LOCUS       NM_017867               1216 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens histone PARylation factor 1 (HPF1), mRNA.
ACCESSION   NM_017867
VERSION     NM_017867.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Hrychova,K., Burdova,K., Polackova,Z., Giamaki,D., Valtorta,B.,
            Brazina,J., Krejcikova,K., Kuttichova,B., Caldecott,K.W. and
            Hanzlikova,H.
  TITLE     Dispensability of HPF1 for cellular removal of DNA single-strand
            breaks
  JOURNAL   Nucleic Acids Res 52 (18), 10986-10998 (2024)
   PUBMED   39162207
  REMARK    GeneRIF: Dispensability of HPF1 for cellular removal of DNA
            single-strand breaks.
REFERENCE   2  (bases 1 to 1216)
  AUTHORS   Le Gall,J., Dehainault,C., Boutte,M., Petitalot,A., Caputo,S.M.,
            Courtois,L., Vacher,S., Bieche,I., Radvanyi,F., Pacquement,H.,
            Doz,F., Lumbroso-Le Rouic,L., Gauthier Villars,M.,
            Stoppa-Lyonnet,D., Lallemand,F., Houdayer,C. and Golmard,L.
  TITLE     Germline HPF1 retrogene insertion in RB1 gene involved in cancer
            predisposition
  JOURNAL   J Med Genet 61 (1), 78-83 (2023)
   PUBMED   37541786
  REMARK    GeneRIF: Germline HPF1 retrogene insertion in RB1 gene involved in
            cancer predisposition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1216)
  AUTHORS   Mohapatra,J., Tashiro,K., Beckner,R.L., Sierra,J., Kilgore,J.A.,
            Williams,N.S. and Liszczak,G.
  TITLE     Serine ADP-ribosylation marks nucleosomes for ALC1-dependent
            chromatin remodeling
  JOURNAL   Elife 10, e71502 (2021)
   PUBMED   34874266
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1216)
  AUTHORS   Langelier,M.F., Billur,R., Sverzhinsky,A., Black,B.E. and
            Pascal,J.M.
  TITLE     HPF1 dynamically controls the PARP1/2 balance between initiating
            and elongating ADP-ribose modifications
  JOURNAL   Nat Commun 12 (1), 6675 (2021)
   PUBMED   34795260
  REMARK    GeneRIF: HPF1 dynamically controls the PARP1/2 balance between
            initiating and elongating ADP-ribose modifications.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1216)
  AUTHORS   Kurgina,T.A., Moor,N.A., Kutuzov,M.M., Naumenko,K.N.,
            Ukraintsev,A.A. and Lavrik,O.I.
  TITLE     Dual function of HPF1 in the modulation of PARP1 and PARP2
            activities
  JOURNAL   Commun Biol 4 (1), 1259 (2021)
   PUBMED   34732825
  REMARK    GeneRIF: Dual function of HPF1 in the modulation of PARP1 and PARP2
            activities.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1216)
  AUTHORS   Bonfiglio,J.J., Fontana,P., Zhang,Q., Colby,T., Gibbs-Seymour,I.,
            Atanassov,I., Bartlett,E., Zaja,R., Ahel,I. and Matic,I.
  TITLE     Serine ADP-Ribosylation Depends on HPF1
  JOURNAL   Mol Cell 65 (5), 932-940 (2017)
   PUBMED   28190768
  REMARK    GeneRIF: Serine residues can be ADP-ribosylated by PARP-1 and
            PARP-2. This serine specificity is conferred by HPF1, a protein
            that interacts with PARP-1/2.
REFERENCE   7  (bases 1 to 1216)
  AUTHORS   Gibbs-Seymour,I., Fontana,P., Rack,J.G.M. and Ahel,I.
  TITLE     HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1
            ADP-Ribosylation Activity
  JOURNAL   Mol Cell 62 (3), 432-442 (2016)
   PUBMED   27067600
  REMARK    GeneRIF: HPF1/C4orf27 Is a PARP-1-interacting protein that
            regulates PARP-1 ADP-ribosylation activity in the DNA damage
            response.
REFERENCE   8  (bases 1 to 1216)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   9  (bases 1 to 1216)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 1216)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106878.3, CB141427.1, DN990093.1, BM905677.1 and AK000541.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017867.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.983173.1,
                                           SRR5189667.168063.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393381.3/ ENSP00000406598.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC106878.3         100137-100138       c
            3-102               CB141427.1         1-100
            103-579             DN990093.1         68-544
            580-815             BM905677.1         498-733
            816-1216            AK000541.1         769-1169
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q33"
     gene            1..1216
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /note="histone PARylation factor 1"
                     /db_xref="GeneID:54969"
                     /db_xref="HGNC:HGNC:26051"
                     /db_xref="MIM:616614"
     exon            1..115
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1108
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /note="UPF0609 protein C4orf27"
                     /codon_start=1
                     /product="histone PARylation factor 1"
                     /protein_id="NP_060337.2"
                     /db_xref="CCDS:CCDS3813.1"
                     /db_xref="GeneID:54969"
                     /db_xref="HGNC:HGNC:26051"
                     /db_xref="MIM:616614"
                     /translation="MVGGGGKRRPGGEGPQCEKTTDVKKSKFCEADVSSDLRKEVENH
                     YKLSLPEDFYHFWKFCEELDPEKPSDSLSASLGLQLVGPYDILAGKHKTKKKSTGLNF
                     NLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDEFPVYVGINEAKKNCIIVPNGDN
                     VFAAVKLFLTKKLREITDKKKINLLKNIDEKLTEAARELGYSLEQRTVKMKQRDKKVV
                     TKTFHGAGLVVPVDKNDVGYRELPETDADLKRICKTIVEAASDEERLKAFAPIQEMMT
                     FVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRNLFAEIIEEHLA
                     NRSQENIDQLAA"
     exon            116..275
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            276..465
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            466..564
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            565..715
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            716..803
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            804..976
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1216
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1194..1199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /note="hexamer: AATAAA"
     polyA_site      1216
                     /gene="HPF1"
                     /gene_synonym="C4orf27"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggtt ggcggcgctc ggaagcggcc gcggatcggg gaattctgct ggcgctgcag
       61 ctgcagaatg gtcggcggtg gcgggaagcg caggcccggc ggagaggggc cgcagtgtga
      121 aaaaacaact gatgtgaaga aaagtaaatt ctgtgaagct gatgtctcca gtgaccttcg
      181 aaaagaagta gaaaatcatt ataagctttc tttacctgaa gatttctatc acttctggaa
      241 gttctgtgaa gaacttgatc ctgaaaagcc atctgattca ctttctgcaa gccttggact
      301 tcaattagtt ggtccttatg atatccttgc tggaaaacat aaaacgaaga aaaaatcaac
      361 aggcctgaat tttaaccttc actggaggtt ttactatgat cctcctgagt tccagaccat
      421 tattattgga gataataaaa ctcagtacca catggggtat ttcagggatt ctcctgatga
      481 atttcctgta tatgttggta taaatgaagc aaagaaaaat tgtataattg ttccaaatgg
      541 agataatgta tttgctgcag tcaaattatt tttgacgaaa aaacttagag aaataacgga
      601 taaaaagaaa atcaatctct tgaaaaacat agatgaaaaa ctcacagaag cagccagaga
      661 attggggtac tcgcttgaac agagaaccgt gaagatgaaa cagagagata agaaagttgt
      721 gacaaagacc tttcatggtg caggcttggt tgttccagta gataaaaatg atgttgggta
      781 ccgagagctc cctgaaacag atgctgacct caagagaatt tgcaagacaa tagttgaggc
      841 tgcaagtgat gaggagagac taaaagcttt tgctcccatt caggaaatga tgacttttgt
      901 gcagtttgct aatgatgaat gtgattatgg catggggctt gaattgggaa tggatctctt
      961 ttgctatggc tcacattatt ttcataaagt tgctggccag cttttacctc ttgcatataa
     1021 tctgttgaag aggaatctgt ttgcagaaat tattgaggag catctggcaa acagaagtca
     1081 agagaacata gaccaacttg ctgcatgagt aaggtggctt tgattggtgt acagtatttc
     1141 aaaggactag tattaaactt gtgatttttg ttttgttttt aaggaataca aaaaataaac
     1201 atttactaaa aacgtt
//
