LOCUS       NM_021192               1705 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens homeobox D11 (HOXD11), mRNA.
ACCESSION   NM_021192
VERSION     NM_021192.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Hong,Q., Liu,Z.X., Liang,H.F., Wu,D.G., Chen,Y. and Yu,B.
  TITLE     Inhibition of HOXD11 promotes cartilage degradation and induces
            osteoarthritis development
  JOURNAL   J Orthop Surg Res 19 (1), 111 (2024)
   PUBMED   38308324
  REMARK    GeneRIF: Inhibition of HOXD11 promotes cartilage degradation and
            induces osteoarthritis development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Tan,X., Liu,Z., Wang,Y., Wu,Z., Zou,Y., Luo,S., Tang,Y., Chen,D.,
            Yuan,G. and Yao,K.
  TITLE     miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by
            activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in
            penile squamous cell carcinoma
  JOURNAL   Cell Death Dis 13 (9), 816 (2022)
   PUBMED   36151071
  REMARK    GeneRIF: miR-138-5p-mediated HOXD11 promotes cell invasion and
            metastasis by activating the FN1/MMP2/MMP9 pathway and predicts
            poor prognosis in penile squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1705)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 1705)
  AUTHORS   de Barros E Lima Bueno,R., Ramao,A., Pinheiro,D.G., Alves,C.P.,
            Kannen,V., Jungbluth,A.A., de Araujo,L.F., Muys,B.R., Fonseca,A.S.,
            Placa,J.R., Panepucci,R.A., Neder,L., Saggioro,F.P., Mamede,R.C.,
            Figueiredo,D.L. and Silva,W.A. Jr.
  TITLE     HOX genes: potential candidates for the progression of laryngeal
            squamous cell carcinoma
  JOURNAL   Tumour Biol 37 (11), 15087-15096 (2016)
   PUBMED   27658780
  REMARK    GeneRIF: High expression of HOXD11 is associated with laryngeal
            squamous cell carcinoma.
REFERENCE   5  (bases 1 to 1705)
  AUTHORS   von Heyking,K., Roth,L., Ertl,M., Schmidt,O., Calzada-Wack,J.,
            Neff,F., Lawlor,E.R., Burdach,S. and Richter,G.H.
  TITLE     The posterior HOXD locus: Its contribution to phenotype and
            malignancy of Ewing sarcoma
  JOURNAL   Oncotarget 7 (27), 41767-41780 (2016)
   PUBMED   27363011
  REMARK    GeneRIF: Knock down of the dickkopf WNT signaling pathway inhibitor
            2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11
            and HOXD13 while over-expression of DKK2 and stimulation with
            factors of the WNT signaling pathway.
REFERENCE   6  (bases 1 to 1705)
  AUTHORS   Del Campo,M., Jones,M.C., Veraksa,A.N., Curry,C.J., Jones,K.L.,
            Mascarello,J.T., Ali-Kahn-Catts,Z., Drumheller,T. and McGinnis,W.
  TITLE     Monodactylous limbs and abnormal genitalia are associated with
            hemizygosity for the human 2q31 region that includes the HOXD
            cluster
  JOURNAL   Am J Hum Genet 65 (1), 104-110 (1999)
   PUBMED   10364522
REFERENCE   7  (bases 1 to 1705)
  AUTHORS   Herault,Y., Beckers,J., Gerard,M. and Duboule,D.
  TITLE     Hox gene expression in limbs: colinearity by opposite regulatory
            controls
  JOURNAL   Dev Biol 208 (1), 157-165 (1999)
   PUBMED   10075849
REFERENCE   8  (bases 1 to 1705)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   9  (bases 1 to 1705)
  AUTHORS   Johnson,R.L. and Tabin,C.J.
  TITLE     Molecular models for vertebrate limb development
  JOURNAL   Cell 90 (6), 979-990 (1997)
   PUBMED   9323126
  REMARK    Review article
REFERENCE   10 (bases 1 to 1705)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009336.13.
            
            On May 17, 2019 this sequence version replaced NM_021192.2.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, located on different
            chromosomes, consisting of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXD genes located in a cluster on
            chromosome 2. Deletions that remove the entire HOXD gene cluster or
            the 5' end of this cluster have been associated with severe limb
            and genital abnormalities. The product of the mouse Hoxd11 gene
            plays a role in forelimb morphogenesis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI139039.1, ERR3218379.153726.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249504.7/ ENSP00000249504.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-857               AC009336.13        91269-92125
            858-1705            AC009336.13        92896-93743
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1705
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /note="homeobox D11"
                     /db_xref="GeneID:3237"
                     /db_xref="HGNC:HGNC:5134"
                     /db_xref="MIM:142986"
     exon            1..857
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1093
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /note="homeo box D11; Hox-4.6, mouse, homolog of; homeo
                     box 4F; homeobox protein Hox-4F"
                     /codon_start=1
                     /product="homeobox protein Hox-D11"
                     /protein_id="NP_067015.2"
                     /db_xref="CCDS:CCDS2265.1"
                     /db_xref="GeneID:3237"
                     /db_xref="HGNC:HGNC:5134"
                     /db_xref="MIM:142986"
                     /translation="MNDFDECGQSAASMYLPGCAYYVAPSDFASKPSFLSQPSSCQMT
                     FPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGGGSAGGGSSGGGPGGGGGGAGG
                     YAPYYAAAAAAAAAAAAAEEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGA
                     ASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQPPPPPAPPQPEGAADKGDPRTGAG
                     GGGGSPCTKATPGSEPKGAAEGSGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKY
                     QIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNRDRLQYFTG
                     NPLF"
     exon            858..1705
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1568..1573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /note="hexamer: AATAAA"
     regulatory      1582..1587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /note="hexamer: AGTAAA"
     polyA_site      1588
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /note="major polyA site"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
                     /note="hexamer: AATACA"
     polyA_site      1606
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
     polyA_site      1624
                     /gene="HOXD11"
                     /gene_synonym="HOX4; HOX4F"
ORIGIN      
        1 ctcttgtgca atcgatggct caggttggct gcgcggggag cggccagagg ctcgctggcg
       61 cgcacgccgc ggagtcatga acgactttga cgagtgcggc cagagcgcag ccagcatgta
      121 cctgccgggc tgcgcctact atgtggcccc gtctgacttc gctagcaagc cttcgttcct
      181 ttcccaaccg tcgtcctgcc agatgacttt cccctactct tccaacctgg ctccgcacgt
      241 ccagcccgtg cgcgaagtgg ccttccgcga ctacggcctg gagcgcgcca agtggccgta
      301 ccgcggcggc ggcggcggcg gcagcgcggg gggcggcagc agcgggggcg gccccggcgg
      361 gggcggcggc ggcgcggggg gctacgctcc ctactacgcg gcggcggcgg cggcggctgc
      421 ggcggccgcg gcggccgagg aggcggccat gcaacgcgag cttctcccgc ccgcgggccg
      481 ccggccggac gtgctcttca aggcgcctga gccggtgtgc gctgcgccgg ggccgccgca
      541 cggccccgcg ggcgccgcct ccaacttcta cagcgcggtg ggccgcaatg gcatcttgcc
      601 acagggcttc gaccagttct acgaggcagc gcccgggccc ccgttcgccg ggccgcagcc
      661 cccgccgcca cccgcgccgc cacagcccga gggcgcagcc gacaagggcg accccaggac
      721 cggggctggt ggcggcgggg gcagtccctg caccaaggcg acccctggct cggagcccaa
      781 gggggcagca gaaggcagcg gtggcgacgg cgagggcccc ccgggagagg cgggggccga
      841 gaagagcagc agcgcagttg ccccccagcg gtcccggaaa aagcgctgtc cctataccaa
      901 gtaccagatc cgcgaactgg aacgcgagtt tttctttaac gtgtacataa acaaagagaa
      961 aagacttcaa ctctctcgga tgctcaacct cactgaccgg caagtcaaaa tctggttcca
     1021 gaatcgcagg atgaaagaaa agaaactgaa cagagaccgt ctgcagtatt tcactggaaa
     1081 ccccttattt tgagagctcc aggaagcgcc ctcaccccag ccccactcac ccaccctcct
     1141 tcccaccagc ctgctctccg caggcccact gtccttgggt ttaatgacgt ctcttctctg
     1201 tggaacttca cgattccttc ccacggtcaa ctcgggacct cccagcgacc actgcagcct
     1261 gcggacgagg ccgggacttg gccgagcgga tcctaataag gggaaaatgg taaatgcaaa
     1321 cgtcccgtta caattttacc gccagtgtgc tgtcgttccc cctccccctc tccgagtcct
     1381 cgtggggaca cggcggggtc tgtaggaagt tgggccgggt tgggggttgc tagaaggcgc
     1441 tggtgttttg ctctgagttt taagagatcc cttccttcct cttcggtgaa tgcaggttat
     1501 ttaaactttg ggaaatgtac ttttagtctg tcatatcaag gcatgagtca ctgtcttttt
     1561 ttgtgtgaat aaatggtttc tagtaaaatg gaggttacag cttcaataca ctgtatgaat
     1621 tctcctcttt gaggtttagt gcctccttag gatattttag tggccagaac ccatgcaact
     1681 gaaaatcgaa tgaaatactt tttag
//
