LOCUS       NM_004502               1363 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens homeobox B7 (HOXB7), mRNA.
ACCESSION   NM_004502
VERSION     NM_004502.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Yin,C., Li,Y., Zhang,C., Zang,S., Wang,Z., Yan,X., Ma,T., Li,X. and
            Li,W.
  TITLE     Sequential gene expression analysis of myelodysplastic syndrome
            transformation identifies HOXB3 and HOXB7 as the novel targets for
            mesenchymal cells in disease
  JOURNAL   BMC Cancer 24 (1), 111 (2024)
   PUBMED   38254070
  REMARK    GeneRIF: Sequential gene expression analysis of myelodysplastic
            syndrome transformation identifies HOXB3 and HOXB7 as the novel
            targets for mesenchymal cells in disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Zhu,M., Xu,T., Ji,L., Jiang,B. and Wu,K.
  TITLE     MIR143HG promotes methylation of transcription factor HOXB7
            promoter by recruiting methyltransferase DNMT1 to prevent the
            progression of colon cancer
  JOURNAL   FASEB J 38 (1), e23378 (2024)
   PUBMED   38127104
  REMARK    GeneRIF: MIR143HG promotes methylation of transcription factor
            HOXB7 promoter by recruiting methyltransferase DNMT1 to prevent the
            progression of colon cancer.
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Ji,J., Xiong,C., Peng,J., Zhang,N., Zhang,Y., Yang,H. and Zhu,W.
  TITLE     Circ_0068631 sponges miR-139-5p to promote the growth and
            metastasis of cutaneous squamous cell carcinoma by upregulating
            HOXB7
  JOURNAL   Skin Res Technol 29 (2), e13248 (2023)
   PUBMED   36823512
  REMARK    GeneRIF: Circ_0068631 sponges miR-139-5p to promote the growth and
            metastasis of cutaneous squamous cell carcinoma by upregulating
            HOXB7.
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Sheng,J., Zhou,M., Wang,C., Jia,J., Chu,J., Ju,C., Wan,J., He,J.
            and He,F.
  TITLE     Long non-coding RNA BBOX1-AS1 exacerbates esophageal squamous cell
            carcinoma development by regulating HOXB7/beta-catenin axis
  JOURNAL   Exp Cell Res 415 (1), 113117 (2022)
   PUBMED   35351402
  REMARK    GeneRIF: Long non-coding RNA BBOX1-AS1 exacerbates esophageal
            squamous cell carcinoma development by regulating
            HOXB7/beta-catenin axis.
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Paco,A., Leitao-Castro,J. and Freitas,R.
  TITLE     Epigenetic Regulation of CDH1 Is Altered after HOXB7-Silencing in
            MDA-MB-468 Triple-Negative Breast Cancer Cells
  JOURNAL   Genes (Basel) 12 (10), 1575 (2021)
   PUBMED   34680970
  REMARK    GeneRIF: Epigenetic Regulation of CDH1 Is Altered after
            HOXB7-Silencing in MDA-MB-468 Triple-Negative Breast Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Baier,L.J., Hannibal,M.C., Hanley,E.W. and Nabel,G.J.
  TITLE     Lymphoid expression and TATAA binding of a human protein containing
            an Antennapedia homeodomain
  JOURNAL   Blood 78 (4), 1047-1055 (1991)
   PUBMED   1678287
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Shen,W.F., Largman,C., Lowney,P., Corral,J.C., Detmer,K.,
            Hauser,C.A., Simonitch,T.A., Hack,F.M. and Lawrence,H.J.
  TITLE     Lineage-restricted expression of homeobox-containing genes in human
            hematopoietic cell lines
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8536-8540 (1989)
   PUBMED   2573064
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG118354.1, BP342702.1,
            BM923808.1 and BQ233410.1.
            
            On May 17, 2019 this sequence version replaced NM_004502.3.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded nuclear protein functions as a sequence-specific
            transcription factor that is involved in cell proliferation and
            differentiation. Increased expression of this gene is associated
            with some cases of melanoma and ovarian carcinoma. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16937.1, SRR5189655.10159.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239165.9/ ENSP00000239165.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BG118354.1         9-13
            6-8                 BP342702.1         9-11
            9-15                BG118354.1         16-22
            16-799              BM923808.1         21-804
            800-1363            BQ233410.1         122-685
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..1363
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="homeobox B7"
                     /db_xref="GeneID:3217"
                     /db_xref="HGNC:HGNC:5118"
                     /db_xref="MIM:142962"
     exon            1..499
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..753
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="homeo box B7; homeo box c1 protein; homeo box 2C;
                     homeobox protein HHO.C1; homeobox protein Hox-2C"
                     /codon_start=1
                     /product="homeobox protein Hox-B7"
                     /protein_id="NP_004493.3"
                     /db_xref="CCDS:CCDS11532.1"
                     /db_xref="GeneID:3217"
                     /db_xref="HGNC:HGNC:5118"
                     /db_xref="MIM:142962"
                     /translation="MSSLYYANTLFSKYPASSSVFATGAFPEQTSCAFASNPQRPGYG
                     AGSGASFAASMQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPG
                     DSAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNR
                     YLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTAGPGTTGQDRAEAEEEEEE"
     exon            500..1363
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="hexamer: AATAAA"
     polyA_site      1363
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="major polyA site"
ORIGIN      
        1 ctttttggtg taaatctgga ctctaattct gtaatatatc aaggaatctc gtaaaaccga
       61 cactaaaacg tccctgccta caaatcatcc ggccaaatta tgagttcatt gtattatgcg
      121 aatactttat tttctaaata tccagcctca agttcggttt tcgctaccgg agccttccca
      181 gaacaaactt cttgtgcgtt tgcttccaac ccccagcgcc cgggctatgg agcgggttcg
      241 ggcgcttcct tcgccgcctc gatgcagggc ttgtaccccg gcgggggggg catggcgggc
      301 cagagcgcgg ccggcgtcta cgcggccggc tatgggctcg agccgagttc cttcaacatg
      361 cactgcgcgc cctttgagca gaacctctcc ggggtgtgtc ccggcgactc cgccaaggcg
      421 gcgggcgcca aggagcagag ggactcggac ttggcggccg agagtaactt ccggatctac
      481 ccctggatgc gaagctcagg aactgaccgc aaacgaggcc gccagaccta cacccgctac
      541 cagaccctgg agctggagaa agaatttcac tacaatcgct acctgacgcg gcggcggcgc
      601 atcgagatcg cgcacacgct ctgcctcacg gaaagacaga tcaagatttg gtttcagaac
      661 cggcgcatga agtggaaaaa ggagaacaag accgcgggcc cggggaccac cggccaagac
      721 agggctgaag cagaggagga agaggaagag tgagggatgg agaaagggca gaggaagaga
      781 catgagaaag ggagaggaag agaagcccag ctctgggaac tgaatcagga aactcaaatc
      841 gaatagggaa gtaaaaaaac aaaacaaaaa acaaaaaaaa caaaaaaaaa accctattta
      901 aatgaaagga gtttaaaaac attttttaag gagggagaaa ggagaaattt tggtttttca
      961 acactgaaaa aatactacct ataggaaagt ctgtcaggtt tggttttttt gtacaatatg
     1021 aaaaggatat tatctacctg ttctgtagct ttctggaatt tacctcccct tttctatgtt
     1081 gctattgtaa ggtctttgta aaatcttgca gttttgtaag ccctctttaa tgctgtcttt
     1141 gtggactgtg ggtctggact aaccctgtgg ttgcctgccc tcctgagcct ccgccttccc
     1201 agcagcggca ccaaggggcc ttagggagcc ccaaaaccta ccactcgcgt gttccccaag
     1261 cgcctggctg ctgcttcttg cttcccgtcc cccagcccca tgctcccttt tacattctgt
     1321 gtgtatctaa aggatggaaa aataaaacgc aattaaaaat aaa
//
