LOCUS       NM_019102               1670 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens homeobox A5 (HOXA5), mRNA.
ACCESSION   NM_019102
VERSION     NM_019102.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Xiao,X., Wang,W., Guo,C., Wu,J., Zhang,S., Shi,H., Kwon,S., Chen,J.
            and Dong,Z.
  TITLE     Hypermethylation leads to the loss of HOXA5, resulting in JAG1
            expression and NOTCH signaling contributing to kidney fibrosis
  JOURNAL   Kidney Int 106 (1), 98-114 (2024)
   PUBMED   38521405
  REMARK    GeneRIF: Hypermethylation leads to the loss of HOXA5, resulting in
            JAG1 expression and NOTCH signaling contributing to kidney
            fibrosis.
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Parrillo,L., Spinelli,R., Longo,M., Zatterale,F., Santamaria,G.,
            Leone,A., Campitelli,M., Raciti,G.A. and Beguinot,F.
  TITLE     The Transcription Factor HOXA5: Novel Insights into Metabolic
            Diseases and Adipose Tissue Dysfunction
  JOURNAL   Cells 12 (16), 2090 (2023)
   PUBMED   37626900
  REMARK    GeneRIF: The Transcription Factor HOXA5: Novel Insights into
            Metabolic Diseases and Adipose Tissue Dysfunction.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Moorthy,R.K., Srinivasan,C., Kannan,M. and Arockiam,A.J.V.
  TITLE     Deregulation of miR-375 Inhibits HOXA5 and Promotes Migration,
            Invasion, and Cell Proliferation in Breast Cancer
  JOURNAL   Appl Biochem Biotechnol 195 (7), 4503-4523 (2023)
   PUBMED   36701095
  REMARK    GeneRIF: Deregulation of miR-375 Inhibits HOXA5 and Promotes
            Migration, Invasion, and Cell Proliferation in Breast Cancer.
REFERENCE   4  (bases 1 to 1670)
  AUTHORS   Jin,W.Y., Zhang,Y., Tian,J., Xu,L.K., Lin,H.J., Yang,Y.Z.,
            Zhang,X.M., Jin,M.H., Mo,W.F., Qi,G.Y. and Zhou,Y.Q.
  TITLE     HOXA5 inhibits the proliferation and metastasis of cervical
            squamous cell carcinoma by suppressing the beta-catenin/Snail
            signaling
  JOURNAL   Neoplasma 70 (1), 82-93 (2023)
   PUBMED   36660797
  REMARK    GeneRIF: HOXA5 inhibits the proliferation and metastasis of
            cervical squamous cell carcinoma by suppressing the
            beta-catenin/Snail signaling.
REFERENCE   5  (bases 1 to 1670)
  AUTHORS   Liang,Y., Cen,J., Huang,Y., Fang,Y., Wang,Y., Shu,G., Pan,Y.,
            Huang,K., Dong,J., Zhou,M., Xu,Y., Luo,J., Liu,M. and Zhang,J.
  TITLE     CircNTNG1 inhibits renal cell carcinoma progression via
            HOXA5-mediated epigenetic silencing of Slug
  JOURNAL   Mol Cancer 21 (1), 224 (2022)
   PUBMED   36536414
  REMARK    GeneRIF: CircNTNG1 inhibits renal cell carcinoma progression via
            HOXA5-mediated epigenetic silencing of Slug.
            Erratum:[Mol Cancer. 2023 Jan 20;22(1):14. doi:
            10.1186/s12943-023-01726-w.. PMID: 36670419]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1670)
  AUTHORS   Miano,J.M., Firulli,A.B., Olson,E.N., Hara,P., Giachelli,C.M. and
            Schwartz,S.M.
  TITLE     Restricted expression of homeobox genes distinguishes fetal from
            adult human smooth muscle cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 900-905 (1996)
   PUBMED   8570656
REFERENCE   7  (bases 1 to 1670)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   8  (bases 1 to 1670)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   9  (bases 1 to 1670)
  AUTHORS   Tournier-Lasserve,E., Odenwald,W.F., Garbern,J., Trojanowski,J. and
            Lazzarini,R.A.
  TITLE     Remarkable intron and exon sequence conservation in human and mouse
            homeobox Hox 1.3 genes
  JOURNAL   Mol Cell Biol 9 (5), 2273-2278 (1989)
   PUBMED   2568583
REFERENCE   10 (bases 1 to 1670)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004080.2, BI822268.1 and
            BC013682.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019102.3.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            Methylation of this gene may result in the loss of its expression
            and, since the encoded protein upregulates the tumor suppressor
            p53, this protein may play an important role in tumorigenesis.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013682.1, ERR279833.10864.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267755, SAMN03267761
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222726.4/ ENSP00000222726.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC004080.2         17039-17051         c
            14-26               BI822268.1         1-13
            27-1178             BC013682.1         1-1152
            1179-1670           AC004080.2         14422-14913         c
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..1670
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="homeobox A5"
                     /db_xref="GeneID:3202"
                     /db_xref="HGNC:HGNC:5106"
                     /db_xref="MIM:142952"
     exon            1..636
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..887
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="homeo box A5; homeo box 1C; homeobox protein HOXA5;
                     homeobox protein Hox-1C"
                     /codon_start=1
                     /product="homeobox protein Hox-A5"
                     /protein_id="NP_061975.2"
                     /db_xref="CCDS:CCDS5406.1"
                     /db_xref="GeneID:3202"
                     /db_xref="HGNC:HGNC:5106"
                     /db_xref="MIM:142952"
                     /translation="MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGR
                     YGYGYNGMDLSVGRSGSGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLP
                     CSAVAPSPGSDSHHGGKNSLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQA
                     SAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNR
                     YLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP"
     exon            637..1670
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="hexamer: AATAAA"
     polyA_site      1670
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="major polyA site"
ORIGIN      
        1 ataaattgtg caagggtgct atagacgcac aaacgaccgc gagccacaaa tcaagcacac
       61 atatcaaaaa acaaatgagc tcttattttg taaactcatt ttgcggtcgc tatccaaatg
      121 gcccggacta ccagttgcat aattatggag atcatagttc cgtgagcgag caattcaggg
      181 actcggcgag catgcactcc ggcaggtacg gctacggcta caatggcatg gatctcagcg
      241 tcggccgctc gggctccggc cactttggct ccggagagcg cgcccgcagc tacgctgcca
      301 gcgccagcgc ggcgcccgcc gagcccaggt acagccagcc ggccacgtcc acgcactctc
      361 ctcagcccga tccgctgccc tgctccgccg tggccccctc gcccggcagc gacagccacc
      421 acggcgggaa aaactcccta agcaactcca gcggcgcctc ggccgacgcc ggcagcaccc
      481 acatcagcag cagagagggg gttggcacgg cgtccggagc cgaggaggac gcccctgcca
      541 gcagcgagca ggcgagtgcg cagagcgagc cgagcccggc gccgcccgcc caaccccaga
      601 tctacccctg gatgcgcaag ctgcacataa gtcatgacaa cataggcggc ccggaaggca
      661 aaagggcccg gacggcctac acgcgctacc agaccctgga gctggagaag gagttccact
      721 tcaaccgtta cctgacccgc agaaggagga ttgaaatagc acatgctctt tgcctctccg
      781 agagacaaat taaaatctgg ttccaaaacc ggagaatgaa gtggaaaaaa gataataagc
      841 tgaaaagcat gagcatggcc gcggcaggag gggccttccg tccctgagta tctgagcgtt
      901 taaagtactg agcagtatta gcggatcccg cgtagtgtca gtactaaggt gactttctga
      961 aactcccttg tgttccttct gtgaagaagc cctgttctcg ttgccctaat tcatctttta
     1021 atcatgagcc tgtttattgc cattatagcg cctgtataag tagatctgct ttctgttcat
     1081 ctctttgtcc tgaatggctt tgtcttgaaa aaaaatagat gttttaactt atttatatga
     1141 agcaagctgt gttacttgaa gtaactataa caaaaaaaga aaagagaaaa aaaaacacac
     1201 aaaaagtccc ccttcaatct cgtttagtgc caatgttgtg tgttgcactc aagttgttta
     1261 actgtgcatg tgcgtggaag tgttcctgtc tcaatagctc caagctgtta aagatatttt
     1321 tattcaaact acctatattc cttgtgtaat taatgctgtt gtagaggtga cttgatgaga
     1381 cacaacttgt tcgacgtgta gtgactagtg actctgtgat gaaaactgtg actccaagcg
     1441 gtgtgtccct gcgtgccttt ataggaccct ttgcacgaac tctggaagtg gctcttataa
     1501 gcgcagcttc agtgatgtat gtttttgtga acaaagttac aaatattgtc caagtctggc
     1561 tgttttaagc aaactgtgat cagctttttt tttttttttt ttttttttgt atttgttttt
     1621 aaggaaaaaa tactgactgg aacaaaaaat aaactttcta ttgtaagttc
//
