LOCUS       NM_017410               2357 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens homeobox C13 (HOXC13), mRNA.
ACCESSION   NM_017410
VERSION     NM_017410.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Li,M., Bai,G., Cen,Y., Xie,Q., Chen,J., Chen,J., Chen,Q., Zhong,W.
            and Zhou,X.
  TITLE     Silencing HOXC13 exerts anti-prostate cancer effects by inducing
            DNA damage and activating cGAS/STING/IRF3 pathway
  JOURNAL   J Transl Med 21 (1), 884 (2023)
   PUBMED   38057852
  REMARK    GeneRIF: Silencing HOXC13 exerts anti-prostate cancer effects by
            inducing DNA damage and activating cGAS/STING/IRF3 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Juarez-Rendon,K.J., Castro-Garcia,M.A., Prada-Ortega,D.G.,
            Rivera,G., Ruiz-Godoy,L.M., Enriquez-Carcamo,V.I. and
            Reyes-Lopez,M.A.
  TITLE     Variants Identified in the HOXC13 and HOXD13 Genes Suggest
            Association with Cervical Cancer in a Cohort of Mexican Women
  JOURNAL   Genes (Basel) 14 (2), 358 (2023)
   PUBMED   36833285
  REMARK    GeneRIF: Variants Identified in the HOXC13 and HOXD13 Genes Suggest
            Association with Cervical Cancer in a Cohort of Mexican Women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Li,J., Zhang,B., Wang,B. and Zhang,X.
  TITLE     LncRNA HOXC-AS5 Affects the Proliferation, Invasion and Cell Cycle
            of Ameloblastoma Cells by Acting on the Target Gene HOXC13
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (5), 124-134 (2022)
   PUBMED   36029503
  REMARK    GeneRIF: LncRNA HOXC-AS5 Affects the Proliferation, Invasion and
            Cell Cycle of Ameloblastoma Cells by Acting on the Target Gene
            HOXC13.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Yu,M., Yu,S., Zhou,W., Yi,B. and Liu,Y.
  TITLE     HOXC6/8/10/13 predict poor prognosis and associate with immune
            infiltrations in glioblastoma
  JOURNAL   Int Immunopharmacol 101 (Pt A), 108293 (2021)
   PUBMED   34763232
  REMARK    GeneRIF: HOXC6/8/10/13 predict poor prognosis and associate with
            immune infiltrations in glioblastoma.
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Dai,M., Song,J., Wang,L., Zhou,K. and Shu,L.
  TITLE     HOXC13 promotes cervical cancer proliferation, invasion and Warburg
            effect through beta-catenin/c-Myc signaling pathway
  JOURNAL   J Bioenerg Biomembr 53 (5), 597-608 (2021)
   PUBMED   34309767
  REMARK    GeneRIF: HOXC13 promotes cervical cancer proliferation, invasion
            and Warburg effect through beta-catenin/c-Myc signaling pathway.
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   de Stanchina,E., Gabellini,D., Norio,P., Giacca,M., Peverali,F.A.,
            Riva,S., Falaschi,A. and Biamonti,G.
  TITLE     Selection of homeotic proteins for binding to a human DNA
            replication origin
  JOURNAL   J Mol Biol 299 (3), 667-680 (2000)
   PUBMED   10835276
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Godwin,A.R. and Capecchi,M.R.
  TITLE     Hair defects in Hoxc13 mutant mice
  JOURNAL   J Investig Dermatol Symp Proc 4 (3), 244-247 (1999)
   PUBMED   10674376
  REMARK    Review article
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   10 (bases 1 to 2357)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF255676.1, AF263466.2,
            BU158600.1, BC090850.1 and AA722686.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017410.2.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXC genes located in a cluster on
            chromosome 12. The product of this gene may play a role in the
            development of hair, nail, and filiform papilla. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090850.1, SRR5189658.196826.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243056.5/ ENSP00000243056.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               AF255676.1         40-399
            361-1080            AF263466.2         357-1076
            1081-1429           BU158600.1         409-757
            1430-2105           BC090850.1         1438-2113
            2106-2116           AA722686.1         244-254             c
            2117-2357           AF263466.2         2112-2352
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2357
                     /gene="HOXC13"
                     /gene_synonym="ECTD9; HOX3; HOX3G"
                     /note="homeobox C13"
                     /db_xref="GeneID:3229"
                     /db_xref="HGNC:HGNC:5125"
                     /db_xref="MIM:142976"
     exon            1..812
                     /gene="HOXC13"
                     /gene_synonym="ECTD9; HOX3; HOX3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1069
                     /gene="HOXC13"
                     /gene_synonym="ECTD9; HOX3; HOX3G"
                     /note="homeo box 3G; NUP98/HOXC13; homeobox protein
                     Hox-3G"
                     /codon_start=1
                     /product="homeobox protein Hox-C13"
                     /protein_id="NP_059106.2"
                     /db_xref="CCDS:CCDS8865.1"
                     /db_xref="GeneID:3229"
                     /db_xref="HGNC:HGNC:5125"
                     /db_xref="MIM:142976"
                     /translation="MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGG
                     GCSGASPGKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAA
                     RQCAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGAL
                     PGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWA
                     LSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELE
                     KEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST"
     exon            813..2357
                     /gene="HOXC13"
                     /gene_synonym="ECTD9; HOX3; HOX3G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC13"
                     /gene_synonym="ECTD9; HOX3; HOX3G"
                     /note="hexamer: AATAAA"
     polyA_site      2357
                     /gene="HOXC13"
                     /gene_synonym="ECTD9; HOX3; HOX3G"
                     /note="major polyA site"
ORIGIN      
        1 aaacaggagc gaggtgtctc cctagctcgc tgcctctggc aagtggagtt tttaaaaagc
       61 tccagcagat catgtcatga cgacttcgct gctcctgcat ccacgctggc cggagagcct
      121 tatgtacgtc tatgaggaca gcgcggcgga gagcggcatc ggcggcggcg gcggaggagg
      181 aggcggcggc acgggcggag cggggggtgg ctgcagcgga gcgagccccg gcaaagcccc
      241 gagcatggat ggtctgggca gcagctgccc ggccagccac tgccgcgacc tgcttccgca
      301 ccccgtgctg ggccgcccgc cggctcccct gggcgcccct cagggcgccg tctatacgga
      361 catcccggcc ccggaggcgg cgcgccagtg tgccccgccg cccgcacccc ccacctcgtc
      421 cagcgccacc ctgggctacg gctacccctt cgggggcagc tactacggct gccgcctgtc
      481 gcacaacgtg aacctgcagc agaagccttg cgcctaccac ccgggcgata aatacccgga
      541 gccgtcgggc gccctgcccg gtgacgacct gtcctctagg gccaaggagt tcgccttcta
      601 ccccagcttc gccagctcct accaggcgat gcccggctac ctggacgtgt cggtggtgcc
      661 cgggatcagc gggcacccgg agccgcgtca cgacgccctc atccccgtcg aaggctacca
      721 gcactgggct ctctccaatg gctgggacag tcaggtgtac tgctccaagg agcagtcgca
      781 gtccgcccac ctctggaagt ctcccttccc agacgtggtt cccctgcagc ccgaggtgag
      841 cagctaccgg cgcgggcgca agaaacgcgt gccctacact aaggtgcagc tgaaggagct
      901 agagaaggaa tacgcggcta gcaagttcat caccaaagag aagcgccggc gcatctccgc
      961 caccacgaac ctctctgagc gccaggtaac catctggttc cagaaccggc gggtcaaaga
     1021 gaagaaggtg gtcagcaaat cgaaagcgcc tcatctccac tccacctgac cacccacccg
     1081 ctgcttgccc catctattta tgtctccgct ttgtaccata accgaaccca cggaaagacg
     1141 ctgcgcgggt gcagaagagt atttaatgtt aaggaaagag aagaaccgcg ccgcccggag
     1201 gcagagaggc tccatggccg tgctgctggg ccatccccaa ctccctatcc catccccagc
     1261 ctccaccccc atccagatgg gactcacgtg gcttcaacag ctttggaaat gggtcccgag
     1321 tgggccgtgc gaggaaggct gtcgacctct actcctcctt gcgctcacct tgccagaaag
     1381 tctggtggca gcgcagagcc caatcattcc aaccaaagca gggttgggga atcccgaatg
     1441 gccccaattc ttgcctcatc ctatgaccag gcttttagag gaccttccct aagggcgcag
     1501 cttcggagca ggatctgtcc agctcatact ttccttcgct gtccctcccg cactccttag
     1561 gcaagatttc ccagtaaaga ttttctgtgc gtattttaaa agtcgtgtta atactcatga
     1621 taattattag ggacctggca gcgtgattgg agtatggatg tttccgtaaa agctggaatt
     1681 ccgtaaaagc attgacgcag cccctacact ccatcccaac caagaaactg catttcctgg
     1741 ggccaggtgg gagctgcctt tgccccactg cctcccctgt tctgctctct cagtcaacat
     1801 gtggaaatcc aaggaggaca aagactccag ccacgctgct aaatagggct cctctctcct
     1861 ctctctctct ctaggtggta aggttgggga ttagtccagg tacagaagca gaactttttt
     1921 ctaaggataa acatctcttc caaggggatg gagagtgggt ccctcaacaa agtccctgtc
     1981 cagtcacctt tccatcaggg cactagccca ggaatgactc ctcacacttt cacctttact
     2041 gatttccaga ggaaagctag aggatctagt tcaagaggca agaagatctg gccctcaatt
     2101 agctagatgt agatgctgcc taacagttcc ctcctcaaag gccaccttgg tgctgtgggg
     2161 gccccttgcc tcttcccttc ccactggtgc attacaaaac agtgttcttt tgaaatgttc
     2221 atcaggaata ggctttttta aaaaatgttg tgtatctgta tatagtattg tgatgtctga
     2281 atgacaatgt actgaatgca aaaaggaaaa aaacccacaa acatgttttt aaaataaaat
     2341 atcttttttt gccttga
//
