LOCUS       NM_005523               2669 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens homeobox A11 (HOXA11), mRNA.
ACCESSION   NM_005523
VERSION     NM_005523.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Wang,C., Ji,J., Jin,Y., Sun,Y., Cai,Q., Jiang,J., Guo,L., Zhou,C.
            and Zhang,J.
  TITLE     Tumor-mesothelium HOXA11-PDGF BB/TGF beta1-miR-181a-5p-Egr1
            feedforward amplifier circuity propels mesothelial fibrosis and
            peritoneal metastasis of gastric cancer
  JOURNAL   Oncogene 43 (3), 171-188 (2024)
   PUBMED   37989866
  REMARK    GeneRIF: Tumor-mesothelium HOXA11-PDGF BB/TGF
            beta1-miR-181a-5p-Egr1 feedforward amplifier circuity propels
            mesothelial fibrosis and peritoneal metastasis of gastric cancer.
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Li,B., Lv,Y., Zhang,C. and Xiang,C.
  TITLE     lncRNA HOXA11-AS maintains the stemness of oral squamous cell
            carcinoma stem cells and reduces the radiosensitivity by targeting
            miR-518a-3p/PDK1
  JOURNAL   J Oral Pathol Med 52 (3), 216-225 (2023)
   PUBMED   36661031
  REMARK    GeneRIF: lncRNA HOXA11-AS maintains the stemness of oral squamous
            cell carcinoma stem cells and reduces the radiosensitivity by
            targeting miR-518a-3p/PDK1.
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Xie,L., Ding,N., Sheng,S., Zhang,H., Yin,H., Gao,L., Zhang,H.,
            Ma,S., Yang,A., Li,G., Jiao,Y., Shi,Q., Jiang,Y. and Zhang,H.
  TITLE     Cooperation between NSPc1 and DNA methylation represses HOXA11
            expression and promotes apoptosis of trophoblast cells during
            preeclampsia
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (2), 1-13 (2023)
   PUBMED   36815373
  REMARK    GeneRIF: Cooperation between NSPc1 and DNA methylation represses
            HOXA11 expression and promotes apoptosis of trophoblast cells
            during preeclampsia.
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Celik,O., Yurci,A., Ersahin,A., Gungor,N.D., Celik,N., Ozcil,M.D.,
            Dogan,S., Dalkilic,S., Dalkilic,L., Ulug,U., Celik,S. and
            Tinelli,A.
  TITLE     Endometrial Injury Upregulates Expression of Receptivity Genes in
            Women with Implantation Failure
  JOURNAL   Int J Environ Res Public Health 20 (5), 3942 (2023)
   PUBMED   36900953
  REMARK    GeneRIF: Endometrial Injury Upregulates Expression of Receptivity
            Genes in Women with Implantation Failure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Wang,S.S., Zhai,G.Q., Chen,G., Huang,Z.G., He,R.Q., Huang,S.N.,
            Liu,J.L., Cheng,J.W., Yan,H.B., Dang,Y.W. and Li,S.H.
  TITLE     Decreased expression of transcription factor Homeobox A11 and its
            potential target genes in bladder cancer
  JOURNAL   Pathol Res Pract 233, 153847 (2022)
   PUBMED   35430506
  REMARK    GeneRIF: Decreased expression of transcription factor Homeobox A11
            and its potential target genes in bladder cancer.
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Miano,J.M., Firulli,A.B., Olson,E.N., Hara,P., Giachelli,C.M. and
            Schwartz,S.M.
  TITLE     Restricted expression of homeobox genes distinguishes fetal from
            adult human smooth muscle cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 900-905 (1996)
   PUBMED   8570656
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (bases 1 to 2669)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   10 (bases 1 to 2669)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004080.2 and BC040948.1.
            
            On Aug 31, 2019 this sequence version replaced NM_005523.5.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            This gene is involved in the regulation of uterine development and
            is required for female fertility. Mutations in this gene can cause
            radio-ulnar synostosis with amegakaryocytic thrombocytopenia.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040948.1, SRR14038194.49626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000006015.4/ ENSP00000006015.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC004080.2         58587-58602         c
            17-797              BC040948.1         1-781
            798-2669            AC004080.2         54527-56398         c
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2669
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
                     /note="homeobox A11"
                     /db_xref="GeneID:3207"
                     /db_xref="HGNC:HGNC:5101"
                     /db_xref="MIM:142958"
     exon            1..797
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1030
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
                     /note="homeo box 1I; homeobox protein HOXA11; homeobox
                     protein Hox-1I"
                     /codon_start=1
                     /product="homeobox protein Hox-A11"
                     /protein_id="NP_005514.1"
                     /db_xref="CCDS:CCDS5411.1"
                     /db_xref="GeneID:3207"
                     /db_xref="HGNC:HGNC:5101"
                     /db_xref="MIM:142958"
                     /translation="MDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMT
                     YSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGV
                     PGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYP
                     GDKSAEKGPPAATATSAAAAAAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPES
                     SSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSR
                     MLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL"
     exon            798..2669
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
                     /note="hexamer: AATAAA"
     polyA_site      2311
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
                     /note="major polyA site"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
                     /note="hexamer: AATAAA"
     polyA_site      2669
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I; RUSAT1"
ORIGIN      
        1 ctacttcacg gatccgcttc aaagaggcag ctgcagtgga gaatcatgtt aagctcggct
       61 actgcggaga gcccaaggta gcccaataat ggattttgat gagcgtggtc cctgctcctc
      121 taacatgtat ttgccaagtt gtacttacta cgtctcgggt ccagatttct ccagcctccc
      181 ttcttttctg ccccagaccc cgtcttcgcg cccaatgaca tactcctact cctccaacct
      241 gccccaggtc caacccgtgc gcgaagtgac cttcagagag tacgccattg agcccgccac
      301 taaatggcac ccccgcggca atctggccca ctgctactcc gcggaggagc tcgtgcacag
      361 agactgcctg caggcgccca gcgcggccgg cgtgcctggc gacgtgctgg ccaagagctc
      421 ggccaacgtc taccaccacc ccacccccgc agtctcgtcc aatttctata gcaccgtggg
      481 caggaacggc gtcctgccac aggctttcga ccagtttttc gagacagcct acggcacccc
      541 ggaaaacctc gcctcctccg actaccccgg ggacaagagc gccgagaagg ggcccccggc
      601 ggccacggcg acctccgcgg cggcggcggc ggctgcaacg ggcgcgccgg caacttcaag
      661 ttcggacagc ggcggcggcg gcggctgccg ggagacggcg gcggcagcag aggagaaaga
      721 gcggcggcgg cgccccgaga gcagcagcag ccccgagtcg tcttccggcc acactgagga
      781 caaggccggc ggctccagtg gccaacgcac ccgcaaaaag cgctgcccct ataccaagta
      841 ccagatccga gagctggaac gggagttctt cttcagcgtc tacattaaca aagagaagcg
      901 cctgcaactg tcccgcatgc tcaacctcac tgatcgtcaa gtcaaaatct ggtttcagaa
      961 caggagaatg aaggaaaaaa aaattaacag agaccgttta cagtactact cagcaaatcc
     1021 actcctctaa gactccagcg gctggaattg ggtggggggc ttcatacaca tgagataata
     1081 tgcagatttt gcccttgaca aagtcaagcc acatggtgac ttttgaaaag aggtgtgcaa
     1141 gagagggatg catggagata gccccacagg aggtggtctg ggactctctt gattaagatc
     1201 tcagtggtta agattcctaa taatcattgg attctgagag ctgtgcatca gctagaatga
     1261 caggtttggg acccctggtg gttcactctt ggagcctgca gagctgcggg ctgggtgtgg
     1321 tctccactgg ggattgggcc cctgccagac cccctggaga ctaaccccac cacaccctcc
     1381 ctctactggg agcctaccca cccccaggac ccctgagtaa aaaagctgtg tgctctccaa
     1441 gcccagttca gcttggggac aggggcagga ggaaggggta ggattactag gtgcccagaa
     1501 tgaggctgct ttccaaagcc aatgtgaaca gcggctggac ttggaggtag ctttgaggtg
     1561 gaagagggct gcaaatcctt gtgggaaaag aaatctatga ttccaggtgg catcagtgtc
     1621 tttccactcc tcctagccac ccaccacact gatccagccc tgagttccta gccaccgcct
     1681 cctacagccc acctggcttt tctttctacc aaatgagggt cttggttcca gcctgccact
     1741 caggcccaaa gcctcgacac agagtggact gttccctgag gtgggagatg tggaaaagcc
     1801 aagaggctgc agccaggcca ctggcccctg agatctctgc aggaaatggc tgtggagtgt
     1861 ggcagtttgg caaactctcc accacacgta atgaaacttg gatttgctca gtgtctggct
     1921 gcagagcagt gggcctggcc agcaggtccc cagctttggc tatgagggcc ttgagtcccc
     1981 caaaacaccg ggttccagca ccacactcag ccctcattgg ctcttgaact gagcttggaa
     2041 gcttctggtg accttccaag agcctgagag tgaggtggaa ttattttaaa agataaatat
     2101 tatattatat atatatatat ttccctgaag gaaccaaagc gaattttaaa agatgcaatg
     2161 tagaggggaa aagagatgat gaaaatattt aaaggcccta tctgtttaca gtgttccgtg
     2221 gttaaactcg ctcactgcta agaatatttg aatgtatgct tcatacaggg atggtgttca
     2281 aaaaacttgt aaataaagga accataatca attttctttt ctttctttct ctttttcttt
     2341 tttcttttgc cattagttga tttcctttag ggtgttggag ggggtggaaa aggtattgag
     2401 aatggtcttt ttaatctctt gcaacatttg gaaagagtta gggaaatgct cagaggcagt
     2461 cggcctggcc ggcctgggga tctcatctgg gaaagccagg caccctccca ttgaatctcc
     2521 tttgcctccc tgtgttaaga aatgtctgtt ggctccattt gtactgggag tgttggcctg
     2581 tcctcaattc tggttcttac ccaccgtgtg tgttgcagca cttatacagg caactgggca
     2641 caaggaaaat aaagacggtg gaaatttga
//
