LOCUS       NM_002147               1859 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens homeobox B5 (HOXB5), mRNA.
ACCESSION   NM_002147
VERSION     NM_002147.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Wei,D., Zeng,J., Rong,F., Xu,Y., Wei,R. and Zou,C.
  TITLE     Circ_0020123 enhances the cisplatin resistance in non-small cell
            lung cancer cells partly by sponging miR-140-3p to regulate
            homeobox B5 (HOXB5)
  JOURNAL   Bioengineered 13 (3), 5126-5140 (2022)
   PUBMED   35170372
  REMARK    GeneRIF: Circ_0020123 enhances the cisplatin resistance in
            non-small cell lung cancer cells partly by sponging miR-140-3p to
            regulate homeobox B5 (HOXB5).
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Zhang,J., Zhang,S., Li,X., Zhang,F. and Zhao,L.
  TITLE     HOXB5 promotes the progression of breast cancer through
            wnt/beta-catenin pathway
  JOURNAL   Pathol Res Pract 224, 153117 (2021)
   PUBMED   34118725
  REMARK    GeneRIF: HOXB5 promotes the progression of breast cancer through
            wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Kim,C.Y., Kim,Y.C., Oh,J.H. and Kim,M.H.
  TITLE     HOXB5 Confers Tamoxifen Resistance in Breast Cancer Cells and
            Promotes Tumor Aggression and Progression
  JOURNAL   Anticancer Res 41 (7), 3409-3417 (2021)
   PUBMED   34230136
  REMARK    GeneRIF: HOXB5 Confers Tamoxifen Resistance in Breast Cancer Cells
            and Promotes Tumor Aggression and Progression.
REFERENCE   4  (bases 1 to 1859)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1859)
  AUTHORS   Feng,W., Huang,W., Chen,J., Qiao,C., Liu,D., Ji,X., Xie,M.,
            Zhang,T., Wang,Y., Sun,M., Tian,D., Fan,D., Nie,Y., Wu,K. and
            Xia,L.
  TITLE     CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer
            metastasis through transactivating CXCR4 and ITGB3
  JOURNAL   Theranostics 11 (6), 2612-2633 (2021)
   PUBMED   33456563
  REMARK    GeneRIF: CXCL12-mediated HOXB5 overexpression facilitates
            Colorectal Cancer metastasis through transactivating CXCR4 and
            ITGB3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1859)
  AUTHORS   Galang,C.K. and Hauser,C.A.
  TITLE     Cooperative DNA binding of the highly conserved human Hox 2.1
            homeodomain gene product
  JOURNAL   New Biol 4 (5), 558-568 (1992)
   PUBMED   1355360
REFERENCE   7  (bases 1 to 1859)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   8  (bases 1 to 1859)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 1859)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 1859)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M92299.1, BC117247.1,
            AC103702.3, CN264645.1 and BQ001097.1.
            
            On Aug 3, 2020 this sequence version replaced NM_002147.3.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a nuclear protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded protein functions as a sequence-specific transcription
            factor that is involved in lung and gut development. Increased
            expression of this gene is associated with a distinct biologic
            subset of acute myeloid leukemia (AML) and the occurrence of
            bronchopulmonary sequestration (BPS) and congenital cystic
            adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M92299.1, BC117247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239151.6/ ENSP00000239151.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                M92299.1           179-255
            78-1021             BC117247.1         1-944
            1022-1022           AC103702.3         97405-97405
            1023-1213           BC117247.1         946-1136
            1214-1438           CN264645.1         194-418
            1439-1859           BQ001097.1         18-438              c
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..1859
                     /gene="HOXB5"
                     /gene_synonym="HHO.C10; HOX2; Hox2.1; HOX2A; HU-1"
                     /note="homeobox B5"
                     /db_xref="GeneID:3215"
                     /db_xref="HGNC:HGNC:5116"
                     /db_xref="MIM:142960"
     exon            1..659
                     /gene="HOXB5"
                     /gene_synonym="HHO.C10; HOX2; Hox2.1; HOX2A; HU-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..907
                     /gene="HOXB5"
                     /gene_synonym="HHO.C10; HOX2; Hox2.1; HOX2A; HU-1"
                     /note="homeo box B5; homeo box 2A; homeobox protein Hu-1;
                     homeobox protein Hox-2A; homeobox protein HHO.C10"
                     /codon_start=1
                     /product="homeobox protein Hox-B5"
                     /protein_id="NP_002138.1"
                     /db_xref="CCDS:CCDS11530.1"
                     /db_xref="GeneID:3215"
                     /db_xref="HGNC:HGNC:5116"
                     /db_xref="MIM:142960"
                     /translation="MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGS
                     YGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPESLPC
                     TNGDSHGAKPSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPE
                     PMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRY
                     LTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP"
     exon            660..1859
                     /gene="HOXB5"
                     /gene_synonym="HHO.C10; HOX2; Hox2.1; HOX2A; HU-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1838..1843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB5"
                     /gene_synonym="HHO.C10; HOX2; Hox2.1; HOX2A; HU-1"
                     /note="hexamer: AATAAA"
     polyA_site      1859
                     /gene="HOXB5"
                     /gene_synonym="HHO.C10; HOX2; Hox2.1; HOX2A; HU-1"
                     /note="major polyA site"
ORIGIN      
        1 acagtgcatc gctataattc attaatacat cataaatcgt gaagcacagg gttataacga
       61 ccacgatcca caaatcaagc cctccaaaat cacccaaatg agctcgtact ttgtaaactc
      121 cttctcgggg cgttatccaa atggcccgga ctatcagttg ctaaattatg gcagtggcag
      181 ctctctgagc ggctcttaca gggatcccgc tgccatgcac accggctctt acggctacaa
      241 ttacaatggg atggacctca gcgtcaaccg ctcctcggcc tcctccagcc actttggggc
      301 ggtgggcgag agctcgcgcg ccttccccgc gcccgcccag gagccccgct tcaggcaagc
      361 ggcttcgagc tgctccctgt cctcgcccga gtccctgccc tgcaccaacg gcgacagcca
      421 cggcgccaag ccctctgctt cgtccccctc cgaccaggcg acctcagcca gctccagcgc
      481 caatttcacc gaaatagacg aggccagcgc gtcctcggag cctgaggaag cggcaagcca
      541 gctaagcagc cccagcctag ctcgggcgca gccagagccc atggccacct ccacagccgc
      601 gcccgagggg cagactccgc aaatattccc ctggatgagg aagcttcaca tcagccatga
      661 tatgaccggg ccggacggga aaagggcccg gaccgcgtat acccgctacc agaccctgga
      721 gctggaaaag gagttccact tcaaccgcta cctgacccgg cgacggcgca tcgagatcgc
      781 ccacgcactc tgcctgtccg agcgccagat caagatctgg ttccagaacc ggcgcatgaa
      841 gtggaagaag gacaacaaat tgaaaagtat gagcctggct acagctggca gcgccttcca
      901 gccctgagcc cgcccagagg agcccagcgg cccaagagcc cgtgccaccc ccagccctgg
      961 cccctccaat cctccccgct ctgccgccgc ccgctgggga ccggttccca caagcctgcc
     1021 tcgccttgtg ttacgatatt tcgtttggtc ttaggtcttc ctgtggctcc ctctctcctg
     1081 gactggttat cttgttatta ttgttaataa taattattat tattattttc cttccatgct
     1141 cccaactccc ttctgcttgt cccaaatccg ccagtgtttc tgaatgtttg tgtctgtggt
     1201 tgcagtcttt cccccaggaa aaaaaaaaaa agaaattcgc atgtttaatg tgaactctcc
     1261 cctccccatc tgtgttctaa cttatttata aaaagatgat cgctgtattt tgagtttcag
     1321 ctggaaactt ctgtaagggg cagcagttga ggtggggtag tgccgcagtg gggtcaagct
     1381 gagctggctt cggagatgga gtcccttttc attctcctcc tcctccctcc tcactcccta
     1441 ggcccaagtc tcctaggggc ttggtcctag ggtgggaagg ggctagggag gaccaaaggg
     1501 atggtattga gaagagagaa agaagatagt gagatttaag ttcctgctgc ctgggtaggc
     1561 cccacaaggc ctggtctggg agtatacgga aacaaaaatg atcctcagtg caaaatgtct
     1621 tgtgtatttc tctgtgaatc catgggtctg gctagagggc ccaaagcttg taaatatggg
     1681 gatagtctgg gtcagaccca tctctccctt acccatcttg cttccaagac catttgtagt
     1741 gagcgagtgg atgctgtgct acgtgtgaaa tctgtctttg cggggcctgt ctcagtgatt
     1801 cgcttttggt atttgtttgt agctttcctg gaagtcaaat aaatgtttcc cccactcca
//
