LOCUS       NM_152739               2064 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens homeobox A9 (HOXA9), mRNA.
ACCESSION   NM_152739
VERSION     NM_152739.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Hemida,A.S., Ahmed,M.M. and Tantawy,M.S.
  TITLE     HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma
            progression
  JOURNAL   Diagn Pathol 19 (1), 141 (2024)
   PUBMED   39462379
  REMARK    GeneRIF: HOXA9 and CD163 potentiate pancreatic ductal
            adenocarcinoma progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Shenoy,U.S., Basavarajappa,D.S., Kabekkodu,S.P. and
            Radhakrishnan,R.
  TITLE     Pan-cancer exploration of oncogenic and clinical impacts revealed
            that HOXA9 is a diagnostic indicator of tumorigenesis
  JOURNAL   Clin Exp Med 24 (1), 134 (2024)
   PUBMED   38904676
  REMARK    GeneRIF: Pan-cancer exploration of oncogenic and clinical impacts
            revealed that HOXA9 is a diagnostic indicator of tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Zhang,M., Hyle,J., Chen,X., Xin,Y., Jin,Y., Zhang,J., Yang,X.,
            Chen,X., Wright,S., Liu,Z., Rosikiewicz,W., Xu,B., He,L., Liu,H.,
            Ping,N., Wu,D., Wen,F., Li,C. and Xu,P.
  TITLE     RNA-binding protein RBM5 plays an essential role in acute myeloid
            leukemia by activating the oncogenic protein HOXA9
  JOURNAL   Genome Biol 25 (1), 16 (2024)
   PUBMED   38216972
  REMARK    GeneRIF: RNA-binding protein RBM5 plays an essential role in acute
            myeloid leukemia by activating the oncogenic protein HOXA9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Agrawal-Singh,S., Bagri,J., Giotopoulos,G., Azazi,D.M.A.,
            Horton,S.J., Lopez,C.K., Anand,S., Bach,A.S., Stedham,F.,
            Antrobus,R., Houghton,J.W., Vassiliou,G.S., Sasca,D., Yun,H.,
            Whetton,A.D. and Huntly,B.J.P.
  TITLE     HOXA9 forms a repressive complex with nuclear matrix-associated
            protein SAFB to maintain acute myeloid leukemia
  JOURNAL   Blood 141 (14), 1737-1754 (2023)
   PUBMED   36577137
  REMARK    GeneRIF: HOXA9 forms a repressive complex with nuclear
            matrix-associated protein SAFB to maintain acute myeloid leukemia.
REFERENCE   5  (bases 1 to 2064)
  AUTHORS   Talarmain,L., Clarke,M.A., Shorthouse,D., Cabrera-Cosme,L.,
            Kent,D.G., Fisher,J. and Hall,B.A.
  TITLE     HOXA9 has the hallmarks of a biological switch with implications in
            blood cancers
  JOURNAL   Nat Commun 13 (1), 5829 (2022)
   PUBMED   36192425
  REMARK    GeneRIF: HOXA9 has the hallmarks of a biological switch with
            implications in blood cancers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2064)
  AUTHORS   Borrow,J., Shearman,A.M., Stanton,V.P. Jr., Becher,R., Collins,T.,
            Williams,A.J., Dube,I., Katz,F., Kwong,Y.L., Morris,C.,
            Ohyashiki,K., Toyama,K., Rowley,J. and Housman,D.E.
  TITLE     The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses
            the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
  JOURNAL   Nat Genet 12 (2), 159-167 (1996)
   PUBMED   8563754
REFERENCE   7  (bases 1 to 2064)
  AUTHORS   Nakamura,T., Largaespada,D.A., Lee,M.P., Johnson,L.A.,
            Ohyashiki,K., Toyama,K., Chen,S.J., Willman,C.L., Chen,I.M.,
            Feinberg,A.P., Jenkins,N.A., Copeland,N.G. and Shaughnessy,J.D. Jr.
  TITLE     Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome
            translocation t(7;11)(p15;p15) in human myeloid leukaemia
  JOURNAL   Nat Genet 12 (2), 154-158 (1996)
   PUBMED   8563753
REFERENCE   8  (bases 1 to 2064)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (bases 1 to 2064)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   10 (bases 1 to 2064)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004080.2, BG258601.1,
            BC006537.2, CA442923.1 and AW612618.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152739.3.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            This gene is highly similar to the abdominal-B (Abd-B) gene of
            Drosophila. A specific translocation event which causes a fusion
            between this gene and the NUP98 gene has been associated with
            myeloid leukemogenesis. Read-through transcription exists between
            this gene and the upstream homeobox A10 (HOXA10) gene.[provided by
            RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006537.2, BQ422016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343483.7/ ENSP00000343619.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC004080.2         38901-38907         c
            8-27                BG258601.1         1-20
            28-981              BC006537.2         1-954
            982-1596            CA442923.1         19-633              c
            1597-2056           AW612618.1         8-467               c
            2057-2064           BC006537.2         2030-2037
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2064
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /note="homeobox A9"
                     /db_xref="GeneID:3205"
                     /db_xref="HGNC:HGNC:5109"
                     /db_xref="MIM:142956"
     exon            1..660
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..899
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /note="homeodomain protein HOXA9; homeobox protein Hox-1G"
                     /codon_start=1
                     /product="homeobox protein Hox-A9"
                     /protein_id="NP_689952.1"
                     /db_xref="CCDS:CCDS5409.1"
                     /db_xref="GeneID:3205"
                     /db_xref="HGNC:HGNC:5109"
                     /db_xref="MIM:142956"
                     /translation="MATTGALGNYYVDSFLLGADAADELSVGRYAPGTLGQPPRQAAT
                     LAEHPDFSPCSFQSKATVFGASWNPVHAAGANAVPAAVYHHHHHHPYVHPQAPVAAAA
                     PDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACG
                     SPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQT
                     LELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE"
     exon            661..2064
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /note="major polyA site"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="HOXA9"
                     /gene_synonym="ABD-B; HOX1; HOX1.7; HOX1G"
                     /note="major polyA site"
ORIGIN      
        1 gccaccaagt tgttacatga aatctgcagt ttcataattt ccgtgggtcg ggccgggcgg
       61 gccaggcgct gggcacggtg atggccacca ctggggccct gggcaactac tacgtggact
      121 cgttcctgct gggcgccgac gccgcggatg agctgagcgt tggccgctat gcgccgggga
      181 ccctgggcca gcctccccgg caggcggcga cgctggccga gcaccccgac ttcagcccgt
      241 gcagcttcca gtccaaggcg acggtgtttg gcgcctcgtg gaacccagtg cacgcggcgg
      301 gcgccaacgc tgtacccgct gcggtgtacc accaccatca ccaccacccc tacgtgcacc
      361 cccaggcgcc cgtggcggcg gcggcgccgg acggcaggta catgcgctcc tggctggagc
      421 ccacgcccgg tgcgctctcc ttcgcgggct tgccctccag ccggccttat ggcattaaac
      481 ctgaaccgct gtcggccaga aggggtgact gtcccacgct tgacactcac actttgtccc
      541 tgactgacta tgcttgtggt tctcctccag ttgatagaga aaaacaaccc agcgaaggcg
      601 ccttctctga aaacaatgct gagaatgaga gcggcggaga caagcccccc atcgatccca
      661 ataacccagc agccaactgg cttcatgcgc gctccactcg gaaaaagcgg tgcccctata
      721 caaaacacca gaccctggaa ctggagaaag agtttctgtt caacatgtac ctcaccaggg
      781 accgcaggta cgaggtggct cgactgctca acctcaccga gaggcaggtc aagatctggt
      841 tccagaaccg caggatgaaa atgaagaaaa tcaacaaaga ccgagcaaaa gacgagtgat
      901 gccatttggg cttatttaga aaaaagggta agctagagag aaaaagaaag aactgtccgt
      961 cccccttccg ccttctccct tctctcaccc ccaccctagc ctccaccatc cccgcacaaa
     1021 gcggctctaa acctcaggcc acatcttttc caaggcaaac cctgttcagg ctggctcgta
     1081 ggcctgccgc tttgatggag gaggtattgt aagctttcca ttttctataa gaaaaaggaa
     1141 aagttgaggg gggggcatta gtgctgatag ctgtgtgtgt tagcttgtat atatattttt
     1201 aaaaatctac ctgttcctga cttaaaacaa aaggaaagaa actacctttt tataatgcac
     1261 aactgttgat ggtaggctgt atagttttta gtctgtgtag ttaatttaat ttgcagtttg
     1321 tgcggcagat tgctctgcca agatacttga acactgtgtt ttattgtggt aattatgttt
     1381 tgtgattcaa acttctgtgt actgggtgat gcacccattg tgattgtgga agatagaatt
     1441 caatttgaac tcaggttgtt tatgagggga aaaaaacagt tgcatagagt atagctctgt
     1501 agtggaatat gtcttctgta taactaggct gttaacctat gattgtaaag tagctgtaag
     1561 aatttcccag tgaaataaaa aaaaatttta agtgttctcg gggatgcata gattcatcat
     1621 tttctccacc ttaaaaatgc gggcatttaa gtctgtccat tatctatata gtcctgtctt
     1681 gtctattgta tatataatct atatgattaa agaaaatatg cataatcaga caagcttgaa
     1741 tattgttttt gcaccagacg aacagtgagg aaattcggag ctatacatat gtgcagaagg
     1801 ttactaccta gggtttatgc ttaattttaa ttggaggaaa tgaatgctga ttgtaacgga
     1861 gttaatttta ttgataataa attatacact atgaaaccgc cattgggcta ctgtagattt
     1921 gtatccttga tgaatctggg gtttccatca gactgaactt acactgtata ttttgcaata
     1981 gttacctcaa ggcctactga ccaaattgtt gtgttgagat gatatttaac tttttgccaa
     2041 ataaaatata ttgattcttt tcta
//
