LOCUS       NM_006361               3039 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens homeobox B13 (HOXB13), mRNA.
ACCESSION   NM_006361
VERSION     NM_006361.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3039)
  AUTHORS   Kanayama,M., Chen,Y., Rabizadeh,D., Vera,L., Lu,C., Nielsen,S.M.,
            Russell,E.M., Esplin,E.D., Wang,H., Isaacs,W.B., Antonarakis,E.S.
            and Luo,J.
  TITLE     Clinical and Functional Analyses of an African-ancestry
            Gain-of-function HOXB13 Variant Implicated in Aggressive Prostate
            Cancer
  JOURNAL   Eur Urol Oncol 7 (4), 751-759 (2024)
   PUBMED   37806842
  REMARK    GeneRIF: Clinical and Functional Analyses of an African-ancestry
            Gain-of-function HOXB13 Variant Implicated in Aggressive Prostate
            Cancer.
REFERENCE   2  (bases 1 to 3039)
  AUTHORS   Jeong,E.A., Lee,M.H., Bae,A.N., Kim,J., Park,J.H. and Lee,J.H.
  TITLE     A Comprehensive Analysis of HOXB13 Expression in Hepatocellular
            Carcinoma
  JOURNAL   Medicina (Kaunas) 60 (5), 716 (2024)
   PUBMED   38792899
  REMARK    GeneRIF: A Comprehensive Analysis of HOXB13 Expression in
            Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3039)
  AUTHORS   Patel,R.A., Sayar,E., Coleman,I., Roudier,M.P., Hanratty,B.,
            Low,J.Y., Jaiswal,N., Ajkunic,A., Dumpit,R., Ercan,C., Salama,N.,
            O'Brien,V.P., Isaacs,W.B., Epstein,J.I., De Marzo,A.M., Trock,B.J.,
            Luo,J., Brennen,W.N., Tretiakova,M., Vakar-Lopez,F., True,L.D.,
            Goodrich,D.W., Corey,E., Morrissey,C., Nelson,P.S., Hurley,P.J.,
            Gulati,R. and Haffner,M.C.
  TITLE     Characterization of HOXB13 expression patterns in localized and
            metastatic castration-resistant prostate cancer
  JOURNAL   J Pathol 262 (1), 105-120 (2024)
   PUBMED   37850574
  REMARK    GeneRIF: Characterization of HOXB13 expression patterns in
            localized and metastatic castration-resistant prostate cancer.
REFERENCE   4  (bases 1 to 3039)
  AUTHORS   Chen,Y., Dufour,C.R., Han,L., Li,T., Xia,H. and Giguere,V.
  TITLE     Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its
            Activity and Oncogenic Function in Prostate Cancer
  JOURNAL   Mol Cancer Res 21 (10), 1050-1063 (2023)
   PUBMED   37409967
  REMARK    GeneRIF: Hierarchical Phosphorylation of HOXB13 by mTOR Dictates
            Its Activity and Oncogenic Function in Prostate Cancer.
REFERENCE   5  (bases 1 to 3039)
  AUTHORS   Soukup,J., Manethova,M., Stejskal,V., Hornychova,H., Cesak,T.,
            Netuka,D., Ryska,A. and Gabalec,F.
  TITLE     Immunoreactivity of HOXB13 in Neuroendocrine Neoplasms Is a
            Sensitive and Specific Marker of Rectal Well-Differentiated
            Neuroendocrine Tumors
  JOURNAL   Endocr Pathol 34 (3), 333-341 (2023)
   PUBMED   37552455
  REMARK    GeneRIF: Immunoreactivity of HOXB13 in Neuroendocrine Neoplasms Is
            a Sensitive and Specific Marker of Rectal Well-Differentiated
            Neuroendocrine Tumors.
REFERENCE   6  (bases 1 to 3039)
  AUTHORS   Komuves,L.G., Ma,X.K., Stelnicki,E., Rozenfeld,S., Oda,Y. and
            Largman,C.
  TITLE     HOXB13 homeodomain protein is cytoplasmic throughout fetal skin
            development
  JOURNAL   Dev Dyn 227 (2), 192-202 (2003)
   PUBMED   12761847
  REMARK    GeneRIF: Epidermal HOXB13 signal was detected over the entire body
            surface, but surprisingly, essentially all of the signal was
            cytoplasmic in developing skin.
REFERENCE   7  (bases 1 to 3039)
  AUTHORS   Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T.,
            Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N.
  TITLE     Complete mutation analysis panel of the 39 human HOX genes
  JOURNAL   Teratology 65 (2), 50-62 (2002)
   PUBMED   11857506
REFERENCE   8  (bases 1 to 3039)
  AUTHORS   Stelnicki,E.J., Arbeit,J., Cass,D.L., Saner,C., Harrison,M. and
            Largman,C.
  TITLE     Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless
            fetal wounds
  JOURNAL   J Invest Dermatol 111 (1), 57-63 (1998)
   PUBMED   9665387
REFERENCE   9  (bases 1 to 3039)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   10 (bases 1 to 3039)
  AUTHORS   Zeltser,L., Desplan,C. and Heintz,N.
  TITLE     Hoxb-13: a new Hox gene in a distant region of the HOXB cluster
            maintains colinearity
  JOURNAL   Development 122 (8), 2475-2484 (1996)
   PUBMED   8756292
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY937237.1 and BC070233.1.
            
            On Sep 27, 2019 this sequence version replaced NM_006361.5.
            
            Summary: This gene encodes a transcription factor that belongs to
            the homeobox gene family. Genes of this family are highly conserved
            among vertebrates and essential for vertebrate embryonic
            development. This gene has been implicated to play a role in fetal
            skin development and cutaneous regeneration. In mice, a similar
            gene was shown to exhibit temporal and spatial colinearity in the
            main body axis of the embryo, but was not expressed in the
            secondary axes, which suggests functions in body patterning along
            the axis. This gene and other HOXB genes form a gene cluster at
            chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY937237.1, SRR11853566.12014.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290295.8/ ENSP00000290295.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               AY937237.1         9-530
            523-1419            BC070233.1         457-1353
            1420-3039           AY937237.1         1428-3047
FEATURES             Location/Qualifiers
     source          1..3039
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3039
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /note="homeobox B13"
                     /db_xref="GeneID:10481"
                     /db_xref="HGNC:HGNC:5112"
                     /db_xref="MIM:604607"
     exon            1..758
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1012
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /codon_start=1
                     /product="homeobox protein Hox-B13"
                     /protein_id="NP_006352.2"
                     /db_xref="CCDS:CCDS11536.1"
                     /db_xref="GeneID:10481"
                     /db_xref="HGNC:HGNC:5112"
                     /db_xref="MIM:604607"
                     /translation="MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSPLTSHPAAPTLMP
                     AVNYAPLDLPGSAEPPKQCHPCPGVPQGTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQ
                     AATLAAYPAETPTAGEEYPSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRH
                     DSLLPVDSYQSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRK
                     KRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLA
                     KVKNSATP"
     exon            759..3039
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /note="hexamer: AATAAA"
     polyA_site      1404
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /note="major polyA site"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /note="hexamer: AATAAA"
     polyA_site      3039
                     /gene="HOXB13"
                     /gene_synonym="HPC9; PSGD"
                     /note="major polyA site"
ORIGIN      
        1 ctcttgcgtc aagacggccg tgctgagcga atgcaggcga cttgcgagct gggagcgatt
       61 taaaacgctt tggattcccc cggcctgggt ggggagagcg agctgggtgc cccctagatt
      121 ccccgccccc gcacctcatg agccgaccct cggctccatg gagcccggca attatgccac
      181 cttggatgga gccaaggata tcgaaggctt gctgggagcg ggaggggggc ggaatctggt
      241 cgcccactcc cctctgacca gccacccagc ggcgcctacg ctgatgcctg ctgtcaacta
      301 tgcccccttg gatctgccag gctcggcgga gccgccaaag caatgccacc catgccctgg
      361 ggtgccccag gggacgtccc cagctcccgt gccttatggt tactttggag gcgggtacta
      421 ctcctgccga gtgtcccgga gctcgctgaa accctgtgcc caggcagcca ccctggccgc
      481 gtaccccgcg gagactccca cggccgggga agagtacccc agccgcccca ctgagtttgc
      541 cttctatccg ggatatccgg gaacctacca gcctatggcc agttacctgg acgtgtctgt
      601 ggtgcagact ctgggtgctc ctggagaacc gcgacatgac tccctgttgc ctgtggacag
      661 ttaccagtct tgggctctcg ctggtggctg gaacagccag atgtgttgcc agggagaaca
      721 gaacccacca ggtccctttt ggaaggcagc atttgcagac tccagcgggc agcaccctcc
      781 tgacgcctgc gcctttcgtc gcggccgcaa gaaacgcatt ccgtacagca aggggcagtt
      841 gcgggagctg gagcgggagt atgcggctaa caagttcatc accaaggaca agaggcgcaa
      901 gatctcggca gccaccagcc tctcggagcg ccagattacc atctggtttc agaaccgccg
      961 ggtcaaagag aagaaggttc tcgccaaggt gaagaacagc gctacccctt aagagatctc
     1021 cttgcctggg tgggaggagc gaaagtgggg gtgtcctggg gagaccagga acctgccaag
     1081 cccaggctgg ggccaaggac tctgctgaga ggcccctaga gacaacaccc ttcccaggcc
     1141 actggctgct ggactgttcc tcaggagcgg cctgggtacc cagtatgtgc agggagacgg
     1201 aaccccatgt gacagcccac tccaccaggg ttcccaaaga acctggccca gtcataatca
     1261 ttcatcctga cagtggcaat aatcacgata accagtacta gctgccatga tcgttagcct
     1321 catattttct atctagagct ctgtagagca ctttagaaac cgctttcatg aattgagcta
     1381 attatgaata aatttggaag gcgatccctt tgcagggaag ctttctctca gacccccttc
     1441 cattacacct ctcaccctgg taacagcagg aagactgagg agaggggaac gggcagattc
     1501 gttgtgtggc tgtgatgtcc gtttagcatt tttctcagct gacagctggg taggtggaca
     1561 attgtagagg ctgtctcttc ctccctcctt gtccacccca tagggtgtac ccactggtct
     1621 tggaagcacc catccttaat acgatgattt ttctgtcgtg tgaaaatgaa gccagcaggc
     1681 tgcccctagt cagtccttcc ttccagagaa aaagagattt gagaaagtgc ctgggtaatt
     1741 caccattaat ttcctccccc aaactctctg agtcttccct taatatttct ggtggttctg
     1801 accaaagcag gtcatggttt gttgagcatt tgggatccca gtgaagtaga tgtttgtagc
     1861 cttgcatact tagcccttcc caggcacaaa cggagtggca gagtggtgcc aaccctgttt
     1921 tcccagtcca cgtagacaga ttcacagtgc ggaattctgg aagctggaga cagacgggct
     1981 ctttgcagag ccgggactct gagagggaca tgagggcctc tgcctctgtg ttcattctct
     2041 gatgtcctgt acctgggctc agtgcccggt gggactcatc tcctggccgc gcagcaaagc
     2101 cagcgggttc gtgctggtcc ttcctgcacc ttaggctggg ggtggggggc ctgccggcgc
     2161 attctccacg attgagcgca caggcctgaa gtctggacaa cccgcagaac cgaagctccg
     2221 agcagcgggt cggtggcgag tagtggggtc ggtggcgagc agttggtggt gggccgcggc
     2281 cgccactacc tcgaggacat ttccctcccg gagccagctc tcctagaaac cccgcggcgg
     2341 ccgccgcagc caagtgttta tggcccgcgg tcgggtggga tcctagccct gtctcctctc
     2401 ctgggaagga gtgagggtgg gacgtgactt agacacctac aaatctattt accaaagagg
     2461 agcccgggac tgagggaaaa ggccaaagag tgtgagtgca tgcggactgg gggttcaggg
     2521 gaagaggacg aggaggagga agatgaggtc gatttcctga tttaaaaaat cgtccaagcc
     2581 ccgtggtcca gcttaaggtc ctcggttaca tgcgccgctc agagcaggtc actttctgcc
     2641 ttccacgtcc tccttcaagg aagccccatg tgggtagctt tcaatatcgc aggttcttac
     2701 tcctctgcct ctataagctc aaacccacca acgatcgggc aagtaaaccc cctccctcgc
     2761 cgacttcgga actggcgaga gttcagcgca gatgggcctg tggggagggg gcaagataga
     2821 tgagggggag cggcatggtg cggggtgacc ccttggagag aggaaaaagg ccacaagagg
     2881 ggctgccacc gccactaacg gagatggccc tggtagagac ctttgggggt ctggaacctc
     2941 tggactcccc atgctctaac tcccacactc tgctatcaga aacttaaact tgaggatttt
     3001 ctctgttttt cactcgcaat aaattcagag caaacaaaa
//
