LOCUS       NM_001384749            3301 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens homeobox B3 (HOXB3), transcript variant 5, mRNA.
ACCESSION   NM_001384749 XM_005257277
VERSION     NM_001384749.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Yin,C., Li,Y., Zhang,C., Zang,S., Wang,Z., Yan,X., Ma,T., Li,X. and
            Li,W.
  TITLE     Sequential gene expression analysis of myelodysplastic syndrome
            transformation identifies HOXB3 and HOXB7 as the novel targets for
            mesenchymal cells in disease
  JOURNAL   BMC Cancer 24 (1), 111 (2024)
   PUBMED   38254070
  REMARK    GeneRIF: Sequential gene expression analysis of myelodysplastic
            syndrome transformation identifies HOXB3 and HOXB7 as the novel
            targets for mesenchymal cells in disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Zhu,S., Yang,Z., Zhang,Z., Zhang,H., Li,S., Wu,T., Chen,X., Guo,J.,
            Wang,A., Tian,H., Yu,J., Zhang,C., Su,L., Shang,Z., Quan,C. and
            Niu,Y.
  TITLE     HOXB3 drives WNT-activation associated progression in
            castration-resistant prostate cancer
  JOURNAL   Cell Death Dis 14 (3), 215 (2023)
   PUBMED   36973255
  REMARK    GeneRIF: HOXB3 drives WNT-activation associated progression in
            castration-resistant prostate cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3301)
  AUTHORS   Yu,Z., Liu,J., Fan,Q., Yu,J., Ren,X. and Wang,X.
  TITLE     Extracellular Vesicle-Encapsulated MicroRNA-375 from Bone
            Marrow-Derived Mesenchymal Stem Cells Inhibits Hepatocellular
            Carcinoma Progression through Regulating HOXB3-Mediated
            Wnt/beta-Catenin Pathway
  JOURNAL   Anal Cell Pathol (Amst) 2022, 9302496 (2022)
   PUBMED   35127344
  REMARK    GeneRIF: Extracellular Vesicle-Encapsulated MicroRNA-375 from Bone
            Marrow-Derived Mesenchymal Stem Cells Inhibits Hepatocellular
            Carcinoma Progression through Regulating HOXB3-Mediated
            Wnt/beta-Catenin Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3301)
  AUTHORS   Tamam,Y., Gunes,B., Akbayir,E., Kizilay,T., Karaaslan,Z., Koral,G.,
            Duzel,B., Kucukali,C.I., Gunduz,T., Kurtuncu,M., Yilmaz,V.,
            Tuzun,E. and Turkoglu,R.
  TITLE     CSF levels of HoxB3 and YKL-40 may predict conversion from
            clinically isolated syndrome to relapsing remitting multiple
            sclerosis
  JOURNAL   Mult Scler Relat Disord 48, 102697 (2021)
   PUBMED   33352356
  REMARK    GeneRIF: CSF levels of HoxB3 and YKL-40 may predict conversion from
            clinically isolated syndrome to relapsing remitting multiple
            sclerosis.
REFERENCE   5  (bases 1 to 3301)
  AUTHORS   Zhou,J., Guo,X., Sun,Y., Ma,L. and Zhe,R.
  TITLE     Levels of serum Hoxb3 and sFlt-1 in pre-eclamptic patients and
            their effects on pregnancy outcomes
  JOURNAL   J Obstet Gynaecol Res 46 (10), 2010-2018 (2020)
   PUBMED   32748508
  REMARK    GeneRIF: Levels of serum Hoxb3 and sFlt-1 in pre-eclamptic patients
            and their effects on pregnancy outcomes.
REFERENCE   6  (bases 1 to 3301)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   7  (bases 1 to 3301)
  AUTHORS   Guazzi,S., Lonigro,R., Pintonello,L., Boncinelli,E., Di Lauro,R.
            and Mavilio,F.
  TITLE     The thyroid transcription factor-1 gene is a candidate target for
            regulation by Hox proteins
  JOURNAL   EMBO J 13 (14), 3339-3347 (1994)
   PUBMED   7913891
REFERENCE   8  (bases 1 to 3301)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 3301)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 3301)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103702.3.
            
            On Jun 26, 2020 this sequence version replaced XM_005257277.3.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a nuclear protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded protein functions as a sequence-specific transcription
            factor that is involved in development. Increased expression of
            this gene is associated with a distinct biologic subset of acute
            myeloid leukemia (AML). [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5), as well as variants 1 and 4,
            encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291182.1, SRR6380202.101736.13
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000498678.6/ ENSP00000420595.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC103702.3         99258-99374
            118-295             AC103702.3         115485-115662
            296-383             AC103702.3         133881-133968
            384-989             AC103702.3         136867-137472
            990-3301            AC103702.3         138318-140629
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3301
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="homeobox B3"
                     /db_xref="GeneID:3213"
                     /db_xref="HGNC:HGNC:5114"
                     /db_xref="MIM:142966"
     exon            1..117
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     exon            118..295
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     exon            296..383
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     exon            384..989
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1837
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="isoform 1 is encoded by transcript variant 5; homeo
                     box 2G; homeobox protein Hox-B3; homeobox protein Hox-2G;
                     homeobox protein Hox-2.7"
                     /codon_start=1
                     /product="homeobox protein Hox-B3 isoform 1"
                     /protein_id="NP_001371678.1"
                     /db_xref="CCDS:CCDS11528.1"
                     /db_xref="GeneID:3213"
                     /db_xref="HGNC:HGNC:5114"
                     /db_xref="MIM:142966"
                     /translation="MQKATYYDNAAAALFGGYSSYPGSNGFGFDVPPQPPFQAATHLE
                     GDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLSAPPGSPPPSAAPTSATSN
                     SSNGGGPSKSGPPKCGPGTNSTLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGG
                     GGGGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRR
                     VEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFM
                     NALHSMTPSYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVL
                     QANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPM
                     APSQHHGPCEPHPTYTDLSSHHAPPPQGRIQEAPKLTHL"
     exon            990..3301
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3277..3282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="hexamer: AATAAA"
     polyA_site      3301
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="major polyA site"
ORIGIN      
        1 gacactttaa ctgctcgctg tggtggggaa gggggcagag gtaggtgagc actctcccag
       61 cctggagcag ccggaccagc ccagaaggca gcggcggccc aggccagcat tcccgcacaa
      121 atctccttgg accggctgtt gggggaaaaa agtgttagcc gtctctcccg gatctgcaag
      181 ggggaaaaaa tttggaacca taaagttgaa aacttttttc tctcagtttg gaagaagccc
      241 ttcgtcatga atgggatctg cagagttcgg gcgagaggag gcgagaggcg caaaggaggg
      301 gagatttgtc gcctgccgct cgctctgggg ctcgatgtga atatatatta tgtctgcctg
      361 ttctcccctc gtcggtggct aaggtcagcc gcttggaaca gaccccggag gaggggggca
      421 gagaggggag gtgggggggg ggggtccggc gtgtcacgtg acccccaggg ttgccaatgt
      481 ccggtcctga gggtatcagg cctttccaag ttgccaccca ctgcccaggc ctcacccagc
      541 gatgcagaaa gccacctact acgacaacgc cgcggctgct ctcttcggag gctattcctc
      601 gtaccctggc agcaatggct tcggcttcga tgtccccccc caacccccat ttcaggccgc
      661 cacgcacctg gagggcgact accagcgctc agcttgctcg ctgcagtccc tgggcaacgc
      721 tgccccacat gccaagagca aggagctcaa cggcagctgc atgaggccgg gtctggcccc
      781 cgagcccctg tcggccccgc ctggctcacc cccgcccagt gccgcaccta ccagtgccac
      841 tagcaacagc agtaatgggg gcgggcccag caaaagtggt cccccaaagt gcggtcccgg
      901 caccaactcc accctcacca aacagatatt cccctggatg aaagagtcga ggcaaacgtc
      961 caagctgaaa aacaactccc ccggcacagc agagggctgt ggtggcggcg gcggtggcgg
     1021 cggcggcgga ggcagtggtg gcagcggggg cggtggcggc ggcggcgggg gaggggacaa
     1081 gagccccccg gggtcggcgg cgtccaagcg ggcgcggacg gcgtacacga gcgcgcagct
     1141 ggtggagctg gagaaggagt tccattttaa ccgctacctg tgccggcctc gccgtgtaga
     1201 gatggccaac ctgctgaacc tcagcgagcg gcagatcaag atctggttcc agaaccggcg
     1261 catgaagtac aagaaggacc agaaggccaa gggattggcc tcgtcgtcgg ggggcccatc
     1321 tccagccggc agccccccgc agcccatgca gtccacggcc ggcttcatga acgccttaca
     1381 ctccatgacc cccagctacg agagcccgtc cccacccgcc ttcggtaaag cccaccagaa
     1441 tgcctacgcg ctgccctcca actaccagcc ccctctcaaa ggctgcggcg ccccgcagaa
     1501 gtaccctccg accccggcgc ccgagtatga gccgcacgtc ctccaagcca acgggggcgc
     1561 ctacgggacg cccaccatgc agggcagtcc ggtgtacgtg ggcgggggcg gctacgcgga
     1621 tccgctgccg ccccctgccg gcccctccct ctatggcctc aaccaccttt cccatcaccc
     1681 ttccgggaac ctggactaca acggggcgcc ccctatggcg cccagccagc accacggacc
     1741 ctgcgaaccc caccccacct acacagacct ctcctctcac cacgcgcctc ctcctcaggg
     1801 tagaatccaa gaagcgccca aattaacaca cctgtgatgg gaaagggcga acgaggatta
     1861 ggggatgggg aggaagagag agactgtgga gctctggggg gcaacctgga ggtctgaaaa
     1921 gaggagccag agaaggtggt acccaggctt cctggtcaga accggcctgg agctccttcc
     1981 cttccccctg gcctgagagg ttgcttttaa gtcttccacc ccttgttcca tctgcctgcc
     2041 aacccatcgg aaaggaatcc acatcatatt ggagatgacc ccatcaaccc cagggctcca
     2101 gcactaccaa gttggaattc cacgcccggg agtggggtag aggaagacga gacaggacga
     2161 ggcagaaaag cacattttaa aaaccagaca agatggctag gccatcacca accaacggac
     2221 ttaccttaca tctttgtagg taattccccc caaatcttga tttttttttt tcctcaatta
     2281 tcctttaaaa aataagaaaa cacatttcaa acccaaaagg cacaaaacac gttcccttcc
     2341 aactttccca aaacctcaaa tttgttccca tttgaggttt attgaggtac acttctagcc
     2401 cccggttttt ctgctctaga acattcatat ctatacatcc cacccccatc aattacagtt
     2461 tttagagggc tcagggatgg tgagagatcc tgaaagagct gcctatatta taaattatat
     2521 acattttttt ttaaggaaaa gtgtggaggc tagggcaggc aggttgttag gactgaaggt
     2581 ttgcccattc tgctgcctcc atctcagctc cagctccatc cccctctcca cagaaagcag
     2641 ttggtgacac gaggttctat acttttcttc tgttgctctc ttgacttaac gtgaaaacag
     2701 ggtatatttg aacaaactgt cccaggcagg ggctgggcag ggcctgtgtg ccttgctcag
     2761 cctcctgaca ggacactttt gttgcactta gaatttacat tttaatggat gtaaaaacaa
     2821 ctgtgagaga tgtctgggcc tgcagaagtc cagcattgct caaaaaagcg tgtgttctag
     2881 tgaacatttt catatatatt tattggttat agcctgttaa aatattttct tttttgtatt
     2941 atttatcccc ctacattatg tatttatatg agggaaaaaa aggaaaaaat tgtacttttt
     3001 tagtatttac ctgttacaaa ggacattgtg tttcctgtca tgtaaaacca gctattttag
     3061 ttactattgt actctagaaa agagctgtag atttatgtta aactcgtact tacgaacaat
     3121 tgtaattagt tctaaaaggc atgaactcag ctcctaatcg tcactgtata gtcctgaatt
     3181 tgtagaacta gagttaattc cctcttggaa ctttctttgt tcttcagtag ttactttttt
     3241 ccttacctaa aagggttgtc tgtcaaacaa ttcttgaata aactttctgt tatcaatttt
     3301 a
//
