LOCUS       NM_018951               2541 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens homeobox A10 (HOXA10), transcript variant 1, mRNA.
ACCESSION   NM_018951
VERSION     NM_018951.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Zhou,H., Deng,C. and Xi,Y.
  TITLE     Mechanism of HOXA10 in nasopharyngeal carcinoma cell proliferation
            through the PTPRG-AS1/USP1 axis
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70025 (2024)
   PUBMED   39445487
  REMARK    GeneRIF: Mechanism of HOXA10 in nasopharyngeal carcinoma cell
            proliferation through the PTPRG-AS1/USP1 axis.
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Zhong,M., Xu,W., Tian,P., Zhang,Q., Wang,Z., Liang,L., Zhang,Q.,
            Yang,Y., Lu,Y. and Wei,G.H.
  TITLE     An Inherited Allele Confers Prostate Cancer Progression and Drug
            Resistance via RFX6/HOXA10-Orchestrated TGFbeta Signaling
  JOURNAL   Adv Sci (Weinh) 11 (32), e2401492 (2024)
   PUBMED   38932472
  REMARK    GeneRIF: An Inherited Allele Confers Prostate Cancer Progression
            and Drug Resistance via RFX6/HOXA10-Orchestrated TGFbeta Signaling.
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Zhao,K., Chen,L., Xie,Y., Ren,N., Li,J., Zhai,X., Zheng,S., Liu,K.,
            Wang,C., Qiu,Q., Peng,X., Wang,W., Liu,J., Che,Q., Fan,J., Hu,H.
            and Liu,M.
  TITLE     m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and
            malignant progression of laryngeal squamous cell carcinoma through
            regulating Notch and Keap1/Nrf2 pathways
  JOURNAL   Cancer Lett 587, 216735 (2024)
   PUBMED   38369001
  REMARK    GeneRIF: m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance
            and malignant progression of laryngeal squamous cell carcinoma
            through regulating Notch and Keap1/Nrf2 pathways.
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Chen,S. and Pan,J.
  TITLE     Importin 7 enhances protective autophagy induced by nuclear
            translocation of homeobox A10 in oral squamous cell carcinoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (3), 241-247 (2024)
   PUBMED   38650127
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Huang,Y., Tao,M., Yan,S. and He,X.
  TITLE     Long non-coding RNA Homeobox D gene cluster antisense
            growth-associated long noncoding RNA/microRNA-182-5p/Homeobox
            protein A10 alleviates postmenopausal osteoporosis via accelerating
            osteoblast differentiation of bone marrow mesenchymal stem cells
  JOURNAL   J Orthop Surg Res 18 (1), 726 (2023)
   PUBMED   37752532
  REMARK    GeneRIF: Long non-coding RNA Homeobox D gene cluster antisense
            growth-associated long noncoding RNA/microRNA-182-5p/Homeobox
            protein A10 alleviates postmenopausal osteoporosis via accelerating
            osteoblast differentiation of bone marrow mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2541)
  AUTHORS   Lowney,P., Corral,J., Detmer,K., LeBeau,M.M., Deaven,L.,
            Lawrence,H.J. and Largman,C.
  TITLE     A human Hox 1 homeobox gene exhibits myeloid-specific expression of
            alternative transcripts in human hematopoietic cells
  JOURNAL   Nucleic Acids Res 19 (12), 3443-3449 (1991)
   PUBMED   1676505
REFERENCE   8  (bases 1 to 2541)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   9  (bases 1 to 2541)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   10 (bases 1 to 2541)
  AUTHORS   Shen,W.F., Largman,C., Lowney,P., Corral,J.C., Detmer,K.,
            Hauser,C.A., Simonitch,T.A., Hack,F.M. and Lawrence,H.J.
  TITLE     Lineage-restricted expression of homeobox-containing genes in human
            hematopoietic cell lines
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8536-8540 (1989)
   PUBMED   2573064
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX439708.2, BC013971.2 and
            BF196481.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018951.3.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor that
            may regulate gene expression, morphogenesis, and differentiation.
            More specifically, it may function in fertility, embryo viability,
            and regulation of hematopoietic lineage commitment. Alternatively
            spliced transcript variants have been described. Read-through
            transcription also exists between this gene and the downstream
            homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: An upstream start codon is selected for this RefSeq
            based on conservation in at least 24 vertebrate species including
            mouse, rat, human, chimp, macaque, dog, cow, chicken, lizard,
            Xenopus tropicalis, Tetraodon and Fugu. Historically, a start codon
            that is 17 aa downstream has been used as the translation AUG start
            codon. No experimental evidence exists regarding which site is
            preferentially used.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013971.2, ERR279867.2368.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283921.5/ ENSP00000283921.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BX439708.2         17-32
            17-2183             BC013971.2         1-2167
            2184-2541           BF196481.1         16-373              c
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2541
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="homeobox A10"
                     /db_xref="GeneID:3206"
                     /db_xref="HGNC:HGNC:5100"
                     /db_xref="MIM:142957"
     exon            1..972
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1247
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="homeo box A10; homeobox protein 1H; homeobox
                     protein HOXA10; homeobox protein Hox-1H; homeobox protein
                     Hox-1.8"
                     /codon_start=1
                     /product="homeobox protein Hox-A10"
                     /protein_id="NP_061824.3"
                     /db_xref="CCDS:CCDS5410.2"
                     /db_xref="GeneID:3206"
                     /db_xref="HGNC:HGNC:5100"
                     /db_xref="MIM:142957"
                     /translation="MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGG
                     GGGGAGGGGGGGYYAHGGVYLPPAADLPYGLQSCGLFPTLGGKRNEAASPGSGGGGGG
                     LGPGAHGYGPSPIDLWLDAPRSCRMEPPDGPPPPPQQQPPPPPQPPQPAPQATSCSFA
                     QNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQ
                     AYGTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPALASGSADAARKERALDSPPPP
                     TLACGSGGGSQGDEEAHASSSAAEELSPAPSESSKASPEKDSLGNSKGENAANWLTAK
                     SGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLK
                     KMNRENRIRELTANFNFS"
     exon            973..2541
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2522..2527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="hexamer: AATAAA"
     polyA_site      2541
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="major polyA site"
ORIGIN      
        1 gttttgcaca agaaatgtca gccagaaagg gctatctgct cccttcgcca aattatccca
       61 caacaatgtc atgctcggag agccccgccg cgaactcttt tttggtcgac tcgctcatca
      121 gctcgggcag aggcgaggca ggcggcggtg gtggtggcgc ggggggcggc ggcggtggcg
      181 gttactacgc ccacggcggg gtctacctgc cgcccgccgc cgacctgccc tacgggctgc
      241 agagctgcgg gctcttcccc acgctgggcg gcaagcgcaa tgaggcagcg tcgccgggca
      301 gcggtggcgg tggcgggggt ctaggtcccg gggcgcacgg ctacgggccc tcgcccatag
      361 acctgtggct agacgcgccc cggtcttgcc ggatggagcc gcctgacggg ccgccgccgc
      421 cgccccagca gcagccgccg cccccgccgc aaccacccca gccagcgccg caggccacct
      481 cgtgctcttt cgcgcagaac atcaaagaag agagctccta ctgcctctac gactcggcgg
      541 acaaatgccc caaagtctcg gccaccgccg ccgaactggc tcccttcccg cggggcccgc
      601 cgcccgacgg ctgcgccctg ggcacctcca gcggggtgcc agtgcctggc tacttccgcc
      661 tttctcaggc ctacggcacc gccaagggct atggcagcgg cggcggcggc gcgcagcaac
      721 tcggggctgg cccgttcccc gcgcagcccc cggggcgcgg tttcgatctc ccgcccgcgc
      781 tagcctccgg ctcggccgat gcggcccgga aggagcgagc cctcgattcg ccgccgcccc
      841 ccacgctggc ttgcggcagc ggcgggggct cgcagggcga cgaggaggcg cacgcgtcgt
      901 cctcggccgc ggaggagctc tccccggccc cttccgagag cagcaaagcc tcgccggaga
      961 aggattccct gggcaattcc aaaggtgaaa acgcagccaa ctggctcacg gcaaagagtg
     1021 gtcggaagaa gcgctgcccc tacacgaagc accagacact ggagctggag aaggagtttc
     1081 tgttcaatat gtaccttact cgagagcggc gcctagagat tagccgcagc gtccacctca
     1141 cggacagaca agtgaaaatc tggtttcaga accgcaggat gaaactgaag aaaatgaatc
     1201 gagaaaaccg gatccgggag ctcacagcca actttaattt ttcctgatga atctccaggc
     1261 gacgcggttt tttcacttcc cgagcgctgg tcccctccct ctgtcttcag gctctgccca
     1321 ggaactcgca cctgtgctgg agccctgttc ctccctccca cactcgccat ctcctgggcc
     1381 gttacatctg tgcagggctg gtttgttctg actttttgtt tctttgtgtt tgcttggtgc
     1441 tggtttattt gttgttttct gggggaaaaa gccatatcat gctaaaattc tatagagata
     1501 gatattgtcc taagtgtcaa gtcctgactg ggctgggttt gctgtcttgg ggtcccactg
     1561 ctcgaaatgg cccctgtctt cggccgagct ggtttcctgc ccagcctggg gcaaacctag
     1621 ccggaaggcc gaggtcccat tgttggcgct gaggtgtctg gcctgaggtc aatggtgcaa
     1681 aggagccgcc accgggcatg tctgcctgga gtgctgtgct gtgtttaatc aggggataca
     1741 ggcccctggg tttctttttt ctttcttcct ttcttccttg gccaagagaa gggcttacag
     1801 gcatggacat gcaggttggc aaacgggctt gactttggct gatttaaaaa gtgagaaaga
     1861 aagtaaaaaa ggttaatttt tccttcctct gtaagatatc ccagctttaa aaagaaaaaa
     1921 aaagaattac caagagaagg ggacttctct tccagtttct gtaaggtctt acattgcctg
     1981 actaaaatgt ttcatttacc tctaaatttc catatccttc tggctgtaga taaataatgt
     2041 agttttgttt atgcatttgg aattagtgga tttttttgtc attaaaattg ttaccactgg
     2101 taacatgtga caagcacacc acaattctcc ctatcttgtg aagttgtttt tttaaatcgc
     2161 cttgaacaaa aagttttttt tttgtttgtt tttgctttct gaaattcaca gaagcctagg
     2221 aggactgggg taagcggaat aaactagaga agggagacat tgtttggatt tcctttatac
     2281 tgtgaagtta catgcataaa agggtcaaac ctgtagatgc agaaaaagaa aaaaactata
     2341 aatacaaatc tgtataaatg tctattatta tgaagaattg ccaatcttgt tttaagcaaa
     2401 tgcattctat cgttattata aatgttagtt ctagctctat ttacttctaa tcttaaatca
     2461 gaataaatta atattgtatt gctgctgtgc gtggaaaaag acgatgttta tgttcttata
     2521 gaataaaagc tgtggaatga a
//
