LOCUS       NM_024016               2176 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens homeobox B8 (HOXB8), mRNA.
ACCESSION   NM_024016
VERSION     NM_024016.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Huang,T., Cai,M., Chen,C., Ling,C., Zhang,B., Zheng,W. and Luo,L.
  TITLE     LINC01116 boosts the progression of pituitary adenoma via
            regulating miR-744-5p/HOXB8 pathway
  JOURNAL   Mol Cell Endocrinol 536, 111350 (2021)
   PUBMED   34098015
  REMARK    GeneRIF: LINC01116 boosts the progression of pituitary adenoma via
            regulating miR-744-5p/HOXB8 pathway.
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Lu,B., Zou,C., Yang,M., He,Y., He,J., Zhang,C., Chen,S., Yu,J.,
            Liu,K.Y., Cao,Q. and Zhao,W.
  TITLE     Pharmacological Inhibition of Core Regulatory Circuitry
            Liquid-liquid Phase Separation Suppresses Metastasis and
            Chemoresistance in Osteosarcoma
  JOURNAL   Adv Sci (Weinh) 8 (20), e2101895 (2021)
   PUBMED   34432948
  REMARK    GeneRIF: Pharmacological Inhibition of Core Regulatory Circuitry
            Liquid-liquid Phase Separation Suppresses Metastasis and
            Chemoresistance in Osteosarcoma.
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Wilmerding,A., Bouteille,L., Rinaldi,L., Caruso,N., Graba,Y. and
            Delfini,M.C.
  TITLE     HOXB8 Counteracts MAPK/ERK Oncogenic Signaling in a Chicken Embryo
            Model of Neoplasia
  JOURNAL   Int J Mol Sci 22 (16), 8911 (2021)
   PUBMED   34445617
  REMARK    GeneRIF: HOXB8 Counteracts MAPK/ERK Oncogenic Signaling in a
            Chicken Embryo Model of Neoplasia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Lu,N., Yin,Y., Yao,Y. and Zhang,P.
  TITLE     SNHG3/miR-2682-5p/HOXB8 promotes cell proliferation and migration
            in oral squamous cell carcinoma
  JOURNAL   Oral Dis 27 (5), 1161-1170 (2021)
   PUBMED   32989886
  REMARK    GeneRIF: SNHG3/miR-2682-5p/HOXB8 promotes cell proliferation and
            migration in oral squamous cell carcinoma.
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Ma,W., Jin,H., Liu,W., Li,X., Zhou,X., Guo,X., Tian,R., Cui,Q.,
            Luo,J., Jiao,Y., Yu,Y., Yang,H. and Zhao,H.
  TITLE     Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9
            and Drives Glioma Progression
  JOURNAL   Neurosci Bull 36 (4), 359-371 (2020)
   PUBMED   31646435
  REMARK    GeneRIF: Homeobox B8 Targets Sterile Alpha Motif Domain-Containing
            Protein 9 and Drives Glioma Progression.
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 2176)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 2176)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103702.3, AK096222.1,
            BF761142.1, AI672407.1, AW612644.1 and AI277015.1.
            
            On May 17, 2019 this sequence version replaced NM_024016.3.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a nuclear protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded protein functions as a sequence-specific transcription
            factor that is involved in development. Increased expression of
            this gene is associated with colorectal cancer. Mice that have had
            the murine ortholog of this gene knocked out exhibit an excessive
            pathologic grooming behavior. This behavior is similar to the
            behavior of humans suffering from the obsessive-compulsive spectrum
            disorder trichotillomania. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096222.1, AW517327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239144.5/ ENSP00000239144.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               AC103702.3         74207-74559
            354-835             AK096222.1         1-482
            836-837             BF761142.1         66-67
            838-1219            AK096222.1         485-866
            1220-1221           AI672407.1         90-91               c
            1222-1936           AK096222.1         869-1583
            1937-1938           AW612644.1         255-256
            1939-2168           AK096222.1         1586-1815
            2169-2176           AI277015.1         12-19               c
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..2176
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="homeobox B8"
                     /db_xref="GeneID:3218"
                     /db_xref="HGNC:HGNC:5119"
                     /db_xref="MIM:142963"
     exon            1..1012
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             589..1320
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="homeo box B8; homeo box 2D; homeobox protein
                     Hox-2D; homeobox protein Hox-2.4"
                     /codon_start=1
                     /product="homeobox protein Hox-B8"
                     /protein_id="NP_076921.1"
                     /db_xref="CCDS:CCDS11533.1"
                     /db_xref="GeneID:3218"
                     /db_xref="HGNC:HGNC:5119"
                     /db_xref="MIM:142963"
                     /translation="MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSS
                     GGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDP
                     DLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLE
                     LEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQE
                     ELEKQKLERAPEAADEGDAQKGDKK"
     exon            1013..2176
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="hexamer: AATAAA"
     polyA_site      2176
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="major polyA site"
ORIGIN      
        1 cgctctctcc tcactccctg gcgctctctc gctctagctc tctctctcgc tcgctctctc
       61 tcgctctcac cctcgctctg cgttctgtcc gggaggagta cgaagaagcc aataggatgc
      121 ggggtctcta atggatgcaa atgatcatga aaagacagtg caaaatatga aacaactcat
      181 ttgcagggaa gtaaatcacc gaaaactgtt tatgaactgg catcccttct tcgaaatgta
      241 aagcgaggac ctctttaagt ggtggtatat ttttgtttgg ggggtggggg gtggggggag
      301 ggcgagcgag ccgcggctgc catgcaagct tagacttttg gaggcttctc tgtccttttc
      361 tattcctgga aaccacaaaa agtgtgtcgg cttcgagatc ttcttcgcct tttctttctt
      421 ttcttttttt ccctcctctc tttccctctc ctttcctggc gagggtgact aggagccggc
      481 gaatccgcgt ttttttctct ctctccctcc ctttccccct ccccaccccc tccccaacag
      541 cccccaacta tagcctccgc cgccgccgcc gcctcaaaat tcaataaaat gagctcttat
      601 ttcgtcaact cactgttctc caaatacaaa accggggagt ccctgcgccc caattattat
      661 gactgcggct tcgcccagga cctgggcggc cgacccaccg tggtgtacgg tcccagcagc
      721 ggcggcagct tccagcaccc gtcgcaaatc caggagttct accacgggcc gtcgtcgctg
      781 tccacggctc cctaccagca gaacccgtgc gccgtggcgt gccacgggga ccccggcaat
      841 ttctacggct acgacccgct gcaacgccag agcctattcg gtgcgcagga tccagacctg
      901 gtgcagtacg cagactgcaa gcttgccgcc gccagcggcc tgggcgagga ggccgagggc
      961 tccgagcaga gcccgtcgcc cacacagctc ttcccctgga tgcgcccgca agcagccgcc
     1021 ggacgcaggc gaggccgaca gacctacagc cgctaccaga ccctggagct ggagaaggag
     1081 ttcctattta atccctatct gactcgtaag cggcgaatcg aggtatcgca cgccctggga
     1141 ctgacagaga gacaggtcaa aatctggttc cagaaccgga ggatgaagtg gaaaaaagag
     1201 aacaacaaag acaagttccc cagcagcaaa tgcgagcagg aggagctgga gaaacagaag
     1261 ctggagcggg ccccagaggc ggcggacgag ggcgacgcgc agaagggcga caagaagtag
     1321 gcttcagctg ggactgccag ggccgcggcc gcccgcacgt ccgcgggtcc cggccgcgcc
     1381 gccgccgcgc gcccctgccc gagagagctc tggccccgct agcggggcca ggagccgggc
     1441 ctcccaccgc agcgtccccc gccgcgccag tccccgctag tggtagtatc tcgtaatagc
     1501 ttctgtgtgt gagctaccgt ggatctcctt cccttctctt gggggccggg gggaaagaaa
     1561 aggatttaag caaaggctcc ctcgccctgt gagggcgagc ggcaaaggcc cggctgagcc
     1621 ccccatgccc ctcccctccc cgtgtaaaaa gcctccttgt gcaattgtct tttttttcct
     1681 ttgaacgtgc ttctttgtaa tgaccaaggt accgatttct gctaagttct cccaacaaca
     1741 tgaaactgcc tattcacgcc gtaattcttt ctgtctccct tctctctctc tctctcgctc
     1801 gctcgctctc gctctcgctc tctctcgctg cgtcctcatt tcccctccca atcctctctc
     1861 ccctctgcaa ccccccagct cgctggcttt ctctctggct tctctctttt cctcctccac
     1921 ccaccccctt tggtttgaca attttgtctt aagtgtttct caaaagaggt tactttagtt
     1981 agcatgcgcg ctgtgggcaa ttgttacaag tgttcttagg tttactgtga agagaatgta
     2041 ttctgtatcc gtgaattgct ttatgggggg gagggagggc taattatata ttttgttgtt
     2101 cctctatact ttgttctgtt gtctgcgcct gaaaagggcg gaagagttac aataaagttt
     2161 acaagcgaga acccga
//
