LOCUS       NM_004503               1651 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens homeobox C6 (HOXC6), transcript variant 1, mRNA.
ACCESSION   NM_004503
VERSION     NM_004503.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Zheng,Y.J., Li,W.M., Zheng,L.C., Zhou,Y.F., Wang,J., Xia,W.M.,
            Ye,W.J. and Yu,J.S.
  TITLE     [Mechanism of HOXC6 promoting the progression of prostate cancer by
            activating the SFRP1/Wnt/beta-catenin signaling pathway]
  JOURNAL   Zhonghua Nan Ke Xue 30 (7), 579-587 (2024)
   PUBMED   39212391
  REMARK    GeneRIF: [Mechanism of HOXC6 promoting the progression of prostate
            cancer by activating the SFRP1/Wnt/beta-catenin signaling pathway].
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Li,Z., Wang,Y., Hou,X., Guo,L., Li,Y., Ma,Y. and Ma,Y.
  TITLE     High expression of HOXC6 predicts a poor prognosis and induces
            proliferation and inflammation in multiple myeloma cells
  JOURNAL   Genes Genomics 45 (7), 945-955 (2023)
   PUBMED   37202556
  REMARK    GeneRIF: High expression of HOXC6 predicts a poor prognosis and
            induces proliferation and inflammation in multiple myeloma cells.
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Chen,S., Dai,J., Wang,W. and Ren,C.
  TITLE     LINC01857 promotes the proliferation, migration, and invasion of
            gastric cancer cells via regulating miR-4731-5p/HOXC6
  JOURNAL   Can J Physiol Pharmacol 100 (7), 689-701 (2022)
   PUBMED   35468304
  REMARK    GeneRIF: LINC01857 promotes the proliferation, migration, and
            invasion of gastric cancer cells via regulating miR-4731-5p/HOXC6.
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Jeong,S., Kim,S.A. and Ahn,S.G.
  TITLE     HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through
            the Inhibition of the Tumor Suppressor FOXN2
  JOURNAL   Int J Mol Sci 23 (1), 9 (2021)
   PUBMED   35008435
  REMARK    GeneRIF: HOXC6-Mediated miR-188-5p Expression Induces Cell
            Migration through the Inhibition of the Tumor Suppressor FOXN2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Qi,L., Ye,C., Zhang,D., Bai,R., Zheng,S., Hu,W. and Yuan,Y.
  TITLE     The Effects of Differentially-Expressed Homeobox Family Genes on
            the Prognosis and HOXC6 on Immune Microenvironment Orchestration in
            Colorectal Cancer
  JOURNAL   Front Immunol 12, 781221 (2021)
   PUBMED   34950145
  REMARK    GeneRIF: The Effects of Differentially-Expressed Homeobox Family
            Genes on the Prognosis and HOXC6 on Immune Microenvironment
            Orchestration in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Simeone,A., Pannese,M., Acampora,D., D'Esposito,M. and
            Boncinelli,E.
  TITLE     At least three human homeoboxes on chromosome 12 belong to the same
            transcription unit
  JOURNAL   Nucleic Acids Res 16 (12), 5379-5390 (1988)
   PUBMED   2898768
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Simeone,A., Mavilio,F., Acampora,D., Giampaolo,A., Faiella,A.,
            Zappavigna,V., D'Esposito,M., Pannese,M., Russo,G., Boncinelli,E.
            et al.
  TITLE     Two human homeobox genes, c1 and c8: structure analysis and
            expression in embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 84 (14), 4914-4918 (1987)
   PUBMED   2885844
REFERENCE   10 (bases 1 to 1651)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from S82986.1 and AC012531.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004503.3.
            
            Summary: This gene belongs to the homeobox family, members of which
            encode a highly conserved family of transcription factors that play
            an important role in morphogenesis in all multicellular organisms.
            Mammals possess four similar homeobox gene clusters, HOXA, HOXB,
            HOXC and HOXD, which are located on different chromosomes and
            consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is
            one of several HOXC genes located in a cluster on chromosome 12.
            Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon.
            Transcripts may include the shared exon spliced to the
            gene-specific exons, or they may include only the gene-specific
            exons. Alternatively spliced transcript variants encoding different
            isoforms have been identified for HOXC6. Transcript variant two
            includes the shared exon, and transcript variant one includes only
            gene-specific exons. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S82986.1, BC074844.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243108.5/ ENSP00000243108.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-979               S82986.1           51-1029
            980-1651            AC012531.11        167756-168427
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1651
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="homeobox C6"
                     /db_xref="GeneID:3223"
                     /db_xref="HGNC:HGNC:5128"
                     /db_xref="MIM:142972"
     exon            1..482
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..790
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="isoform 1 is encoded by transcript variant 1; homeo
                     box C8 protein; homeo box 3C; homeobox protein CP25;
                     homeobox protein HHO.C8; homeobox protein Hox-3C"
                     /codon_start=1
                     /product="homeobox protein Hox-C6 isoform 1"
                     /protein_id="NP_004494.1"
                     /db_xref="CCDS:CCDS8871.1"
                     /db_xref="GeneID:3223"
                     /db_xref="HGNC:HGNC:5128"
                     /db_xref="MIM:142972"
                     /translation="MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAV
                     AQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQ
                     DFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEF
                     HFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSL
                     GGKEEKREETEEEKQKE"
     exon            483..1651
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1622..1627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="hexamer: AATAAA"
     polyA_site      1651
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="major polyA site"
ORIGIN      
        1 ataaccatct agttccgagt acaaactgga gacagaaata aatattaaag aaatcataga
       61 ccgaccaggt aaaggcaaag ggatgaattc ctacttcact aacccttcct tatcctgcca
      121 cctcgccggg ggccaggacg tcctccccaa cgtcgccctc aattccaccg cctatgatcc
      181 agtgaggcat ttctcgacct atggagcggc cgttgcccag aaccggatct actcgactcc
      241 cttttattcg ccacaggaga atgtcgtgtt cagttccagc cgggggccgt atgactatgg
      301 atctaattcc ttttaccagg agaaagacat gctctcaaac tgcagacaaa acaccttagg
      361 acataacaca cagacctcaa tcgctcagga ttttagttct gagcagggca ggactgcgcc
      421 ccaggaccag aaagccagta tccagattta cccctggatg cagcgaatga attcgcacag
      481 tggggtcggc tacggagcgg accggaggcg cggccgccag atctactcgc ggtaccagac
      541 cctggaactg gagaaggaat ttcacttcaa tcgctaccta acgcggcgcc ggcgcatcga
      601 gatcgccaac gcgctttgcc tgaccgagcg acagatcaaa atctggttcc agaaccgccg
      661 gatgaagtgg aaaaaagaat ctaatctcac atccactctc tcggggggcg gcggaggggc
      721 caccgccgac agcctgggcg gaaaagagga aaagcgggaa gagacagaag aggagaagca
      781 gaaagagtga ccaggactgt ccctgccacc cctctctccc tttctccctc gctccccacc
      841 aactctcccc taatcacaca ctctgtattt atcactggca caattgatgt gttttgattc
      901 cctaaaacaa aattagggag tcaaacgtgg acctgaaagt cagctctgga ccccctccct
      961 caccgcacaa ctctctttca ccacgcgcct cctcctcctc gctcccttgc tagctcgttc
     1021 tcggcttgtc tacaggccct tttccccgtc caggccttgg gggctcggac cctgaactca
     1081 gactctacag attgccctcc aagtgaggac ttggctcccc cactccttcg acgcccccac
     1141 ccccgccccc cgtgcagaga gccggctcct gggcctgctg gggcctctgc tccagggcct
     1201 cagggcccgg cctggcagcc ggggagggcc ggaggcccaa ggagggcgcg ccttggcccc
     1261 acaccaaccc ccagggcctc cccgcagtcc ctgcctagcc cctctgcccc agcaaatgcc
     1321 cagcccaggc aaattgtatt taaagaatcc tgggggtcat tatggcattt tacaaactgt
     1381 gaccgtttct gtgtgaagat ttttagctgt atttgtggtc tctgtattta tatttatgtt
     1441 tagcaccgtc agtgttccta tccaatttca aaaaaggaaa aaaaagaggg aaaattacaa
     1501 aaagagagaa aaaaagtgaa tgacgtttgt ttagccagta ggagaaaata aataaataaa
     1561 taaatccctt cgtgttaccc tcctgtataa atccaacctc tgggtccgtt ctcgaatatt
     1621 taataaaact gatattattt ttaaaacttt a
//
