LOCUS       NM_022658               2417 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens homeobox C8 (HOXC8), mRNA.
ACCESSION   NM_022658
VERSION     NM_022658.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2417)
  AUTHORS   Chen,Y., Sun,L. and Li,L.
  TITLE     Human papillomavirus type 16 E7 promotes cell viability and
            migration in cervical cancer by regulating the miR-23a/HOXC8 axis
  JOURNAL   J Obstet Gynaecol 44 (1), 2311658 (2024)
   PUBMED   38348790
  REMARK    GeneRIF: Human papillomavirus type 16 E7 promotes cell viability
            and migration in cervical cancer by regulating the miR-23a/HOXC8
            axis.
REFERENCE   2  (bases 1 to 2417)
  AUTHORS   Li,J., Xu,X., Xu,K., Zhou,X., Wu,K., Yao,Y., Liu,Z., Chen,C.,
            Wang,L., Sun,Z., Jiao,D. and Han,X.
  TITLE     N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic
            cholangiocarcinoma progression via regulating HOXC8 and PD-L1
  JOURNAL   J Exp Clin Cancer Res 43 (1), 119 (2024)
   PUBMED   38641828
  REMARK    GeneRIF: N6-methyladenosine-modified circSLCO1B3 promotes
            intrahepatic cholangiocarcinoma progression via regulating HOXC8
            and PD-L1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2417)
  AUTHORS   Xie,X., Tang,S. and Yu,Z.
  TITLE     DNA Methylation-Regulated HOXC8's Role in HER2-Positive Breast
            Cancer Function and its Contribution to Herceptin Resistance
  JOURNAL   Discov Med 36 (182), 559-570 (2024)
   PUBMED   38531796
  REMARK    GeneRIF: DNA Methylation-Regulated HOXC8's Role in HER2-Positive
            Breast Cancer Function and its Contribution to Herceptin
            Resistance.
REFERENCE   4  (bases 1 to 2417)
  AUTHORS   Xu,D., Gao,C., Cao,Y. and Xiao,B.
  TITLE     HOXC8 alleviates high glucose-triggered damage of trophoblast cells
            during gestational diabetes mellitus via activating
            TGFbeta1-mediated Notch1 pathway
  JOURNAL   Hum Cell 36 (1), 195-208 (2023)
   PUBMED   36308681
  REMARK    GeneRIF: HOXC8 alleviates high glucose-triggered damage of
            trophoblast cells during gestational diabetes mellitus via
            activating TGFbeta1-mediated Notch1 pathway.
REFERENCE   5  (bases 1 to 2417)
  AUTHORS   Yu,M., Yu,S., Zhou,W., Yi,B. and Liu,Y.
  TITLE     HOXC6/8/10/13 predict poor prognosis and associate with immune
            infiltrations in glioblastoma
  JOURNAL   Int Immunopharmacol 101 (Pt A), 108293 (2021)
   PUBMED   34763232
  REMARK    GeneRIF: HOXC6/8/10/13 predict poor prognosis and associate with
            immune infiltrations in glioblastoma.
REFERENCE   6  (bases 1 to 2417)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   7  (bases 1 to 2417)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   8  (bases 1 to 2417)
  AUTHORS   Cannizzaro,L.A., Croce,C.M., Griffin,C.A., Simeone,A.,
            Boncinelli,E. and Huebner,K.
  TITLE     Human homeo box-containing genes located at chromosome regions
            2q31----2q37 and 12q12----12q13
  JOURNAL   Am J Hum Genet 41 (1), 1-15 (1987)
   PUBMED   2886047
REFERENCE   9  (bases 1 to 2417)
  AUTHORS   Simeone,A., Mavilio,F., Acampora,D., Giampaolo,A., Faiella,A.,
            Zappavigna,V., D'Esposito,M., Pannese,M., Russo,G., Boncinelli,E.
            et al.
  TITLE     Two human homeobox genes, c1 and c8: structure analysis and
            expression in embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 84 (14), 4914-4918 (1987)
   PUBMED   2885844
REFERENCE   10 (bases 1 to 2417)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012531.11, BC053898.1 and
            BU618342.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022658.3.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXC genes located in a cluster on
            chromosome 12. The product of this gene may play a role in the
            regulation of cartilage differentiation. It could also be involved
            in chondrodysplasias or other cartilage disorders. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053898.1, AK290959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000040584.6/ ENSP00000040584.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC012531.11        146589-146709
            122-1056            BC053898.1         1-935
            1057-1987           BC053898.1         937-1867
            1988-2411           BU618342.1         3-426               c
            2412-2417           AC012531.11        150368-150373
FEATURES             Location/Qualifiers
     source          1..2417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2417
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="homeobox C8"
                     /db_xref="GeneID:3224"
                     /db_xref="HGNC:HGNC:5129"
                     /db_xref="MIM:142970"
     exon            1..736
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1029
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="homeo box C8; homeo box 3A; Hox-3.1, mouse, homolog
                     of; homeobox protein Hox-3A"
                     /codon_start=1
                     /product="homeobox protein Hox-C8"
                     /protein_id="NP_073149.1"
                     /db_xref="CCDS:CCDS8870.1"
                     /db_xref="GeneID:3224"
                     /db_xref="HGNC:HGNC:5129"
                     /db_xref="MIM:142970"
                     /translation="MSSYFVNPLFSKYKAGESLEPAYYDCRFPQSVGRSHALVYGPGG
                     SAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGA
                     QQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQ
                     TLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARD
                     EEKVEEEGNEEEEKEEEEKEENKD"
     exon            737..2417
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="hexamer: AATAAT"
     polyA_site      1941
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="major polyA site"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="hexamer: AATATA"
     polyA_site      2289
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="hexamer: AATAAA"
     polyA_site      2417
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
ORIGIN      
        1 aagtgagaga gcgcgagctc tacctaccga cagtgaggag cgccgccgcc gccgccgccg
       61 cccgctcgcc gcccgccgcc gccgccgccc gcgccccagc cccgggagct ctgctgatcc
      121 ggccgagctc agcaccgagg cgccccccaa cctgcccagc ccccagccca ccagcccagc
      181 ccagtcccgg ggagccagct ggcctggggt tcggtcccgg ggggagggga gtttcggggg
      241 tactgggcgg ggtactcgtg agccagaggg gagggggccg cgggttttca tgtacccagc
      301 atgagctcct acttcgtcaa ccccctgttc tccaaataca aagccggcga gtccctggaa
      361 ccggcctatt acgactgccg gttccctcag agcgtgggca ggagccatgc gctggtgtac
      421 gggcccggcg gctcggcgcc cggcttccag cacgcttcgc accacgttca agacttcttc
      481 caccacggca cctccggcat ctccaactca ggctaccagc agaacccgtg ctcgcttagc
      541 tgccacggag acgcctccaa attctatggc tacgaggcgc tccccagaca gtccctttat
      601 ggggctcagc aagaggcgag cgtggtgcaa tatcccgact gtaaatcctc cgccaacact
      661 aacagtagcg aaggacaagg ccacttaaat caaaactcgt ctcccagcct catgtttcca
      721 tggatgagac cccacgctcc ggggaggcgc agtggacggc aaacttacag ccggtatcag
      781 accttggaac tagaaaagga gtttctcttt aatccttatt tgacacgaaa acgtcggatt
      841 gaagtctctc atgccctggg actgaccgag agacaagtga agatctggtt ccagaaccga
      901 aggatgaagt ggaaaaagga gaacaacaag gataaactgc cgggagcccg agatgaggag
      961 aaggtggagg aagaaggaaa tgaggaagag gagaaagaag aggaggaaaa ggaagaaaac
     1021 aaggactaag caaaaaagaa agaccccccc ccccttagca actcccttga agtttcgttt
     1081 tatggtagca gataaattga gaagtttacg actgtcattt gcttttatag agaatagaat
     1141 gacactcaca actctaacta cctgtcagat acttgcagct ctggttttat tacctttgga
     1201 cttcccccac tctttatttg tttgggggct ggagggggga gacggagaaa cagtgaaaag
     1261 ttcggactct ctgtctcact ccttgcccca cacacacttg tccctgcccc cacccttctg
     1321 agtccttcct ggattttaag gtctgagacc tggcctccgt gctcctcggt ctgtctctca
     1381 ccacactccc acctccctgc ttctctggta tttattttag aggggagccc cctcgaaatg
     1441 cagaaaagga cttgtggttt tgtttttatg ctaaggctag tgtactagat gtactttttc
     1501 taaaaaggaa aggacagaaa aaaatgaaga aaggaaagga agacaaatgt aaagaaataa
     1561 ggaaaaaagc aaggaatatc ccctccccct ccccctcccc ctccccaggg ctccctgctt
     1621 agaaaaaccc ccttgacttt ctctaggaac ctgatggaaa cctgaaggag atgtgggtct
     1681 ttcccctccc cccatttcca gaagggtaga taggagcctg cagtcgcctc taaaatccta
     1741 cctaaccatc ccatggtcac tcgggcccat gccttcctct ccttcgctgt ttgatttcta
     1801 ttctgttggg cccgccttcc tctgagctgc attagtgtta gtgctcagaa atcaccataa
     1861 tcacgaaaat aataataata aatctttaac atactaccta aagggaacct gcaataatct
     1921 tgaaaaagaa aaagagaaaa attttaaaat cctgctatag gagaaaaaaa gagaaaaaaa
     1981 taaaaatcaa aaaaaaaaaa aagaaagaaa gaaacctcca gcgtatttta tcactaccta
     2041 tagaaagaaa tcctgctttg agagtatttg taatgcggtt ttgttgtcgt ttgttgctgc
     2101 ttatttcact aagaaaaccc aacaactgag actgcctagc ccgccggtcc tgtgcgcttt
     2161 tattgtgctt ctaaccccag tagagtagaa ctaaattgca ctgaatgtat agttaactct
     2221 gtcttgaatt ctctgtttat gcaatgtgct cgaaagaaaa aaatgttaaa aatatatcta
     2281 taataataat tttttgtcat ttgtctttat gtccagctat gaatgtagat tttgtgtccc
     2341 gacagccctg ttcctggtcc aagtactttg tattgtatac gtgagtcata ataataaaaa
     2401 gaagaagaaa aataata
//
