LOCUS       NM_013312               2542 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens hook microtubule tethering protein 2 (HOOK2),
            transcript variant 1, mRNA.
ACCESSION   NM_013312
VERSION     NM_013312.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Christensen,J.R., Kendrick,A.A., Truong,J.B., Aguilar-Maldonado,A.,
            Adani,V., Dzieciatkowska,M. and Reck-Peterson,S.L.
  TITLE     Cytoplasmic dynein-1 cargo diversity is mediated by the
            combinatorial assembly of FTS-Hook-FHIP complexes
  JOURNAL   Elife 10, e74538 (2021)
   PUBMED   34882091
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Qiao,C., Jia,H., Zhang,H., Wang,H., Liang,J., Song,J., Li,L.,
            Duan,X., Cao,K. and Hu,J.
  TITLE     Coding Variants in HOOK2 and GTPBP3 May Contribute to Risk of
            Primary Angle Closure Glaucoma
  JOURNAL   DNA Cell Biol 39 (6), 949-957 (2020)
   PUBMED   32397755
  REMARK    GeneRIF: Coding Variants in HOOK2 and GTPBP3 May Contribute to Risk
            of Primary Angle Closure Glaucoma
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Mattera,R., Williamson,C.D., Ren,X. and Bonifacino,J.S.
  TITLE     The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate
            perinuclear distribution of AP-4 and its cargo ATG9A
  JOURNAL   Mol Biol Cell 31 (9), 963-979 (2020)
   PUBMED   32073997
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2542)
  AUTHORS   Szebenyi,G., Wigley,W.C., Hall,B., Didier,A., Yu,M., Thomas,P. and
            Kramer,H.
  TITLE     Hook2 contributes to aggresome formation
  JOURNAL   BMC Cell Biol 8, 19 (2007)
   PUBMED   17540036
  REMARK    GeneRIF: Hook2 contributes to the establishment and maintenance of
            the pericentrosomal localization of aggresomes by promoting the
            microtubule-based delivery of protein aggregates to pericentriolar
            aggresomes.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2542)
  AUTHORS   Szebenyi,G., Hall,B., Yu,R., Hashim,A.I. and Kramer,H.
  TITLE     Hook2 localizes to the centrosome, binds directly to
            centriolin/CEP110 and contributes to centrosomal function
  JOURNAL   Traffic 8 (1), 32-46 (2007)
   PUBMED   17140400
REFERENCE   8  (bases 1 to 2542)
  AUTHORS   Simpson,F., Martin,S., Evans,T.M., Kerr,M., James,D.E.,
            Parton,R.G., Teasdale,R.D. and Wicking,C.
  TITLE     A novel hook-related protein family and the characterization of
            hook-related protein 1
  JOURNAL   Traffic 6 (6), 442-458 (2005)
   PUBMED   15882442
REFERENCE   9  (bases 1 to 2542)
  AUTHORS   Walenta,J.H., Didier,A.J., Liu,X. and Kramer,H.
  TITLE     The Golgi-associated hook3 protein is a member of a novel family of
            microtubule-binding proteins
  JOURNAL   J Cell Biol 152 (5), 923-934 (2001)
   PUBMED   11238449
REFERENCE   10 (bases 1 to 2542)
  AUTHORS   Kramer,H. and Phistry,M.
  TITLE     Genetic analysis of hook, a gene required for endocytic trafficking
            in drosophila
  JOURNAL   Genetics 151 (2), 675-684 (1999)
   PUBMED   9927460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB474423.1, AF044924.1 and BC012443.1.
            
            On Jun 2, 2019 this sequence version replaced NM_013312.2.
            
            Summary: Hook proteins are cytosolic coiled-coil proteins that
            contain conserved N-terminal domains, which attach to microtubules,
            and more divergent C-terminal domains, which mediate binding to
            organelles. The Drosophila Hook protein is a component of the
            endocytic compartment.[supplied by OMIM, Apr 2004].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF044924.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397668.8/ ENSP00000380785.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DB474423.1         69-97
            30-1229             AF044924.1         1-1200
            1230-1566           BC012443.1         1221-1557
            1567-2542           AF044924.1         1538-2513
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..2542
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /note="hook microtubule tethering protein 2"
                     /db_xref="GeneID:29911"
                     /db_xref="HGNC:HGNC:19885"
                     /db_xref="MIM:607824"
     exon            1..148
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2263
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Hook homolog 2; hHK2; h-hook2; hook homolog 2"
                     /codon_start=1
                     /product="protein Hook homolog 2 isoform 1"
                     /protein_id="NP_037444.2"
                     /db_xref="CCDS:CCDS42508.1"
                     /db_xref="GeneID:29911"
                     /db_xref="HGNC:HGNC:19885"
                     /db_xref="MIM:607824"
                     /translation="MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQI
                     DPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLI
                     GEFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPD
                     SLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGL
                     RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAEL
                     QHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQL
                     EERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRN
                     LEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA
                     EILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ
                     QLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEE
                     LEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGA
                     PPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEER
                     APAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH"
     exon            149..234
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..307
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..358
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..491
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..559
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..622
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..703
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..864
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1005
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1207
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1318
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1406
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1476
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1614
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1702
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1708
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1743
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1826
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1930
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2041
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2113
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2542
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2523..2528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /note="hexamer: AATAAA"
     polyA_site      2542
                     /gene="HOOK2"
                     /gene_synonym="HK2"
                     /note="major polyA site"
ORIGIN      
        1 aggccgagcg ggaggtcggg gctgcgggcg ctcgctggtg gcggacccgg aggctgctgc
       61 ggcgccgggg ctccgtggcc tggattgaat ccgatcggga gccatgagcg tggacaaagc
      121 tgagctatgc gggtctctgc tcacctggtt acagacgttc cacgttccgt ctccctgtgc
      181 cagccctcag gacctgagca gcggccttgc cgtagcctat gtgctgaacc agatagaccc
      241 ctcctggttc aacgaggcat ggctccaggg catctcggaa gatccaggtc ccaactggaa
      301 gctgaaggtc agcaatctga agatggtctt acggagccta gtagagtact cccaggatgt
      361 cctggcgcat cctgtgtcag aagagcatct cccagatgtg agcctcattg gagagttctc
      421 agacccggca gagctcggca agctgcttca gctggtgctg ggctgtgcca tcagttgcga
      481 gaaaaagcag gaccacatcc agagaatcat gacgctggaa gaatcggttc agcatgtggt
      541 gatggaagcc atccaagagc tcatgaccaa agacactcct gactccctgt caccagagac
      601 gtatggcaac tttgacagcc agtcccgcag gtactatttc ctaagtgagg aggctgagga
      661 gggggacgaa ttacagcagc gctgtctgga tctggagcgg cagctgatgc tcctgtcaga
      721 ggagaagcag agcctggcgc aagagaatgc agggctgcgg gagcggatgg gccggcctga
      781 aggcgagggt accccaggtc tcactgccaa gaagctgctg ctgctgcaat cccagctgga
      841 gcagttgcag gaggagaact tcaggctgga gagtggcagg gaggatgagc gcctgcgctg
      901 tgccgagctg gagagggagg ttgcggagct gcagcaccgg aaccaggcgc tgactagcct
      961 ggcccaggag gcacaggccc tgaaggatga gatggatgaa ctacggcagt cttcggagcg
     1021 tgctgggcag ctggaggcca cgctgaccag ttgccggcgc cgcttgggcg agctgaggga
     1081 gctgcggcgg caggtgcggc agctggagga acgcaacgcc ggccacgccg agcgcacgcg
     1141 acaactggag gatgagctac gccgagcggg ctccctgcgc gcccagctgg aggcgcagcg
     1201 gcggcaggtg caggaactgc agggccagcg gcaggaggag gccatgaagg ccgagaaatg
     1261 gctatttgaa tgccgcaacc tggaggaaaa gtatgagtcg gtgacaaagg agaaggagcg
     1321 gctgttggcg gagcgggact ccttgcggga ggccaatgag gagctgcgct gcgcccagct
     1381 gcagccgcgg gggttgaccc aggccgatcc ctcactggat cccacctcca cacccgtgga
     1441 taacttagcc gcagagatcc tgcctgcgga gctcagggag acgctcctgc ggcttcagct
     1501 ggagaacaag cggctgtgca ggcaggaggc ggccgaccgg gagcggcagg aggagctgca
     1561 gcgccacctg gaggatgcca accgcgcgcg ccacgggttg gagacgcagc accggctgaa
     1621 ccagcagcag ctatccgagc tgcgggccca ggtggaggac ctgcagaaag ccctgcagga
     1681 gcaggggggc aagactgaag atgccatttc cattttgctg aaaaggaagc tggaggaaca
     1741 tttgcagaag cttcatgagg cagatctgga gttgcagagg aagcgggagt acattgagga
     1801 gctggagcca cccactgaca gcagcacagc ccggcggatc gaggagctgc agcataactt
     1861 gcagaagaag gacgcggact tgcgggccat ggaggagcga taccgccgct acgtggacaa
     1921 ggcccgcatg gtcatgcaga ccatggaacc caagcagcgg ccagctgcgg gggcacctcc
     1981 agaactccat tccctgagga cacagctccg agaacgggat gtccgcatcc gacacctgga
     2041 gatggacttt gagaaaagcc gaagtcagcg ggagcaggaa gaaaagctgc tcatcagtgc
     2101 ctggtataat atgggcatgg ccttgcagca gcgagctggg gaggagcggg cgcctgccca
     2161 tgcccagtca ttcctggcac agcagcggct ggcaaccaat tctcgccgtg gacccttggg
     2221 acgcctggca tctctgaacc ttcgccccac tgacaagcac tgacagacct cacaatcaag
     2281 ccagcctggg ctccacccac cctggcttcc tccagctcac atggcgccca gcactgggct
     2341 tcagccaggt gctcgagagc tttgaggcca tgatctctgc tcttccctct cccagattgg
     2401 tggggaggga gggcgggagg tagatatagg cctgttcttt ttagcaatgt gattcttgtt
     2461 gttgattctc tctctggagt tcatgtgctg cctcaggaga ctctgatttt atatttgaga
     2521 aaaataaagg cgttcaatct gc
//
