LOCUS       NM_024015               2002 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens homeobox B4 (HOXB4), mRNA.
ACCESSION   NM_024015
VERSION     NM_024015.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Liu,J., Zhu,Y., Wang,H., Han,C., Wang,Y. and Tang,R.
  TITLE     LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits
            glycolysis and ovarian cancer progression by destabilizing c-Myc
  JOURNAL   Cancer Sci 115 (3), 804-819 (2024)
   PUBMED   38182548
  REMARK    GeneRIF: LINC00629, a HOXB4-downregulated long noncoding RNA,
            inhibits glycolysis and ovarian cancer progression by destabilizing
            c-Myc.
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Li,J.X., He,X.J., Li,F., Lei,Y.T., Yang,Y.B., Li,J., Zong,G.Y.,
            Zhao,M.C. and Chang,S.E.
  TITLE     [miRNA-181a-5p inhibits proliferation and migration of osteosarcoma
            cell line HOS by targeting HOXB4]
  JOURNAL   Zhongguo Gu Shang 35 (11), 1097-1103 (2022)
   PUBMED   36415199
  REMARK    GeneRIF: [miRNA-181a-5p inhibits proliferation and migration of
            osteosarcoma cell line HOS by targeting HOXB4].
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Lei,D., Yang,W.T. and Zheng,P.S.
  TITLE     HOXB4 inhibits the proliferation and tumorigenesis of cervical
            cancer cells by downregulating the activity of Wnt/beta-catenin
            signaling pathway
  JOURNAL   Cell Death Dis 12 (1), 105 (2021)
   PUBMED   33479226
  REMARK    GeneRIF: HOXB4 inhibits the proliferation and tumorigenesis of
            cervical cancer cells by downregulating the activity of
            Wnt/beta-catenin signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Li,N., Gou,J.H., Xiong,J., You,J.J. and Li,Z.Y.
  TITLE     HOXB4 promotes the malignant progression of ovarian cancer via
            DHDDS
  JOURNAL   BMC Cancer 20 (1), 222 (2020)
   PUBMED   32178630
  REMARK    GeneRIF: HOXB4 promotes the malignant progression of ovarian cancer
            via DHDDS.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Dumas,P.Y., Mansier,O., Prouzet-Mauleon,V., Koya,J.,
            Villacreces,A., Brunet de la Grange,P., Luque Paz,D., Bidet,A.,
            Pasquet,J.M., Praloran,V., Salin,F., Kurokawa,M., Mahon,F.X.,
            Cardinaud,B. and Lippert,E.
  TITLE     MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative
            neoplasms
  JOURNAL   BMC Cancer 18 (1), 1098 (2018)
   PUBMED   30419846
  REMARK    GeneRIF: our data confirms that CaP growth and
            chemo-/radioresistance in vivo is associated with over-expression
            of EpCAM, which serves both a functional biomarker and promising
            therapeutic target.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Petrini,M., Quaranta,M.T., Testa,U., Samoggia,P., Tritarelli,E.,
            Care,A., Cianetti,L., Valtieri,M., Barletta,C. and Peschle,C.
  TITLE     Expression of selected human HOX-2 genes in B/T acute lymphoid
            leukemia and interleukin-2/interleukin-1 beta-stimulated natural
            killer lymphocytes
  JOURNAL   Blood 80 (1), 185-193 (1992)
   PUBMED   1351762
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC049204.1, AC103702.3 and
            AL137449.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024015.4.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a nuclear protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded protein functions as a sequence-specific transcription
            factor that is involved in development. Intracellular or ectopic
            expression of this protein expands hematopoietic stem and
            progenitor cells in vivo and in vitro, making it a potential
            candidate for therapeutic stem cell expansion. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL137449.1, BC049204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332503.6/ ENSP00000328928.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1538              BC049204.1         32-1569
            1539-1540           AC103702.3         113529-113530
            1541-1996           BC049204.1         1572-2027
            1997-2002           AL137449.1         1951-1956
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..2002
                     /gene="HOXB4"
                     /gene_synonym="HOX-2.6; HOX2; HOX2F"
                     /note="homeobox B4"
                     /db_xref="GeneID:3214"
                     /db_xref="HGNC:HGNC:5115"
                     /db_xref="MIM:142965"
     exon            1..488
                     /gene="HOXB4"
                     /gene_synonym="HOX-2.6; HOX2; HOX2F"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..787
                     /gene="HOXB4"
                     /gene_synonym="HOX-2.6; HOX2; HOX2F"
                     /note="homeo box B4; homeo box 2F; homeobox protein
                     Hox-2F; homeobox protein Hox-2.6"
                     /codon_start=1
                     /product="homeobox protein Hox-B4"
                     /protein_id="NP_076920.1"
                     /db_xref="CCDS:CCDS11529.1"
                     /db_xref="GeneID:3214"
                     /db_xref="HGNC:HGNC:5115"
                     /db_xref="MIM:142965"
                     /translation="MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRR
                     ESSFQPEAGFGRRAACTVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGAL
                     LPEPGQRCEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGG
                     EPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWK
                     KDHKLPNTKIRSGGAAGSAGGPPGRPNGGPRAL"
     exon            489..2002
                     /gene="HOXB4"
                     /gene_synonym="HOX-2.6; HOX2; HOX2F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB4"
                     /gene_synonym="HOX-2.6; HOX2; HOX2F"
                     /note="hexamer: AATAAA"
     polyA_site      2002
                     /gene="HOXB4"
                     /gene_synonym="HOX-2.6; HOX2; HOX2F"
                     /note="major polyA site"
ORIGIN      
        1 agtatatttt gtgggcaatt cccagaaatt aatggctatg agttcttttt tgatcaactc
       61 aaactatgtc gaccccaagt tccctccatg cgaggaatat tcacagagcg attacctacc
      121 cagcgaccac tcgcccgggt actacgccgg cggccagagg cgagagagca gcttccagcc
      181 ggaggcgggc ttcgggcggc gcgcggcgtg caccgtgcag cgctacgcgg cctgccggga
      241 ccctgggccc ccgccgcctc cgccaccacc cccgccgccc ccgccaccgc ccggtctgtc
      301 ccctcgggct cctgcgccgc cacccgccgg ggccctcctc ccggagcccg gccagcgctg
      361 cgaggcggtc agcagcagcc ccccgccgcc tccctgcgcc cagaaccccc tgcaccccag
      421 cccgtcccac tccgcgtgca aagagcccgt cgtctacccc tggatgcgca aagttcacgt
      481 gagcacggta aaccccaatt acgccggcgg ggagcccaag cgctctcgga ccgcctacac
      541 gcgccagcag gtcttggagc tggagaagga atttcactac aaccgctacc tgacacggcg
      601 ccggagggtg gagatcgccc acgcgctctg cctctccgag cgccagatca agatctggtt
      661 ccagaaccgg cgcatgaagt ggaaaaaaga ccacaagttg cccaacacca agatccgctc
      721 gggtggtgcg gcaggctcag ccggagggcc ccctggccgg cccaatggag gcccccgcgc
      781 gctctagtgc ccccgcacgc gggagccacg aacctcgggg tgggggtggg cagtgagtgc
      841 aggggatggg gtggggggac aggagggggc cctggggcct gggccccgga aaaatctatc
      901 tgccctcccc cacactttat atacgaataa acgcagaaga gggggagggg aagctttatt
      961 tatagaaatg acaatagagg gccacgggga ggccccccca gaagcaagat tcaaatctct
     1021 tgctttcttt cttaaaaaaa agaaaaagaa aaagcaagaa gaaggaagaa agaaaaagac
     1081 agaaagagaa ataggaggag gctgcagctc ctcgttttca gctttggcga agatggatcc
     1141 acgtttcatc tttaatcacg ccaggtccag gcccatctgt cttgtttcct ctgccgagga
     1201 gaagacgggc ctcggtggcg accattacct cgacacccgc taacaaatga ggcccggctc
     1261 ggccgcctcc gcctctgcta ctgccgctgc tggaagacag cctggatttc ctttctttgt
     1321 cccccactcc cgatacccag cgaaagcacc ctctgactgc cagatagtgc agtgttttgg
     1381 tcacggtaac acacacacac tctccctcat ctttcgtgcc cattcactga gggccagaat
     1441 gactgctcac ccacttccac cgtggggttg ggggtgggca acagaggagg ggagcaagta
     1501 gggaaggggg tggccttgac aactcaggag tgagcaggaa aattgagtcc aaggaaaaag
     1561 agagactcag agacccggga gggccttcct ctgaaaggcc aagccaagcc atgcttggca
     1621 gggtgagggg ccagttgagt tctgggagct gggcactact ctgccagtcc agagttgtac
     1681 agcagaagcc tctctcctag actgaaaatg aatgtgaaac taggaaataa aatgtgcccc
     1741 tcccagtctg ggaggaggat gttgcagagc cctctcccat agtttattat gttgcatcgt
     1801 ttattattat tattgataat attattatta ctattttttt gtgtcatgtg agtcctctct
     1861 ccttttctct ttctgacatt ccaaaaccag gccccttcct acctctgggg ctgcttgagt
     1921 ctagaaccct tcgtatgtgt gaatatctgt gtgctgtaca gagtgacaat agaaataaat
     1981 gtttggtttc ttgtgaccag ca
//
