtgtg tagttgtatt gctattgcct gcttgtggcc cagtgataaa
     1201 tccctttgac attttacaaa aatgaatcaa aagagggaac tccccaacaa agatgaaagt
     1261 gcagcaaagg aacaaaaact gataatcctg gaatgaaatt caaactgaat ataaagagtt
     1321 atcgagaaaa gagctgactg tgggaatctg acacggctca aaaggctcta gatatgcagc
     1381 cagagaaact tgtaaagatg aatttactga catgaataaa gttgttgtga tgagaaaaat
     1441 gtagataccc cagagatcaa gagaaggaga agacaagcca cagacttgga gaaaatactt
     1501 gtaaaacatg tatctgacaa aagactatta ttcaaaatta tatagaactc ataaaactcg
     1561 gctgactctc ttttcggact cagcccacct gcaccc
//
