LOCUS       NM_006735               1686 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens homeobox A2 (HOXA2), mRNA.
ACCESSION   NM_006735
VERSION     NM_006735.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Song,Y.P., Xian,P., Luo,H., Dai,J.Y., Bai,Y., Li,Y. and Tang,X.L.
  TITLE     Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential
            Biomarkers for Predicting Progression and Prognosis in Prostate
            Cancer
  JOURNAL   J Immunol Res 2022, 5740971 (2022)
   PUBMED   35372588
  REMARK    GeneRIF: Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as
            Potential Biomarkers for Predicting Progression and Prognosis in
            Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Chen,Z., Zheng,J., Hong,H., Chen,D., Deng,L., Zhang,X., Ling,J. and
            Wu,L.
  TITLE     lncRNA HOTAIRM1 promotes osteogenesis of hDFSCs by epigenetically
            regulating HOXA2 via DNMT1 in vitro
  JOURNAL   J Cell Physiol 235 (11), 8507-8519 (2020)
   PUBMED   32324272
  REMARK    GeneRIF: lncRNA HOTAIRM1 promotes osteogenesis of hDFSCs by
            epigenetically regulating HOXA2 via DNMT1 in vitro.
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Si,N., Meng,X., Lu,X., Zhao,X., Li,C., Yang,M., Zhang,Y., Wang,C.,
            Guo,P., Zhang,X., Pan,B. and Jiang,H.
  TITLE     Identification of loss-of-function HOXA2 mutations in Chinese
            families with dominant bilateral microtia
  JOURNAL   Gene 757, 144945 (2020)
   PUBMED   32649979
  REMARK    GeneRIF: Identification of loss-of-function HOXA2 mutations in
            Chinese families with dominant bilateral microtia.
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Liu,Z., Shen,F., Wang,H., Li,A., Wang,J., Du,L., Liu,B., Zhang,B.,
            Lian,X., Pang,B., Liu,L. and Gao,Y.
  TITLE     Abnormally high expression of HOXA2 as an independent factor for
            poor prognosis in glioma patients
  JOURNAL   Cell Cycle 19 (13), 1632-1640 (2020)
   PUBMED   32436804
  REMARK    GeneRIF: Abnormally high expression of HOXA2 as an independent
            factor for poor prognosis in glioma patients.
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Deneyer,N., Bridoux,L., Bombled,C., Pringels,T., Bergiers,I., Pyr
            Dit Ruys,S., Vertommen,D., Twizere,J.C. and Rezsohazy,R.
  TITLE     HOXA2 activity regulation by cytoplasmic relocation, protein
            stabilization and post-translational modification
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1862 (9), 194404 (2019)
   PUBMED   31323436
  REMARK    GeneRIF: our experiments support that PPP1CB and KPC2 together
            inhibit the activity of HOXA2 by activating its nuclear export, but
            favored HOXA2 de-ubiquitination and stabilization thereby
            establishing a store of HOXA2 in the cytoplasm.
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Alasti,F., Sadeghi,A., Sanati,M.H., Farhadi,M., Stollar,E.,
            Somers,T. and Van Camp,G.
  TITLE     A mutation in HOXA2 is responsible for autosomal-recessive microtia
            in an Iranian family
  JOURNAL   Am J Hum Genet 82 (4), 982-991 (2008)
   PUBMED   18394579
  REMARK    GeneRIF: A missense mutation in the HOXA2 in a consanguineous
            iranian family with bilateral microtia was reported.
            Erratum:[Am J Hum Genet. 2008 Sep;83(3):424]
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T.,
            Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N.
  TITLE     Complete mutation analysis panel of the 39 human HOX genes
  JOURNAL   Teratology 65 (2), 50-62 (2002)
   PUBMED   11857506
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF509655.1, AW292406.1,
            BE465040.1, AI581335.1 and AI796505.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006735.3.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            The encoded protein may be involved in the placement of hindbrain
            segments in the proper location along the anterior-posterior axis
            during development. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130571.1, CN431833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222718.7/ ENSP00000222718.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               BF509655.1         1-398               c
            399-517             AW292406.1         7-125
            518-999             BE465040.1         75-556
            1000-1347           AI581335.1         1-348               c
            1348-1686           AI796505.1         14-352              c
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..1686
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /note="homeobox A2"
                     /db_xref="GeneID:3199"
                     /db_xref="HGNC:HGNC:5103"
                     /db_xref="MIM:604685"
     exon            1..574
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1314
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /note="homeobox protein Hox-1K"
                     /codon_start=1
                     /product="homeobox protein Hox-A2"
                     /protein_id="NP_006726.1"
                     /db_xref="CCDS:CCDS5403.1"
                     /db_xref="GeneID:3199"
                     /db_xref="HGNC:HGNC:5103"
                     /db_xref="MIM:604685"
                     /translation="MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSH
                     STLIPPPFEQTIPSLNPGSHPRHGAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKK
                     AAKKTALLPAAAAAATAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEK
                     EFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLE
                     DSEKVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSP
                     LTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEALEVPSLQDFSVFSTDSCL
                     QLSDAVSPSLPGSLDSPVDISADSLDFFTDTLTTIDLQHLNY"
     exon            575..1686
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /note="hexamer: AACAAA"
     polyA_site      1351
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /note="major polyA site"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="HOXA2"
                     /gene_synonym="HOX1K; MCOHI"
                     /note="major polyA site"
ORIGIN      
        1 agtttaatag tagcgcggtc cccatacggc tgtaatcagt gaattagaaa aaaaacaccc
       61 tagcagcgat attctatgat agattttttt tcctctgcgc tcgccttttt cctaggcctt
      121 gcccccccaa agcccctcca aaagagggaa ctttttctct gagggggctc caaggagaag
      181 gccatgaatt acgaatttga gcgagagatt ggttttatca atagccagcc gtcgctcgct
      241 gagtgcctga catcttttcc ccctgtcgct gatacatttc aaagttcatc aatcaagacc
      301 tcgacgcttt cacactcgac actgattcct cctccttttg agcagaccat tcccagcctg
      361 aaccccggca gtcaccctcg ccacggcgct ggcggccgcc ccaagccgag ccccgcgggc
      421 agccgcggca gcccggtgcc cgccggcgcc ctgcagccgc ccgagtaccc ctggatgaag
      481 gagaagaagg cggccaagaa aaccgcactt ctgccggccg ccgccgccgc cgccaccgcc
      541 gcagccaccg gccctgcttg cctcagccac aaagaatccc tggaaatcgc cgatggcagc
      601 ggcgggggat cgcggcgcct gagaactgct tacaccaaca cacagcttct agagctggaa
      661 aaagaatttc atttcaacaa gtacctttgc agaccccgaa gggtggagat tgcagcgctg
      721 ctggatttga ctgagagaca agtgaaagtg tggtttcaga accggaggat gaagcacaag
      781 aggcagaccc agtgcaagga aaaccaaaac agcgaaggga aatgtaaaag ccttgaggac
      841 tccgagaaag tagaggagga cgaggaagag aagacgctct ttgagcaagc ccttagcgtc
      901 tctggggccc ttctggagag ggaaggctac acttttcagc aaaatgccct ctctcagcag
      961 caggctccca atggacacaa tggcgactcc caaagtttcc cagtctcgcc tttaaccagc
     1021 aatgagaaaa atctgaaaca ttttcagcac cagtcaccca ctgttcccaa ctgcttgtca
     1081 acaatgggcc agaactgtgg agctggccta aacaatgaca gtcctgaggc ccttgaggtc
     1141 ccctctttgc aggactttag cgttttctcc acagattcct gcctgcagct ttcagatgca
     1201 gtttcaccca gtttgccagg ttccctcgac agtcccgtag atatttcagc tgacagctta
     1261 gactttttta cagacacact caccacaatc gacttgcagc atctgaatta ctaaaaacat
     1321 taaagcaaaa caaagcatca ccaaacaaaa actcctttga ccaggtggtt ttgccttctt
     1381 ttatttggga gtttattttt tattttcttc ttgacctacc ccttccctcc tttaagtgtt
     1441 gaggattttc tgtttagtga ttccctgacc cagtttcaaa cagagccatc ttttacagat
     1501 tattttggag ttttagttgt tttaaaccta actcaacaac cctttatgtg attcctgaga
     1561 gcagtatgag gcctgcaaga aagtgatcat ataattgtat cttcactttc tttttatttt
     1621 tgtattacat tgggatgcat tgtcatgcat attttttgta gaataaattc tcctttgcta
     1681 taagta
//
