LOCUS       NM_032495               1123 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens HOP homeobox (HOPX), transcript variant 1, mRNA.
ACCESSION   NM_032495
VERSION     NM_032495.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1123)
  AUTHORS   Yang,Q., Patrick,M., Lu,J., Chen,J., Zhang,Y., Hemani,H.,
            Lehrmann,E., De,S. and Weng,N.P.
  TITLE     Homeodomain-only protein suppresses proliferation and contributes
            to differentiation- and age-related reduced CD8+ T cell expansion
  JOURNAL   Front Immunol 15, 1360229 (2024)
   PUBMED   38410516
  REMARK    GeneRIF: Homeodomain-only protein suppresses proliferation and
            contributes to differentiation- and age-related reduced CD8[+] T
            cell expansion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1123)
  AUTHORS   Kashyap,S., Rabbani,M., de Lima,I., Kondrachuk,O., Patel,R.,
            Shafiei,M.S., Mukker,A., Rajakumar,A. and Gupta,M.K.
  TITLE     HOPX Plays a Critical Role in Antiretroviral Drugs Induced
            Epigenetic Modification and Cardiac Hypertrophy
  JOURNAL   Cells 10 (12), 3458 (2021)
   PUBMED   34943964
  REMARK    GeneRIF: HOPX Plays a Critical Role in Antiretroviral Drugs Induced
            Epigenetic Modification and Cardiac Hypertrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1123)
  AUTHORS   Pavlova,O., Lefort,K., Mariotto,A., Huber,M. and Hohl,D.
  TITLE     HOPX Exhibits Oncogenic Activity during Squamous Skin
            Carcinogenesis
  JOURNAL   J Invest Dermatol 141 (10), 2354-2368 (2021)
   PUBMED   33845078
  REMARK    GeneRIF: HOPX Exhibits Oncogenic Activity during Squamous Skin
            Carcinogenesis.
REFERENCE   4  (bases 1 to 1123)
  AUTHORS   Lott,A., Oroz,J. and Zweckstetter,M.
  TITLE     Molecular basis of the interaction of Hsp90 with its co-chaperone
            Hop
  JOURNAL   Protein Sci 29 (12), 2422-2432 (2020)
   PUBMED   33040396
  REMARK    GeneRIF: Molecular basis of the interaction of Hsp90 with its
            co-chaperone Hop.
REFERENCE   5  (bases 1 to 1123)
  AUTHORS   Hng,C.H., Camp,E., Anderson,P., Breen,J., Zannettino,A. and
            Gronthos,S.
  TITLE     HOPX regulates bone marrow-derived mesenchymal stromal cell fate
            determination via suppression of adipogenic gene pathways
  JOURNAL   Sci Rep 10 (1), 11345 (2020)
   PUBMED   32647304
  REMARK    GeneRIF: HOPX regulates bone marrow-derived mesenchymal stromal
            cell fate determination via suppression of adipogenic gene
            pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1123)
  AUTHORS   Kook,H., Lepore,J.J., Gitler,A.D., Lu,M.M., Wing-Man Yung,W.,
            Mackay,J., Zhou,R., Ferrari,V., Gruber,P. and Epstein,J.A.
  TITLE     Cardiac hypertrophy and histone deacetylase-dependent
            transcriptional repression mediated by the atypical homeodomain
            protein Hop
  JOURNAL   J Clin Invest 112 (6), 863-871 (2003)
   PUBMED   12975471
REFERENCE   7  (bases 1 to 1123)
  AUTHORS   Asanoma,K., Matsuda,T., Kondo,H., Kato,K., Kishino,T., Niikawa,N.,
            Wake,N. and Kato,H.
  TITLE     NECC1, a candidate choriocarcinoma suppressor gene that encodes a
            homeodomain consensus motif
  JOURNAL   Genomics 81 (1), 15-25 (2003)
   PUBMED   12573257
  REMARK    GeneRIF: Loss of NECC1 expression is involved in malignant
            conversion of placental trophoblasts.
REFERENCE   8  (bases 1 to 1123)
  AUTHORS   Chen,Y., Petersen,S., Pacyna-Gengelbach,M., Pietas,A. and
            Petersen,I.
  TITLE     Identification of a novel homeobox-containing gene, LAGY, which is
            downregulated in lung cancer
  JOURNAL   Oncology 64 (4), 450-458 (2003)
   PUBMED   12759545
  REMARK    GeneRIF: Gene mapping locates LAGY on chromosome 4q11-13.1. In 72
            primary lung tumors, this gene was significantly down-regulated
            compared to 9 normal lung tissue samples.
REFERENCE   9  (bases 1 to 1123)
  AUTHORS   Adu,J., Leong,F.T., Smith,N.R., Leek,J.P., Markham,A.F.,
            Robinson,P.A. and Mighell,A.J.
  TITLE     Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain
            protein, during mouse development
  JOURNAL   Mech Dev 119 Suppl 1, S43-S47 (2002)
   PUBMED   14516659
REFERENCE   10 (bases 1 to 1123)
  AUTHORS   Weaver,A.J., Sullivan,W.P., Felts,S.J., Owen,B.A. and Toft,D.O.
  TITLE     Crystal structure and activity of human p23, a heat shock protein
            90 co-chaperone
  JOURNAL   J Biol Chem 275 (30), 23045-23052 (2000)
   PUBMED   10811660
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA512059.1 and AB059408.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_032495.5.
            
            Summary: The protein encoded by this gene is a homeodomain protein
            that lacks certain conserved residues required for DNA binding. It
            was reported that choriocarcinoma cell lines and tissues failed to
            express this gene, which suggested the possible involvement of this
            gene in malignant conversion of placental trophoblasts. Studies in
            mice suggest that this protein may interact with serum response
            factor (SRF) and modulate SRF-dependent cardiac-specific gene
            expression and cardiac development. Multiple alternatively spliced
            transcript variants have been identified for this gene. [provided
            by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.124401.1,
                                           SRR5189667.283528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420433.6/ ENSP00000396275.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA512059.1         411-452
            43-1123             AB059408.1         13-1093
FEATURES             Location/Qualifiers
     source          1..1123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..1123
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /note="HOP homeobox"
                     /db_xref="GeneID:84525"
                     /db_xref="HGNC:HGNC:24961"
                     /db_xref="MIM:607275"
     exon            1..42
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /inference="alignment:Splign:2.1.0"
     exon            43..167
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..401
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /note="isoform a is encoded by transcript variant 1; not
                     expressed in choriocarcinoma clone 1; lung
                     cancer-associated Y protein; homeodomain-only protein; odd
                     homeobox protein 1"
                     /codon_start=1
                     /product="homeodomain-only protein isoform a"
                     /protein_id="NP_115884.4"
                     /db_xref="CCDS:CCDS47062.1"
                     /db_xref="GeneID:84525"
                     /db_xref="HGNC:HGNC:24961"
                     /db_xref="MIM:607275"
                     /translation="MLIFLGCYRRRLEERAGTMSAETASGPTEDQVEILEYNFNKVDK
                     HPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSEGLPSECRSVTD"
     exon            168..323
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /inference="alignment:Splign:2.1.0"
     exon            324..1123
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /note="hexamer: AATAAA"
     polyA_site      1123
                     /gene="HOPX"
                     /gene_synonym="CAMEO; HOD; HOP; LAGY; NECC1; OB1; SMAP31;
                     TOTO"
                     /note="major polyA site"
ORIGIN      
        1 gcttccaaac ccagggcttg cgcttgcctt tgcctcttcc acactaatga cagactgccc
       61 cactgagaag ggtctagcgg agcacaggtc accagctggg caacattcag aaagttagtc
      121 ttcctatgct cattttcctg ggctgttaca gaagaagact ggaagagcgc gcagggacca
      181 tgtcggcgga gaccgcgagc ggccccacag aggaccaggt ggaaatcctg gagtacaact
      241 tcaacaaggt cgacaagcac ccggattcca ccacgctgtg cctcatcgcg gccgaggcag
      301 gcctttccga ggaggagacc cagaaatggt ttaagcagcg cctggcaaag tggcggcgct
      361 cagaaggcct gccctcagag tgcagatccg tcacagacta aggagatggc aggcattgac
      421 agcttcactc catgaaggcc atctctgttt ctctcctccg cttaaccaag ctgttgtggt
      481 ttttcagcat agtgttgtat gttccattgc tagctgtcct gctgtttaac acagtgttgt
      541 attttttttc taaatgtaca taattagaaa agaaaataac aataggaagc tatgtgtatc
      601 ttctgtgtaa agcagtggct tcactggaaa aatggtgtgg ctagcatttc cctttgagtc
      661 atgatgacag atggtgtgaa aaccatctaa gtttgctttt gaccatcacc tcccagtagc
      721 aatttgcttt cataatccat ttagcaatcc aggcctctgt tgaaaagata atatgaggga
      781 gaagggaaca catttccttc tgaacttact tccctaagtc actttcctta tgtatcatct
      841 aatacaatga tggttgagtg aaaatacaga aggggtgttt gagtattcag atttcataaa
      901 acacttcctt ggaatatagc tgcattaact tggaaagaag cctgttgggc cagaagacag
      961 aaactccaac tggcaaaaaa gcaagcatct aagaaaaaaa accaccaaag ttcttgaatt
     1021 tactatattt aaatgcattg gttaagttta ttttgctaaa taaagtgaac tgctttttgt
     1081 ctctaaaatg atattctaaa taaaacctta actttttgtt gaa
//
