LOCUS       NM_032132               1904 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens HORMA domain containing 1 (HORMAD1), transcript
            variant 1, mRNA.
ACCESSION   NM_032132
VERSION     NM_032132.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Zhang,X., Xu,Y. and Zhou,J.
  TITLE     Expression of HORMAD1 in Chronic Rhinosinusitis and Its Correlation
            with Inflammatory Factors
  JOURNAL   J Coll Physicians Surg Pak 34 (1), 54-57 (2024)
   PUBMED   38185961
  REMARK    GeneRIF: Expression of HORMAD1 in Chronic Rhinosinusitis and Its
            Correlation with Inflammatory Factors.
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Wang,H., Xie,R., Niu,F., Yang,Q., An,L., Wu,C., Liu,X. and Yang,X.
  TITLE     Structural and biochemical insights into the interaction mechanism
            underlying HORMAD1 and its partner proteins
  JOURNAL   Structure 31 (12), 1578-1588 (2023)
   PUBMED   37794593
  REMARK    GeneRIF: Structural and biochemical insights into the interaction
            mechanism underlying HORMAD1 and its partner proteins.
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Herrera,L.R., Johnson,R.A., McGlynn,K., Gibbs,Z.A., Davis,A.J. and
            Whitehurst,A.W.
  TITLE     The cancer testes antigen, HORMAD1, limits genomic instability in
            cancer cells by protecting stalled replication forks
  JOURNAL   J Biol Chem 299 (11), 105348 (2023)
   PUBMED   37838177
  REMARK    GeneRIF: The cancer testes antigen, HORMAD1, limits genomic
            instability in cancer cells by protecting stalled replication
            forks.
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Gantchev,J., Messina-Pacheco,J., Martinez Villarreal,A.,
            Ramchatesingh,B., Lefrancois,P., Xie,P., Amar,L., Xu,H.H.,
            Raveendra,K., Sikorski,D., Guerra Ordaz,D.J., Gill,R.P.K.,
            Lambert,M. and Litvinov,I.V.
  TITLE     Ectopically Expressed Meiosis-Specific Cancer Testis Antigen
            HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas
  JOURNAL   Cells 12 (12), 1627 (2023)
   PUBMED   37371097
  REMARK    GeneRIF: Ectopically Expressed Meiosis-Specific Cancer Testis
            Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell
            Carcinomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1904)
  AUTHORS   Shahzad,M.M., Shin,Y.H., Matsuo,K., Lu,C., Nishimura,M., Shen,D.Y.,
            Kang,Y., Hu,W., Mora,E.M., Rodriguez-Aguayo,C., Kapur,A.,
            Bottsford-Miller,J., Lopez-Berestein,G., Rajkovic,A. and Sood,A.K.
  TITLE     Biological significance of HORMA domain containing protein 1
            (HORMAD1) in epithelial ovarian carcinoma
  JOURNAL   Cancer Lett 330 (2), 123-129 (2013)
   PUBMED   22776561
  REMARK    GeneRIF: HORMAD1 gene silencing resulted in significantly reduced
            VEGF protein levels and microvessel density compared to controls in
            epithelial ovarian carcinoma.
            Review article
REFERENCE   6  (bases 1 to 1904)
  AUTHORS   Miyamoto,T., Tsujimura,A., Miyagawa,Y., Koh,E., Namiki,M.,
            Horikawa,M., Saijo,Y. and Sengoku,K.
  TITLE     Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for
            azoospermia caused by meiotic arrest in Japanese patients
  JOURNAL   Asian J Androl 14 (4), 580-583 (2012)
   PUBMED   22407170
  REMARK    GeneRIF: This is the first report showing that HORMAD1
            single-nucleotide polymorphisms (SNPs) may predispose men to a
            defect in spermatogenesis, although the causal and potential
            mechanistic relationships between these HORMAD1 SNPs and
            azoospermia remain unclear.
REFERENCE   7  (bases 1 to 1904)
  AUTHORS   Adelaide,J., Finetti,P., Bekhouche,I., Repellini,L., Geneix,J.,
            Sircoulomb,F., Charafe-Jauffret,E., Cervera,N., Desplans,J.,
            Parzy,D., Schoenmakers,E., Viens,P., Jacquemier,J., Birnbaum,D.,
            Bertucci,F. and Chaffanet,M.
  TITLE     Integrated profiling of basal and luminal breast cancers
  JOURNAL   Cancer Res 67 (24), 11565-11575 (2007)
   PUBMED   18089785
REFERENCE   8  (bases 1 to 1904)
  AUTHORS   Aung,P.P., Oue,N., Mitani,Y., Nakayama,H., Yoshida,K., Noguchi,T.,
            Bosserhoff,A.K. and Yasui,W.
  TITLE     Systematic search for gastric cancer-specific genes based on SAGE
            data: melanoma inhibitory activity and matrix metalloproteinase-10
            are novel prognostic factors in patients with gastric cancer
  JOURNAL   Oncogene 25 (17), 2546-2557 (2006)
   PUBMED   16331256
REFERENCE   9  (bases 1 to 1904)
  AUTHORS   Chen,Y.T., Venditti,C.A., Theiler,G., Stevenson,B.J., Iseli,C.,
            Gure,A.O., Jongeneel,C.V., Old,L.J. and Simpson,A.J.
  TITLE     Identification of CT46/HORMAD1, an immunogenic cancer/testis
            antigen encoding a putative meiosis-related protein
  JOURNAL   Cancer Immun 5, 9 (2005)
   PUBMED   15999985
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1904)
  AUTHORS   Pangas,S.A., Yan,W., Matzuk,M.M. and Rajkovic,A.
  TITLE     Restricted germ cell expression of a gene encoding a novel
            mammalian HORMA domain-containing protein
  JOURNAL   Gene Expr Patterns 5 (2), 257-263 (2004)
   PUBMED   15567723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356292.21, BU570274.1,
            BC047406.1 and AA991355.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032132.4.
            
            Summary: This gene encodes a HORMA domain-containing protein. HORMA
            domains are involved in chromatin binding and play a role in cell
            cycle regulation. The encoded protein may play a role in meiosis,
            and expression of this gene is a potential marker for cancer. A
            pseudogene of this gene is located on the long arm of chromosome 6.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Dec
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.256906.1, BC047406.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361824.7/ ENSP00000355167.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL356292.21        73601-73607         c
            8-19                BU570274.1         4-15
            20-1898             BC047406.1         1-1879
            1899-1904           AA991355.1         3-8                 c
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1904
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /note="HORMA domain containing 1"
                     /db_xref="GeneID:84072"
                     /db_xref="HGNC:HGNC:25245"
                     /db_xref="MIM:609824"
     exon            1..92
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            93..158
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1310
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 46; HORMA domain-containing protein
                     1; newborn ovary HORMA protein; testis tissue
                     sperm-binding protein Li 86P"
                     /codon_start=1
                     /product="HORMA domain-containing protein 1 isoform 1"
                     /protein_id="NP_115508.2"
                     /db_xref="CCDS:CCDS967.1"
                     /db_xref="GeneID:84072"
                     /db_xref="HGNC:HGNC:25245"
                     /db_xref="MIM:609824"
                     /translation="MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYL
                     RGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVY
                     TNPEDPQTISECYQFKFKYTNNGPLMDFISKNQSNESSMLSTDTKKASILLIRKIYIL
                     MQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTP
                     FHIFKVKVTTERERMENIDSTILSPKQIKTPFQKILRDKDVEDEQEHYTSDDLDIETK
                     MEEQEKNPASSELEEPSLVCEEDEIMRSKESPDLSISHSQVEQLVNKTSELDMSESKT
                     RSGKVFQNKMANGNQPVKSSKENRKRSQHESGRIVLHHFDSSSQESVPKRRKFSEPKE
                     HI"
     exon            159..303
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            304..367
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            368..404
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            405..425
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            426..452
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            453..520
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            521..672
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            673..929
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            930..996
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1073
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1157
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1229
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1904
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1497..1502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /note="hexamer: AATAAA"
     polyA_site      1521
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /note="hexamer: AATAAA"
     polyA_site      1904
                     /gene="HORMAD1"
                     /gene_synonym="CT46; NOHMA"
                     /note="major polyA site"
ORIGIN      
        1 gaccgttgaa ggaaagcgca tgcgcgtcgg gcacagcgcg tgcagcctcg tgcagctctt
       61 ctggtctccg gcgcccgccc ctcagacgta atgttgaatt aaagaaaata ctttatcaga
      121 agaagatggc cactgcccag ttgcagagga ctcccatgag tgcactggta tttcccaata
      181 agatatcaac tgaacaccag tctttggtgt tagtgaagag gcttctagca gtttcagtat
      241 cctgtatcac gtatttgagg ggaatattcc cagaatgcgc ttatggaaca agatatctag
      301 atgatctttg tgtcaaaata ctgagagaag ataaaaattg cccaggatct acacagttag
      361 tgaaatggat gctaggatgt tatgatgctt tacagaaaaa atatctaagg atggttgttc
      421 tagctgtata cacaaaccca gaagatcctc agacaatttc agaatgttac caattcaaat
      481 tcaaatacac caataatgga ccactcatgg acttcataag taaaaaccaa agcaacgaat
      541 ctagcatgtt gtctactgac accaagaaag caagcattct cctcattcgc aagatttata
      601 tcctaatgca aaatctgggg cctttaccta atgatgtttg tttgaccatg aaactttttt
      661 actatgatga agttacaccc ccagattacc agcctcccgg ttttaaggat ggtgattgtg
      721 aaggagttat atttgaaggg gaacctatgt atttaaatgt gggagaagtc tcaacacctt
      781 ttcacatctt caaagtaaaa gtgaccactg agagagaacg aatggaaaat attgactcaa
      841 ctatactatc accaaaacaa ataaaaacac catttcaaaa aatcctgagg gacaaagatg
      901 tagaagatga acaggagcat tatacaagtg atgatttgga cattgaaact aaaatggaag
      961 aacaggaaaa aaaccctgca tcttctgaac ttgaagaacc aagtttagtt tgtgaggaag
     1021 atgaaattat gaggtctaaa gaaagtccag atctttctat ttctcattct caggttgagc
     1081 agttagtcaa taaaacatct gaacttgata tgtctgaaag caaaacaaga agtggaaaag
     1141 tctttcagaa taaaatggca aatggaaatc aaccagtaaa atcttccaaa gaaaatcgga
     1201 agagaagtca acatgaatct gggagaatag tcctccatca ctttgattct tctagtcaag
     1261 agtcagtgcc aaaaaggaga aagtttagtg aaccaaagga acatatataa aaattatttt
     1321 tgttctgcag gcttgcagag ttcttctcac catttaaact gaaggaccct atattatatt
     1381 tccctaactc tgaagatgta tatgtagttt aaagcagttt gtacactaaa actaagtttt
     1441 tggctgactg tcatattgtg gtccttaatc ttgagataaa tccaatagaa cttttgaata
     1501 aaagcaaaag tacaaatgtc ataattgatt cggtaataag taaaatttca aaattgattt
     1561 tgttcattac ctacttaata tttcctttaa atatatacta actgttaagg ccctctaatg
     1621 ccatttttct aaacagtaat gtttactttg gtattaaaat ttggtatgga ttcacttttt
     1681 acttatgtta aaattatacc atttaactgg ctcttttgtc attgtgctgt tattaaaaca
     1741 atgttcttca atattttgac ataatgtatt aacattttaa tatataatgt acaatttaag
     1801 aattggtgct ttacctttac tatgcttttt tttacaggac aaaaagactg atttttaaag
     1861 tatggcattt tttgcagcat aaataaaata ttgttcagta cgta
//
