LOCUS       NM_006896               2016 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens homeobox A7 (HOXA7), mRNA.
ACCESSION   NM_006896
VERSION     NM_006896.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Li,J., Han,J., Zhao,A. and Zhang,G.
  TITLE     CircPAPPA Regulates the Proliferation, Migration, Invasion,
            Apoptosis, and Cell Cycle of Trophoblast Cells Through the
            miR-3127-5p/HOXA7 Axis
  JOURNAL   Reprod Sci 29 (4), 1215-1225 (2022)
   PUBMED   34978042
  REMARK    GeneRIF: CircPAPPA Regulates the Proliferation, Migration,
            Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through
            the miR-3127-5p/HOXA7 Axis.
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Wang,S., Diao,Y.J. and Zhu,B.B.
  TITLE     MiR-193a-5p suppresses cell proliferation and induces cell
            apoptosis by regulating HOXA7 in human ovarian cancer
  JOURNAL   Neoplasma 67 (4), 825-833 (2020)
   PUBMED   32305054
  REMARK    GeneRIF: MiR-193a-5p suppresses cell proliferation and induces cell
            apoptosis by regulating HOXA7 in human ovarian cancer.
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Xu,P., Zhou,D., Yan,G., Ouyang,J. and Chen,B.
  TITLE     Correlation of miR-181a and three HOXA genes as useful biomarkers
            in acute myeloid leukemia
  JOURNAL   Int J Lab Hematol 42 (1), 16-22 (2020)
   PUBMED   31670914
  REMARK    GeneRIF: Correlation of miR-181a and three HOXA genes as useful
            biomarkers in acute myeloid leukemia.
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Cao,X.Y., Sun,Z.Y., Zhang,L.J., Chen,M.K. and Yuan,B.
  TITLE     microRNA-144-3p suppresses human neuroblastoma cell proliferation
            by targeting HOXA7
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (2), 716-723 (2019)
   PUBMED   30720179
  REMARK    GeneRIF: Study found the miR-144-3p expression was reduced in
            neuroblastoma (NB) tissues and cell lines and resulted in the
            stimulation of cell proliferation, cell cycle progression, and cell
            migration in vitro. Homeobox protein A7 (HOXA7) was validated as a
            direct target of miR-144-3p. Results demonstrated the tumor
            suppressive role of miR-144-3p in NB.
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Balling,R., Mutter,G., Gruss,P. and Kessel,M.
  TITLE     Craniofacial abnormalities induced by ectopic expression of the
            homeobox gene Hox-1.1 in transgenic mice
  JOURNAL   Cell 58 (2), 337-347 (1989)
   PUBMED   2568891
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004080.2 and AF026397.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006896.3.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            For example, the encoded protein represses the transcription of
            differentiation-specific genes during keratinocyte proliferation,
            but this repression is then overcome by differentiation signals.
            This gene is highly similar to the antennapedia (Antp) gene of
            Drosophila. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1100454.1,
                                           SRR1803614.291174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242159.5/ ENSP00000242159.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AC004080.2         29816-30045         c
            231-951             AF026397.1         233-953
            952-2016            AC004080.2         27086-28150         c
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2016
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="homeobox A7"
                     /db_xref="GeneID:3204"
                     /db_xref="HGNC:HGNC:5108"
                     /db_xref="MIM:142950"
     exon            1..509
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..823
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="homeo box A7; homeobox protein HOX-1A; homeobox
                     protein Hox 1.1"
                     /codon_start=1
                     /product="homeobox protein Hox-A7"
                     /protein_id="NP_008827.2"
                     /db_xref="CCDS:CCDS5408.1"
                     /db_xref="GeneID:3204"
                     /db_xref="HGNC:HGNC:5108"
                     /db_xref="MIM:142950"
                     /translation="MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGA
                     GAFASTVPGLYNVNSPLYQSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACD
                     KTDEGALHGAAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRR
                     IEIAHALCLTERQIKIWFQNRRMKWKKEHKDEGPTAAAAPEGAVPSAAATAAADKADE
                     EDDDEEEEDEEE"
     exon            510..2016
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1989..1994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="major polyA site"
ORIGIN      
        1 gctgcggcga gctccgtcca aaagaaaatg gggtttggtg taaatctggg ggtgtaatgt
       61 tatcatatat cactctacct cgtaaaaccg acactgaaag ctgccggaca acaaatcaca
      121 ggtcaaaatt atgagttctt cgtattatgt gaacgcgctt tttagcaaat atacggcggg
      181 ggcttctctg ttccaaaatg ccgagccgac ttcttgctcc tttgctccca actcacagag
      241 aagcggctac ggggcgggcg ccggcgcctt cgcctcgacc gttccgggct tatacaatgt
      301 caacagcccc ctttatcaga gcccctttgc gtccggctac ggcctgggcg ccgacgccta
      361 cggcaacctg ccctgcgcct cctacgacca aaacatcccc gggctctgca gtgacctcgc
      421 caaaggcgcc tgcgacaaga cggacgaggg cgcgctgcat ggcgcggctg aggccaattt
      481 ccgcatctac ccctggatgc ggtcttcagg acctgacagg aagcggggcc gccagaccta
      541 cacgcgctac cagacgctgg agctggagaa ggagttccac ttcaaccgct acctgacgcg
      601 gcgccgccgc attgaaatcg cccacgcgct ctgcctcacc gagcgccaga ttaagatctg
      661 gttccagaac cgccgcatga agtggaagaa agagcataag gacgaaggtc cgactgccgc
      721 cgcagctccc gagggcgccg tgccctctgc cgccgccact gctgccgcgg acaaggccga
      781 cgaggaggac gatgatgaag aagaggaaga cgaggaggaa tgaggggccg atccggggcc
      841 ctctctgcac cggacagtcg gaaaagcgtc tttaagagac tcactggttt tacttacaaa
      901 aatgggaaaa ataaaagaaa atgtaaaaaa caaaaacaaa aacaaaaaag caacccagtc
      961 cccaacctgc actctaccca cccccatcac ctactccagc tcccaacttt tgtggactga
     1021 gcggccgcag agactgggtc gccttggatt ccctctgcct ccgaggaccc caaaagacac
     1081 ccccaacccc aggccagccg gccctgctct ggcgcgtcca aaatactacc tagcacaggc
     1141 ctctgctcga ggcaccccca aactacctat gtatccagcc ccagagggcc tccattccca
     1201 ggaagtccct atgtatccca acactggcag acacccagca ccaccctccc agacccgcaa
     1261 gaaagtgaat ctcactacta cctactcccc taaaactacc tattttgtgc tggctggctt
     1321 gcctgctacc tagtgccgac tgctcccagg caagtcccct gctgcttaca gcccgcagct
     1381 tttggggtcc ctgaggctgc cctgagaatg tgctgaggtc caggatcagg gtattggcat
     1441 ctatttaaat cgaaaaataa tatatttatt ccaaaaagca tcctaagtgc ttgcacccta
     1501 gaatcaatcc ctccttctct ggcttggcac ccacagctca ggcccatcaa cccccacttc
     1561 tggaggggaa tgttcctgag ctggctgcag atctgtgggt tagcttctgc ttagcaggac
     1621 tgtggagatg cttccagctt cgctgtcctt tcctctggct cctgtatctt actgttcagc
     1681 tgtgttaaat atgtacgccc tgatgtttcc tataatagca gatactgtat atttgaacaa
     1741 gatttttttt tatcatttct atagtcttgg agttcatttg taaggcagtg tcttgacttg
     1801 gaaaggatgt gttaatgggg tgactttgta gcatggtatg ttgtcttgag ttaactgtag
     1861 tgggtgggga ggtccaatgc cctccgcaat gcccttcatc tcctgtgttg tcctgtaccc
     1921 tgctcagctc catcctgggg ttcagggaag gcacacttcc cagcccagct gtgttttatg
     1981 taaccgaaaa taaagatgcg tggtgacaaa gaaaaa
//
