LOCUS       NM_002148               1785 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens homeobox D10 (HOXD10), mRNA.
ACCESSION   NM_002148
VERSION     NM_002148.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Lee,H., Machado,C.R.L., Hammaker,D., Choi,E., Prideaux,E.B.,
            Wang,W., Boyle,D.L. and Firestein,G.S.
  TITLE     Joint-specific regulation of homeobox D10 expression in rheumatoid
            arthritis fibroblast-like synoviocytes
  JOURNAL   PLoS One 19 (6), e0304530 (2024)
   PUBMED   38829908
  REMARK    GeneRIF: Joint-specific regulation of homeobox D10 expression in
            rheumatoid arthritis fibroblast-like synoviocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Zhang,L. and Liu,M.
  TITLE     Circ_0077109 sponges miR-139-5p and upregulates HOXD10 in
            trophoblast cells as potential mechanism for preeclampsia
            progression
  JOURNAL   Am J Reprod Immunol 88 (5), e13609 (2022)
   PUBMED   35964231
  REMARK    GeneRIF: Circ_0077109 sponges miR-139-5p and upregulates HOXD10 in
            trophoblast cells as potential mechanism for preeclampsia
            progression.
REFERENCE   3  (bases 1 to 1785)
  AUTHORS   Ren,Z., Niu,Y., Fan,B. and Zhang,A.
  TITLE     Upregulation of homeobox D10 expression suppresses invasion and
            migration of clear cell renal cell carcinoma through targeting of
            E-cadherin
  JOURNAL   Mol Biol Rep 49 (3), 1837-1846 (2022)
   PUBMED   34825321
  REMARK    GeneRIF: Upregulation of homeobox D10 expression suppresses
            invasion and migration of clear cell renal cell carcinoma through
            targeting of E-cadherin.
REFERENCE   4  (bases 1 to 1785)
  AUTHORS   Lai,F.J., Yu,H., Xie,Y.Y. and He,N.
  TITLE     Circ_0000317/microRNA-520g/HOXD10 axis affects the biological
            characteristics of colorectal cancer
  JOURNAL   Kaohsiung J Med Sci 37 (11), 951-963 (2021)
   PUBMED   34292663
  REMARK    GeneRIF: Circ_0000317/microRNA-520g/HOXD10 axis affects the
            biological characteristics of colorectal cancer.
REFERENCE   5  (bases 1 to 1785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1785)
  AUTHORS   Tabin,C.J.
  TITLE     Why we have (only) five fingers per hand: hox genes and the
            evolution of paired limbs
  JOURNAL   Development 116 (2), 289-296 (1992)
   PUBMED   1363084
  REMARK    Review article
REFERENCE   7  (bases 1 to 1785)
  AUTHORS   Redline,R.W., Williams,A.J., Patterson,P. and Collins,T.
  TITLE     Human HOX4E: a gene strongly expressed in the adult male and female
            urogenital tracts
  JOURNAL   Genomics 13 (2), 425-430 (1992)
   PUBMED   1351871
REFERENCE   8  (bases 1 to 1785)
  AUTHORS   Zappavigna,V., Renucci,A., Izpisua-Belmonte,J.C., Urier,G.,
            Peschle,C. and Duboule,D.
  TITLE     HOX4 genes encode transcription factors with potential auto- and
            cross-regulatory capacities
  JOURNAL   EMBO J 10 (13), 4177-4187 (1991)
   PUBMED   1756725
REFERENCE   9  (bases 1 to 1785)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   10 (bases 1 to 1785)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL526269.3, BC069619.1,
            BX114645.1, AW243295.1, AW299531.1 and AA653427.1.
            
            On Oct 2, 2019 this sequence version replaced NM_002148.3.
            
            Summary: This gene is a member of the Abd-B homeobox family and
            encodes a protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox D genes located on chromosome 2.
            The encoded nuclear protein functions as a sequence-specific
            transcription factor that is expressed in the developing limb buds
            and is involved in differentiation and limb development. Mutations
            in this gene have been associated with Wilm's tumor and congenital
            vertical talus (also known as 'rocker-bottom foot' deformity or
            congenital convex pes valgus) and/or a foot deformity resembling
            that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069619.1, X59373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249501.5/ ENSP00000249501.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL526269.3         15-20
            7-1150              BC069619.1         1-1144
            1151-1190           BX114645.1         533-572
            1191-1546           AW243295.1         1-356               c
            1547-1752           AW299531.1         33-238              c
            1753-1785           AA653427.1         32-64               c
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1785
                     /gene="HOXD10"
                     /gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
                     /note="homeobox D10"
                     /db_xref="GeneID:3236"
                     /db_xref="HGNC:HGNC:5133"
                     /db_xref="MIM:142984"
     exon            1..801
                     /gene="HOXD10"
                     /gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1079
                     /gene="HOXD10"
                     /gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
                     /note="homeo box D10; homeo box 4D; homeobox protein
                     Hox-4D; homeobox protein Hox-4E"
                     /codon_start=1
                     /product="homeobox protein Hox-D10"
                     /protein_id="NP_002139.2"
                     /db_xref="CCDS:CCDS2266.1"
                     /db_xref="GeneID:3236"
                     /db_xref="HGNC:HGNC:5133"
                     /db_xref="MIM:142984"
                     /translation="MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMG
                     TYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCS
                     FTTNIKEESNCCMYSDKRNKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYAT
                     GKTQEYNNSPEGSSTVMLQLNPRGAAKPQLSAAQLQMEKKMNEPVSGQEPTKVSQVES
                     PEAKGGLPEERSCLAEVSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKH
                     QTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELT
                     ANLTFS"
     exon            802..1785
                     /gene="HOXD10"
                     /gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1768..1773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXD10"
                     /gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
                     /note="hexamer: AATAAA"
     polyA_site      1785
                     /gene="HOXD10"
                     /gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
                     /note="major polyA site"
ORIGIN      
        1 ctagagatgt cagcctacaa aggacacaat ctctcttctt caaattcttc cccaaaatgt
       61 cctttcccaa cagctctcct gctgctaata cttttttagt agattccttg atcagtgcct
      121 gcaggagtga cagtttttat tccagcagcg ccagcatgta catgccacca cctagcgcag
      181 acatggggac ctatggaatg caaacctgtg gactgctccc gtctctggcc aaaagagaag
      241 tgaaccacca aaatatgggt atgaatgtgc atccttatat acctcaagta gacagttgga
      301 cagatccgaa cagatcttgt cgaatagagc aacctgttac acagcaagtc cccacttgct
      361 ccttcaccac caacattaag gaagaatcca attgctgcat gtattctgat aagcgcaaca
      421 aactcatttc ggccgaggtc ccttcgtacc agaggctggt ccctgagtct tgtcccgttg
      481 agaaccctga ggttcccgtc cctggatatt ttagactgag tcagacctac gccaccggga
      541 aaacccaaga gtacaataat agccccgaag gcagctccac tgtcatgctc cagctcaacc
      601 ctcgtggcgc ggccaagccg cagctctccg ctgcccagct gcagatggaa aagaagatga
      661 acgagcccgt gagcggccag gagcccacca aagtctccca ggtggagagc cccgaggcca
      721 aaggcggcct tcccgaagag aggagctgcc tggctgaggt ctccgtgtcc agtcccgaag
      781 tgcaggagaa ggaaagcaaa gaggaaatca agtctgatac accaaccagc aattggctca
      841 ctgcaaagag tggcagaaag aagaggtgcc cttacactaa gcaccaaacg ctggaattag
      901 aaaaagagtt cttgttcaat atgtacctca cccgcgagcg ccgcctagag atcagtaaga
      961 gcgttaacct caccgacagg caggtcaaga tttggtttca aaaccgccga atgaaactca
     1021 agaagatgag ccgagagaac cggatccgag aactgaccgc caacctcacg ttttcttagg
     1081 tctgaggccg gtctgaggcc ggtcagaggc caggattgga gagggggcac cgcgttccag
     1141 ggcccagtgc tggaggactg ggaaagcgga aacaaaacct tcaccgctct ttgtttgttg
     1201 ttttgttgta ttttgttttc ctgctagaat gtgactttgg ggtcattatg ttcgtgctgc
     1261 aagtgatctg taatccctat gagtatatat atatatatat atatatatat ataaaaactt
     1321 agcacgtgta atttattatt ttttcatcgt aatgcagggt aactattatt gcgcattttc
     1381 atttgggtct taacttattg gaactgtaga gcatccatcc atccatccat ccagcaatgt
     1441 gactttttca tgtctttcct aacacaaaag gtctatgtgt gtggttagtc catgaactca
     1501 tggcattttg aatacatcca gtactttaaa aatgacatat atatttaaaa aaaaaagatt
     1561 aagaaaaccc acaagttgga gggaggggga cttaaaaagc acattacaat gtatcttttc
     1621 acaaatgaat ttagcagttg tccttggtga gatgggatat tggcgattta tgccttgtag
     1681 cctttccctt gtggtgcatc tgtggtttgg tagaagtaca acagcaacct gtcctttctg
     1741 tgcatgttct ggtcgcatgt ataatgcaat aaactctgga aatga
//
