LOCUS       NM_019558               2618 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens homeobox D8 (HOXD8), transcript variant 1, mRNA.
ACCESSION   NM_019558 XM_001132822
VERSION     NM_019558.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2618)
  AUTHORS   Liu,J., Li,J., Su,Y., Ma,Z., Yu,S. and Meng,X.
  TITLE     CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation
            and Metastasis of Colorectal Cancer by Regulating HOXD8
  JOURNAL   Biochem Genet 60 (6), 2399-2415 (2022)
   PUBMED   35426617
  REMARK    GeneRIF: CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the
            Proliferation and Metastasis of Colorectal Cancer by Regulating
            HOXD8.
REFERENCE   2  (bases 1 to 2618)
  AUTHORS   Loi,E., Zavattari,C., Tommasi,A., Moi,L., Canale,M., Po,A.,
            Sabato,C., Vega-Benedetti,A.F., Ziranu,P., Puzzoni,M., Lai,E.,
            Faloppi,L., Rullan,M., Carrascosa,J., Amat,I., Urman,J.M.,
            Arechederra,M., Berasain,C., Ferretti,E., Casadei-Gardini,A.,
            Avila,M.A., Alonso,S., Scartozzi,M. and Zavattari,P.
  TITLE     HOXD8 hypermethylation as a fully sensitive and specific biomarker
            for biliary tract cancer detectable in tissue and bile samples
  JOURNAL   Br J Cancer 126 (12), 1783-1794 (2022)
   PUBMED   35177798
  REMARK    GeneRIF: HOXD8 hypermethylation as a fully sensitive and specific
            biomarker for biliary tract cancer detectable in tissue and bile
            samples.
REFERENCE   3  (bases 1 to 2618)
  AUTHORS   Zhang,Y., Yu,Y., Su,X. and Lu,Y.
  TITLE     HOXD8 inhibits the proliferation and migration of triple-negative
            breast cancer cells and induces apoptosis in them through
            regulation of AKT/mTOR pathway
  JOURNAL   Reprod Biol 21 (4), 100544 (2021)
   PUBMED   34454307
  REMARK    GeneRIF: HOXD8 inhibits the proliferation and migration of
            triple-negative breast cancer cells and induces apoptosis in them
            through regulation of AKT/mTOR pathway.
REFERENCE   4  (bases 1 to 2618)
  AUTHORS   Meng,L., Xing,Z., Guo,Z. and Liu,Z.
  TITLE     LINC01106 post-transcriptionally regulates ELK3 and HOXD8 to
            promote bladder cancer progression
  JOURNAL   Cell Death Dis 11 (12), 1063 (2020)
   PUBMED   33311496
  REMARK    GeneRIF: LINC01106 post-transcriptionally regulates ELK3 and HOXD8
            to promote bladder cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2618)
  AUTHORS   Limongi,M.Z., Pelliccia,F., Gaddini,L. and Rocchi,A.
  TITLE     Clustering of two fragile sites and seven homeobox genes in human
            chromosome region 2q31-->q32.1
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 151-153 (2000)
   PUBMED   11060466
REFERENCE   6  (bases 1 to 2618)
  AUTHORS   Manohar,C.F., Salwen,H.R., Furtado,M.R. and Cohn,S.L.
  TITLE     Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression
            in human neuroblastoma cells following chemical induction of
            differentiation
  JOURNAL   Tumour Biol 17 (1), 34-47 (1996)
   PUBMED   7501971
REFERENCE   7  (bases 1 to 2618)
  AUTHORS   Guazzi,S., Lonigro,R., Pintonello,L., Boncinelli,E., Di Lauro,R.
            and Mavilio,F.
  TITLE     The thyroid transcription factor-1 gene is a candidate target for
            regulation by Hox proteins
  JOURNAL   EMBO J 13 (14), 3339-3347 (1994)
   PUBMED   7913891
REFERENCE   8  (bases 1 to 2618)
  AUTHORS   Redline,R.W., Williams,A.J., Patterson,P. and Collins,T.
  TITLE     Human HOX4E: a gene strongly expressed in the adult male and female
            urogenital tracts
  JOURNAL   Genomics 13 (2), 425-430 (1992)
   PUBMED   1351871
REFERENCE   9  (bases 1 to 2618)
  AUTHORS   Zappavigna,V., Renucci,A., Izpisua-Belmonte,J.C., Urier,G.,
            Peschle,C. and Duboule,D.
  TITLE     HOX4 genes encode transcription factors with potential auto- and
            cross-regulatory capacities
  JOURNAL   EMBO J 10 (13), 4177-4187 (1991)
   PUBMED   1756725
REFERENCE   10 (bases 1 to 2618)
  AUTHORS   Oliver,G., Sidell,N., Fiske,W., Heinzmann,C., Mohandas,T.,
            Sparkes,R.S. and De Robertis,E.M.
  TITLE     Complementary homeo protein gradients in developing limb buds
  JOURNAL   Genes Dev 3 (5), 641-650 (1989)
   PUBMED   2568311
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009336.13 and AW140108.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019558.3.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, located on different
            chromosomes, consisting of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXD genes located in a cluster on
            chromosome 2. Deletions that remove the entire HOXD gene cluster or
            the 5' end of this cluster have been associated with severe limb
            and genital abnormalities. In addition to effects during
            embryogenesis, this particular gene may also play a role in adult
            urogenital tract function. Alternate splicing results in multiple
            transcript variants.[provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.31639.1, ERR279832.9862.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313173.6/ ENSP00000315949.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1239              AC009336.13        113694-114932
            1240-2160           AC009336.13        115306-116226
            2161-2618           AW140108.1         17-474              c
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2618
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
                     /note="homeobox D8"
                     /db_xref="GeneID:3234"
                     /db_xref="HGNC:HGNC:5139"
                     /db_xref="MIM:142985"
     exon            1..1239
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             663..1535
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
                     /note="isoform 1 is encoded by transcript variant 1; homeo
                     box D8; homeobox protein 5.4; homeo box 4E; homeobox
                     protein Hox-D8; Hox-4.5; homeobox protein Hox-4E; homeobox
                     protein Hox-5.4"
                     /codon_start=1
                     /product="homeobox protein Hox-D8 isoform 1"
                     /protein_id="NP_062458.1"
                     /db_xref="CCDS:CCDS2268.1"
                     /db_xref="GeneID:3234"
                     /db_xref="HGNC:HGNC:5139"
                     /db_xref="MIM:142985"
                     /translation="MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRH
                     AAAAAALQLYGNSAAGFPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPA
                     AAYQAAPPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYP
                     DCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLF
                     NPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKE
                     AQELEEDRAEGLTN"
     exon            1240..2618
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2252..2257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
                     /note="hexamer: AATAAT"
     polyA_site      2274
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
                     /note="major polyA site"
     regulatory      2597..2602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
                     /note="hexamer: AATAAA"
     polyA_site      2618
                     /gene="HOXD8"
                     /gene_synonym="HOX4; HOX4E; HOX5.4"
ORIGIN      
        1 ctccgcgggg ctcctcgtcc ccgtcacgct gactttccgt gcagtgctgt ggtgcgaaaa
       61 tgcctcgccg gtgcgcaccg ggtcggcagc ctcggcggcg ggggcgagat tggcgggagg
      121 ggggcgcggg gggggcgcgg taagaggtgg cggcgggcag agggtgtttt ttttcttttc
      181 cctccagagc cggggtttgt aaaccgaggc cagagtgtcc ccgtgggccg agcgcacttt
      241 tttcttgtcc gggtgcgctc agtcactggt gcctgagagg aaacagtgga ggcagcgggg
      301 caggtcgcct ggggcgtcgg cgattatatt gcggccgagc cggggcgcgc cgggaaaggc
      361 cgggagggcg gcggcgcgcg ggggctgggc gaggccccgc gacccgcgag ggaggcggcg
      421 cgaagccgag gcggcgggcg caagagccgg gcatgagcgc ccagtagctg agcgcccgcg
      481 gctgcctggc ctcagaagcg acgcgcgagc gcgggcgggc ggcagcagcg acgtagcccg
      541 gcggtcccgg cggcgagagc agccgcccca caggcccccg cggcagtgcg gccgagtcga
      601 ggctcgctct ctggctgctt agcgccgccc gcccgcccgg ggccgccgcc gctgacgccc
      661 caatgagttc gtacttcgtg aacccgctgt actccaagta caaggcggcg gctgcggcgg
      721 cggcggcggc gggcgaggcc atcaatccca cttactacga ctgtcacttc gcgcccgagg
      781 tcggcggccg tcacgccgcc gccgcagcag ccctgcagct ctatggcaac agcgccgccg
      841 gcttcccgca cgcgcccccg caggcgcacg cgcacccgca cccgtccccg ccgccctccg
      901 ggactgggtg cggcggtagg gaaggccggg gccaggagta cttccacccc ggcgggggca
      961 gcccggccgc tgcctaccag gccgcccccc ctcctcctcc gcatcctccg cctccgccgc
     1021 cacctccccc ctgcggcggg attgcctgtc acggggagcc cgcgaagttt tacggatacg
     1081 ataacttaca gagacagccg atttttacga cccagcaaga ggccgagctg gtacaatatc
     1141 ctgactgtaa atcgtccagt ggtaatattg gcgaggaccc agaccactta aatcagagct
     1201 cgtctccttc tcaaatgttt ccgtggatga gaccacaagc agctcctggt agacgaagag
     1261 gaagacaaac ctacagtcgc ttccaaactc tagagttgga aaaggaattt ctttttaacc
     1321 cctatctgac caggaaaaga agaatcgagg tttcccacgc cctagccctc accgagagac
     1381 aggtaaaaat ctggttccag aacaggagaa tgaaatggaa aaaggaaaac aacaaggaca
     1441 aatttcccgt ttcccggcag gaggtgaagg acggggaaac gaaaaaggaa gcccaagagc
     1501 tggaggaaga cagagccgaa ggcctgacaa attaacttct acctttaaaa tttaccacag
     1561 actattaaaa ctaataatca ccatatgctg tggacaccac ctattttctt tgttggaaag
     1621 gaccttacct gtgtttcaag ctaccttcat gtcactgctc ttgaggtttt ctgtgctttg
     1681 agagggattt gggtgtttaa aaaagtttct agtatcacat agaagctgtc cttgagctgt
     1741 cctatggaag ggtaatttga tactgacctt gtagctatat ttttataatg gtttttaatg
     1801 tctgagctag tgatttgcct caacaacgta aacttcctaa tgattagcac ttaataattg
     1861 catataaaat gctttattaa ttaaacaagt gcacttgaac attttaatat ttgtggtgag
     1921 taaattaaaa ggagtttatt aattaaaaaa aattatgtct gcagaatact ttatattatt
     1981 tgattacaat gtattattta tggatttttt attctttcct ttataatgaa tagttcgggt
     2041 gcgttttgtt tactcctaaa aggtttcttt gcgtattttc taaatgtaat atctcgggga
     2101 aaatattaga aaagcacgta ttagctgaag aatgtaactt gtagtccagc tctgcagctt
     2161 ccttaaactt aagaaaaaga ttgggccagt gacaagaatt taaagacaat gtccaagttg
     2221 acaattattt ttctatagtc catacaaatt aaataatctg gcaactctgg caaatcgcct
     2281 tgtaaaatgc gtctcatttt ttaacttgct ttcgttttga accgcccttg taatcgcctg
     2341 aaatcgctag ttctttatgc ggtggctgcc gctgtgttcc gttattttca gtaggtgtca
     2401 tatttatttg tattgccttt gttctgttcg ccgctggttt taaaccagct tgctgtgtgc
     2461 atctcagacg tcggttggta cgtcctccgc tgttcttcag gaaagcgata gcctcaccta
     2521 tttgaaacaa gccctgagag gaaacgcaga aaaacctgag tgtaaacaac tccggaatgt
     2581 cgctagctcc ttagtaaata aatgaatctc tttctgga
//
