LOCUS       NM_001372052            6406 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens heterochromatin protein 1 binding protein 3 (HP1BP3),
            transcript variant 1, mRNA.
ACCESSION   NM_001372052
VERSION     NM_001372052.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6406)
  AUTHORS   Yu,T., Zhou,F., Tian,W., Xu,R., Wang,B., Zeng,A., Zhou,Z., Li,M.,
            Wang,Y. and Zhang,J.
  TITLE     EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that
            promotes temozolomide resistance in glioblastoma
  JOURNAL   Oncogene 42 (6), 461-470 (2023)
   PUBMED   36517590
  REMARK    GeneRIF: EZH2 interacts with HP1BP3 to epigenetically activate
            WNT7B that promotes temozolomide resistance in glioblastoma.
REFERENCE   2  (bases 1 to 6406)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6406)
  AUTHORS   Oshikawa,K., Matsumoto,M., Kodama,M., Shimizu,H. and Nakayama,K.I.
  TITLE     A fail-safe system to prevent oncogenesis by senescence is targeted
            by SV40 small T antigen
  JOURNAL   Oncogene 39 (10), 2170-2186 (2020)
   PUBMED   31819167
  REMARK    GeneRIF: A fail-safe system to prevent oncogenesis by senescence is
            targeted by SV40 small T antigen.
REFERENCE   4  (bases 1 to 6406)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 6406)
  AUTHORS   Liu,H., Liang,C., Kollipara,R.K., Matsui,M., Ke,X., Jeong,B.C.,
            Wang,Z., Yoo,K.S., Yadav,G.P., Kinch,L.N., Grishin,N.V., Nam,Y.,
            Corey,D.R., Kittler,R. and Liu,Q.
  TITLE     HP1BP3, a Chromatin Retention Factor for Co-transcriptional
            MicroRNA Processing
  JOURNAL   Mol Cell 63 (3), 420-432 (2016)
   PUBMED   27425409
  REMARK    GeneRIF: HP1BP3 promotes co-transcriptional miRNA processing via
            chromatin retention of nascent pri-miRNA transcripts.
REFERENCE   6  (bases 1 to 6406)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
  REMARK    GeneRIF: HP1BP3 protein maintains heterochromatin integrity during
            G1-S progression and regulates the duration of G1 phase to
            critically influence cell proliferative capacity.
REFERENCE   7  (bases 1 to 6406)
  AUTHORS   Kaminsky,Z. and Payne,J.
  TITLE     Seeing the future: epigenetic biomarkers of postpartum depression
  JOURNAL   Neuropsychopharmacology 39 (1), 233-234 (2014)
   PUBMED   24317310
  REMARK    GeneRIF: found two biomarker loci at HP1BP3 and TTC9B, which
            predicted postpartum depression
REFERENCE   8  (bases 1 to 6406)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6406)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
  REMARK    GeneRIF: HP1-BP74 directly binds to HP1, and its middle region
            associates with linker DNA at the entry/exit site of nucleosomal
            DNA in vitro
REFERENCE   10 (bases 1 to 6406)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Maccarrone,G., Dias-Neto,E. and Turck,C.W.
  TITLE     Prefrontal cortex shotgun proteome analysis reveals altered calcium
            homeostasis and immune system imbalance in schizophrenia
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)
   PUBMED   19165527
  REMARK    GeneRIF: Using shotgun mass spectrometry, we found this protein
            differentially expressed in the dorsolateral prefrontal cortex from
            patients with schizophrenia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606477.11 and AL663074.13.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.178027.1,
                                           SRR1660803.212741.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438032.6/ ENSP00000403039.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AL606477.11        32141-32253         c
            114-309             AL606477.11        25291-25486         c
            310-409             AL606477.11        24758-24857         c
            410-563             AL606477.11        21543-21696         c
            564-723             AL606477.11        18397-18556         c
            724-867             AL606477.11        15876-16019         c
            868-948             AL606477.11        12530-12610         c
            949-1103            AL606477.11        10323-10477         c
            1104-1194           AL606477.11        2112-2202           c
            1195-1354           AL663074.13        78454-78613         c
            1355-1466           AL663074.13        76275-76386         c
            1467-1580           AL663074.13        74274-74387         c
            1581-6406           AL663074.13        68997-73822         c
FEATURES             Location/Qualifiers
     source          1..6406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..6406
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="heterochromatin protein 1 binding protein 3"
                     /db_xref="GeneID:50809"
                     /db_xref="HGNC:HGNC:24973"
                     /db_xref="MIM:616072"
     exon            1..113
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            114..309
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1875
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform 1"
                     /protein_id="NP_001358981.1"
                     /db_xref="CCDS:CCDS30621.1"
                     /db_xref="GeneID:50809"
                     /db_xref="HGNC:HGNC:24973"
                     /db_xref="MIM:616072"
                     /translation="MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRT
                     VNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATSSEAEQPKGEPEN
                     EEKEENKSSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPK
                     MDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQ
                     VKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEA
                     SYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEK
                     PLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCE
                     KNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEE
                     PPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKK
                     TRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFRVKK"
     exon            310..409
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            410..563
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            564..723
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            724..867
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            868..948
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1103
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1194
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1354
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1466
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1580
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..6406
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3441..3446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="hexamer: AATAAA"
     polyA_site      3462
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="major polyA site"
     regulatory      3970..3975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="hexamer: AATAAA"
     polyA_site      3993
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="major polyA site"
     polyA_site      4017
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
     regulatory      4232..4237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="hexamer: ATTAAA"
     polyA_site      4254
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
     regulatory      6380..6385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
                     /note="hexamer: ATTAAA"
     polyA_site      6406
                     /gene="HP1BP3"
                     /gene_synonym="HP1-BP74; HP1BP74"
ORIGIN      
        1 agagctcggc ggctgggact ggaggacagc ggtggcggag gcgactagcg gcggcgggag
       61 cggcgccgag aggccgtgcg ggacgcgggc gccaggaccg gccgaacgca gaggttgatt
      121 cttcaccaca ctgaaaccat taggaaaaat ccttgtggtt aacagcagag gcttcagagt
      181 gtaacctgta ctcgggccta gaaattattt aaaatggcga ctgatacgtc tcaaggtgaa
      241 ctcgtccatc ctaaggcact cccacttata gtaggagctc agctgatcca cgcggacaag
      301 ttaggtgaga aggtagaaga tagcaccatg ccgattcgtc gaactgtgaa ttctacccgg
      361 gaaactcctc ccaaaagcaa gcttgctgaa ggggaggaag aaaagccaga accagacata
      421 agttcagagg aatctgtctc cactgtagaa gaacaagaga atgaaactcc acctgctact
      481 tcgagtgagg cagagcagcc aaagggggaa cctgagaatg aagagaagga agaaaataag
      541 tcttctgagg aaaccaaaaa ggatgagaaa gatcagtcta aagaaaagga gaagaaagtg
      601 aaaaaaacaa ttccttcctg ggctaccctt tctgccagcc agctagccag ggcccagaaa
      661 caaacaccga tggcttcttc cccacgtccc aagatggatg caatcttaac tgaggccatt
      721 aaggcatgct tccagaagag tggtgcatca gtggttgcta ttcgaaaata catcatccat
      781 aagtatcctt ctctggagct ggagagaagg ggttatctcc ttaaacaagc actgaaaaga
      841 gaattaaata gaggagtcat caaacaggtt aaaggaaaag gtgcttctgg aagttttgtt
      901 gtggttcaga aatcaagaaa aacacctcag aaatccagaa acagaaagaa taggagctct
      961 gcagtggatc cagaaccaca agtaaaattg gaggatgtcc tcccactggc ctttactcgc
     1021 ctttgtgaac ctaaagaagc ttcctacagt ctcatcagga aatatgtgtc tcagtattat
     1081 cctaagctta gagtggacat caggcctcag ctgttgaaga acgctctgca gagagcagta
     1141 gagaggggcc agttagaaca gataactggc aaaggtgctt cggggacatt ccagctgaag
     1201 aaatcagggg agaaacccct gcttggtgga agcctgatgg aatatgcaat cttgtctgcc
     1261 attgctgcca tgaatgagcc gaagacctgc tctaccactg ctctgaagaa gtatgtccta
     1321 gagaatcacc caggaaccaa ttctaactat caaatgcatt tgctgaaaaa aaccctgcag
     1381 aaatgcgaaa agaatgggtg gatggaacag atctctggga aagggttcag tggcaccttc
     1441 cagctctgtt ttccctatta tcccagccca ggagttctgt ttccgaagaa agagccagat
     1501 gattctagag atgaggatga agatgaagat gagtcatcag aagaagactc tgaggatgaa
     1561 gagccgccac ctaagagaag gttgcagaag aaaaccccag ccaagtcccc agggaaggcc
     1621 gcatctgtga agcagagagg gtccaaacct gcacctaaag tctcagctgc ccagcggggg
     1681 aaagctaggc ccttgcctaa gaaagcacct cctaaggcca aaacgcctgc caagaagacc
     1741 agaccctcat ccacagtcat caagaaacct agtggtggct cctcaaagaa gcctgcaacc
     1801 agtgcaagaa aggaagtaaa attgccgggc aagggcaaat ccaccatgaa gaagtctttc
     1861 agagtgaaaa agtaaatttt ataggaaaaa agggtatcat gatgaaattc aaaatcttat
     1921 tttctaaggt cagtgtgcat ttgtttagtt ttgatgcttt tcaaattaca ttattttcct
     1981 cccctatgaa cattgtgggg agggactcta aataaaccag tttaggcatt tgctagcttt
     2041 aggtgctttt attggtgcct gcccttttcc ttgttcattt taatttctgc aataatcctg
     2101 gactttccta aactatgtaa tgtatacttg tcctttttct ctgcctcccc caaccccctg
     2161 ttgtttttat ggtcagcttt gccttttttt tttcttccaa ttttatctaa acagttgcag
     2221 agatttttat atttgtagaa agcatcaaga acggtatgcc agtcaggtcc tggaagtaaa
     2281 atggaggcac aatatagcac tgactgagtt gtaaagcctc ctgcctggag acttcagtta
     2341 tagctgtaat aattaatctt atttataaaa gccactccac taaccttttc tctccaactg
     2401 taaacacaga gacagctttg ggaataagcc aaaaacaggg tgatctcatt agattttgaa
     2461 gatatatgac tcctttgggc tacatttcat attgatcaat ttctaggtat ttttcactgg
     2521 cccaaagtat tgcattccct taacagcaag cacaagttct ctatatcact tgttttttgt
     2581 tgttgttgtt gttgtcgtcg ttgttttgag acggagtctt gctcaggtgc cccggagtgc
     2641 agtggtgcaa tctcagctca ctgcaacctc cacctcctgg gttcaagcaa ttctcctgct
     2701 tcagcctccc gagtagctgg gattacaggt gtgtaccacc acgcctggca atttttttgt
     2761 atttttagta gagatggggt ttcgccgtgt tggtcaggct ggtctcgaac tcctgacctc
     2821 aggtgatccg cctgcctcgg cctcccaaag tgctgggatt acaggagtga gccactgtgc
     2881 ctggcctatc ccacttggtt tttgactgaa ggggaagtgt agaaatatat tgatttgtga
     2941 tttctggtgt cacctgtgtt accaaaaatc aaaacaaatc ttttttattt tttattatta
     3001 ttattatttt tgagacagag tctcgctctg tcgcccagtg tggagtgcag tggtgtgatc
     3061 ttggctcact gcaaactccg cctcccaggt tcaagcgatt ctcccacctc agcctcctga
     3121 gttgggtcct acaggcgcac acgaccacgc ccagctaatt ttttgtattt ttagtagagt
     3181 tggggtttca ccatgttagc caggatggtc tcgatctcct gacctcgtga tccactcacc
     3241 tcagcctccc aaaatcctgg ggttacagat gtgagctacc actcacggcc caaatcttct
     3301 tgatcatatg tttaaatata ttttttaata tttggagcat gagttgtcac ttcttgtttg
     3361 ccttttttat aaggaaatgt tggagagtta catcattgct aatgtagaaa tgttaagtgg
     3421 aaaaatatac agtttggtaa aataaactag attctacatt tatttgtggg tttttttccc
     3481 ctcctttctt tccacagcac ttttgatatc aagcaagtgg cttccttttt gagatattaa
     3541 aaaaaaaaag aaaaggaaaa aagtaaatga agcccaacta cctaaccctt tcttatttgt
     3601 atttgtttta gtattgtgaa gttgtgttaa atagtactag ctagaaatac aaatttctgg
     3661 ttatcatttc tcttccctgt ggcacttgac attttaattg tcttaaagtt tttgaagtac
     3721 atcttctggc cccttgagta ctgccagagg caaaagatgt ttgtttctta ttcattccac
     3781 ttttgtctcc tgggatccct tctgtagcct aaagtatggc tgggaaatgg acttgagaag
     3841 attggcttga attagatcat aatcatgtgt gatcccatca tgaattcatt ggaatttgtg
     3901 ttgcatgtaa ggcaatcttt cctgttgtaa atcttccttt tttaatgtac atatattttg
     3961 aaaaatatga ataaacatga aattttaaaa gctgctgaac cgtagcttat atttaaaggt
     4021 tttgagtata gtatatcctc agaagtagct aagtgtcgcc ctcactttaa gtcttttcta
     4081 ctccttgaaa tgaacaccat cattttcctt tttaaataca agctccagtt catgtgtttt
     4141 ggaattctta tagagggtaa acgatgtttc cagatacatt gaatgctaat tacttaatga
     4201 atcaaaggtt taaaaaatca ttttgtattt tattaaagac tgcttccaag atcatagagt
     4261 acaatcatgt tcaataaatg ttcaatattc agataagtcc ttggactaga aaaaattaca
     4321 gtactgcaaa agataacaga taaatcctag acatcaaatt ctagaagtaa ttgtagtaat
     4381 tactcctgtg ctctctagca agtaatgatt cttaatagta tggatgttag gtacctgtgc
     4441 tcagaattct gtactcttct ggaatcaaaa gttgggagat tttggttggt ttctttgctt
     4501 tatgatactg cttttaaaga gacttactga ataatcacct ggtggctgta ttgcacacca
     4561 ggcacttaag cacaggctga gaagtttaga tcatttaaag tttcttccaa ctctaacgtt
     4621 ctgttaacta taaggacagt ttgtttcagt gtgatgtaaa gggaaaagac aggaaggtca
     4681 tcgcactctt ccacgaacat ccacaactgt caaagacata cgccttactt acattgagat
     4741 aaaagaatgt ttgatttttc ccttccaggc attccaaagg agcagaacac atttataatt
     4801 tttacttcca tgttcagaaa ggggaacaac aaaccccaga ggtaatccca gaaatctcta
     4861 gcatggatca atagcttcag tactctgttg gtggcttagt gacctcattt acagtgtttc
     4921 atacactctg aaactaccta caagctacct ttgataaatg agtctcagaa agtgctggga
     4981 gagagattgt tggcttctta acctacaaaa tgaggaagga aagatactat tgttgagaaa
     5041 tgtggagacc tttccttagc actatgacag aagcattcat tgcacatgga ttctgactat
     5101 gcatccacat ggacttaatt aaaggaaacc tggtcctgta taaatcttag gaaacaggtg
     5161 tatgttttaa tcatgtcttt tgggtataat taacaggaaa atgacatgaa aacaaaacta
     5221 aacaatctgc taacaccttt tgacatttgt tttttcatca ttgctgtttt tccaaatttt
     5281 gttagccctt gtcaaggttt gctaaccaat tcttaattaa tacttacttt aaagagcctg
     5341 tgaaattatt ctctctcagg ctgtgaccct cttgccatct tgatacgtca tgagaacgaa
     5401 actcaccagc catgttcatt aaatactgca tttaactaag agaaacttta aaaatttggg
     5461 attatagtta aggtctccta tctttggaac ctgattaatt tatctttctt tggattaagc
     5521 aaaaattcta attttagcta tgaaagaaaa gaaattctat tcttaattgg aaaagaccat
     5581 taaactgttt ccccagaggt tctggttgac attactttct agcatgtaga ttttgctttt
     5641 gcattttcat ggtggaacag atggtcactc acttctgcag agccaaagcc aaggaagcag
     5701 aactgttgaa gttttggctt aggaaccact tgacaaagat ttgtttagaa gccattacag
     5761 atggttaaac agtaccccta atcagctgca ttattttctt aagaaattaa tctctaccgt
     5821 ctttataact atattctttt acttattatt tttttgagat ggagtttgct gtgtcactaa
     5881 ggctgcagcg cagtggtgtg atcttggctc actgcagctt tgaactcgtg tgctcaagca
     5941 gttctcccca cctcagcctc ccaagtagcc aggactacag gcaagctaat aaatgcctgg
     6001 ctaatttatc ttttctagag atggggcctc actgtgttgc ccaggctggt cttgaactcg
     6061 tggcctcacg tgatcttccc acctgggctt tccaaagtgc caggattaca ggcgtgagtc
     6121 gccatacctg gccctattct ttcttctgtt cttttccaca agactgttaa cttcagtggc
     6181 ttttttcctg ttggaaaact ttctaccttt gatgatttaa ttttatcagc tttttaactg
     6241 ttttaactgt tcttaattct gtcttgtcaa ccactggtat gtcaaaggag gcctcaaaag
     6301 gctgaagcga ttttcctcaa aaattacaac tctttttttt cctgatattg tatataatgt
     6361 ataattaaca ctgttcacta ttaaatcttt gcttagcaaa agagaa
//
