LOCUS       NM_005522               2543 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens homeobox A1 (HOXA1), transcript variant 1, mRNA.
ACCESSION   NM_005522
VERSION     NM_005522.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2543)
  AUTHORS   Zhu,R., Mao,Y., Xu,X., Li,Y. and Zheng,J.
  TITLE     HOXA1 silencing inhibits cisplatin resistance of oral squamous cell
            carcinoma cells via IkappaB/NF-kappaB signaling pathway
  JOURNAL   Anticancer Drugs 35 (6), 492-500 (2024)
   PUBMED   38477942
  REMARK    GeneRIF: HOXA1 silencing inhibits cisplatin resistance of oral
            squamous cell carcinoma cells via IkappaB/NF-kappaB signaling
            pathway.
REFERENCE   2  (bases 1 to 2543)
  AUTHORS   Marchese,D., Guislain,F., Pringels,T., Bridoux,L. and Rezsohazy,R.
  TITLE     A poly-histidine motif of HOXA1 is involved in regulatory
            interactions with cysteine-rich proteins
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1867 (1), 194993 (2024)
   PUBMED   37952572
  REMARK    GeneRIF: A poly-histidine motif of HOXA1 is involved in regulatory
            interactions with cysteine-rich proteins.
REFERENCE   3  (bases 1 to 2543)
  AUTHORS   Chen,Q., Chen,Q., Song,Y., Xiang,Y., Li,Q., Sang,Y., Zhang,L.,
            Bai,L. and Zhu,Y.
  TITLE     Downregulation of homeobox A1 in human granulosa cells is involved
            in diminished ovarian reserve through promoting cell apoptosis and
            mitochondrial dysfunction
  JOURNAL   Mol Cell Endocrinol 580, 112084 (2024)
   PUBMED   37923054
  REMARK    GeneRIF: Downregulation of homeobox A1 in human granulosa cells is
            involved in diminished ovarian reserve through promoting cell
            apoptosis and mitochondrial dysfunction.
REFERENCE   4  (bases 1 to 2543)
  AUTHORS   Zhang,Z., Peng,J., Li,B., Wang,Z., Wang,H., Wang,Y. and Hong,L.
  TITLE     HOXA1 promotes aerobic glycolysis and cancer progression in
            cervical cancer
  JOURNAL   Cell Signal 109, 110747 (2023)
   PUBMED   37286120
  REMARK    GeneRIF: HOXA1 promotes aerobic glycolysis and cancer progression
            in cervical cancer.
REFERENCE   5  (bases 1 to 2543)
  AUTHORS   Chen,L., Luo,C., Xu,Y., Hu,J. and Chen,H.
  TITLE     Circ_0058063 regulates the development of esophageal cancer through
            miR-377-3p/HOXA1 axis
  JOURNAL   Anticancer Drugs 34 (4), 495-506 (2023)
   PUBMED   36729977
  REMARK    GeneRIF: Circ_0058063 regulates the development of esophageal
            cancer through miR-377-3p/HOXA1 axis.
REFERENCE   6  (bases 1 to 2543)
  AUTHORS   Studer,M., Gavalas,A., Marshall,H., Ariza-McNaughton,L.,
            Rijli,F.M., Chambon,P. and Krumlauf,R.
  TITLE     Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in
            regulation of early hindbrain patterning
  JOURNAL   Development 125 (6), 1025-1036 (1998)
   PUBMED   9463349
  REMARK    GeneRIF: In mice, establishing Hoxb1 in rhombomere 4 is dependent
            on the early activation of Hoxa1 and Hoxb1 and that together both
            are essential for patterning the r4 territory.
REFERENCE   7  (bases 1 to 2543)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   8  (bases 1 to 2543)
  AUTHORS   Chariot,A., Moreau,L., Senterre,G., Sobel,M.E. and Castronovo,V.
  TITLE     Retinoic acid induces three newly cloned HOXA1 transcripts in MCF7
            breast cancer cells
  JOURNAL   Biochem Biophys Res Commun 215 (2), 713-720 (1995)
   PUBMED   7488013
REFERENCE   9  (bases 1 to 2543)
  AUTHORS   Hong,Y.S., Kim,S.Y., Bhattacharya,A., Pratt,D.R., Hong,W.K. and
            Tainsky,M.A.
  TITLE     Structure and function of the HOX A1 human homeobox gene cDNA
  JOURNAL   Gene 159 (2), 209-214 (1995)
   PUBMED   7622051
REFERENCE   10 (bases 1 to 2543)
  AUTHORS   Jacob,P., Bhat,V. and Patil,S.J.
  TITLE     HOXA1-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39541495
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004079.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 19, 2019 this sequence version replaced NM_005522.4.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            The encoded protein may be involved in the placement of hindbrain
            segments in the proper location along the anterior-posterior axis
            during development. Two transcript variants encoding two different
            isoforms have been found for this gene, with only one of the
            isoforms containing the homeodomain region. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032547.2, S79910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643460.2/ ENSP00000494260.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-740               AC004079.1         77656-78395         c
            741-2543            AC004079.1         75388-77190         c
FEATURES             Location/Qualifiers
     source          1..2543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2543
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /note="homeobox A1"
                     /db_xref="GeneID:3198"
                     /db_xref="HGNC:HGNC:5099"
                     /db_xref="MIM:142955"
     exon            1..740
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1096
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /note="isoform a is encoded by transcript variant 1; homeo
                     box A1; homeobox 1F; Hox 1.6-like protein; lab-like
                     protein; homeobox protein HOX-A1; HOX A1 homeodomain
                     protein; homeobox protein Hox-1F"
                     /codon_start=1
                     /product="homeobox protein Hox-A1 isoform a"
                     /protein_id="NP_005513.2"
                     /db_xref="CCDS:CCDS5401.1"
                     /db_xref="GeneID:3198"
                     /db_xref="HGNC:HGNC:5099"
                     /db_xref="MIM:142955"
                     /translation="MDNARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSA
                     NSCGGDDRFLVGRGVQIGSPHHHHHHHHRHPQPATYQTSGNLGVSYSHSSCGPSYGSQ
                     NFSAPYSPYALNQEADVSGGYPQCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYI
                     HHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTG
                     KVGEYGYLGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIW
                     FQNRRMKQKKREKEGLLPISPATPPGNDEKAEESSEKSSSSPCVPSPGSSTSDTLTTS
                     H"
     exon            741..2543
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2205..2210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /note="hexamer: AATAAA"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /note="hexamer: AATATA"
     polyA_site      2233
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /note="major polyA site"
     polyA_site      2243
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
     regulatory      2355..2360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /note="hexamer: AATAAA"
     polyA_site      2386
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
     regulatory      2514..2519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
                     /note="hexamer: TATAAA"
     polyA_site      2543
                     /gene="HOXA1"
                     /gene_synonym="BSAS; HOX1; HOX1F"
ORIGIN      
        1 atcatttttc ttctccggcc ccatggagga agtgagaaag ttggcacagt cacgccgggc
       61 ttcgcaggac caggtcactc agtgacagat ggacaatgca agaatgaact ccttcctgga
      121 ataccccata cttagcagtg gcgactcggg gacctgctca gcccgagcct acccctcgga
      181 ccataggatt acaactttcc agtcgtgcgc ggtcagcgcc aacagttgcg gcggcgacga
      241 ccgcttccta gtgggcaggg gggtgcagat cggttcgccc caccaccacc accaccacca
      301 ccatcgccac ccccagccgg ctacctacca gacttccggg aacctggggg tgtcctactc
      361 ccactcaagt tgtggtccaa gctatggctc acagaacttc agtgcgcctt acagccccta
      421 cgcgttaaat caggaagcag acgtaagtgg tgggtacccc cagtgcgctc ccgctgttta
      481 ctctggaaat ctctcatctc ccatggtcca gcatcaccac caccaccagg gttatgctgg
      541 gggcgcggtg ggctcgcctc aatacattca ccactcatat ggacaggagc accagagcct
      601 ggccctggct acgtataata actccttgtc ccctctccac gccagccacc aagaagcctg
      661 tcgctccccc gcatcggaga catcttctcc agcgcagact tttgactgga tgaaagtcaa
      721 aagaaaccct cccaaaacag ggaaagttgg agagtacggc tacctgggtc aacccaacgc
      781 ggtgcgcacc aacttcacta ccaagcagct cacggaactg gagaaggagt tccacttcaa
      841 caagtacctg acgcgcgccc gcagggtgga gatcgctgca tccctgcagc tcaacgagac
      901 ccaagtgaag atctggttcc agaaccgccg aatgaagcaa aagaaacgtg agaaggaggg
      961 tctcttgccc atctctccgg ccaccccgcc aggaaacgac gagaaggccg aggaatcctc
     1021 agagaagtcc agctcttcgc cctgcgttcc ttccccgggg tcttctacct cagacactct
     1081 gactacctcc cactgaggcg gctccagccc cagacaacag cccaggcatc tccttgggct
     1141 gggacttctt acccaaagca catgcttagc ttatctttct ttccatttac agtctctttc
     1201 ttcctttcta atcctatctg gggagctcct ggccaggata atatatttgc agataattct
     1261 ggaccagaga cttggtgcgg ggttaacacc ttcatccaga ttgggtgcca gcatacattt
     1321 tctggtgggc cttaacatcc ctcctgcttt taggagaatt cacagaacct actgttcctt
     1381 tcagatgacc ttttggaaaa tagttccctt tgccaacaga aacatgccag aaggaatctt
     1441 ctcatctttt atctaactat atgtacagct ctcccctccc ttgtccttga aagtaggata
     1501 tagcgaaagg cgagtccagg agctcaggaa gaagagatgc actatatgtt tacacaatta
     1561 attcatccct taatttaagt cattttcatg tgtgtgagtt tgctggttgt aaatactttg
     1621 tcctaagaga tttatcttta tacagatttt ctagaaatgt ttaggttact aaaacagggt
     1681 gggcaaactc tctaaactgg tacaatttta taggtgaaag aaaaaattcc ctcatttaaa
     1741 cccaatcaga tgcctcagag ggtagccttg atttgttctt acagttaaga agccctgcag
     1801 agcacaaact tcagaaaccc ggcttcctgt gctaagtctt tcccaatctc tacccctttc
     1861 ttctcgggcc accctctgtt taaaatttgt gctgggttat tcagaaccta aaagtattat
     1921 tcaaaccaat ttcttccttc cacagttatc ttagctggat ataatgtatt ttcagctcaa
     1981 ttgttaatgt gatggatggc acaatgaatg tatattttgt gttattcgtg aatagtcttt
     2041 tgcatgtcgc acaatgtttg atgtccccaa agtaccacac tgagttctat cagttatcct
     2101 ttgtgagcct atgatattcc ccatttcctg tacaatcatg aacagctctg agatcctgga
     2161 gtgatatgat ccagagcaga gtttacgggt cttaggatgt ctgtaataaa taaatatact
     2221 caagtttcag gtatgcttaa gcatccgtgt atttggctgg gctacaattt gttaattcct
     2281 atgaagttgg cacatttcat gaggggaaag ggagaagggt ggtaaatatt ttcaaagaga
     2341 tgggcctttt cttgaataaa agttaataac agctccttta ttataatcaa agctcataat
     2401 ggaaaaaaag actgatgaag aaatttatga agcagattta tttttgaaac aaacatggat
     2461 acttcctggg tcaagtgcta accttttcac ctccaactgg atgttgacgt atatataaac
     2521 agaactccct tcaaaagcca aaa
//
