LOCUS       NM_024017               2586 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens homeobox B9 (HOXB9), mRNA.
ACCESSION   NM_024017
VERSION     NM_024017.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Zhang,D., Qiu,Y., Zhang,W., Du,D., Liu,Y., Liu,L., Li,J., Chen,Z.,
            Yu,X., Ye,M., Wang,W., Li,Z. and Shao,J.
  TITLE     Homeobox B9 promotes the invasion and metastasis of hepatocellular
            carcinoma cells via the EZH2-MIR203A-SNAI2 axis
  JOURNAL   J Transl Med 22 (1), 918 (2024)
   PUBMED   39390614
  REMARK    GeneRIF: Homeobox B9 promotes the invasion and metastasis of
            hepatocellular carcinoma cells via the EZH2-MIR203A-SNAI2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Han,J., Ji,R., Zheng,S., Xia,X., Du,W., He,H., Han,C., Zhao,W.,
            Li,X., Wang,Y. and Zhang,L.
  TITLE     HOXB9 promotes osteosarcoma cell survival and malignancy under
            glucose starvation via upregulating SPP1 expression
  JOURNAL   Biochem Pharmacol 224, 116208 (2024)
   PUBMED   38621423
  REMARK    GeneRIF: HOXB9 promotes osteosarcoma cell survival and malignancy
            under glucose starvation via upregulating SPP1 expression.
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Sun,C., Deng,H., Li,Q., Wang,P., Chen,Y., Sun,Y. and Han,C.
  TITLE     HOXB9 promotes laryngeal squamous cell carcinoma progression by
            upregulating MMP12
  JOURNAL   Funct Integr Genomics 24 (3), 78 (2024)
   PUBMED   38632141
  REMARK    GeneRIF: HOXB9 promotes laryngeal squamous cell carcinoma
            progression by upregulating MMP12.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2586)
  AUTHORS   Yuan,L., Cheng,F., Wu,Z., Li,X. and Shen,W.
  TITLE     Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3
  JOURNAL   Dig Dis Sci 68 (8), 3324-3340 (2023)
   PUBMED   37258980
  REMARK    GeneRIF: Homeobox B9 Promotes Colon Cancer Progression by Targeting
            SRSF3.
REFERENCE   5  (bases 1 to 2586)
  AUTHORS   Liu,K., Li,X., Yang,Z. and Zhang,R.
  TITLE     Activation of CTHRC1 by HOXB9 Promotes Angiogenesis through Fatty
            Acid Metabolism in Lung Adenocarcinoma
  JOURNAL   Rev Invest Clin 75 (2), 63-75 (2022)
   PUBMED   37205792
  REMARK    GeneRIF: Activation of CTHRC1 by HOXB9 Promotes Angiogenesis
            through Fatty Acid Metabolism in Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 2586)
  AUTHORS   Deguchi,Y. and Kehrl,J.H.
  TITLE     Selective expression of two homeobox genes in CD34-positive cells
            from human bone marrow
  JOURNAL   Blood 78 (2), 323-328 (1991)
   PUBMED   1712647
REFERENCE   7  (bases 1 to 2586)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   8  (bases 1 to 2586)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 2586)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 2586)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA696753.1, AK056123.1,
            BC015565.1, BX114117.1, AK056414.1 and CA426693.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024017.4.
            
            Summary: This gene is a member of the Abd-B homeobox family and
            encodes a protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded nuclear protein functions as a sequence-specific
            transcription factor that is involved in cell proliferation and
            differentiation. Increased expression of this gene is associated
            with some cases of leukemia, prostate cancer and lung cancer.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056123.1, SRR14038195.2392763.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311177.7/ ENSP00000309439.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               DA696753.1         116-221
            107-810             AK056123.1         1-704
            811-1038            BC015565.1         817-1044
            1039-1553           BX114117.1         137-651
            1554-2055           AK056414.1         1492-1993
            2056-2579           BC015565.1         1755-2278
            2580-2586           CA426693.1         11-17               c
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..2586
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
                     /note="homeobox B9"
                     /db_xref="GeneID:3219"
                     /db_xref="HGNC:HGNC:5120"
                     /db_xref="MIM:142964"
     exon            1..606
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..842
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
                     /note="homeo box B9; homeo box 2E; homeobox protein
                     Hox-2E; homeobox protein Hox-2.5"
                     /codon_start=1
                     /product="homeobox protein Hox-B9"
                     /protein_id="NP_076922.1"
                     /db_xref="CCDS:CCDS11534.1"
                     /db_xref="GeneID:3219"
                     /db_xref="HGNC:HGNC:5120"
                     /db_xref="MIM:142964"
                     /translation="MSISGTLSSYYVDSIISHESEDAPPAKFPSGQYASSRQPGHAEH
                     LEFPSCSFQPKAPVFGASWAPLSPHASGSLPSVYHPYIQPQGVPPAESRYLRTWLEPA
                     PRGEAAPGQGQAAVKAEPLLGAPGELLKQGTPEYSLETSAGREAVLSNQRPGYGDNKI
                     CEGSEDKERPDQTNPSANWLHARSSRKKRCPYTKYQTLELEKEFLFNMYLTRDRRHEV
                     ARLLNLSERQVKIWFQNRRMKMKKMNKEQGKE"
     exon            607..2586
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2555..2560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
                     /note="hexamer: AACAAA"
     regulatory      2562..2567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
                     /note="hexamer: AATATA"
     polyA_site      2577
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
     polyA_site      2586
                     /gene="HOXB9"
                     /gene_synonym="HOX-2.5; HOX2; HOX2E"
                     /note="major polyA site"
ORIGIN      
        1 acaccggtcc gggtgccacc tctccctgct tgggcgccgc cgcgcgagcg cttcccttcc
       61 ccctgcaagc gcccggataa tgtctgagaa tgtccatttc tgggacgctt agcagctatt
      121 atgtcgactc gatcataagt cacgagagtg aggacgcgcc tccagccaag tttccttctg
      181 gccagtacgc gagctcgcgg cagccgggcc acgcggagca cctggagttc ccctcgtgca
      241 gcttccagcc caaagcgccg gtgttcggcg cctcctgggc gccgctgagc ccgcacgcgt
      301 ccgggagcct gccgtccgtc taccaccctt acatccagcc ccagggcgtc ccgccggccg
      361 agagcaggta cctccgcacc tggctggagc cggcgccgcg cggcgaagcg gccccggggc
      421 agggccaggc ggcggtgaag gcggagccgc tgctgggcgc gcctggggag ctgctcaaac
      481 agggcacgcc cgagtacagt ttggaaactt cggcgggcag ggaggccgtg ctgtctaatc
      541 aaagacccgg ctacggggac aataaaattt gcgaaggaag cgaggacaaa gagaggccgg
      601 atcaaaccaa cccctccgcc aactggctgc acgctcgctc ttcccggaaa aagcgctgtc
      661 cctacaccaa ataccagacg ctggagctag agaaggagtt tctgttcaat atgtacctca
      721 ccagggaccg taggcacgaa gtggccagac tcctcaatct gagtgagaga caagtcaaaa
      781 tctggtttca gaaccggcgg atgaaaatga agaaaatgaa taaggagcag ggcaaagagt
      841 aaagattaaa gattaccccc agtcctccct agctcttccc catctcactc ttagttatgt
      901 gacgactgca aagccagtgc tgtctgggat gtattcaagt gaatggggaa gggagtctct
      961 cttccaagtc ctttatctgc acctagaacc tccctccttt cctttgccct tacctgtctc
     1021 tctcttctct ctaggtgtca ggagaaagtt ttgttgattt agaagataga aatagttggt
     1081 tcctaagaat gtgatgggcc acaaggaaag agagacccca gtcaagctcc tagtatgccc
     1141 tgtaattttt ctgggaagtc ctagcccctc acttccagct tgcctgtttc ttctctacac
     1201 ccacccaaaa gtcacccagg gacactccaa ctctacacag ctcagcagac atccacacac
     1261 agtaatgggg tgagctcaca accaccattc agtcaagtga ggtgacactc cagttgcaga
     1321 ccatcgcaca ccaaatttgg caaaacagcc ctcagactgt caggcaagcc cgggttctac
     1381 ccctaatgca aatacccacc agggagatgt ctagaggcag actcctgagt gaggtgttgc
     1441 agcccaaagg ctgcagcatt gccataccat tcccatggag ttgccaacta ttctcaggcc
     1501 aagggccatg gggaagatgg agcaaaccta gcccccaagc cggtgggcta gaaagtacaa
     1561 gaaaaggcag cacgtggttt tatgaagcta tcttaggtgg agctactccc cacctcccac
     1621 caacatatac attttgttgc aggaaatgtt taattccgca tgatgtttcc ctctccttcc
     1681 aacaaaagaa ggtcaaactg tgggtcgtag agccttgaca atgttgtcct cctgttcatc
     1741 tgtgcaccac ttgacagact gtagcttctc ttgctctcga ccggccctgc attcttccgc
     1801 accctcccta gctctgaaat caactctctt cggtcgtatc caccttgcac ccgcaagtca
     1861 agccgcccct tgtagaaaaa tccctccacc ttccgttccc cgctaggtca accccactgt
     1921 agacaggaaa gccaggccag gagagtccga atgagaattt attgtgaatc gattcccaag
     1981 ctcccttccg ggacaagtgg tctgggacag ggaggagcaa cggccccagc gcgcaacgct
     2041 ctgcgcgttc ctccgaatcc cgtcggcttc tcgacccacg cagagaagcc ccgggcttgg
     2101 cggctctagc cccagcgcca aaggagaccc gccccagggc cgggcttggc ctcctgcttc
     2161 atgggcctgg atgcagatct gcgtggctgg tgcgtgcgcg cgcttctggg aaacagtccc
     2221 gcgtgcaaag gaaaggggca aaatggcacc taagcatcag atggaagctt actctctgct
     2281 tccgttcctc cccctgctcc cctacttctc agtccccttc aatttgtaga ctcttgctcc
     2341 tgcttctcct gatcctgcaa ggggacattc cagtagaagt tttttgcttt gtcggtggct
     2401 gtcgtgaaat tgtgcttgtg tttcgtgatt tctttggggg tgattgtctc gcttgttttc
     2461 agttgtcgat tatatgggag ggttctgggt gggagtgggg agggcgaggg gcctagagct
     2521 ctaattgttt gttttggaag aaaaaaagaa aaagaacaaa aaatatatat cactctagaa
     2581 aataaa
//
