LOCUS       NM_032410              14348 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens hook microtubule tethering protein 3 (HOOK3), mRNA.
ACCESSION   NM_032410
VERSION     NM_032410.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 14348)
  AUTHORS   Mattera,R., Williamson,C.D., Ren,X. and Bonifacino,J.S.
  TITLE     The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate
            perinuclear distribution of AP-4 and its cargo ATG9A
  JOURNAL   Mol Biol Cell 31 (9), 963-979 (2020)
   PUBMED   32073997
REFERENCE   3  (bases 1 to 14348)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 14348)
  AUTHORS   Siddiqui,N., Zwetsloot,A.J., Bachmann,A., Roth,D., Hussain,H.,
            Brandt,J., Kaverina,I. and Straube,A.
  TITLE     PTPN21 and Hook3 relieve KIF1C autoinhibition and activate
            intracellular transport
  JOURNAL   Nat Commun 10 (1), 2693 (2019)
   PUBMED   31217419
  REMARK    GeneRIF: Study demonstrates that PTPN21 activates KIF1C by binding
            to the stalk region. This function does not require catalytic
            activity of the phosphatase, and its N-terminal FERM domain alone
            is sufficient to stimulate the transport of KIF1C cargoes in cells
            as well as increasing the landing rate of KIF1C on microtubules in
            vitro. The cargo adapter Hook3 binds KIF1C in the same region and
            activates KIF1C in a similar way.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 14348)
  AUTHORS   Simpson,F., Martin,S., Evans,T.M., Kerr,M., James,D.E.,
            Parton,R.G., Teasdale,R.D. and Wicking,C.
  TITLE     A novel hook-related protein family and the characterization of
            hook-related protein 1
  JOURNAL   Traffic 6 (6), 442-458 (2005)
   PUBMED   15882442
REFERENCE   7  (bases 1 to 14348)
  AUTHORS   Kaiser,F., Kaufmann,S.H. and Zerrahn,J.
  TITLE     IIGP, a member of the IFN inducible and microbial defense mediating
            47 kDa GTPase family, interacts with the microtubule binding
            protein hook3
  JOURNAL   J Cell Sci 117 (Pt 9), 1747-1756 (2004)
   PUBMED   15075236
REFERENCE   8  (bases 1 to 14348)
  AUTHORS   Shotland,Y., Kramer,H. and Groisman,E.A.
  TITLE     The Salmonella SpiC protein targets the mammalian Hook3 protein
            function to alter cellular trafficking
  JOURNAL   Mol Microbiol 49 (6), 1565-1576 (2003)
   PUBMED   12950921
  REMARK    GeneRIF: Salmonella SpiC targets the function of Hook3, a mammalian
            protein implicated in cellular trafficking.
REFERENCE   9  (bases 1 to 14348)
  AUTHORS   Walenta,J.H., Didier,A.J., Liu,X. and Kramer,H.
  TITLE     The Golgi-associated hook3 protein is a member of a novel family of
            microtubule-binding proteins
  JOURNAL   J Cell Biol 152 (5), 923-934 (2001)
   PUBMED   11238449
REFERENCE   10 (bases 1 to 14348)
  AUTHORS   Kramer,H. and Phistry,M.
  TITLE     Genetic analysis of hook, a gene required for endocytic trafficking
            in drosophila
  JOURNAL   Genetics 151 (2), 675-684 (1999)
   PUBMED   9927460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048304.1, BC056146.1, AC110275.13 and BM716064.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032410.3.
            
            Summary: Hook proteins are cytosolic coiled-coil proteins that
            contain conserved N-terminal domains, which attach to microtubules,
            and more divergent C-terminal domains, which mediate binding to
            organelles. The Drosophila Hook protein is a component of the
            endocytic compartment.[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.131458.1,
                                           SRR1660809.7356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307602.9/ ENSP00000305699.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BC048304.1         106-136
            32-2984             BC056146.1         1-2953
            2985-13733          AC110275.13        121369-132117
            13734-14348         BM716064.1         1-615
FEATURES             Location/Qualifiers
     source          1..14348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..14348
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /note="hook microtubule tethering protein 3"
                     /db_xref="GeneID:84376"
                     /db_xref="HGNC:HGNC:23576"
                     /db_xref="MIM:607825"
     exon            1..211
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2311
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /note="hHK3; h-hook3; hook homolog 3"
                     /codon_start=1
                     /product="protein Hook homolog 3"
                     /protein_id="NP_115786.1"
                     /db_xref="CCDS:CCDS6139.1"
                     /db_xref="GeneID:84376"
                     /db_xref="HGNC:HGNC:23576"
                     /db_xref="MIM:607825"
                     /translation="MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQV
                     LQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPD
                     VNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSK
                     ESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLA
                     ENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELE
                     KEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLR
                     RQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKL
                     DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQES
                     SDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELET
                     ENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKR
                     AIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ
                     GAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAE
                     DRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR"
     exon            212..297
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            298..370
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..421
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            422..554
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..622
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..685
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..769
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            770..933
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1074
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1276
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1387
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1475
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1545
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1686
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1774
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1809
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1892
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1993
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2098
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2170
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..14348
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14329..14334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /note="hexamer: AATAAA"
     polyA_site      14348
                     /gene="HOOK3"
                     /gene_synonym="HK3"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgctg ccagcgctgg gcgagagtcg gcggccggat ccgaggagca ggcgggcctg
       61 aggccgagtc agctgcgcgg gcccccggat cccccgacag agcggcggcg gtgtctggcc
      121 aggcggtagg cgctgcctgg ccgcggcggg gaagatgttc agcgtagagt cgctggagcg
      181 ggcggagctg tgcgagagcc tcctcacttg gatccagaca tttaatgtgg atgcaccatg
      241 ccagaccgtg gaagatttaa cgaatggggt tgtgatggcc caggttcttc aaaagataga
      301 tcctgcatat tttgatgaaa attggctaaa cagaatcaaa actgaagtag gagataattg
      361 gaggctaaag ataagcaatt taaagaaaat tttaaaagga atcttggatt ataatcatga
      421 gattttagga cagcaaatta atgactttac ccttcctgat gtgaacctta ttggggagca
      481 ttctgatgca gcagagcttg gaaggatgct tcagctcatc ttaggctgtg ctgtgaactg
      541 tgaacagaag caagagtaca tccaagccat tatgatgatg gaggaatctg ttcaacatgt
      601 tgtcatgaca gccattcaag agctgatgag taaagaatct cctgtctctg ctggaaatga
      661 tgcctatgtt gaccttgatc gtcagctgaa gaaaactaca gaggaactaa atgaagcttt
      721 gtcagcaaag gaagaaattg ctcaaagatg ccatgaactg gatatgcagg ttgcagcatt
      781 gcaggaagag aaaagtagtt tgttggcaga gaatcaggta ttaatggaaa gactcaatca
      841 atctgattct atagaagacc ctaacagtcc agcaggaaga aggcatttgc agctccagac
      901 tcaattagaa cagctccaag aagaaacatt cagactagaa gcagccaaag atgattatcg
      961 aatacgttgt gaagagttag aaaaggagat ctctgaactt cggcaacaga atgatgaact
     1021 gaccactttg gcagatgaag ctcagtctct gaaagatgag atcgacgtgc tgagacattc
     1081 ttctgataaa gtatctaaac tagaaggtca agtagaatct tataaaaaga agctagaaga
     1141 ccttggtgat ttaaggcggc aggttaaact cttagaagag aagaatacca tgtatatgca
     1201 gaatactgtc agtctagagg aagagttaag aaaggccaac gcagcgcgaa gtcaacttga
     1261 aacctacaag agacaggtag tagaactaca aaacagatta tccgaagaat caaagaaagc
     1321 agataaacta gattttgaat ataagcggct aaaagaaaaa gttgacagtc ttcaaaaaga
     1381 aaaggacagg ctgagaacag aaagggattc tctgaaggaa accattgaag agcttcgttg
     1441 tgtacaagct caagaagggc agctcacaac acaagggtta atgcctcttg gaagtcagga
     1501 gtcttcagac agtctagctg cagagattgt tacacctgaa atcagggaga aacttattcg
     1561 tcttcagcat gagaataaga tgttaaagct taaccaagaa ggttcggaca atgaaaaaat
     1621 agccttattg cagagccttc tagatgatgc aaatctacgc aagaatgaac tggagacaga
     1681 gaataggctg gtgaatcaaa gacttctgga agtacagtca caagttgaag aattacaaaa
     1741 atctttacag gatcaaggct caaaagcaga agattcagtc cttctaaaaa agaagcttga
     1801 agaacatcta gagaagctgc atgaggccaa taatgaacta cagaagaaga gagccattat
     1861 tgaagatctc gagccaagat ttaacaacag ctccttaaaa attgaagaat tacaagaagc
     1921 tttacgaaag aaagaggaag aaatgaagca aatggaagaa cgatacaaaa aatacttaga
     1981 gaaagccaaa agtgtcatcc gtactttaga tcctaaacag aatcaaggag cagcaccaga
     2041 aatacaagct cttaaaaatc agctccagga acgagaccga ctgttccact cattagagaa
     2101 agaatatgag aaaacaaaga gtcagagaga gatggaagag aaatatattg ttagtgcctg
     2161 gtacaatatg ggaatgaccc tgcataaaaa ggcagctgaa gatagactgg caagcacagg
     2221 ctcagggcag tcatttctgg cgaggcagag gcaagcgacc agcagcagaa gatcataccc
     2281 aggccacgtg cagccggcca cagcaaggta gagaagttgt gccgctcaat cacagacacc
     2341 tgcacccaca acatacttct gttacacaca agaacatttc aggaaactca gccagcttat
     2401 tttttgtttc tcttctatgt caatacttag tgtttctcat tttgaggact ttttctctct
     2461 cctgtatctt tgttttagtt tctttggttt ttattttgta gtcctttcag ttatttttaa
     2521 tgtgccaaaa atttgtacat gttcaattaa aaatgttgta taatagtgta atacttttct
     2581 ttgtatgaaa atgtcctctt cttcaaaggt ataggctttg taatgaatta gattttctgc
     2641 caataattga tatacaattt atattcttta ttgtgcctgt gtgttaccat gctaagaatg
     2701 tctttgttta aagggaatta atctttttat gatgtattaa tctgtgtttt caattgtttt
     2761 ccaagtacag ttcaaataac ttgcatattt actatacaaa atggttgaca agtgttcttt
     2821 ttgcaaagac ttgaatacat tggcagaggt gctaatcaca tcttccctaa ggcacctgga
     2881 agaattattt gaggaaaaaa tgagttttca cattgtttta taggaaatta aatttgtcca
     2941 aagatttgga gactattttt aaaacataaa tacataaaat ttcattattt cctgctatct
     3001 tgtttgctgg cagaagtgaa tgtttggtga ggttattttg ggataaatta caaaagaaaa
     3061 aaaattagac actgcattaa tttcttgttc ttttggaata tcttagtaac tgaggatcat
     3121 tttctaacaa tgtggttgac ataccttcag ttgctttcca catctaaaag agttatcttt
     3181 catatatgta caagttattg gtagtcttat ttttgggctg tttgttgact tatgccccat
     3241 ttgttttact tgttctttaa tataaaccct tccatttttt aacaattcct aacacttgat
     3301 atcttaatat cagtcactaa cattagtaac ttcttgtatg ttatattatg gcagatctct
     3361 ttacgttttt tctcacatct atctgctagt ccaggaattt gttactaaat agattttctt
     3421 ggatatttgg ttgcctcaaa gtgcttacat ttgttaacag attgtaaacc acatttattt
     3481 acattgatga atgggctgtt gaataatcat tgtaaagcac tttgtatata taaggtgcta
     3541 tataagtgtg aaatatcatt catttataaa tgaaatgcct tctaactttc catattgact
     3601 tatgtatttg gtcccaaatt atatttaagt cttttttctt gcaacgtagc ccattttttg
     3661 aaagcaaaac atttctgaaa ttaggtcatg gtttttttgt ttatttttag gttaggtcac
     3721 ttaatatagg aggatgtttt ctcatgtact tgctatttgc aagttcaggt ttcatttggt
     3781 tctttatgtt aaatacgaat aagtaacctc aaatcaagct aaatgtaatt aagaattttc
     3841 agcaactata ttcaagtgtt tgatttttaa attctttctt tctttttaat aagaaagatg
     3901 acctaaaaat cagtggtatt tgtttgtcct cagaagccgt agttgaagaa agatattaga
     3961 gtatacacag aactggagcc atacattgtg ctaatttttt acattaagta cagaagtctg
     4021 agcacagcat gaatgcttct gcctgacagg accacaaagc agcagaagtt agggataaat
     4081 ggagatagcc atgagtagaa ctgctgtagg gcttcaggag gctacgcaga cctgatcaac
     4141 tgcaaagttt ccaaagtaaa agattaaaaa ctttcagacg gttcttacct ctacccgtgt
     4201 ttcacaaata gcctgaggat ccaactattt ttaaagcaaa ttggggccag acgtggtgcc
     4261 tcacgcctgc aatctcacca tttgggagac ctaggtgggg gtggatcact tgaggtcagg
     4321 agtttgagac cagcctggcc aacatggtga aaccccatct ctactaaatt acaaaaatta
     4381 gctgggcatg gtggcatgtg gctgtaatcc cagctacttg ggaggctgag gcaggagagt
     4441 cacttgaact caggagccag agactgcagt gagctgagat cgcaccactg cattccagcc
     4501 tgggcgacag agtgagactc tgtctcaatc agtcaatcaa tcaatcaatc aaattggaat
     4561 atgagcacta accttggtaa gttaaaattt tgggaaaatt gtacctgcag aatatgatgg
     4621 atgaaaacaa cagccaggtg cagtggctca cgcgtataat cccagcactt tgggaggccg
     4681 agacaggcac atcatctgag gtcaggactt ccagaccagc ctgtccaaca tggtgaaact
     4741 ccgtctctac taaaaataca aacaattagc caggcatggt ggtgtgtgcc tgtagtccca
     4801 gctacttggg agggtgaggc aggagaattg cttgaacctg ggagacagag attgcagtga
     4861 gccgagatgg cgccattgca ccccagcctg gcgacaagag cgaaactctg tcgcaagaaa
     4921 aaaaaaaaaa aaaaaaaaaa aaaaaacagt ctgtgaacta ctcactgaat gaattttgtt
     4981 ctgtgagatg agaggttttc attttcattt tctatttaca gccccagtcc taatctccta
     5041 cccatccacc tacccagata ttttttctct atctgggttg gaaaggcccc aggcttttag
     5101 aggggagttt tacttctgac ttttttttcc ccccgagacg gagcctcgtt ccgtcaccca
     5161 ggctgtagtg ccgtggcatg atctcggctc actgcagcct ctgcctcccg ggttcaagca
     5221 attctcctgc ctcagcctcc agagtagctg ggattacagg tgcccaccac catggctggc
     5281 taatttttgt aatttagtag agatggtgtt tcaccatgtt ggccaggctg gtctcaaact
     5341 cctgacctcg tgatctaccc acctcggcct cccaaagtgc tgagattaca ggcacgagcc
     5401 accgcgccca gtcgtacttc tgacttttct tcagcatctg ttgtatgcta ttattttgat
     5461 gtttacattt ataattttct ttcttttttt tttttttgtg agatgatgtc tcgctctgtc
     5521 acccaggctg gagtgcagtg gcgcgatctc ggctcactgc aagctccgcc tcccgggttc
     5581 acgccattct cctgcctcag cctcctgagt agcggggact acaggcgccc gccactacgc
     5641 ccgactaatt ttttgtattt tttagtagag acggggtttc accatgttag ccaggatggt
     5701 ctcgatctcc tgacctcgtg atccacccgc ctcagcctcc cagagtgctg ggattacagg
     5761 cgtgagccac cgcgcccagc ctacatttat aattttcatt ctcttttacc tataaaattc
     5821 agtgtattag tttcattaca taggagaaat tatatttcta aacattttat gatgtttaaa
     5881 aacaaaacag gctgttgtaa aaaaaaaaaa aaaaaaaact tctgaatata ctttaggtat
     5941 cagaaagcca agaataaaat ttagctctaa cggtggcaac tccatgtccg gtgtccagct
     6001 ttggacaggg tttatgacgt ttctgtttct ctagtaatga ttaatgattc ctcaggagat
     6061 tcgtgatgtt gtctggtcta tctggaaatt taaagtcact aggagctttg cctcatcgtg
     6121 agtgatgctg tgctgtattt ttacaaactc tcgcatacag caccttcctg gggccacgtt
     6181 ggcttgtgca gtggagcttg tccaggcacc agcatggagc aagtacaggg ttgctgtgtt
     6241 gggttggagc acactgtcac cacagtgtct gaagtcttat aaacaggaag atcattttct
     6301 gttttccttc taaccagggt gagaaaatac aaagtaaaga actaaagaat attaaaacct
     6361 agcatttatg ttccacagtg tgtatttcag aagtttgtaa tccagaaaat atagtagtgt
     6421 ataatatctg aaaagagaat caagtataca attgtacata tttttaaaga actttgaaaa
     6481 actccgtcat atcttttacc atttgtctat ttgatagtaa tgcagaaaaa agtccctaaa
     6541 gaccctgtgt tccaaaattt accaagattg acatttctat tagacatcct taacctaagt
     6601 gttttaatta gattattaga ctataataag gatgaaattg ctgtctgtaa ttttgttgag
     6661 gttttattgt taatataata aaagctcaac tgtacaaaat taagctaaat gttatccagt
     6721 cagaaacatc agcctgtggc caggtgcggt ggctcacgcc tgtaatccca gcactttggg
     6781 aggccaaggc aggcggatca cctgaggtca ggagttcaag accagcctgg ctaatatggt
     6841 gaaaccccat ctctactaaa aatacagtat tagccaggca tggtggcagg cgcctgtgat
     6901 cccagctact tgggaggctg aggcaggaga atcatgtgaa cccaggaggt ggaggttgca
     6961 gtaagccgag attgtgccac tgcactccag cctgggccac agagtgagac tccatctcaa
     7021 aaaaaaaaaa aaaaaaaaaa agaaacatca gcctgtatat tccagtagtt ctcacagaag
     7081 aatgaaaatc cgtgctgtgc aaatagatca gtagtgagtg agtgttaagt gaaagatgag
     7141 ctaggttgaa gaaaatatac attttattga tgagccactt tgctatctct ccttccttcc
     7201 tccttccttc cttccttcct tccttccttc cttcccttct tttctttttt cttttctttt
     7261 cttttctccc tcctttcttc cttcccttcc cttcccctcc cctcccccag gctggagtgc
     7321 agaggcacga tcctggctga ctgcaaactc tgcctaccag gttcaagcga ttctcctgcc
     7381 tcatcctccc tagtagctag gattacaggc atctgccacc acgcccagct aatttttgta
     7441 tttttacaaa atacaaagag acggggtttc accatgttgg ccaggctggt ctctaactcc
     7501 tgacctcagg tgatccgtcc accttggcct cccaaagtgc tgggattaca ggcgtgtgtt
     7561 actgccccag cctcctattt ccttttcgaa agtagcagtt tggtttattc tcgtttgcta
     7621 agtaattgtt tgaaatattt ttcagcctct cctgctccct cacaaaaatt cacctgtcat
     7681 tttaatgata acagcatgtt aaaaacttgg aagtctttat cccaatataa gaattatctt
     7741 gaaacaaaaa tctaaattac ttttaaaaat tctcttaact ctgcatttag tctcctatta
     7801 tctagatctc tgagtccagg ataactccag ttatccccag ttggatcatg tgtgatttat
     7861 ctgagaaagc atccacaacc cacagctagt ggaaaccgag ctagtttaca gccacgtgga
     7921 taagaacatc tttgtttcta aagtgagagg aaagtgcttg gtatcttgct ttttgctgag
     7981 ggcaaaataa caacatgaag acaaagtgct ttttgttgtc tattcatgaa actgtagaag
     8041 aatattttga gtttttattc ttatattatg aagggattct ttgcctagca gtggccgtca
     8101 aactgatgta gcattgtact tctcaacagt gaagcctgtg taataccata cagtaggatg
     8161 aaagactatt ctgagcaaaa tcaaatggga tgtcagaatc tttgaaaatt attttatcat
     8221 tttttctatt ttttcatttt tataaattag aaggattttc cattcaataa ggataatctc
     8281 tcttcctatc attctgtcaa aatggcagtt tcttttggta attatccaac ctagtttcat
     8341 tacatttaga aggaggtttc agagcttatt cttgataact ataataatga tttgaatgtt
     8401 ttatatcatg aagttttttc tatgaggaag gctattctca atgtatctgt cgtctaattt
     8461 tttattttct atctataaag aatatttaaa taataattgg tgtatgttcc ttttgttgaa
     8521 aatgttttat tgtccagttt taacacagaa gtggtctaaa gttttgcagc aaatgctgtt
     8581 cagttcccag aagcctaaaa aacataacat aatatgctaa cagagctaat ttccacccaa
     8641 tccctcaaat taccgaagta ttaatattta gcttcctttc tagaaaacaa ggggcagcac
     8701 aaatggggtg gcatccatct cttttaaatc actgatgatt ttctggggaa gtatatatag
     8761 atgattttat tttttaaata gccttttatc aaaccatttc acatgtatta tctatatgac
     8821 tatagaaact tataaaacat ttaattcatg ttgacttaaa acatgggcat ccttggattc
     8881 tccacattga ctgaaatgat agagaaaggg acatttgttt gagaaacaag agacctgtac
     8941 ctaattatgg caagtatatg agttttggtg attgtggggg gttataaatg ttttcctatg
     9001 atagataaat atatagatat agatcaggaa ttacttgatg tctcttcaga agttttctgt
     9061 tttcttataa tttccagtaa tactctgtaa gactcggttt gcatgctgtg tgtgtttgca
     9121 tgagtataga aacctaagaa cataatggaa ggctattaag gcaaattcat tcctagaaag
     9181 tggagtggat cattgggata agaaatagcc taattataaa caaatatgca ggcagaggga
     9241 agtcctaata caatgaaaac ttgcattatc taaacagatg ttcccaaagc aatagtttgc
     9301 ctaaaatcct ctgtattaca tgattattca gtaaaagagt aaacaaatat ctaatttatt
     9361 ttctaattgt ccttcccttc attgagtatt aactaggtgc ataatgtagt tgtatatgtt
     9421 tactagtaaa gggaaaaaca cttattttca ttttgagact gtttggctat tactaaagct
     9481 gagaaagtga ttttaggtcg ccaaggatac tatgatttga tgagatgaga agaaatctgc
     9541 ggtggctgaa aatcgtgacc aacttggtgt tatctagatc tgctttatct agtttgcaag
     9601 ccataggctc aattttatgt ccttcttact tacacacagt agccccacac agttttgttt
     9661 taaatgaagg caaaagtaga catttttaaa gtatattcaa cattgtgcca ttatttacct
     9721 gataaaggtg aaatcagagg tgtccacggc ctcaaagttt gggcccatgg gactatcaaa
     9781 tccgaattat atctacttag agcttagagg aagaattagg tatcatgaga aaagcaactc
     9841 ctacttgaga gaaagaagac taccaaagca tgttgaggct ttaacatggg agacttccag
     9901 gtaggcgtta acacttgagt ggtaactagc ttgatgaagg aaaataatta ctttagcagt
     9961 tatgttgtaa aattaataaa aaggactcat gtttattctg gtgtatttgt caacccatgg
    10021 gtagtgatta ctccgtgtac attctatagt gtgtgtattt tatttagtgt cttaatatat
    10081 agtctttata tagtatctta atattattta ctgttacttc tagtcattta tgtagtatat
    10141 tttactgcaa aatttgtagc actttactaa tattagatca ttattttccc tcttcccctc
    10201 tacctttctg gcattttctg ttatcttaga gtcaggaatc taaaggtcta agtctagaaa
    10261 tctgttggaa gctgggttgg agctactgga tatgagttac tttttacatg tctccttaag
    10321 aagactcttt tataatgtaa tacttagaag ccaaatcctt tcaaacgcaa acacccttga
    10381 aacttgatgc tttctgaagt tgtattcata aaaattatcc catcttacag ttaatcagaa
    10441 gatgttctta cctttggttt gcctgcctcc tgaaacacaa acctgcagat tgcccctaac
    10501 ttcagcagtg cctccgtcac tgcatgtacc taaaagacag gaaagccaag ttctgggagc
    10561 tgtcaagtcg gaggatcagg aaaatggtgg ggaagaggtg actggaaagg caggcactaa
    10621 agatggcagg ctgcaaaagc attctgagtt cccctgtaac agataggttt tatgaactca
    10681 gctgttttct tttttctttt tttttctttt gagatggagt ctcactctga gtctcactct
    10741 gttgcccagg ctggagtgca gtggcacaat ctcagctcac tgcagcctcc acctcccggt
    10801 ttcaagtgat tctcccacct cagcctcccg agtagttagg attacaggtg cccaccacca
    10861 cgcccaacta atttttgtat ttttagtaaa gacagggtgt cgccatattg gctaggctgg
    10921 ttttgaactc ctgacctcag gtaatccacc cgcctcagcc tcccaaagtg ctgggattat
    10981 tataggcgtg agccaccatg cccagtgaac ttggccattt tcttacattc atatatagca
    11041 aagttttcaa cttgtctacc gagagacttt ctttaggagc caggacttct acatttgtaa
    11101 cttgagtata ttaatattca aatcatagtt caaaaatact gaaatacttg tttattatgt
    11161 tacataaata tggacacaat tactgccaaa gaatagagag atttgcttat gagaacattc
    11221 tgtcatttgt tctgtttgta gatgagagac atgcttttaa agtacaaaac gtttctcttc
    11281 taccttaccc cctgttctac tgacgtgctt tgcatgagaa gctcatctag aagagagcaa
    11341 cgctggaata gagaagtcta gaccctggcc tttgagggaa aggactgctt tttttctctc
    11401 ccaaattaga aaattaaaag tgaaacataa cacataagga cgaaatacaa tgttctgaat
    11461 atcttccact aattaattgt tgaatgatta agtctctaag tatcttaact tccattgtct
    11521 tcttgttaac ctagacaaga gtagattatt cagtagccac atgtgacagt taaaattaag
    11581 taaaattaaa actatagttt ctcagtggcc tagccacatt tcaagtgttc cacagtcaca
    11641 tgtggatagt agttacctat cagacagtac aggtatagaa catttccagt attgccaaaa
    11701 atgctattca acagcacttt tattgcccag agagaaaata aggacaaaat aaaggcagtg
    11761 aagtaactta agacaactct gagattttac caccatactt agagaaagtt tttctgttat
    11821 aaaaattaat actaatcctt tttaaagacc ttggaaaaaa tcaaaacccc attcctttaa
    11881 gctagtcttc agtatatatt tttctaagaa cagattctca atactttatt tttcaagtga
    11941 taaaatcatt ttataaatca tttcttaata tcttcagtgt tttttccctt tttatgtaaa
    12001 ctcttttaaa attgatatta gctgggcatg gtagctcatg cctgtagtcc cagctactcc
    12061 agaggtcgag gcaggagcat cgcttaagcc caggaggttc aggctgcagt aaggtctgat
    12121 cacacctgac tgcactccag cctgggtggc aaagcaagac ccctgtctct aaaaaaaaat
    12181 aatataaatt gatgttatat agttaacatt tatcaggcaa attcatatga atgcttattt
    12241 caaataaaga ttgatagatt taatgatatc cttcctttta aatttatata gatctaatga
    12301 acattgccaa cagttttttt tgtttctgtc ccttaaacat ttcccctgaa agtccacctc
    12361 aaaggtacat caagatgcaa acaatttttt tatcttcata acttcctgct cttattaact
    12421 tgtattatga atcaaattaa gttttatgta taaggcattt actattccag tgacttagct
    12481 aatgaaaaca tttaaaaata tgtattaatt tacttggcct gctactaaag tgcttaacat
    12541 aactaaatgg atctatagta acatgtctaa attttttaat ggaaataagg gactaaccat
    12601 aatccttttg agtcagcttg gtgcttacaa ttattttgtt aggaaatctt gatgctttct
    12661 tctttctctt taaatttttg taatcaagca acagacttga tccagcagtg tcgaattcca
    12721 agcaagttat gatgattctt attgtagttc aagtacagat gagtaagtgg tgtgacttca
    12781 gtttattatc ttcttggtga cctactttag tatgtgttct gtagcgattc atattagtta
    12841 agggacgttt tcaatatgct tgaaataaga aatagcattt tactctaaat acaagaaatg
    12901 actgtacaca aatgctaatc agtgatttgg ggccttttaa tgtctttaac agcaatcttt
    12961 tatttattta tttatttatt tttgagacgg agtcttgctg tgtcaccagg ctggagcagt
    13021 ggcacgatct cgcctcactg caacctccgc ctcccaggtt caagctattc tcctgcctca
    13081 gcctcccaag taactgggac tgcaggcaca tgccaccaca tccagctaat ttttgtattt
    13141 ttagtagaga cggggtttca ccttgttggc caggatgatc tcgatctctt gatctcgtga
    13201 tctgcccgca ttggcctcct gaagtgctgg gattacaggc atgagccact gcgcccggcc
    13261 caaatctttt attttttaac agccttagtt atttataatt caaatgcact aaaatatcat
    13321 cgctgtcatg aactttgctg tttacaggtt ctgtgtaatt cagaatgctt tgtacttaga
    13381 aaataatttc taggcttatc ttgttttgca gttttcatgt tttgacaatt gcccaccatt
    13441 tacaatactc aatttttgat tatgaaatga atagtaaaat tcaaacatat ctaataataa
    13501 tttgccttag tttgattaat aaattatatc aaaaaacttg gggatagaaa gaggcttttt
    13561 tttccccctg tagtattttt aaaacttttt agatgagctg gatgaaacct tagtacattg
    13621 gagctggagt tgtattgagt acagccccaa ctctgaagcc ttatattcat gtcttaagta
    13681 ccattgattg ttctgtgaat tgttgttagt ttcatatttg acattgtagt aatccacctt
    13741 gcattttagt ctttgcaaaa aggatattgc taggtatatt cttatttctg attgagtatt
    13801 gaatttacat ttttcagaat ttcattcttt gtcattataa tccaaaaaca atgtccacat
    13861 cagacttgga acttctcact tcaaaaatga aatacagatt tagcagtgtt gtacataatg
    13921 atgtccaagc atttttccac ctgtttactg agttttccaa ccatttacta tgtgttgaga
    13981 ttggtgggtt ttctggctgt ttttctgagg tgaatgactt gttacagagc ctcagtaaga
    14041 aatttcaact aaaatcacaa aaacataaag tccaggaaac caccagaaga tggattttta
    14101 gtgtttttga aatcttgtat ttccttttga tatcatttac tcattttaat tttacgactg
    14161 ccaacttgtt acggtattaa ttatatgtat gtgtttatat gtatgcatat aatatatgta
    14221 tatgtatatg aagaataaag ttaagatttg gtcaaactat attttcccat tcaagtacaa
    14281 aaatgttttc aaggctgcaa aaagtgtaca gttgttaaac aagttgtaaa taaagacttg
    14341 tataaaaa
//
