LOCUS       NM_024014                989 bp    mRNA    linear   PRI 23-JUN-2024
DEFINITION  Homo sapiens homeobox A6 (HOXA6), mRNA.
ACCESSION   NM_024014
VERSION     NM_024014.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 989)
  AUTHORS   Xiulin,J., Wang,C., Guo,J., Wang,C., Pan,C. and Nie,Z.
  TITLE     Next-generation sequencing identifies HOXA6 as a novel oncogenic
            gene in low grade glioma
  JOURNAL   Aging (Albany NY) 14 (6), 2819-2854 (2022)
   PUBMED   35349479
  REMARK    GeneRIF: Next-generation sequencing identifies HOXA6 as a novel
            oncogenic gene in low grade glioma.
REFERENCE   2  (bases 1 to 989)
  AUTHORS   Lin,J., Zhu,H., Hong,L., Tang,W., Wang,J., Hu,H., Wu,X., Chen,Y.,
            Liu,G., Yang,Q., Li,J., Wang,Y., Lin,Z., Xiao,Y., Dai,W., Huang,M.,
            Li,G., Li,A., Wang,J., Xiang,L. and Liu,S.
  TITLE     Coexpression of HOXA6 and PBX2 promotes metastasis in gastric
            cancer
  JOURNAL   Aging (Albany NY) 13 (5), 6606-6624 (2021)
   PUBMED   33535170
  REMARK    GeneRIF: Coexpression of HOXA6 and PBX2 promotes metastasis in
            gastric cancer.
REFERENCE   3  (bases 1 to 989)
  AUTHORS   Wu,F., Wu,S., Tong,H., He,W. and Gou,X.
  TITLE     HOXA6 inhibits cell proliferation and induces apoptosis by
            suppressing the PI3K/Akt signaling pathway in clear cell renal cell
            carcinoma
  JOURNAL   Int J Oncol 54 (6), 2095-2105 (2019)
   PUBMED   31081053
  REMARK    GeneRIF: Study revealed that the mRNA and protein expression levels
            of HOXA6 were suppressed in clear cell renal cell carcinoma (ccRCC)
            tissues. Its overexpression suppresses cell proliferation and
            promotes apoptosis, which may occur via inhibition of the
            PI3K/Akt/ERK cascade.
REFERENCE   4  (bases 1 to 989)
  AUTHORS   Wu,S., Wu,F. and Jiang,Z.
  TITLE     Effect of HOXA6 on the proliferation, apoptosis, migration and
            invasion of colorectal cancer cells
  JOURNAL   Int J Oncol 52 (6), 2093-2100 (2018)
   PUBMED   29620285
  REMARK    GeneRIF: Results demonstrated thatHOXA6 is up-regulated in
            colorectal cancer (CRC) and promoted cell proliferation, migration
            and invasion, but inhibited apoptosis, whereas the downregulated
            expression of HOXA6 produced the opposite effects. HOXA6 regulated
            apoptosis through the Bcl-2 signaling pathway, and regulated
            migration and invasion through the EMT process.
REFERENCE   5  (bases 1 to 989)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 989)
  AUTHORS   Walters,J.R., Howard,A., Rumble,H.E., Prathalingam,S.R.,
            Shaw-Smith,C.J. and Legon,S.
  TITLE     Differences in expression of homeobox transcription factors in
            proximal and distal human small intestine
  JOURNAL   Gastroenterology 113 (2), 472-477 (1997)
   PUBMED   9247466
REFERENCE   7  (bases 1 to 989)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   8  (bases 1 to 989)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (bases 1 to 989)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   10 (bases 1 to 989)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC104915.1 and AC004080.2.
            
            On May 17, 2019 this sequence version replaced NM_024014.3.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104915.1, EL736261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222728.3/ ENSP00000222728.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-802               BC104915.1         1-802
            803-989             AC004080.2         18766-18952         c
FEATURES             Location/Qualifiers
     source          1..989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..989
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /note="homeobox A6"
                     /db_xref="GeneID:3203"
                     /db_xref="HGNC:HGNC:5107"
                     /db_xref="MIM:142951"
     exon            1..467
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..727
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /note="homeo box A6; homeo box 1B; homeobox protein HOXA6;
                     homeobox protein Hox-1B"
                     /codon_start=1
                     /product="homeobox protein Hox-A6"
                     /protein_id="NP_076919.1"
                     /db_xref="CCDS:CCDS5407.1"
                     /db_xref="GeneID:3203"
                     /db_xref="HGNC:HGNC:5107"
                     /db_xref="MIM:142951"
                     /translation="MSSYFVNPTFPGSLPSGQDSFLGQLPLYQAGYDALRPFPASYGA
                     SSLPDKTYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGSGKQRGPGDY
                     LHFSPEQQYKPDSSSGQGKALHDEGADRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQ
                     TYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLIN
                     STQPSGEDSEAKAGE"
     exon            468..989
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagtcctg cagaggggcg cgcaaatgag ttcctatttt gtgaatccca ctttccccgg
       61 gagccttccc agcggccagg actccttctt gggccagctg cccctctacc aggctggcta
      121 tgacgcgctg aggcccttcc cggcctcgta cggggcgtcg agtctcccgg acaagacgta
      181 cacctcacct tgtttctacc aacagtccaa ctcggtcctg gcctgcaacc gggcgtccta
      241 cgagtacggg gcctcgtgtt tctattctga taaggacctc agtggcgcct cgccctcggg
      301 cagtggcaag cagaggggcc ccggggacta cctgcacttt tctcccgagc agcagtacaa
      361 acccgacagc agcagcgggc agggcaaagc actccatgac gaaggcgccg accggaagta
      421 cacgagcccg gtttaccctt ggatgcagcg gatgaactcc tgcgcgggtg ctgtgtatgg
      481 gagccatggg cgccgaggcc gccagaccta cacgcgctac cagacactgg agctggagaa
      541 ggagttccac ttcaaccgct acctgacacg gcgccgccgc atcgagatcg ccaacgcgct
      601 ctgcctcacc gagcgccaga tcaagatctg gttccagaac cgccgcatga agtggaaaaa
      661 ggaaaacaag ctcatcaatt ccacgcagcc cagcggggag gactcagagg caaaggcggg
      721 cgagtagatg cctgggcagg gaccaggcca gcgctgcaac ctccttcggc tttgccccct
      781 tgccctcgcc tgttccccaa cttttctccc cgcctgctcc catctggggg cttccgcagc
      841 ttcaggggag cccggagctt tgcaagcgtc tgtgcattta tttcttacaa aacaaaacaa
      901 aacaaaacaa aacaaaacaa aacaaaacaa aacaaaacct cacacacagc caataccagc
      961 ggtggagcgg ggcgcactgc acacaccca
//
