LOCUS       NM_017409               1976 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens homeobox C10 (HOXC10), mRNA.
ACCESSION   NM_017409
VERSION     NM_017409.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Zhou,X. and Lin,S.
  TITLE     HOXC10 promotes hypertrophic scar fibroblast fibrosis through the
            regulation of STMN2 and the TGF-beta/Smad signaling pathway
  JOURNAL   Histochem Cell Biol 162 (5), 403-413 (2024)
   PUBMED   39152325
  REMARK    GeneRIF: HOXC10 promotes hypertrophic scar fibroblast fibrosis
            through the regulation of STMN2 and the TGF-beta/Smad signaling
            pathway.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Li,K., Yang,B., Du,Y., Ding,Y., Shen,S., Sun,Z., Liu,Y., Wang,Y.,
            Cao,S., Ren,W., Wang,X., Li,M., Zhang,Y., Wu,J., Zheng,W., Yan,W.
            and Li,L.
  TITLE     The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of
            pan-KRAS-mutant lung cancer
  JOURNAL   Bone Res 12 (1), 47 (2024)
   PUBMED   39191757
  REMARK    GeneRIF: The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis
            of pan-KRAS-mutant lung cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Zhou,Y., Huang,Q., Wu,C., Xu,Y., Guo,Y., Yuan,X., Xu,C. and Zhou,L.
  TITLE     m6A-modified HOXC10 promotes HNSCC progression via co-activation of
            ADAM17/EGFR and Wnt/beta-catenin signaling
  JOURNAL   Int J Oncol 64 (2) (2024)
   PUBMED   38063205
  REMARK    GeneRIF: m[6]A-modified HOXC10 promotes HNSCC progression via
            co-activation of ADAM17/EGFR and Wnt/beta-catenin signaling.
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Tan,X., Li,Z., Xie,H., Chen,J., Xiao,J., Zhi,Y., Mo,H., Huang,Y.
            and Liu,A.
  TITLE     Pan-cancer analysis of homeodomain-containing gene C10 and its
            carcinogenesis in lung adenocarcinoma
  JOURNAL   Aging (Albany NY) 15 (24), 15243-15266 (2023)
   PUBMED   38154103
  REMARK    GeneRIF: Pan-cancer analysis of homeodomain-containing gene C10 and
            its carcinogenesis in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Lin,Z.H., He,J.M., Lai,S.C., Ding,N., Jiang,Y., He,X.K., Liu,X.S.
            and Huang,Z.H.
  TITLE     HOXC10 indicates poor survival outcome in gastric cancer and
            promotes G1/S cell cycle transition through transcriptional
            repression of p21
  JOURNAL   Neoplasma 69 (6), 1303-1313 (2022)
   PUBMED   36264773
  REMARK    GeneRIF: HOXC10 indicates poor survival outcome in gastric cancer
            and promotes G1/S cell cycle transition through transcriptional
            repression of p21.
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   de Stanchina,E., Gabellini,D., Norio,P., Giacca,M., Peverali,F.A.,
            Riva,S., Falaschi,A. and Biamonti,G.
  TITLE     Selection of homeotic proteins for binding to a human DNA
            replication origin
  JOURNAL   J Mol Biol 299 (3), 667-680 (2000)
   PUBMED   10835276
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Flagiello,D., Gibaud,A., Dutrillaux,B., Poupon,M.F. and Malfoy,B.
  TITLE     Distinct patterns of all-trans retinoic acid dependent expression
            of HOXB and HOXC homeogenes in human embryonal and small-cell lung
            carcinoma cell lines
  JOURNAL   FEBS Lett 415 (3), 263-267 (1997)
   PUBMED   9357979
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012531.11, AL558161.3 and
            BC001293.1.
            
            On Nov 24, 2018 this sequence version replaced NM_017409.3.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXC genes located in a cluster on
            chromosome 12. The protein level is controlled during cell
            differentiation and proliferation, which may indicate this protein
            has a role in origin activation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001293.1, AF255675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303460.5/ ENSP00000307321.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC012531.11        122750-122765
            17-43               AL558161.3         1-27
            44-1412             BC001293.1         1-1369
            1413-1946           AC012531.11        127320-127853
            1947-1976           BC001293.1         1903-1932
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1976
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
                     /note="homeobox C10"
                     /db_xref="GeneID:3226"
                     /db_xref="HGNC:HGNC:5122"
                     /db_xref="MIM:605560"
     exon            1..865
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1143
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
                     /note="homeo box C10; homeoprotein C10; homeobox protein
                     Hox-3I"
                     /codon_start=1
                     /product="homeobox protein Hox-C10"
                     /protein_id="NP_059105.2"
                     /db_xref="CCDS:CCDS8868.1"
                     /db_xref="GeneID:3226"
                     /db_xref="HGNC:HGNC:5122"
                     /db_xref="MIM:605560"
                     /translation="MTCPRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVM
                     RGCGLAPSLSKRDEGSSPSLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYP
                     PSVKEENVCCMYSAEKRAKSGPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDK
                     TPHCSGANDFEAPFEQRASLNPRAEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQ
                     SLAGPKGSPSESEKERAKAADSSPDTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYT
                     KHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRE
                     LTSNFNFT"
     exon            866..1976
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1236..1241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
                     /note="hexamer: TATAAA"
     polyA_site      1261
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
     regulatory      1948..1953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
                     /note="hexamer: AATAAA"
     polyA_site      1976
                     /gene="HOXC10"
                     /gene_synonym="HOX3I"
                     /note="major polyA site"
ORIGIN      
        1 ccccttcttt ttcctccctc ccctccaacc gcgccccccc tcccggatgg ggaaaaaaaa
       61 agatgtcagc tcctccgctg tagtattgct ccttaaaaac ccctctctct gaaaatgaca
      121 tgccctcgca atgtaactcc gaactcgtac gcggagccct tggctgcgcc cggcggagga
      181 gagcgctata gccggagcgc aggcatgtat atgcagtctg ggagtgactt caattgcggg
      241 gtgatgaggg gctgcgggct cgcgccctcg ctctccaaga gggacgaggg cagcagcccc
      301 agcctcgccc tcaacaccta tccgtcctac ctctcgcagc tggactcctg gggcgacccc
      361 aaagccgcct atcgcctgga acaacctgtt ggcaggccgc tgtcctcctg ctcctaccca
      421 cctagtgtca aggaggagaa tgtctgctgc atgtacagcg cagagaagcg ggcgaaaagt
      481 ggccccgagg cagctctcta ctcccacccc ttgccggagt cctgccttgg ggagcacgag
      541 gtacccgtgc ccagctacta ccgcgccagc ccgagctact ccgcgctgga caagacgccc
      601 cactgttctg gggccaacga cttcgaagcc cctttcgagc agcgggccag tctcaacccg
      661 cgcgccgaac atctggaatc gcctcagctg gggggcaaag tgagtttccc tgagaccccc
      721 aagtccgaca gccagacccc cagccccaat gaaatcaaga cggagcagag cctggcgggc
      781 cctaaaggga gcccctcgga gagcgaaaag gagagggcca aagctgccga ctccagccca
      841 gacacctcgg ataacgaagc gaaagaggag ataaaggcag aaaacaccac aggaaattgg
      901 ctgacagcaa agagcggaag gaagaagagg tgcccctata ctaaacacca gacgctggaa
      961 ttggagaaag aatttctgtt caatatgtat ttgacgcgag agcgccgcct ggagattagc
     1021 aagaccatta accttacaga cagacaagtc aaaatctggt ttcaaaatcg cagaatgaaa
     1081 ctcaagaaaa tgaaccgaga gaatcggatc cgggaactga cctccaattt taatttcacc
     1141 tgagagcgcg gcctctcctc ctcccttccc gctccttcct ctccccgccc ctcctccctt
     1201 tgtgcctggt gatatatttt tttttcctcc ctgagtataa atgcaatgcg actgcaaaaa
     1261 aggcaaagac ctcagactct ccttccaagg gacctgtggt tcgtgctgcg aagatgcttc
     1321 cacttaaagc atgagaaatg gggtgccggg atgtggggtg tggtgtgtgc cctcatagat
     1381 gggggtggga gtgtggctgg tgtgtgtgtc aagccctcac tcacccacgc actcacacac
     1441 agcattctgt tctccatgca aagttaagat cgaatccatc cgcttgtagg ggaaaaaaag
     1501 gaaaaaaatt aaccagagag ggtctgtaat ctcgcagagc acaggcagaa tcgttccttc
     1561 cttgctgcat ttcctcctta gactaataga cgttttggaa agttcggcta gtgttcgtgt
     1621 gtttgtcgta gcacccagag cctccaccaa accctctcca tgtctttacc tcccagtcgc
     1681 tctaagaatc tgcttgaagt ctcgtatttg tactgctttc tgcttttctc ccacccctcc
     1741 tagcaccccc acatccccca tctagtaaca tctcagaaat ttcatccaga ggaacaaaaa
     1801 aattaaaaat agaacatagc aaagcaaaga cagaatgccc ccccccccaa atattgtcct
     1861 gtccctgtct gggagttgtg ttatttaaag atattctgta tgttgtatct tttgcatgta
     1921 gcttccttaa tggagaaaaa aaaacctaat aaatttccag aatcataatc ctcaaa
//
