LOCUS       NM_014213               1871 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens homeobox D9 (HOXD9), mRNA.
ACCESSION   NM_014213
VERSION     NM_014213.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Li,J., Yang,P., Hong,L., Xiao,W., Zhang,L., Yu,Z., Zhang,J.,
            Pei,M., Peng,Y., Wei,X., Wu,X., Tang,W., Zhao,Y., Yang,J., Lin,Z.,
            Jiang,P., Xiang,L., Zhang,H., Lin,J. and Wang,J.
  TITLE     BST2 promotes gastric cancer metastasis under the regulation of
            HOXD9 and PABPC1
  JOURNAL   Mol Carcinog 63 (4), 663-676 (2024)
   PUBMED   38197534
  REMARK    GeneRIF: BST2 promotes gastric cancer metastasis under the
            regulation of HOXD9 and PABPC1.
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Zhong,Y., Yu,F., Yang,L., Wang,Y., Liu,L., Jia,C., Cai,H., Yang,J.,
            Sheng,S., Lv,Z., Weng,L., Wu,B. and Zhang,X.
  TITLE     HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell
            proliferation and metastasis via PI3K/AKT signaling pathway in
            human anaplastic thyroid carcinoma
  JOURNAL   J Transl Med 21 (1), 817 (2023)
   PUBMED   37974228
  REMARK    GeneRIF: HOXD9/miR-451a/PSMB8 axis is implicated in the regulation
            of cell proliferation and metastasis via PI3K/AKT signaling pathway
            in human anaplastic thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Xu,S., Xiao,H., Song,T., Zeng,Y., Wei,C., Chen,T., Hu,Z., Guo,R.,
            Li,D. and Jiang,M.
  TITLE     HOXD9 is a potential prognostic biomarker involved in immune
            microenvironment of glioma
  JOURNAL   J Cancer Res Clin Oncol 149 (16), 14911-14926 (2023)
   PUBMED   37603105
  REMARK    GeneRIF: HOXD9 is a potential prognostic biomarker involved in
            immune microenvironment of glioma.
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Wan,K., Shao,J., Liu,X., Cai,Y., Xu,Y., Li,L., Xiong,L. and
            Liang,S.
  TITLE     HOXD9 contributes to the Warburg effect and tumor metastasis in
            non-small cell lung cancer via transcriptional activation of PFKFB3
  JOURNAL   Exp Cell Res 427 (1), 113583 (2023)
   PUBMED   37004946
  REMARK    GeneRIF: HOXD9 contributes to the Warburg effect and tumor
            metastasis in non-small cell lung cancer via transcriptional
            activation of PFKFB3.
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   He,J., Jiang,M., Liu,J., Zhu,R., Lv,W., Lian,R., Yang,Y. and
            Wang,R.
  TITLE     Homeobox D9 drives the malignant phenotypes and enhances the
            Programmed death ligand-1 expression in non-small cell lung cancer
            cells via binding to Angiopoietin-2 promoter
  JOURNAL   World J Surg Oncol 21 (1), 93 (2023)
   PUBMED   36907878
  REMARK    GeneRIF: Homeobox D9 drives the malignant phenotypes and enhances
            the Programmed death ligand-1 expression in non-small cell lung
            cancer cells via binding to Angiopoietin-2 promoter.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Zappavigna,V., Renucci,A., Izpisua-Belmonte,J.C., Urier,G.,
            Peschle,C. and Duboule,D.
  TITLE     HOX4 genes encode transcription factors with potential auto- and
            cross-regulatory capacities
  JOURNAL   EMBO J 10 (13), 4177-4187 (1991)
   PUBMED   1756725
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Oliver,G., Sidell,N., Fiske,W., Heinzmann,C., Mohandas,T.,
            Sparkes,R.S. and De Robertis,E.M.
  TITLE     Complementary homeo protein gradients in developing limb buds
  JOURNAL   Genes Dev 3 (5), 641-650 (1989)
   PUBMED   2568311
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC044855.1, X59372.1,
            BU732638.1 and AC009336.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014213.3.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, located on different
            chromosomes, consisting of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXD genes located at 2q31-2q37
            chromosome regions. Deletions that removed the entire HOXD gene
            cluster or 5' end of this cluster have been associated with severe
            limb and genital abnormalities. The exact role of this gene has not
            been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044855.1, X59372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249499.8/ ENSP00000249499.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               BC044855.1         35-512
            479-705             X59372.1           435-661
            706-1757            BC044855.1         740-1791
            1758-1851           BU732638.1         18-111              c
            1852-1871           AC009336.13        108907-108926
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1871
                     /gene="HOXD9"
                     /gene_synonym="Hox-4.3; Hox-5.2; HOX4; HOX4C"
                     /note="homeobox D9"
                     /db_xref="GeneID:3235"
                     /db_xref="HGNC:HGNC:5140"
                     /db_xref="MIM:142982"
     exon            1..867
                     /gene="HOXD9"
                     /gene_synonym="Hox-4.3; Hox-5.2; HOX4; HOX4C"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1109
                     /gene="HOXD9"
                     /gene_synonym="Hox-4.3; Hox-5.2; HOX4; HOX4C"
                     /note="homeo box D9; Hox-4.3, mouse, homolog of; homeobox
                     protein Hox-4C; homeobox protein Hox-5.2"
                     /codon_start=1
                     /product="homeobox protein Hox-D9"
                     /protein_id="NP_055028.3"
                     /db_xref="CCDS:CCDS2267.2"
                     /db_xref="GeneID:3235"
                     /db_xref="HGNC:HGNC:5140"
                     /db_xref="MIM:142982"
                     /translation="MLGGSAGRLKMSSSGTLSNYYVDSLIGHEGDEVFAARFGPPGPG
                     AQGRPAGVADGPAATAAEFASCSFAPRSAVFSASWSAVPSQPPAAAAMSGLYHPYVPP
                     PPLAASASEPGRYVRSWMEPLPGFPGGAGGGGGGGGGGPGRGPSPGPSGPANGRHYGI
                     KPETRAAPAPATAASTTSSSSTSLSSSSKRTECSVARESQGSSGPEFSCNSFLQEKAA
                     AATGGTGPGAGIGAATGTGGSSEPSACSDHPIPGCSLKEEEKQHSQPQQQQLDPNNPA
                     ANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQ
                     NRRMKMKKMSKEKCPKGD"
     exon            868..1871
                     /gene="HOXD9"
                     /gene_synonym="Hox-4.3; Hox-5.2; HOX4; HOX4C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1826..1831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXD9"
                     /gene_synonym="Hox-4.3; Hox-5.2; HOX4; HOX4C"
                     /note="hexamer: AATAAA"
     polyA_site      1871
                     /gene="HOXD9"
                     /gene_synonym="Hox-4.3; Hox-5.2; HOX4; HOX4C"
                     /note="major polyA site"
ORIGIN      
        1 agtcggtggc tcgggcgccg gcggggagct gctcggcggc ggacagtgta atgttgggtg
       61 ggagtgcggg acgcctcaaa atgtcttcca gtggcaccct cagcaactac tacgtggact
      121 cgcttatagg ccatgagggc gacgaggtgt tcgcggcgcg cttcgggccg ccggggccag
      181 gcgcgcaggg ccggcctgca ggtgtggctg atggcccggc cgccaccgcc gccgagttcg
      241 cctcgtgtag ttttgccccc agatcggccg tgttctctgc ctcgtggtcc gcggtgccct
      301 cccagccccc ggcagcggcg gcgatgagcg gcctctacca cccgtacgtt cccccgccgc
      361 ccctggccgc ctctgcctcc gagcccggcc gctacgtgcg ctcctggatg gagccgctgc
      421 ccggcttccc gggcggtgcg ggcggtggcg gtggtggtgg aggcggcggt ccgggccgcg
      481 gtcccagccc tggccccagc ggcccagcca acgggcgcca ctacgggatt aagcctgaaa
      541 cccgagcggc cccggccccc gccacggccg cctccaccac ctcctcctcc tccacttcct
      601 tatcctcctc ctccaaacgg actgagtgct ccgtggcccg ggagtcccag gggagcagcg
      661 gccccgagtt ctcgtgcaac tcgttcctgc aggagaaggc ggcagcggcg acggggggaa
      721 ccgggcctgg ggcagggatc ggggccgcga ctgggacggg cggctcgtcg gagccctcag
      781 cttgcagcga ccacccgatc ccaggctgtt cgctgaagga ggaggagaag cagcattcgc
      841 agccgcagca gcagcaactt gacccaaaca accccgccgc gaactggatc cacgctcgct
      901 ccacccggaa aaagcgctgt ccctacacca aataccagac gcttgagctg gagaaagaat
      961 tcctcttcaa catgtacctc acccgggacc ggcgctacga ggtggccagg attctcaacc
     1021 taacagagag acaggtcaaa atctggtttc agaaccgtag gatgaaaatg aaaaagatga
     1081 gcaaggagaa atgccccaaa ggagactgac ccggcgcggt gctggcggga gcgctcaagg
     1141 gcagcggatt tgttgttgtt gctgttttcc tttgtgggtg tttggtgctt gatttccaga
     1201 aactctccag cgacttggac ttcttcttct tttttttttt ctttttagat agaagtgact
     1261 gtgtggttgg tctctgaggt atttggggga ctctgtattt gctcgtttac gtgttggaaa
     1321 aaccaagtgg ctttggggtt tcgccctatc ccactccctc tctttcctgc tccattggtt
     1381 ccttaagaaa tgctatattt tgtgagtgca agctggcttg gggagccctc tcttgtgtaa
     1441 atgtccccca tgtttctgaa aagtgctgta gtttagtccc ctcaccccca gcactgccca
     1501 aacaggggcc aagtgcgccc caattccaag aatgaaggca gagcgacaac agtgcggaca
     1561 ccccggctgc tagcccacgg tgaagcccgg cggggttgcc caccagttgc gaaagccccc
     1621 tttcctcagg gagcacgcgg gacctcggtg gagatctcca gtgaggctta gaggagccca
     1681 gggcctcggg cgggttgggg tttgtcctca gtgcattgga cgcgctgctc tctcccctga
     1741 aggctgggct cgcgtgggcg gccgcgggtg gtggccctcc cggttcctgc ccgaggacca
     1801 gttgtaaatg ttactgcttc ctactaataa atgctgacct gatcaaatgg agcccagacg
     1861 ctggccctaa a
//
