LOCUS       NM_014212               3261 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens homeobox C11 (HOXC11), mRNA.
ACCESSION   NM_014212
VERSION     NM_014212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3261)
  AUTHORS   Peng,X., Liu,X., Hu,W., Zhou,Y., Ouyang,L., Peng,X., Long,Y.,
            Sun,J., Tao,T., Chen,L., Shi,Y., Tao,Y., Xiao,D. and Liu,S.
  TITLE     HOXC11 drives lung adenocarcinoma progression through
            transcriptional regulation of SPHK1
  JOURNAL   Cell Death Dis 14 (2), 153 (2023)
   PUBMED   36823149
  REMARK    GeneRIF: HOXC11 drives lung adenocarcinoma progression through
            transcriptional regulation of SPHK1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3261)
  AUTHORS   Liu,L., Jia,S., Jin,X., Zhu,S. and Zhang,S.
  TITLE     HOXC11 Expression Is Associated with the Progression of Colon
            Adenocarcinoma and Is a Prognostic Biomarker
  JOURNAL   DNA Cell Biol 40 (9), 1158-1166 (2021)
   PUBMED   34415792
  REMARK    GeneRIF: HOXC11 Expression Is Associated with the Progression of
            Colon Adenocarcinoma and Is a Prognostic Biomarker.
REFERENCE   3  (bases 1 to 3261)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3261)
  AUTHORS   Zhang,X., Hamada,J., Nishimoto,A., Takahashi,Y., Murai,T., Tada,M.
            and Moriuchi,T.
  TITLE     HOXC6 and HOXC11 increase transcription of S100beta gene in
            BrdU-induced in vitro differentiation of GOTO neuroblastoma cells
            into Schwannian cells
  JOURNAL   J Cell Mol Med 11 (2), 299-306 (2007)
   PUBMED   17488478
  REMARK    GeneRIF: HOXC11 increases transcription of S100beta gene in
            BrdU-induced in vitro differentiation of GOTO neuroblastoma cells
            into Schwann cells.
REFERENCE   5  (bases 1 to 3261)
  AUTHORS   Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T.,
            Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N.
  TITLE     Complete mutation analysis panel of the 39 human HOX genes
  JOURNAL   Teratology 65 (2), 50-62 (2002)
   PUBMED   11857506
REFERENCE   6  (bases 1 to 3261)
  AUTHORS   Mitchelmore,C., Troelsen,J.T., Sjostrom,H. and Noren,O.
  TITLE     The HOXC11 homeodomain protein interacts with the lactase-phlorizin
            hydrolase promoter and stimulates HNF1alpha-dependent transcription
  JOURNAL   J Biol Chem 273 (21), 13297-13306 (1998)
   PUBMED   9582375
REFERENCE   7  (bases 1 to 3261)
  AUTHORS   Flagiello,D., Gibaud,A., Dutrillaux,B., Poupon,M.F. and Malfoy,B.
  TITLE     Distinct patterns of all-trans retinoic acid dependent expression
            of HOXB and HOXC homeogenes in human embryonal and small-cell lung
            carcinoma cell lines
  JOURNAL   FEBS Lett 415 (3), 263-267 (1997)
   PUBMED   9357979
REFERENCE   8  (bases 1 to 3261)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   9  (bases 1 to 3261)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   10 (bases 1 to 3261)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012531.11, AJ000041.1 and
            BC001543.1.
            
            On Nov 28, 2018 this sequence version replaced NM_014212.3.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXC genes located in a cluster on
            chromosome 12. The product of this gene binds to a promoter element
            of the lactase-phlorizin hydrolase. It also may play a role in
            early intestinal development. An alternatively spliced variant
            encoding a shorter isoform has been described but its full-length
            nature has not been determined. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001543.1, AJ000041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546378.1/ ENSP00000446680.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC012531.11        110730-110881
            153-1383            AJ000041.1         81-1311
            1384-1503           BC001543.1         1365-1484
            1504-1761           BC001543.1         1503-1760
            1762-2037           BC001543.1         1762-2037
            2038-3261           AC012531.11        114024-115247
FEATURES             Location/Qualifiers
     source          1..3261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..3261
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /note="homeobox C11"
                     /db_xref="GeneID:3227"
                     /db_xref="HGNC:HGNC:5123"
                     /db_xref="MIM:605559"
     exon            1..798
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1031
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /note="homeo box C11; homeobox protein Hox-3H"
                     /codon_start=1
                     /product="homeobox protein Hox-C11"
                     /protein_id="NP_055027.1"
                     /db_xref="CCDS:CCDS8867.1"
                     /db_xref="GeneID:3227"
                     /db_xref="HGNC:HGNC:5123"
                     /db_xref="MIM:605559"
                     /translation="MFNSVNLGNFCSPSRKERGADFGERGSCASNLYLPSCTYYMPEF
                     STVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHR
                     ECLPPSTVTEILMKNEGSYGGHHHPSAPHATPAGFYSSVNKNSVLPQAFDRFFDNAYC
                     GGGDPPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVA
                     KEPAKGAAPNAPRTRKKRCPYSKFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQV
                     KIWFQNRRMKEKKLSRDRLQYFSGNPLL"
     exon            799..3261
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /note="hexamer: GATAAA"
     polyA_site      2037
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /note="major polyA site"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /note="hexamer: AATACA"
     polyA_site      2994
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
                     /note="hexamer: AGTAAA"
     polyA_site      3261
                     /gene="HOXC11"
                     /gene_synonym="HOX3H"
ORIGIN      
        1 gtgctcagag agagagagac taagacggat aacgcgtcat ctcgccttcc caaattttcc
       61 cccctcgcta gaccgggtcc aaaacctcca tccggagccg gcaggagagg agaacgatgt
      121 ttaactcggt caacctgggc aacttctgct ctccgtcgcg caaggagagg ggcgcagatt
      181 tcggcgagcg agggagctgc gcctccaacc tctatctgcc cagttgcact tactacatgc
      241 ccgagttctc cacggtctcc tccttcctgc cccaggcccc ctctcgtcag atctcctatc
      301 cctactcggc ccaagtgccc ccggtccggg aggtctccta cggcctggag ccatccggca
      361 agtggcacca tcggaacagc tactcctcct gctatgcggc ggccgacgag cttatgcacc
      421 gggagtgcct gcctccttcc accgtcaccg agatcctcat gaaaaacgaa ggctcctacg
      481 gcggccacca ccaccccagc gccccgcacg caacccccgc cggcttctac tcctcagtca
      541 acaagaacag cgtcctgcct caagccttcg accgtttctt cgacaacgcc tactgcggtg
      601 gcggcgaccc gcccgccgag cccccctgct ccggcaaggg cgaggccaag ggggagcccg
      661 aggcaccccc ggcctcggga ctggcgtccc gggctgaggc gggtgccgag gcggaggctg
      721 aggaggagaa cacaaatccc agctcgtccg gttcagccca ctccgtggcc aaggagccgg
      781 ccaaaggagc cgcccccaac gccccccgca cccgcaagaa gcgctgccct tattcgaaat
      841 tccagatccg ggaactggag cgagagtttt tcttcaacgt gtatatcaac aaagagaagc
      901 ggctgcagct gtcccggatg ctgaacctga cggaccgaca agtgaaaatt tggtttcaga
      961 acagaaggat gaaagaaaag aaactgagca gagaccggct gcagtatttc tcgggaaatc
     1021 ctctgctgta acctgcagac cgggcccttt tgggggcggg gggaggggaa aattatttta
     1081 ttttattttt attttttatt ttctaactcg tcttctttcc gccggtggaa aactggactg
     1141 tggccagggc tggcccccac cgctgtggcc ggcactccat tccggaacct cctggaccct
     1201 ctatctgact ctcgctgtgg gacagggacc gggcctggaa agggggtgaa gggaagtgtc
     1261 tgatgcacgg cgagtgaaca ccgttggcgc cgaggccaag actttgattt aaaagaaaac
     1321 acacctcggc gacaatgtct tgctgctcgg attaggtggg ggaggggcga cagtagtgag
     1381 cgcctgagcc gaacaatcct cgaactaaaa gccttccctt gcccatgtga aaagatccgc
     1441 taagacagca tgtctgccag cggaaacttc tcgagctccc ccctctaccc cgccccacct
     1501 tgcagctaaa tgtgatcctg ccttgctgtg aaatttctgt accttcaacc tggtgttagg
     1561 tgtgcaaagt ccgtgtccta cctccgtctt cgccaaggcc ccgcccgagc ctagttgttc
     1621 tccccctgaa tgtgtagaac cttcctttga aatttcttaa tcggtgcatt gaggtttcca
     1681 catctttttc caagcagtgc cccacttcat ggatttatag ctatagtcta tgcagtcgtt
     1741 acctcttttt tttttttttt taagaaaatt gaagattggg gtggtggagg cagtagggag
     1801 atgggattgg gcacctcccc cgtgctgggg cctggatttt tgtaaataaa tttcccaagc
     1861 gtttctttcc acctggaggg aaaggggggg acgcccccag tgagattcaa atcacgcatc
     1921 tctactcctc tgcgtgagtg cgtgtgtaca tgtgcactcc ccaccctgct cccttcccag
     1981 agggattgct gtgaaatttt tttggtggca aataaagata aatttcattc tgttcaatat
     2041 tatgatttta tttgaccctt ttattaaccc ctctcctctt aaaatcctcc atgctcccat
     2101 ggcagcggcg gaggaggagg aggcaggcag gcagagccca gcgggtgagg acaggcaggc
     2161 agaggtgaga taggccggtg ctagccggcc tggagctcct ctccgctggc agggccaaga
     2221 gtatggccgt agtctcctca cattctcaag ctgaggacat tccatagcta ctctgaagct
     2281 ctcctttctc acgtgcagct cgagctgtgt ccaaacgccc agcaacggct ttctgtttaa
     2341 gtacacgttt gttgtggagt taattgtaac catcatcgaa tttaaattta taggaatttt
     2401 tttggctcca ccgcccttct gccagatgtc tccgtctgtc gcagttaaat gtgtagtgtg
     2461 gaggttaggg cttttttttt tttttctcta ggagaaatct gtattggaat ttttatacac
     2521 tgtttttaag gaaggagggg acagaaggag aaaccagccc cctccctctc ctctccacag
     2581 ctcctggggg tgggaaggtg gggcctggct gctttccctc tggcacaaat ggccaggctc
     2641 ttccagacac aacaagacgc ctatactggg gccaccctga tgtttataca ttgggtgtcc
     2701 cacagtagaa agccccagag gtttgttttg taggggttgg cactggggat ggagatgacc
     2761 tgcggggaca gtcaccatac ccatctatat ttgctgcatg tttcttctgt ataaagataa
     2821 tcatggccct tgcagtgctt tcagtgaggg cacttcgttg gtctctgttt caaattcgtt
     2881 atttgggggc agaggttcag gacaactcat ctcatctttc cctcctcttt ctgtctttgt
     2941 ataattcaaa gaaaatattt ttgtcaatac aattctgttg gatgaaagga aaaagcatca
     3001 tgactatcaa atctaggttc tgtcattttt gatggtagga atccctgcag cttaggtatc
     3061 taaatttcta atttgtaaac gtgggtcggg tcgtgagaca agatttgcaa actagggtgt
     3121 atatgcagcc cacaattccc tcatgtgccc acacacaaac gttttattta actcggtgtg
     3181 cctatgggtg cacataagaa ggaatattat ttatatgctt ttgtctgttg catggagtaa
     3241 acctgaccac atacacatct a
//
