LOCUS       NM_020834               4986 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens homeobox and leucine zipper encoding (HOMEZ), mRNA.
ACCESSION   NM_020834 NM_001010849 XM_033391
VERSION     NM_020834.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Xuan,C., Jia,K.G., Wang,B.B., Bai,X.Y., Gao,G., Yang,Q., Wang,X.L.,
            Liu,X.C., Ma,X. and He,G.W.
  TITLE     Identification of two novel mutations of the HOMEZ gene in Chinese
            patients with isolated ventricular septal defect
  JOURNAL   Genet Test Mol Biomarkers 17 (5), 390-394 (2013)
   PUBMED   23574532
  REMARK    GeneRIF: study identified two novel heterozygous missense mutations
            in HOMEZ gene exon-2 in isolated VSD patients in the Chinese
            population and have found that these two mutations resulted in
            alteration of the hydropathicity of the HOMEZ protein
REFERENCE   4  (bases 1 to 4986)
  AUTHORS   McGregor,T.L., Misri,A., Bartlett,J., Orabona,G., Friedman,R.D.,
            Sexton,D., Maheshwari,S. and Morgan,T.M.
  TITLE     Consanguinity mapping of congenital heart disease in a South Indian
            population
  JOURNAL   PLoS One 5 (4), e10286 (2010)
   PUBMED   20422016
  REMARK    GeneRIF: no single gene of major effect could be convincingly
            identified in a sample of Indian CHD cases born to consanguineous
            parents. The possibility that noncoding regions of HOMEZ may harbor
            recessive mutations leading to CHD could not be excluded.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4986)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 4986)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 4986)
  AUTHORS   Bayarsaihan,D., Enkhmandakh,B., Makeyev,A., Greally,J.M.,
            Leckman,J.F. and Ruddle,F.H.
  TITLE     Homez, a homeobox leucine zipper gene specific to the vertebrate
            lineage
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10358-10363 (2003)
   PUBMED   12925734
REFERENCE   8  (bases 1 to 4986)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049829.4, DC398645.1, AF463523.1 and BC045733.1.
            
            On May 17, 2019 this sequence version replaced NM_020834.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.16997.1,
                                           SRR1660803.92548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2156266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357460.7/ ENSP00000350049.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL049829.4         68159-68190         c
            33-108              DC398645.1         18-93
            109-347             AF463523.1         1-239
            348-1083            BC045733.1         162-897
            1084-1787           AF463523.1         976-1679
            1788-1937           BC045733.1         1601-1750
            1938-3773           AF463523.1         1827-3662
            3774-4986           AL049829.4         54480-55692         c
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..4986
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="homeobox and leucine zipper encoding"
                     /db_xref="GeneID:57594"
                     /db_xref="HGNC:HGNC:20164"
                     /db_xref="MIM:608119"
     exon            1..220
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1833
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="homeodomain leucine zipper-containing factor"
                     /codon_start=1
                     /product="homeobox and leucine zipper protein Homez"
                     /protein_id="NP_065885.2"
                     /db_xref="CCDS:CCDS45085.1"
                     /db_xref="GeneID:57594"
                     /db_xref="HGNC:HGNC:20164"
                     /db_xref="MIM:608119"
                     /translation="MVRGWEPPPGLDCAISEGHKSEGTMPPNKEASGLSSSPAGLICL
                     PPISEELQLVWTQAAQTSELDSNEHLLKTFSYFPYPSLADIALLCLRYGLQMEKVKTW
                     FMAQRLRCGISWSSEEIEETRARVVYRRDQLHFKSLLSFTHHAGRPPEEVPPPPVPAP
                     EQVGIGIGPPTLSKPTQTKGLKVEPEEPSQMPPLPQSHQKLKESLMTPGSGAFPYQSD
                     FWQHLQSSGLSKEQAGRGPNQSHGIGTASWNHSTTVPQPQARDKPPPIALIASSCKEE
                     SASSVTPSSSSTSSSFQVLANGATAASKPLQPLGCVPQSVSPSEQALPPHLEPAWPQG
                     LRHNSVPGRVGPTEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYQKLEQI
                     TGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAIPTPPPSTRSLNERAE
                     TPPLPIPPPPPDIQPLERYWAAHQQLRETDIPQLSQASRLSTQQVLDWFDSRLPQPAE
                     VVVCLDEEEEEEEEELPEDDEEEEEEEEEDDDDDDDDVIIQD"
     exon            221..4986
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1899..1904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="hexamer: AAGAAA"
     polyA_site      1943
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="major polyA site"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="hexamer: AATAAA"
     regulatory      3346..3351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="hexamer: AATAAA"
     polyA_site      3352
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="major polyA site"
     polyA_site      3367
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="major polyA site"
     regulatory      3938..3943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="hexamer: AATAAA"
     polyA_site      3970
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
     polyA_site      3986
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
     regulatory      4067..4072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="hexamer: AATAAA"
     polyA_site      4090
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
     regulatory      4825..4830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="hexamer: ATTAAA"
     polyA_site      4850
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
ORIGIN      
        1 atccgccccg cctccaactt gctcgagcag ggctgggtag accggcgcgc tcccggggac
       61 ggtggggggg gcagtcccgg tttcggccat cgctggggtg ggctcggagc ggccgcaccg
      121 ggcagcaacc ccactcccac tcggaggccc cctgccctct cccccacttc cccccggccc
      181 atggtgcgag gctgggagcc gccgcccggg ctggactgcg ctatctctga agggcacaaa
      241 tcagaaggca ccatgcctcc taataaagag gccagcggtc tcagtagttc accagcgggg
      301 ctcatctgcc tccctccaat ctctgaggag ctacagcttg tgtggacgca agcagcccag
      361 accagtgagc tagacagcaa tgaacacctg ctcaaaacct tcagctactt tccctatccc
      421 agcctagcag acattgccct tctctgccta cgttatgggt tgcagatgga gaaagtcaag
      481 acttggttta tggcccagcg cctccgctgt ggtattagct ggtcatctga agaaatagaa
      541 gagactcgag cccgagtagt ctaccgtcgg gaccaactcc atttcaaatc ccttctctct
      601 tttactcatc atgcgggacg gcccccagag gaggtgcctc ctcctccagt gccagctcca
      661 gagcaagttg gtattggaat aggtcctcca actcttagca agcctaccca gacgaaagga
      721 ttgaaggtag agcctgagga gccctctcag atgccaccac tgccacagag tcaccagaaa
      781 ttaaaggagt ccctgatgac acctggcagt ggagcattcc cctaccaatc agatttttgg
      841 caacatcttc aaagcagtgg cctctcaaag gagcaggcag gcaggggtcc caaccagtca
      901 catggcatag gtactgcttc ctggaaccac tccacaaccg tcccccagcc acaagctcgg
      961 gataaacccc caccaattgc attaattgcc agtagttgta aggaggagtc agcatctagt
     1021 gttactccct cttcttcctc tacctcttct tctttccagg tactggctaa tggagctact
     1081 gccgcctcta aacccctcca gccactaggc tgtgtcccac agtcagtgtc acccagtgaa
     1141 caggcattac ccccacatct ggaaccagcc tggccccaag ggctacggca taactcagta
     1201 ccaggtagag ttggccccac agagtacctt tccccagata tgcaacgcca gcgaaagacc
     1261 aagcgcaaaa ccaaagagca gctggctatc cttaaatcct tttttttaca gtgccagtgg
     1321 gcacggcgtg aggattacca aaagttagaa cagatcactg gtttacctcg gcctgagatc
     1381 attcagtggt ttggtgacac acgctatgcc ttgaagcatg ggcaactaaa gtggtttcgg
     1441 gacaacgcag tacctggtgc ccctagtttc caagacccag caattcctac accaccacca
     1501 tcaacccgct ccttgaacga aagggctgag acaccacctc tgccgatccc tccaccccca
     1561 ccggatatac aacccttgga gaggtactgg gcagcccacc aacagctacg ggaaactgat
     1621 atccctcaat tgagtcaggc atcaaggctt agcacccagc aggtgctgga ttggtttgac
     1681 tctcgattac ctcagccagc tgaggtggta gtttgtctag atgaagaaga ggaagaggag
     1741 gaggaagaac tgccagaaga tgatgaggaa gaggaggagg aggaggagga agatgatgat
     1801 gatgatgatg atgatgtgat catacaagac tgagtgggga gctgggggag gggaggtctg
     1861 ttactgaaag atgaaccaac ttagtaactg tttaaacaaa gaaaccacat ttttaaaatt
     1921 accttgtggc agagaactaa aaagctttgt gttcttcagg gtgggtggca gggggatata
     1981 gtgagggtgg accagggaga atgaccatag ggcactaagt aaggctggga ttggatcagc
     2041 agaaatccaa ccctctaacc ttagggtagg gagtgctaag gatctgggga aaccatgggc
     2101 tgggaagctg ctcttgctct cctcgtgtct gctgtttttt tcccttggtg tactatacag
     2161 aggccagatg ttggcaccac ctctccagga ggattggaaa ggaggagtaa aggattctga
     2221 tttgattgat gattccagtg catccccaat cccaccatct tacctggaat ataaggctgc
     2281 cttgtacccc ttttctgagc acaagtctgt gcgtaatgca actgactctc ttactttttt
     2341 cttagtaact gatcatttcc tagacaacca agattctcaa taagtcccag tctcatcaca
     2401 aatattaata tttccttttc ctcataccaa cttgactatg tttcacccgc ttcatgacta
     2461 aatcacaggt ggcagaattt ttcagttctt tttttttttt ttgaggtgga gtcttgctct
     2521 gtcgcccagg ctgtagtgca atggcgcaat ctcagctcac tgcaagctcc gcctcccagg
     2581 ttcatgccat tctcctgcct cagcctcccg agtagctggg actacaggca cctgccacca
     2641 cacccggcta cttttttata tttttagtag agacgggttt catcatgtta gccaggatgg
     2701 tcttgatctc ctgacctcat gatccgccca ccttggcctc ccaaagtgct gggattatag
     2761 gcatgagcca ccgtgcccgg ctattttcag ttcttatgct gtgaccactt tgccttgtag
     2821 ctttttctat ctttccaaaa tcctcactct gttcattgtt tgtctcaggg aaaatcttcc
     2881 cccaccgagc ttgtaaaaaa ctttaataat tgggtggaga ataatttaga atggatattt
     2941 attggaggtg gtaattaggg aagatgtcct tttaaacagt agaattgtgt tacaaagggg
     3001 tgaaagagag ggaatagttt ctccttgttg aagggcagtg aaggtaggtt tcaggtttgg
     3061 ttttacaaac ctgttaacta cctcctgtcc agcttgacag agactaattt ttcatctttt
     3121 tgctgtcaat ttgtttccag aaaagagact tttccctctc ttgataggat ctgtcttagg
     3181 gacagaggga ccatcgtctt taagtgaatt aattattgat gttttagaat ggttttcatc
     3241 agttgggatc agctatatgg caaataggta tcatcaatga gttaaccatc taaaaataaa
     3301 agagtggaag ccctaaaatg ctagaataat aataaaaagg ccaaaaataa aattgtttct
     3361 ctctcaacca ctttgccact cctatggttt agggattaat ggaaccaaat ccattaacat
     3421 tctaactcag catactttta acttattgtt tggaggggca ggacttattg aggtaaatta
     3481 aaagaacaaa aactgtaaaa aggaagtagt tcagcatcta tcgccagcca ggttgtttct
     3541 cagccatcaa atgataatga ctaaaatttc tgaggcttca ggagtaacag agatacaaca
     3601 gtcttggagg taactccatt tgctacagga caggcccttg cctaaaagag aaggtatcta
     3661 gaaatgcctt taaaataaat tcagagtacc agaaagggta tggggatcct agttcagata
     3721 caagatcatt cccaagacct aatttatttc tggcagatgc ctgctatttt ctgtttttcc
     3781 agtatttttg cttaaggcca gcttgtgagt ggctaaccta tttaattcgt catttctgcc
     3841 ttttaaaacc caaagtagaa tacatgtttg atctcagtga tagtgttgtt cgcccattcc
     3901 accattctag agcttgtaaa agtgatagaa ttgtagcaat aaaagggcat cgtctttatt
     3961 ttactatcta tatactaagc tgaaaatcag tgtctccaac agttgttttc aatagaaagg
     4021 aaaattaaca tttaatagta actaagcata gaggaaataa tagacaaata aaaaagtata
     4081 ataaggaaaa gaacagagat attgctcgtt aacattggca atgggacagt atatccaaag
     4141 ctaaaaatga aatccagaaa tgaaacagtg atgagtatat gatccatcac aatccccatt
     4201 cccaactccc aaccaagcat gatgccaaga attatttttt tgacctttgt tccaaattgt
     4261 aggaaatgag gggagctacc agtgtcttct ggaagagata taaacatctt cctgaagcac
     4321 tagccttttg taagacctga ccactgtcct gggaggtgat aagggtgaat agggtaaaga
     4381 tggggggagc ataaggtaca gagtgaaact aggaaacaat gcagggatac attttccagg
     4441 gccatcaccc ctaatgcgta ctggaagcta cagtccatcc ttcagcagca tgtatagatc
     4501 agatcttgaa gatgatctat ctagaagtgg tccatgcttc tctcccactg ggtaatccca
     4561 tatgcctccg ttgttggtag agagtctgca gcagaggaca agaaggtaga tgtgggtgtt
     4621 tataacagca aaaagggcaa gcaagtctct ctgacctgtt gtatgaagct tatcgagaca
     4681 gacaccactg cttttgcttc cccatagttt tcttcattgc atgataacta acttttccaa
     4741 actaggattt gctacatcta gtgtgacaat ctctggaaca tttcagtagc ttatggtgat
     4801 aataataagg atgaatattt gaaaattaaa ctattttgga aaatctggga catatgacta
     4861 ccacacccag agatgactac cagggaggca gagttcttag gcctctgagg aggtggcatt
     4921 tccttcaata actttaaaat tttttcacat tttcggttgt ttgtttgttt gtttgtttgt
     4981 tgtttt
//
