LOCUS       NM_015888               5713 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens hook microtubule tethering protein 1 (HOOK1), mRNA.
ACCESSION   NM_015888
VERSION     NM_015888.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5713)
  AUTHORS   Suarez-Martinez,E., Piersma,S.R., Pham,T.V., Bijnsdorp,I.V.,
            Jimenez,C.R. and Carnero,A.
  TITLE     Protein homeostasis maintained by HOOK1 levels promotes the
            tumorigenic and stemness properties of ovarian cancer cells through
            reticulum stress and autophagy
  JOURNAL   J Exp Clin Cancer Res 43 (1), 150 (2024)
   PUBMED   38807192
  REMARK    GeneRIF: Protein homeostasis maintained by HOOK1 levels promotes
            the tumorigenic and stemness properties of ovarian cancer cells
            through reticulum stress and autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5713)
  AUTHORS   Yin,L., Li,W., Chen,X., Wang,R., Zhang,T., Meng,J., Li,Z., Xu,L.,
            Yin,R., Cheng,B. and Yang,H.
  TITLE     HOOK1 Inhibits the Progression of Renal Cell Carcinoma via TGF-beta
            and TNFSF13B/VEGF-A Axis
  JOURNAL   Adv Sci (Weinh) 10 (17), e2206955 (2023)
   PUBMED   37085921
  REMARK    GeneRIF: HOOK1 Inhibits the Progression of Renal Cell Carcinoma via
            TGF-beta and TNFSF13B/VEGF-A Axis.
REFERENCE   3  (bases 1 to 5713)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5713)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5713)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5713)
  AUTHORS   Weimer,J.M., Chattopadhyay,S., Custer,A.W. and Pearce,D.A.
  TITLE     Elevation of Hook1 in a disease model of Batten disease does not
            affect a novel interaction between Ankyrin G and Hook1
  JOURNAL   Biochem Biophys Res Commun 330 (4), 1176-1181 (2005)
   PUBMED   15823567
REFERENCE   7  (bases 1 to 5713)
  AUTHORS   Luiro,K., Yliannala,K., Ahtiainen,L., Maunu,H., Jarvela,I.,
            Kyttala,A. and Jalanko,A.
  TITLE     Interconnections of CLN3, Hook1 and Rab proteins link Batten
            disease to defects in the endocytic pathway
  JOURNAL   Hum Mol Genet 13 (23), 3017-3027 (2004)
   PUBMED   15471887
  REMARK    GeneRIF: novel interactions between the microtubule-binding Hook1
            and the large family of Rab GTPases also suggest a link between
            CLN3 function, microtubule cytoskeleton and endocytic membrane
            trafficking
REFERENCE   8  (bases 1 to 5713)
  AUTHORS   Mendoza-Lujambio,I., Burfeind,P., Dixkens,C., Meinhardt,A.,
            Hoyer-Fender,S., Engel,W. and Neesen,J.
  TITLE     The Hook1 gene is non-functional in the abnormal spermatozoon head
            shape (azh) mutant mouse
  JOURNAL   Hum Mol Genet 11 (14), 1647-1658 (2002)
   PUBMED   12075009
REFERENCE   9  (bases 1 to 5713)
  AUTHORS   Walenta,J.H., Didier,A.J., Liu,X. and Kramer,H.
  TITLE     The Golgi-associated hook3 protein is a member of a novel family of
            microtubule-binding proteins
  JOURNAL   J Cell Biol 152 (5), 923-934 (2001)
   PUBMED   11238449
REFERENCE   10 (bases 1 to 5713)
  AUTHORS   Kramer,H. and Phistry,M.
  TITLE     Genetic analysis of hook, a gene required for endocytic trafficking
            in drosophila
  JOURNAL   Genetics 151 (2), 675-684 (1999)
   PUBMED   9927460
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035416.7 and AC113175.2.
            
            On Aug 31, 2019 this sequence version replaced NM_015888.5.
            
            Summary: This gene encodes a member of the hook family of
            coiled-coil proteins, which bind to microtubules and organelles
            through their N- and C-terminal domains, respectively. The encoded
            protein localizes to discrete punctuate subcellular structures, and
            interacts with several members of the Rab GTPase family involved in
            endocytosis. It is thought to link endocytic membrane trafficking
            to the microtubule cytoskeleton. Several alternatively spliced
            transcript variants have been identified, but the full-length
            nature of some of these variants has not been determined. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011621.2, AF044923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371208.5/ ENSP00000360252.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AL035416.7         50090-50321         c
            233-318             AL035416.7         43327-43412         c
            319-391             AL035416.7         36418-36490         c
            392-442             AC113175.2         1020-1070
            443-575             AC113175.2         2262-2394
            576-643             AC113175.2         4202-4269
            644-706             AC113175.2         5730-5792
            707-790             AC113175.2         9165-9248
            791-957             AC113175.2         12289-12455
            958-1098            AC113175.2         15902-16042
            1099-1300           AC113175.2         17172-17373
            1301-1411           AC113175.2         17930-18040
            1412-1499           AC113175.2         27285-27372
            1500-1560           AC113175.2         27842-27902
            1561-1701           AC113175.2         29045-29185
            1702-1795           AC113175.2         31641-31734
            1796-1830           AC113175.2         33489-33523
            1831-1913           AC113175.2         34020-34102
            1914-2014           AC113175.2         34729-34829
            2015-2116           AC113175.2         37107-37208
            2117-2185           AC113175.2         39899-39967
            2186-5713           AC113175.2         41652-45179
FEATURES             Location/Qualifiers
     source          1..5713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.1"
     gene            1..5713
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /note="hook microtubule tethering protein 1"
                     /db_xref="GeneID:51361"
                     /db_xref="HGNC:HGNC:19884"
                     /db_xref="MIM:607820"
     exon            1..232
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2356
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /note="hook homolog 1; hHK1; h-hook1"
                     /codon_start=1
                     /product="protein Hook homolog 1"
                     /protein_id="NP_056972.1"
                     /db_xref="CCDS:CCDS612.1"
                     /db_xref="GeneID:51361"
                     /db_xref="HGNC:HGNC:19884"
                     /db_xref="MIM:607820"
                     /translation="MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMA
                     QVLHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALI
                     PDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELM
                     SKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSL
                     VSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCE
                     ELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLN
                     DLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRA
                     DTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKS
                     YENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELET
                     EQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQK
                     KQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKL
                     NPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWYNKSLAFQKLGME
                     SRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKVPATTSD"
     exon            233..318
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..391
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..442
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..575
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..643
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..706
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..790
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..957
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1098
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1300
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1411
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1499
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1560
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1701
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1795
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1830
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1913
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2014
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2116
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2185
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..5713
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /note="hexamer: AATAAA"
     polyA_site      2974
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /note="major polyA site"
     regulatory      4407..4412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /note="hexamer: AATAAA"
     polyA_site      4429
                     /gene="HOOK1"
                     /gene_synonym="HK1"
     regulatory      5691..5696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /note="hexamer: AATAAA"
     polyA_site      5713
                     /gene="HOOK1"
                     /gene_synonym="HK1"
                     /note="major polyA site"
ORIGIN      
        1 gtgacgccgg acgcgtcgac agcgcgaggg ttcgcgcgtg agctgcgcgg gtcgggcctg
       61 gtaccgagct ttcctggggg ctagcaggtc gtggacgccg gctcctggag gagagccggt
      121 aggagggagt gtgaaggtgt ccgcggcgtc gtcgacggcg gcgccggcca tggaggagac
      181 gcagccgccg ccgcagccta agctgcccct gtgcgacagc ctcatgatct ggctgcagac
      241 attcaatact gcctcacctt gtcaagatgt caaacagctg actagtggag ttgccatggc
      301 acaagttctt catcaaattg atgcagcttg gtttaacgaa tcttggttaa gccgaattaa
      361 agaggatgtt ggggacaact ggagaataaa ggccagtaat gtaaagaagg tccttcaagg
      421 aattatgagt tattatcatg agtttttggg gcagcagatt tcagaagcac ttatccctga
      481 tttaaaccaa ataaccgaat gttcagatcc agtggagctt gggaggttgc tccagcttat
      541 tttaggttgt gcgatcaact gtgaaaagaa gcaagaacat attcaaaata taatgacact
      601 ggaagagtct gttcaacatg tggtcatgac tgctattcaa gagttgatga gtaaagaaat
      661 attgagctct cctccaaatg atgctgttgg agaattggag caacagctta aaagagcctt
      721 ggaagaactt caggaagcac tagcagaaaa agaagagctg aggcaaagat gtgaagaatt
      781 ggatatgcag gtgactacac ttcaagatga aaagaattca ctggtttctg aaaatgagat
      841 gatgaatgaa aaacttgacc agttggatgg ctcttttgat gatccaaaca cagtggttgc
      901 aaaaaagtat tttcatgcac aattacaact agaacaatta caggaagaaa acttcaggct
      961 tgaagctgca aaagatgatt accgtgttca ctgtgaagaa cttgaaaagc agctaatcga
     1021 attccagcat aggaatgatg aattgactag tcttgcagaa gaaacaagag ccctgaaaga
     1081 tgaaatagat gttcttaggg ctacctctga taaagcaaat aaactggagt caacagttga
     1141 gatatatcgt cagaagctac aagatctgaa tgaccttcgc aagcaggtga aaactttaca
     1201 ggaaaccaac atgatgtata tgcataatac agtcagctta gaagaagaat taaaaaaagc
     1261 aaatgcagca cgtacacaat tagaaacata caaaaggcag gttcaagatc ttcatgttaa
     1321 actttcctcc gaatccaaga gggcagacac actagcgttt gaaatgaagc ggcttgaaga
     1381 aaaacatgaa gctttactta aggaaaaaga gagactaatt gagcagcgtg atactttgaa
     1441 agaaacaaat gaagagcttc gatgttcaca agtacaacag gaccacctaa accaaacaga
     1501 tgcatctgct acaaaaagtt atgagaatct tgctgctgag attatgccag tggaatatag
     1561 ggaggtgttt attcgactgc aacatgaaaa taagatgctt cgcttacagc aagaaggctc
     1621 tgagaatgaa cgtattgagg aacttcagga gcagctagaa cagaaacacc gtaaaatgaa
     1681 tgaactggaa actgagcaga ggctgagcaa agagcgtatt agagaattgc agcagcagat
     1741 tgaggacctc cagaaatctt tacaggaaca aggttccaag tctgaaggcg aaagttccag
     1801 caaattaaag cagaagttgg aagctcatat ggaaaaactc acagaggtcc atgaagaatt
     1861 acagaagaaa caagaactca ttgaagatct tcagccagat ataaatcaaa atgtacaaaa
     1921 gatcaatgaa cttgaagctg ctcttcagaa gaaagatgaa gatatgaaag caatggagga
     1981 aagatataaa atgtacttgg agaaagccag aaatgtaata aaaactttgg atcccaagtt
     2041 aaatccagca tcagctgaaa taatgctact aagaaagcag ttggcagaga aagagagaag
     2101 aattgagatt ctggagagtg aatgcaaagt agcaaaattc cgtgattatg aagaaaaact
     2161 cattgtttct gcgtggtata ataagagtct agcattccag aaactgggga tggaatctag
     2221 acttgtgagc ggcggtggtg cctgcagtga cactggtgcg tgcactcctg cgcggtcttt
     2281 cttagcgcag caacggcaca tcaccaacac cagaagaaat ctctctgtta aagtccctgc
     2341 tacaacatct gattaaactg caaaaaaaac aaaacaaaac aaaaaaacca cataaaatag
     2401 aagtgtcctt aaaatatttt gtacctttca actaactacc agattgaaaa agagtttatg
     2461 atgcgggata tcaggtattt taaaatcaac atgcatcaaa ttaattttgc cagttgactt
     2521 taaaaacaaa ttatagaatt agccatctct ctgagggagc acatttgaat aattggagat
     2581 gcagttatac acacatttca aacaaacatt tgtcttttga gagtattata atttcaaatt
     2641 ggccttgtat attttagtta aatgttttca gttgtattag taacttaatt aattttcaat
     2701 agctattcag taatacttaa tcttagaaca ttaattggat ttgtttaatc tttttttgtt
     2761 ttttgttgat ttatatgaaa acagtcttga ggcagggaca tggagaacta tgcaagggtg
     2821 atttctttga cttaatatat acaaggcttt acttctgtcc cctaattctt ccattgaatg
     2881 tgtacctcta ccttgtcatg tcatggaaga tacaacattt ggaagatctg acaattggaa
     2941 tgactttgga ataataaaat tgactaattg gaaattttgc atattctgaa aatctaatct
     3001 catagttcta atttgtacct atggcaaata agggcttctg gacatcatgt ttaaaatgtt
     3061 aagcataaga aataaactga catttgtaat aggtgacttt ctgatggaaa gcaagctata
     3121 tatatatata tatatatata tatatatata tatatacttt ttgtgaaatg tctatatact
     3181 ttttaaggta attaatgaag atttcagtta ttgcttttaa gcataaagtt gtatttagct
     3241 tctgctgaaa aattgtatca tataataatt ttgcttcatt gaaaagggat gttgcagtga
     3301 tgaaacaagg tgggatcagt ttgattttgt ttacttatta aggagtttat cttgggctca
     3361 gtttgtggta ttcagttcgt ttctgcccaa agctcttatt ttcagaggtg ttacttttga
     3421 acttttgggg tcatttttaa aagttagcac ttttgaattt tagttgtgtt aaatatgtgc
     3481 tgtcgtatat catagccatg agccatatat gacaatttaa atttaattaa ttataaactc
     3541 agtctcttgg ttgcaccagc cacatttcag atgctcaata gccacatgtg gctagtgggt
     3601 accatattgg acagggcagc tatagaatat ttccatcatt gcagaaagtt ctattggata
     3661 gtaccataat ctttttatag taacttggaa atactatttg atattagatg ttagaccaca
     3721 aaaagaagaa aaatgttagg actatttcag atataaaaag gaactgaatt gtgacataat
     3781 tagcatctta cattccatac agttgaatac cttatgctgt gacaaccata gttaatcatt
     3841 tcagtgctgt tcaacataca tacctatcag cagtgtgttt agaccagggg tctgcaaact
     3901 ttctgtgaat ggacaaagag taaatacttt agtaaatgtc ttaggctttg tggcctacat
     3961 gatctttgtt gcaagtactc aactctgcca ttatagagtt aaagcagcca tacacaatat
     4021 ataaacaaaa tgggcatagt tgtatttcag taaaacttta tttacaaaga caggcggtag
     4081 gccagatttg gcttgcatgc tgtagagctg tggtctaaat tttattcata gactttcttt
     4141 gcaaatacag tgtgagtatt gttccattta cagtattatt attttttaga tacctggttt
     4201 ttagattctt gcctggtaac tttttactga aaatacaaga atttcgtact gcatttgcat
     4261 ctccgagatt agggagcacc tgtcaggata tgttgttcta tcagggttac ttctgttgac
     4321 tacctcttag attttgatac agttatattg ttgagtttca ttttcatata ttcttgtagt
     4381 gtctgcttgc ctgtgacttc tggtaaaata aaataagcct ttgaaaatat tttagcatgg
     4441 tatttaacat tttctaaata ttatggcatt ttgacatatt ttagtcagcg aagacatctg
     4501 cccctttggt gtttctactt gcttatgatt gagattttac aagcccttca aactccgttt
     4561 taaaggaatt tattgtaaaa cattaacttt aataaattag tgttttcaca gatcagatca
     4621 ttatacttgg aacttctaaa tcatgcaatt tctgaataag gacataaggc tagattcatt
     4681 tttcttaata gagaaaaagg aaatttctga tttatcactt ttctagttga taagtaggat
     4741 tcaaaacgtt tgatatgtaa gtatttatat aagactaatg taatttaaag ttctgtatta
     4801 ttgtgattaa tcatacagaa attcaggaac tgatcagaag tgagattctt ttccacatct
     4861 ggttaatgta gtgagttgac accctgtggg tggtaaagca ttataaacat ttcatcttga
     4921 accatgattt atacacatct gtgttataag ggaggcttga gtacatatac caatgaagag
     4981 atattcagca tttgtctatt tgataaggaa ttaaatgtcc tagtgattat aaagtaaaac
     5041 cacagaccaa tttgcaaatg atcttcaatg ttaagcactt gctctaagat taaaattcct
     5101 tttcttttta aggttaaggg tgtgtacgta tggcagtgat gtctatgttg agattaactt
     5161 atgtattgag gaaaatttga agtttatttt ttcgatgaat aaggctgtca aatgatttag
     5221 tatagattaa tgacatcttt tttagaaata ttaaagtgag tattcctcat tatgtcatca
     5281 tttctgataa ttagagtgct aatttgaatg ttagataatg tttccacatc tatacctatt
     5341 tctttctagg gcacttctga ccctggggct tggggatggc ctttaggcca cagtagtgtc
     5401 tgtgttaagt tcactaaatg tgtatttaat gagaaacatt cctatgtaaa aatgtgtgta
     5461 tgtgaacgta tgcatacatt tttattgtgc acctgtacat tgtgaagaag tagtttggaa
     5521 atttgtaaag cacaaaccat aaaagagtgt ggagttatta aatgatgtag cacaaatgta
     5581 atgtttagct tataaaaggt cctttctatt ttctatggca aagactttga cacttgaaaa
     5641 ataaaaccaa tatttgattt atttttgtaa gtatttagga tattatttta aataaatgat
     5701 tgtccattat caa
//
