LOCUS       NM_001330322            3000 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens homeobox B3 (HOXB3), transcript variant 2, mRNA.
ACCESSION   NM_001330322 XM_005257280
VERSION     NM_001330322.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Yin,C., Li,Y., Zhang,C., Zang,S., Wang,Z., Yan,X., Ma,T., Li,X. and
            Li,W.
  TITLE     Sequential gene expression analysis of myelodysplastic syndrome
            transformation identifies HOXB3 and HOXB7 as the novel targets for
            mesenchymal cells in disease
  JOURNAL   BMC Cancer 24 (1), 111 (2024)
   PUBMED   38254070
  REMARK    GeneRIF: Sequential gene expression analysis of myelodysplastic
            syndrome transformation identifies HOXB3 and HOXB7 as the novel
            targets for mesenchymal cells in disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Zhu,S., Yang,Z., Zhang,Z., Zhang,H., Li,S., Wu,T., Chen,X., Guo,J.,
            Wang,A., Tian,H., Yu,J., Zhang,C., Su,L., Shang,Z., Quan,C. and
            Niu,Y.
  TITLE     HOXB3 drives WNT-activation associated progression in
            castration-resistant prostate cancer
  JOURNAL   Cell Death Dis 14 (3), 215 (2023)
   PUBMED   36973255
  REMARK    GeneRIF: HOXB3 drives WNT-activation associated progression in
            castration-resistant prostate cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Yu,Z., Liu,J., Fan,Q., Yu,J., Ren,X. and Wang,X.
  TITLE     Extracellular Vesicle-Encapsulated MicroRNA-375 from Bone
            Marrow-Derived Mesenchymal Stem Cells Inhibits Hepatocellular
            Carcinoma Progression through Regulating HOXB3-Mediated
            Wnt/beta-Catenin Pathway
  JOURNAL   Anal Cell Pathol (Amst) 2022, 9302496 (2022)
   PUBMED   35127344
  REMARK    GeneRIF: Extracellular Vesicle-Encapsulated MicroRNA-375 from Bone
            Marrow-Derived Mesenchymal Stem Cells Inhibits Hepatocellular
            Carcinoma Progression through Regulating HOXB3-Mediated
            Wnt/beta-Catenin Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Tamam,Y., Gunes,B., Akbayir,E., Kizilay,T., Karaaslan,Z., Koral,G.,
            Duzel,B., Kucukali,C.I., Gunduz,T., Kurtuncu,M., Yilmaz,V.,
            Tuzun,E. and Turkoglu,R.
  TITLE     CSF levels of HoxB3 and YKL-40 may predict conversion from
            clinically isolated syndrome to relapsing remitting multiple
            sclerosis
  JOURNAL   Mult Scler Relat Disord 48, 102697 (2021)
   PUBMED   33352356
  REMARK    GeneRIF: CSF levels of HoxB3 and YKL-40 may predict conversion from
            clinically isolated syndrome to relapsing remitting multiple
            sclerosis.
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Zhou,J., Guo,X., Sun,Y., Ma,L. and Zhe,R.
  TITLE     Levels of serum Hoxb3 and sFlt-1 in pre-eclamptic patients and
            their effects on pregnancy outcomes
  JOURNAL   J Obstet Gynaecol Res 46 (10), 2010-2018 (2020)
   PUBMED   32748508
  REMARK    GeneRIF: Levels of serum Hoxb3 and sFlt-1 in pre-eclamptic patients
            and their effects on pregnancy outcomes.
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Guazzi,S., Lonigro,R., Pintonello,L., Boncinelli,E., Di Lauro,R.
            and Mavilio,F.
  TITLE     The thyroid transcription factor-1 gene is a candidate target for
            regulation by Hox proteins
  JOURNAL   EMBO J 13 (14), 3339-3347 (1994)
   PUBMED   7913891
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299265.1, AK316245.1,
            CN430280.1 and CN430281.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001330322.1.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a nuclear protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded protein functions as a sequence-specific transcription
            factor that is involved in development. Increased expression of
            this gene is associated with a distinct biologic subset of acute
            myeloid leukemia (AML). [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream translation
            start site. The encoded isoform (2) has a shorter N-terminus than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299265.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               AK299265.1         76-612
            538-2058            AK316245.1         389-1909
            2059-2420           CN430280.1         168-529
            2421-2638           CN430280.1         534-751
            2639-3000           CN430281.1         253-614
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3000
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="homeobox B3"
                     /db_xref="GeneID:3213"
                     /db_xref="HGNC:HGNC:5114"
                     /db_xref="MIM:142966"
     exon            1..88
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     exon            89..266
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     exon            267..354
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     exon            355..688
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..1536
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="isoform 2 is encoded by transcript variant 2; homeo
                     box 2G; homeobox protein Hox-B3; homeobox protein Hox-2G;
                     homeobox protein Hox-2.7"
                     /codon_start=1
                     /product="homeobox protein Hox-B3 isoform 2"
                     /protein_id="NP_001317251.1"
                     /db_xref="CCDS:CCDS82154.1"
                     /db_xref="GeneID:3213"
                     /db_xref="HGNC:HGNC:5114"
                     /db_xref="MIM:142966"
                     /translation="MRPGLAPEPLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKC
                     GPGTNSTLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGG
                     GGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIK
                     IWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYESPSP
                     PAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANGGAYGTPTMQGS
                     PVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHHGPCEPHPTY
                     TDLSSHHAPPPQGRIQEAPKLTHL"
     exon            689..3000
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="hexamer: AATAAA"
     polyA_site      3000
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="major polyA site"
ORIGIN      
        1 acacacaata gtggacagga gagagctcag ctgttgcccg gcgcgtccgc gggcggctcg
       61 gcggccggcg gggctgggga gcctcccgca aatctccttg gaccggctgt tgggggaaaa
      121 aagtgttagc cgtctctccc ggatctgcaa gggggaaaaa atttggaacc ataaagttga
      181 aaactttttt ctctcagttt ggaagaagcc cttcgtcatg aatgggatct gcagagttcg
      241 ggcgagagga ggcgagaggc gcaaaggagg ggagatttgt cgcctgccgc tcgctctggg
      301 gctcgatgtg aatatatatt atgtctgcct gttctcccct cgtcggtggc taaggccgcc
      361 acgcacctgg agggcgacta ccagcgctca gcttgctcgc tgcagtccct gggcaacgct
      421 gccccacatg ccaagagcaa ggagctcaac ggcagctgca tgaggccggg tctggccccc
      481 gagcccctgt cggccccgcc tggctcaccc ccgcccagtg ccgcacctac cagtgccact
      541 agcaacagca gtaatggggg cgggcccagc aaaagtggtc ccccaaagtg cggtcccggc
      601 accaactcca ccctcaccaa acagatattc ccctggatga aagagtcgag gcaaacgtcc
      661 aagctgaaaa acaactcccc cggcacagca gagggctgtg gtggcggcgg cggtggcggc
      721 ggcggcggag gcagtggtgg cagcgggggc ggtggcggcg gcggcggggg aggggacaag
      781 agccccccgg ggtcggcggc gtccaagcgg gcgcggacgg cgtacacgag cgcgcagctg
      841 gtggagctgg agaaggagtt ccattttaac cgctacctgt gccggcctcg ccgtgtagag
      901 atggccaacc tgctgaacct cagcgagcgg cagatcaaga tctggttcca gaaccggcgc
      961 atgaagtaca agaaggacca gaaggccaag ggattggcct cgtcgtcggg gggcccatct
     1021 ccagccggca gccccccgca gcccatgcag tccacggccg gcttcatgaa cgccttacac
     1081 tccatgaccc ccagctacga gagcccgtcc ccacccgcct tcggtaaagc ccaccagaat
     1141 gcctacgcgc tgccctccaa ctaccagccc cctctcaaag gctgcggcgc cccgcagaag
     1201 taccctccga ccccggcgcc cgagtatgag ccgcacgtcc tccaagccaa cgggggcgcc
     1261 tacgggacgc ccaccatgca gggcagtccg gtgtacgtgg gcgggggcgg ctacgcggat
     1321 ccgctgccgc cccctgccgg cccctccctc tatggcctca accacctttc ccatcaccct
     1381 tccgggaacc tggactacaa cggggcgccc cctatggcgc ccagccagca ccacggaccc
     1441 tgcgaacccc accccaccta cacagacctc tcctctcacc acgcgcctcc tcctcagggt
     1501 agaatccaag aagcgcccaa attaacacac ctgtgatggg aaagggcgaa cgaggattag
     1561 gggatgggga ggaagagaga gactgtggag ctctgggggg caacctggag gtctgaaaag
     1621 aggagccaga gaaggtggta cccaggcttc ctggtcagaa ccggcctgga gctccttccc
     1681 ttccccctgg cctgagaggt tgcttttaag tcttccaccc cttgttccat ctgcctgcca
     1741 acccatcgga aaggaatcca catcatattg gagatgaccc catcaacccc agggctccag
     1801 cactaccaag ttggaattcc acgcccggga gtggggtaga ggaagacgag acaggacgag
     1861 gcagaaaagc acattttaaa aaccagacaa gatggctagg ccatcaccaa ccaacggact
     1921 taccttacat ctttgtaggt aattcccccc aaatcttgat tttttttttt cctcaattat
     1981 cctttaaaaa ataagaaaac acatttcaaa cccaaaaggc acaaaacacg ttcccttcca
     2041 actttcccaa aacctcaaat ttgttcccat ttgaggttta ttgaggtaca cttctagccc
     2101 ccggtttttc tgctctagaa cattcatatc tatacatccc acccccatca attacagttt
     2161 ttagagggct cagggatggt gagagatcct gaaagagctg cctatattat aaattatata
     2221 catttttttt taaggaaaag tgtggaggct agggcaggca ggttgttagg actgaaggtt
     2281 tgcccattct gctgcctcca tctcagctcc agctccatcc ccctctccac agaaagcagt
     2341 tggtgacacg aggttctata cttttcttct gttgctctct tgacttaacg tgaaaacagg
     2401 gtatatttga acaaactgtc ccaggcaggg gctgggcagg gcctgtgtgc cttgctcagc
     2461 ctcctgacag gacacttttg ttgcacttag aatttacatt ttaatggatg taaaaacaac
     2521 tgtgagagat gtctgggcct gcagaagtcc agcattgctc aaaaaagcgt gtgttctagt
     2581 gaacattttc atatatattt attggttata gcctgttaaa atattttctt ttttgtatta
     2641 tttatccccc tacattatgt atttatatga gggaaaaaaa ggaaaaaatt gtactttttt
     2701 agtatttacc tgttacaaag gacattgtgt ttcctgtcat gtaaaaccag ctattttagt
     2761 tactattgta ctctagaaaa gagctgtaga tttatgttaa actcgtactt acgaacaatt
     2821 gtaattagtt ctaaaaggca tgaactcagc tcctaatcgt cactgtatag tcctgaattt
     2881 gtagaactag agttaattcc ctcttggaac tttctttgtt cttcagtagt tacttttttc
     2941 cttacctaaa agggttgtct gtcaaacaat tcttgaataa actttctgtt atcaatttta
//
