LOCUS       NM_004838               1560 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens homer scaffold protein 3 (HOMER3), transcript variant
            2, mRNA.
ACCESSION   NM_004838
VERSION     NM_004838.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Chen,L., Shan,X., Wan,X., Zha,W. and Fan,R.
  TITLE     HOMER3 promotes liver hepatocellular carcinoma cancer progression
            by -upregulating EZH2 and mediating miR-361/GPNMB axis
  JOURNAL   Pathol Res Pract 254, 155150 (2024)
   PUBMED   38266459
  REMARK    GeneRIF: HOMER3 promotes liver hepatocellular carcinoma cancer
            progression by -upregulating EZH2 and mediating miR-361/GPNMB axis.
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Peixoto,A., Ferreira,D., Azevedo,R., Freitas,R., Fernandes,E.,
            Relvas-Santos,M., Gaiteiro,C., Soares,J., Cotton,S., Teixeira,B.,
            Paulo,P., Lima,L., Palmeira,C., Martins,G., Oliveira,M.J.,
            Silva,A.M.N., Santos,L.L. and Ferreira,J.A.
  TITLE     Glycoproteomics identifies HOMER3 as a potentially targetable
            biomarker triggered by hypoxia and glucose deprivation in bladder
            cancer
  JOURNAL   J Exp Clin Cancer Res 40 (1), 191 (2021)
   PUBMED   34108014
  REMARK    GeneRIF: Glycoproteomics identifies HOMER3 as a potentially
            targetable biomarker triggered by hypoxia and glucose deprivation
            in bladder cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Liu,Q., He,L., Li,S., Li,F., Deng,G., Huang,X., Yang,M., Xiao,Y.,
            Chen,X., Ouyang,Y., Chen,J., Wu,X., Wang,X., Song,L. and Lin,C.
  TITLE     HOMER3 facilitates growth factor-mediated beta-Catenin tyrosine
            phosphorylation and activation to promote metastasis in triple
            negative breast cancer
  JOURNAL   J Hematol Oncol 14 (1), 6 (2021)
   PUBMED   33407765
  REMARK    GeneRIF: HOMER3 facilitates growth factor-mediated beta-Catenin
            tyrosine phosphorylation and activation to promote metastasis in
            triple negative breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Ishiguro,K. and Xavier,R.
  TITLE     Homer-3 regulates activation of serum response element in T cells
            via its EVH1 domain
  JOURNAL   Blood 103 (6), 2248-2256 (2004)
   PUBMED   14645007
  REMARK    GeneRIF: Homer-3 may be involved in the regulation of SRE
            activation in T cells via interaction between its EVH1 domain and
            C/EBP beta.
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Norton,N., Williams,H.J., Williams,N.M., Spurlock,G., Zammit,S.,
            Jones,G., Jones,S., Owen,R., O'Donovan,M.C. and Owen,M.J.
  TITLE     Mutation screening of the Homer gene family and association
            analysis in schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 120B (1), 18-21 (2003)
   PUBMED   12815733
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Soloviev,M.M., Ciruela,F., Chan,W.Y. and McIlhinney,R.A.
  TITLE     Molecular characterisation of two structurally distinct groups of
            human homers, generated by extensive alternative splicing
  JOURNAL   J Mol Biol 295 (5), 1185-1200 (2000)
   PUBMED   10653696
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Tu,J.C., Xiao,B., Yuan,J.P., Lanahan,A.A., Leoffert,K., Li,M.,
            Linden,D.J. and Worley,P.F.
  TITLE     Homer binds a novel proline-rich motif and links group 1
            metabotropic glutamate receptors with IP3 receptors
  JOURNAL   Neuron 21 (4), 717-726 (1998)
   PUBMED   9808459
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Xiao,B., Tu,J.C., Petralia,R.S., Yuan,J.P., Doan,A., Breder,C.D.,
            Ruggiero,A., Lanahan,A.A., Wenthold,R.J. and Worley,P.F.
  TITLE     Homer regulates the association of group 1 metabotropic glutamate
            receptors with multivalent complexes of homer-related, synaptic
            proteins
  JOURNAL   Neuron 21 (4), 707-716 (1998)
   PUBMED   9808458
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002985.1, BC012113.1 and
            CN284196.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004838.3.
            
            Summary: This gene encodes a member of the HOMER family of
            postsynaptic density scaffolding proteins that share a similar
            domain structure consisting of an N-terminal
            Enabled/vasodilator-stimulated phosphoprotein homology 1 domain
            which mediates protein-protein interactions, and a carboxy-terminal
            coiled-coil domain and two leucine zipper motifs that are involved
            in self-oligomerization. The encoded protein binds numerous other
            proteins including group I metabotropic glutamate receptors,
            inositol 1,4,5-trisphosphate receptors and amyloid precursor
            proteins and has been implicated in diverse biological functions
            such as neuronal signaling, T-cell activation and trafficking of
            amyloid beta peptides. Alternative splicing results in multiple
            transcript variants.[provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2), termed Homer-3A01, differs in
            the 5' UTR compared to variant 1. Both variants 1 and 2 encode the
            same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012113.1, SRR3476690.354747.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392351.8/ ENSP00000376162.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC002985.1         34417-34459         c
            44-504              BC012113.1         1-461
            505-505             AC002985.1         31627-31627         c
            506-1259            BC012113.1         463-1216
            1260-1260           AC002985.1         22745-22745         c
            1261-1560           CN284196.1         33-332
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1560
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /note="homer scaffold protein 3"
                     /db_xref="GeneID:9454"
                     /db_xref="HGNC:HGNC:17514"
                     /db_xref="MIM:604800"
     exon            1..167
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            168..248
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1320
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /note="isoform 1 is encoded by transcript variant 2;
                     Homer, neuronal immediate early gene, 3; homer protein
                     homolog 3; homer homolog 3; homer scaffolding protein 3"
                     /codon_start=1
                     /product="homer protein homolog 3 isoform 1"
                     /protein_id="NP_004829.3"
                     /db_xref="CCDS:CCDS12391.1"
                     /db_xref="GeneID:9454"
                     /db_xref="HGNC:HGNC:17514"
                     /db_xref="MIM:604800"
                     /translation="MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDAT
                     RNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQF
                     AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSA
                     DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLE
                     AQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKS
                     QTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR
                     AAQLLDVSLFELSELREGLARLAEAAP"
     exon            249..405
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            406..537
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..645
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..767
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..924
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1041
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1128
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1560
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1543..1548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /note="hexamer: ATTACA"
     polyA_site      1560
                     /gene="HOMER3"
                     /gene_synonym="HOMER-3; VESL3"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcggcg gcggcgcaga caaaggcacg ggcggcgtgg agggcggcgc ggagggcgcg
       61 ggcccgggag ccagggagcg agcggggcgc ccggcagcgc ggagtcagcg ccgcgggggc
      121 cgcacccgac tcgcgcctgg acactcgcgg ggcgccgacc tggcaggggg ccaaaccagt
      181 gctcctgcca cctctctggc tgccccctag agcctgccca tcccagcctg accaatgtcc
      241 acagccaggg agcagccaat cttcagcaca cgggcgcacg tgttccaaat tgacccagcc
      301 accaagcgaa actggatccc agcgggcaag cacgcactca ctgtctccta tttctacgat
      361 gccacccgca atgtgtaccg catcatcagc atcggaggcg ccaaggccat catcaacagc
      421 actgtcactc ccaacatgac cttcaccaaa acttcccaga agttcgggca gtgggccgac
      481 agtcgcgcca acacagtcta cggcctgggc tttgcctctg aacagcatct gacacagttt
      541 gccgagaagt tccaggaagt gaaggaagca gccaggctgg ccagggagaa atctcaggat
      601 ggcggggagc tcaccagtcc agccctgggg ctcgcctccc accaggtgcc cccgagccct
      661 ctcgtcagtg ccaacggccc cggcgaggaa aaactgttcc gcagccagag cgctgatgcc
      721 cccggcccca cagagcgcga gcggctaaag aagatgttgt ctgagggctc cgtgggcgag
      781 gtacagtggg aggccgagtt tttcgcactg caggacagca acaacaagct ggcaggcgcc
      841 ctgcgagagg ccaacgccgc cgcagcccag tggaggcagc agctggaggc tcagcgtgca
      901 gaggccgagc ggctgcggca gcgggtggct gagctggagg ctcaggcagc ttcagaggtg
      961 acccccaccg gtgagaagga ggggctgggc cagggccagt cgctggaaca gctggaagct
     1021 ctggtgcaaa ccaaggacca ggagattcag accctgaaga gtcagactgg ggggccccgc
     1081 gaggccctgg aggctgccga gcgtgaggag actcagcaga aggtgcagga cctggagacc
     1141 cgcaatgcgg agttggagca ccagctgcgg gcgatggagc gcagcctgga ggaggcacgg
     1201 gcagagcggg agcgggcgcg ggctgaggtg ggccgggcag cgcagctgct ggacgtcagc
     1261 ctgtttgagc tgagtgagct gcgtgagggc ctggcccgcc tggctgaggc tgcgccctga
     1321 gccggggctg gttttctatg aacgattccg gcctgggatg cgggccaggc tgcaggcggc
     1381 atagttgggc ccattcgtcc tggaaaggga ctggggggtc ccaacttagc cctgggtggg
     1441 ccgggccggg ctgggctggg gtgggcccca gtcggctctg gttgttggca gctttggggc
     1501 tgtttttgag cttctcattg tgtagaattt ctagatcccc cgattacatt tctaagcgtg
//
