LOCUS       NM_000860               2619 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens 15-hydroxyprostaglandin dehydrogenase (HPGD),
            transcript variant 1, mRNA.
ACCESSION   NM_000860
VERSION     NM_000860.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   de Assis,V., Kayisli,U.A., Ozmen,A., Semerci,N., Totary-Jain,H.,
            Pakasticali,N., Halade,G.V., Lockwood,C.J. and Guzeloglu-Kayisli,O.
  TITLE     Decidual Cells Block Inflammation-Mediated Inhibition of
            15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts
  JOURNAL   Am J Pathol 194 (9), 1724-1736 (2024)
   PUBMED   38879084
  REMARK    GeneRIF: Decidual Cells Block Inflammation-Mediated Inhibition of
            15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts.
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Alban,J.J., Arango-Ramirez,A., Olave-Rodriguez,J.A.,
            Nastasi-Catanese,J.A. and Rodriguez,L.X.
  TITLE     Reclassification of the HPGD p.Ala13Glu variant causing primary
            hypertrophic osteoarthropathy
  JOURNAL   Cold Spring Harb Mol Case Stud 9 (4), a006291 (2024)
   PUBMED   37591693
  REMARK    GeneRIF: Reclassification of the HPGD p.Ala13Glu variant causing
            primary hypertrophic osteoarthropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Lu,Q., Xu,Y., Li,S., Zhang,Z., Sheng,J. and Zhang,Z.
  TITLE     Clinical and biochemical characteristics of 12 Chinese primary
            hypertrophic osteoarthropathy patients with HPGD mutations
  JOURNAL   Int J Biol Sci 18 (9), 3908-3917 (2022)
   PUBMED   35813463
  REMARK    GeneRIF: Clinical and biochemical characteristics of 12 Chinese
            primary hypertrophic osteoarthropathy patients with HPGD mutations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2619)
  AUTHORS   Zhang,J., Chen,W., Ma,W., Song,K., Lee,S., Han,C. and Wu,T.
  TITLE     Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by
            Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma
  JOURNAL   Mol Cancer Res 20 (3), 350-360 (2022)
   PUBMED   34880125
  REMARK    GeneRIF: Epigenetic Silencing of 15-Hydroxyprostaglandin
            Dehydrogenase by Histone Methyltransferase EHMT2/G9a in
            Cholangiocarcinoma.
REFERENCE   5  (bases 1 to 2619)
  AUTHORS   Palla,A.R., Ravichandran,M., Wang,Y.X., Alexandrova,L., Yang,A.V.,
            Kraft,P., Holbrook,C.A., Schurch,C.M., Ho,A.T.V. and Blau,H.M.
  TITLE     Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates
            aged muscle mass and strength
  JOURNAL   Science 371 (6528) (2021)
   PUBMED   33303683
  REMARK    GeneRIF: Inhibition of prostaglandin-degrading enzyme 15-PGDH
            rejuvenates aged muscle mass and strength.
REFERENCE   6  (bases 1 to 2619)
  AUTHORS   Pichaud,F., Frendo,J.L., Delage-Mourroux,R., de Vernejoul,M.C.,
            Moukhtar,M.S. and Jullienne,A.
  TITLE     Sequence of a novel mRNA coding for a C-terminal-truncated form of
            human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
  JOURNAL   Gene 162 (2), 319-322 (1995)
   PUBMED   7557451
REFERENCE   7  (bases 1 to 2619)
  AUTHORS   Erwich,J.J. and Keirse,M.J.
  TITLE     Placental localization of 15-hydroxy-prostaglandin dehydrogenase in
            early and term human pregnancy
  JOURNAL   Placenta 13 (3), 223-229 (1992)
   PUBMED   1635910
REFERENCE   8  (bases 1 to 2619)
  AUTHORS   Ensor,C.M. and Tai,H.H.
  TITLE     Site-directed mutagenesis of the conserved tyrosine 151 of human
            placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
            yields a catalytically inactive enzyme
  JOURNAL   Biochem Biophys Res Commun 176 (2), 840-845 (1991)
   PUBMED   2025296
REFERENCE   9  (bases 1 to 2619)
  AUTHORS   Ensor,C.M., Yang,J.Y., Okita,R.T. and Tai,H.H.
  TITLE     Cloning and sequence analysis of the cDNA for human placental
            NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
  JOURNAL   J Biol Chem 265 (25), 14888-14891 (1990)
   PUBMED   1697582
REFERENCE   10 (bases 1 to 2619)
  AUTHORS   Krook,M., Marekov,L. and Jornvall,H.
  TITLE     Purification and structural characterization of placental
            NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary
            structure reveals the enzyme to belong to the short-chain alcohol
            dehydrogenase family
  JOURNAL   Biochemistry 29 (3), 738-743 (1990)
   PUBMED   2337593
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC420578.1, BC018986.2,
            AI435471.1 and AC096751.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000860.5.
            
            Summary: This gene encodes a member of the short-chain
            nonmetalloenzyme alcohol dehydrogenase protein family. The encoded
            enzyme is responsible for the metabolism of prostaglandins, which
            function in a variety of physiologic and cellular processes such as
            inflammation. Mutations in this gene result in primary autosomal
            recessive hypertrophic osteoarthropathy and cranioosteoarthropathy.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.436478.1, AK058013.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296522.11/ ENSP00000296522.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DC420578.1         411-438
            29-2565             BC018986.2         1-2537
            2566-2617           AI435471.1         18-69               c
            2618-2619           AC096751.3         51280-51281         c
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..2619
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="15-hydroxyprostaglandin dehydrogenase"
                     /db_xref="GeneID:3248"
                     /db_xref="HGNC:HGNC:5154"
                     /db_xref="MIM:601688"
     exon            1..130
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..838
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /EC_number="1.1.1.141"
                     /EC_number="1.1.1.232"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NAD+-dependent 15-hydroxyprostaglandin dehydrogenase;
                     prostaglandin dehydrogenase 1; short chain
                     dehydrogenase/reductase family 36C member 1;
                     hydroxyprostaglandin dehydrogenase 15-(NAD);
                     15-hydroxyprostaglandin dehydrogenase (NAD(+));
                     eicosanoid/docosanoid dehydrogenase"
                     /codon_start=1
                     /product="15-hydroxyprostaglandin dehydrogenase [NAD(+)]
                     isoform 1"
                     /protein_id="NP_000851.2"
                     /db_xref="CCDS:CCDS3821.1"
                     /db_xref="GeneID:3248"
                     /db_xref="HGNC:HGNC:5154"
                     /db_xref="MIM:601688"
                     /translation="MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ
                     CKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEK
                     TLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVG
                     FTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYG
                     ILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ"
     exon            131..254
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..361
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..458
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..535
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..699
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..2619
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="hexamer: AATAAA"
     polyA_site      1724
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="major polyA site"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="hexamer: AATAAA"
     polyA_site      1781
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="major polyA site"
     regulatory      2289..2294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="hexamer: AGTAAA"
     polyA_site      2314
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
     regulatory      2435..2440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="hexamer: AATAAA"
     polyA_site      2463
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
     regulatory      2541..2546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="hexamer: AATAAA"
     polyA_site      2562
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
                     /note="hexamer: ATTAAA"
     polyA_site      2619
                     /gene="HPGD"
                     /gene_synonym="15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1"
ORIGIN      
        1 gagctcgccc accgcccgcc ccagcagtgg ctgcaccatg cacgtgaacg gcaaagtggc
       61 gctggtgacc ggcgcggctc agggcatagg cagagccttt gcagaggcgc tgctgcttaa
      121 gggcgccaag gtagcgctgg tggattggaa tcttgaagca ggtgtacagt gtaaagctgc
      181 cctggatgag cagtttgaac ctcagaagac tctgttcatc cagtgcgatg tggctgacca
      241 gcaacaactg agagacactt ttagaaaagt tgtagaccac tttggaagac tggacatttt
      301 ggtcaataat gctggagtga ataatgagaa aaactgggaa aaaactctgc aaattaattt
      361 ggtttctgtt atcagtggaa cctatcttgg tttggattac atgagtaagc aaaatggagg
      421 tgaaggcggc atcattatca atatgtcatc tttagcagga ctcatgcccg ttgcacagca
      481 gccggtttat tgtgcttcaa agcatggcat agttggattc acacgctcag cagcgttggc
      541 tgctaatctt atgaacagtg gtgtgagact gaatgccatt tgtccaggct ttgttaacac
      601 agccatcctt gaatcaattg aaaaagaaga aaacatggga caatatatag aatataagga
      661 tcatatcaag gatatgatta aatactatgg aattttggac ccaccattga ttgccaatgg
      721 attgataaca ctcattgaag atgatgcttt aaatggtgct attatgaaga tcacaacttc
      781 taagggaatt cattttcaag actatgatac aactccattt caagcaaaaa cccaatgaac
      841 agcttatgtg ttagccatag ctgaaaataa gcacaaatag cttatattca gatcctatct
      901 tcatttgaat atagctttta aatgaaatgt tacagtttga agttttcctt catgcacttg
      961 gtgataaacg ttttctaaat ttttagttaa gtatatggat aaaaagttat gaactattaa
     1021 aaatgtgatg tggaccaaag gctaggttgt aatcttgata gtctaaaaaa tgatcaaaac
     1081 aaatgatttt caaggaatat tcaatattct gcctttcaga aagtgtattt atatctgtgc
     1141 ttcataaata ttaatgttct tcagaacatc attttaaagg agatacttga attgttattt
     1201 aaatcaaacc agatgtaaaa cactcacata caagttcata ctttaaaaga ggaaagctac
     1261 ttaacaatga caaatatttc acaataataa tttttactta tataccatct ttcaactgaa
     1321 catttcagtt cttccaagag cttcttagag tagtatattt tgggggcagt caaggaataa
     1381 actacagtgt aaacatatcc cagatgaaaa ctgctgtatg gaaaaatgac agaaagtaac
     1441 tgattgacac tgttgattca cagttcagcc tcctatctgg gaaagacatt tctttcctct
     1501 gctcacttta agaactttta ccgactccaa aaatctcagg aattaaactt ttaacagtta
     1561 cagcaataaa gaatagttag tactccaaaa atattatatt taagatgctc aacaagaaaa
     1621 aaatgcaaat gtaatatttt tttcaaatta cttctttatt gacttgtcca aatttcaaaa
     1681 gtgcctaccc ttcaataaaa cttttttatt ctgatctcca taaattactt agtcttctat
     1741 gtatagctat caaggaaata aaaccaattt tgccacagcc acaactgtaa atgtttttgt
     1801 acccatgctg aaactcataa caacacagac ataaaaatag ctgtgaggtt ttgctttttt
     1861 tgttgtcagc tatcttaaga atcattaaat acacctgctt tgggtaaaac tctttgcaag
     1921 cagtaattaa cactagtaac agtgaaagca caagatttcc aaatcagtcg ttttctcaaa
     1981 aaaatatcgt ataagtgact catcctgtct gctaactcca gacctcccag cttgaagcca
     2041 aatctttcca tgtgagattg atatggattt cctagaagta ctggaatgtt gtcatatctt
     2101 gccctatttt aattctgcta tagaaaacaa ttgccttcac ttttaaggag taatttgaat
     2161 attaataact ctggtctaga ttttcatata atgtattaaa gacaaagtag tgaacatcaa
     2221 tgaacatctg atagagataa actgtaatca ggcataagct tgtttgtatg ttctggcagt
     2281 gactaatcag taaatgatgt cggtttgccc agtatcactt atcttctgta tttttcctct
     2341 gtcgtgtaaa tagtataacc ttttcattta tggacaattt tttggactag tagccttcaa
     2401 tatacattct gctttgaatt aattttttca aatcaataaa ttatgtagac atttaaaatc
     2461 aaatatcaag tagaattgaa aaatgtgagt tacataagtt aaaaacttac tttaaatctt
     2521 accttctata ggtagctcta aataaattca tatggttata tggcatctct ggtgtatact
     2581 gattgagaaa ataattaaac tgaagttagg ggaggggga
//
