LOCUS       NM_004272               5798 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant
            1, mRNA.
ACCESSION   NM_004272
VERSION     NM_004272.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5798)
  AUTHORS   Singer,A., Ramos,A. and Keating,A.E.
  TITLE     Elaboration of the Homer1 recognition landscape reveals incomplete
            divergence of paralogous EVH1 domains
  JOURNAL   Protein Sci 33 (8), e5094 (2024)
   PUBMED   38989636
  REMARK    GeneRIF: Elaboration of the Homer1 recognition landscape reveals
            incomplete divergence of paralogous EVH1 domains.
REFERENCE   2  (bases 1 to 5798)
  AUTHORS   Shu,S., Xu,Z., Lu,H., Li,Z. and Zhang,Y.
  TITLE     CircHOMER1 aggravates oxidative stress, inflammation and
            extracellular matrix deposition in high glucose-induced human
            mesangial cells
  JOURNAL   Nephrology (Carlton) 27 (12), 983-993 (2022)
   PUBMED   36181383
  REMARK    GeneRIF: CircHOMER1 aggravates oxidative stress, inflammation and
            extracellular matrix deposition in high glucose-induced human
            mesangial cells.
REFERENCE   3  (bases 1 to 5798)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5798)
  AUTHORS   Lin,R., Learman,L.N., Bangash,M.A., Melnikova,T., Leyder,E.,
            Reddy,S.C., Naidoo,N., Park,J.M., Savonenko,A. and Worley,P.F.
  TITLE     Homer1a regulates Shank3 expression and underlies behavioral
            vulnerability to stress in a model of Phelan-McDermid syndrome
  JOURNAL   Cell Rep 37 (7), 110014 (2021)
   PUBMED   34788607
  REMARK    GeneRIF: Homer1a regulates Shank3 expression and underlies
            behavioral vulnerability to stress in a model of Phelan-McDermid
            syndrome.
REFERENCE   5  (bases 1 to 5798)
  AUTHORS   Reshetnikov,V.V. and Bondar,N.P.
  TITLE     The Role of Stress-Induced Changes of Homer1 Expression in Stress
            Susceptibility
  JOURNAL   Biochemistry (Mosc) 86 (6), 613-626 (2021)
   PUBMED   34225586
  REMARK    GeneRIF: The Role of Stress-Induced Changes of Homer1 Expression in
            Stress Susceptibility.
            Review article
REFERENCE   6  (bases 1 to 5798)
  AUTHORS   Roche,K.W., Tu,J.C., Petralia,R.S., Xiao,B., Wenthold,R.J. and
            Worley,P.F.
  TITLE     Homer 1b regulates the trafficking of group I metabotropic
            glutamate receptors
  JOURNAL   J Biol Chem 274 (36), 25953-25957 (1999)
   PUBMED   10464340
REFERENCE   7  (bases 1 to 5798)
  AUTHORS   Tu,J.C., Xiao,B., Naisbitt,S., Yuan,J.P., Petralia,R.S.,
            Brakeman,P., Doan,A., Aakalu,V.K., Lanahan,A.A., Sheng,M. and
            Worley,P.F.
  TITLE     Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of
            postsynaptic density proteins
  JOURNAL   Neuron 23 (3), 583-592 (1999)
   PUBMED   10433269
REFERENCE   8  (bases 1 to 5798)
  AUTHORS   Tu,J.C., Xiao,B., Yuan,J.P., Lanahan,A.A., Leoffert,K., Li,M.,
            Linden,D.J. and Worley,P.F.
  TITLE     Homer binds a novel proline-rich motif and links group 1
            metabotropic glutamate receptors with IP3 receptors
  JOURNAL   Neuron 21 (4), 717-726 (1998)
   PUBMED   9808459
REFERENCE   9  (bases 1 to 5798)
  AUTHORS   Xiao,B., Tu,J.C., Petralia,R.S., Yuan,J.P., Doan,A., Breder,C.D.,
            Ruggiero,A., Lanahan,A.A., Wenthold,R.J. and Worley,P.F.
  TITLE     Homer regulates the association of group 1 metabotropic glutamate
            receptors with multivalent complexes of homer-related, synaptic
            proteins
  JOURNAL   Neuron 21 (4), 707-716 (1998)
   PUBMED   9808458
REFERENCE   10 (bases 1 to 5798)
  AUTHORS   Brakeman,P.R., Lanahan,A.A., O'Brien,R., Roche,K., Barnes,C.A.,
            Huganir,R.L. and Worley,P.F.
  TITLE     Homer: a protein that selectively binds metabotropic glutamate
            receptors
  JOURNAL   Nature 386 (6622), 284-288 (1997)
   PUBMED   9069287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093270.3, AK312481.1, BC047438.1 and AC020898.6.
            
            On May 17, 2019 this sequence version replaced NM_004272.4.
            
            Summary: This gene encodes a member of the homer family of
            dendritic proteins. Members of this family regulate group 1
            metabotrophic glutamate receptor function. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047438.1, SRR1163657.511109.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267760 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334082.11/ ENSP00000334382.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1033              AC093270.3         63856-64888
            1034-2425           AK312481.1         1-1392
            2426-2978           BC047438.1         2128-2680
            2979-2979           AC020898.6         37618-37618
            2980-4471           BC047438.1         2682-4173
            4472-5798           AC020898.6         39111-40437
FEATURES             Location/Qualifiers
     source          1..5798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..5798
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /note="homer scaffold protein 1"
                     /db_xref="GeneID:9456"
                     /db_xref="HGNC:HGNC:17512"
                     /db_xref="MIM:604798"
     exon            1..1365
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1361..2425
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homer, neuronal immediate early gene, 1; homer protein
                     homolog 1; homer-1; homer homolog 1; homer scaffolding
                     protein 1"
                     /codon_start=1
                     /product="homer protein homolog 1 isoform 1"
                     /protein_id="NP_004263.1"
                     /db_xref="CCDS:CCDS43335.1"
                     /db_xref="GeneID:9456"
                     /db_xref="HGNC:HGNC:17512"
                     /db_xref="MIM:604798"
                     /translation="MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNV
                     YRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEK
                     FQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNS
                     EPRAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAY
                     QEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDN
                     ARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILD
                     GKIFELTELRDNLAKLLECS"
     exon            1366..1522
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1654
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1747
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1887
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2044
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2155
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2236
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..5798
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5317..5322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /note="hexamer: CATAAA"
     polyA_site      5336
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /note="major polyA site"
     regulatory      5617..5622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
                     /note="hexamer: ATTAAA"
     polyA_site      5641
                     /gene="HOMER1"
                     /gene_synonym="HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47;
                     Ves-1"
ORIGIN      
        1 actctgccgc cgcgctagct tcacgccggc ggcgctgacc gggaaagcag caccctcttc
       61 tctgccagcc ggccggccgg cggaggcgga ggcagcggca ggcttcaggc cgccggggct
      121 ggcgctgctc tgcccggcgg tagccggagg cgggcgctga tggaagtgtg aagaggcggc
      181 ggcggggccc ggggaatgtg aggcggcgcg tggcggcggc gcggagcgtg agagacgagg
      241 agtaggggtg ggggcgctgg agcggcggct gcgcttcggc ttcgagccca gctctcctgg
      301 ccccaacgcg ggcttagcct cccgccttgg ctcgggcagg cgcccgtcga cccttcggcc
      361 cctttcgccc gccctggagc tgggggcagg gtgccagtgg aagcgtgggg cttggctctg
      421 tgattcattc attctccgcc gacgggagcc tcagacccgc tgtgctctga agagaggagg
      481 gaagaggggg cagccgcgaa tgaagggccg ggcaccagcc gggctccatt gtgctcggcg
      541 gcggggggcg ggaaggggct gagggaggtg ggatcgggtc ccctcctcca gctctccggc
      601 gtgcgctgcg cccccagcct gctgccagcc tggaaatggc tccgtttatt ctcttcggga
      661 gaatgaatcg atcctgccta gccttctctt cgtcctcccc acctcttctc tgctccgagt
      721 cttaggagga gaaacattta aaaagacaga ttccaatgtg gagtgccgtg caggttgcga
      781 gctgccgggt ttgcacttcg aggagatttt cctgtgtagt ttttttccta atgtgagcgc
      841 agggaagccg tggcattact gcttttggga tttttattca cgtgcacgtc gcgtttggtt
      901 gctcgctcca cccccggaga cctggtgtgg tggagaaatt tgaacccgca gccttagctc
      961 cgaaaaggcc gagttacctg gctctccctg agtgtcgagg aggacatgag tgaaatgacc
     1021 agcgaactca ttttttatag gactcggtga agccggattc tgcatttccc tacttgtaga
     1081 ctcattttgt ggaatagagt tgatcgctgt ctcctccgca aagcatttta actcgaataa
     1141 gcaaatgccg cctctgtttg aacgttttgg tatttacaag agagaaatca ttttacctaa
     1201 gagaactaat tgaattggca gcatccttga aatacctccg gacaaggatc tgggggtggg
     1261 ggtggaaaag caactgcgaa atagcagacg gagaaattcc tttggaagtt attccgtagc
     1321 ataagagctg aaacttcaga gcaagttttc attgggcaaa atgggggaac aacctatctt
     1381 cagcactcga gctcatgtct tccaaattga cccaaacaca aagaagaact gggtacccac
     1441 cagcaagcat gcagttactg tgtcttattt ctatgacagc acaagaaatg tgtataggat
     1501 aatcagttta gatggctcaa aggcaataat aaatagtacc atcaccccaa acatgacatt
     1561 tactaaaaca tctcagaagt ttggccagtg ggctgatagc cgggcaaaca ccgtttatgg
     1621 attgggattc tcctctgagc atcatctttc gaaatttgca gaaaagtttc aggaatttaa
     1681 agaagctgct cgactagcaa aggaaaaatc acaagagaag atggaactta ccagtacacc
     1741 ttcacaggaa tccgcaggcg gggatcttca gtctccttta acaccggaaa gtatcaacgg
     1801 gacagatgat gaaagaacac ctgatgtgac acagaactca gagccaaggg ctgaaccaac
     1861 tcagaatgca ttgccatttt cacatagttc agcaatcagc aaacattggg aggctgaact
     1921 ggctaccctc aaaggaaata atgccaaact cactgcagcc ctgctggagt ccactgccaa
     1981 tgtgaaacaa tggaaacagc aacttgctgc ctatcaagag gaagcagaac gtctgcacaa
     2041 gcgggtgact gaacttgaat gtgttagtag ccaagcaaat gcagtacata ctcataagac
     2101 agaattaaat cagacaatac aagaactgga agagacactg aaactgaagg aagaggaaat
     2161 agaaaggtta aaacaagaaa ttgataatgc cagagaacta caagaacaga gggattcttt
     2221 gactcagaaa ctacaggaag tagaaattcg gaacaaagac ctggagggac aactgtctga
     2281 cttagagcaa cgtctggaga aaagtcagaa tgaacaagaa gcttttcgca ataacctgaa
     2341 gacactctta gaaattctgg atggaaagat atttgaacta acagaattac gagataactt
     2401 ggccaagcta ctagaatgca gctaaggaaa gtgaaatttc agtgccaatt aattaaaaga
     2461 tacactgtct ctcttcatag gactgtttag gctctgcatc aagattgcac aaaaaaaaaa
     2521 aaaaaaaaat tgaatatcac tcctccagga ggaggatctt ttgaaattgg aattgtatat
     2581 ttcactgtaa attttagaat ccagcttgta gctagttggg gaaaaaagat gaaaaacttg
     2641 aactacaaat tacctccatg tatattattg gccatagtta actagaaagt tataaataga
     2701 cacttaatgc aatctttttt cctgatatta gccaatggga gaattaacaa tgtctaggtc
     2761 acatcccctt tttgtgttca acacagtgaa gattatctgc tttttaaatt aatttattta
     2821 cgatatctag agctgtgttt tgtgcaaaaa cttagtgatg aaagcctgtc ttttgttgta
     2881 atctgaataa tttctcagga tatttttgca ctgctgagaa gcagtgccat taccaattaa
     2941 ttcttgccag gagtgagaga gagctgtatc tttaattgaa atatactata actgggtgta
     3001 tagagttctt cccttttttg tgctggaaga tatttcactc tggtgactac tctggtacac
     3061 tctggtgttc tctaatcttg tctgttgtat agtttacttt tccatattga ttccatgtat
     3121 ttatgagaag atattgtctc ccattttatt acacatttta aagccaacta acgaaggcag
     3181 ctgagtccct cagaaatttt tctttttaag tttctaataa atttgacaca cagtactgaa
     3241 atacagcagc ccgtcattga caggctggtc tagcaatgtt aagtatattt acagaatatg
     3301 cagttacatt tatttatata ttttgcaaga aatcttttct gaatgatcaa tgcatttcaa
     3361 tttacgaata ataatggtta ttggggaact gtttattata gataatttta aggtgtatag
     3421 ctattttaaa gggggtccat ttacatcaaa cagctgatca gaggactcta tctaaattgt
     3481 gatcgtggca gatagagatg gagtcatgta ctctatctgg ctctacacat caatcacatc
     3541 ttgattcaaa cctcacaagg caatattctg aattgttaac taggtatttc aaaacaggaa
     3601 ttaaattcaa taggctcttc tcagtgaaca ggttttaatg ttgttttgat gtaattttaa
     3661 aagactttta gcaaacatgc atttctttat atgatatatt tcttttacga agctatttta
     3721 aaagtaagcc aagtgctgtc tagtctgctt ataaagtagg aattgcatca gagtacatat
     3781 attcttgctg tacaatgcct gtgatgttga ggagggttct tttttaaagt gtatgcttga
     3841 gtaactgact ctatggagtc tataaatgca ctgacttctt gtttgtaccc caaaatgatc
     3901 gaattgttaa gtacaaaatt aagctaatta accaatttgt aaccattttt tcactcataa
     3961 acagctactc aatactagac aattttgttt tttatgtatg tgtatgtacg taaatacata
     4021 catattaatt tacattagag tgaaaaataa atggtttgtt tctgaagtta gtttcttaag
     4081 tgagttttca ggtgtctctg aaaaatttat aacaatcatg tattatatgt gctgtaacat
     4141 catgtacgtt acctccatct attttaggat attttcctca cctatatatt atagggagaa
     4201 taatttagat acacatgctc agagctgaga tatttctctg ataaatcagg taacaaaatg
     4261 tatttgattg atggaatttt gaagtaaatg tgtttttatc catcagtttc tgagtaacaa
     4321 agagcaccaa gttttaattt aaataggaga tttaacacta gggatcaggg agtttagtat
     4381 gaagagttaa aaaaatttaa aaaacagtgt aagctgttga aatggcaagt gaattatttt
     4441 aatgatgtaa taaaatattt ttaaattttg acatagtgat catttaatga aaaaactcac
     4501 caaaatgtct ccatttgaat tgtattgata atgtgggaca tatgtgtgat tcaatatata
     4561 catataccca tatgtatata cagaaaatta tttttaatac tttcctactg ataatgaaat
     4621 ttaaaattgg aaattttgtg agtgtttttc ttgtccaata gagcctaatt gtttcctttt
     4681 ttagtgattt aacaatctct tgagggctgc acctttaaat tcccagattg tcaatagaca
     4741 tgtacagtat atgggataag gtggacacaa gtgcacatat aaataaaatc ttcttaagac
     4801 ttttaactat tcatttacag taggagagta tgtagaaatc atcatccaca agtcataatt
     4861 aggttgtgtg cctactgtag ttttttccat ttctgtatta tataaacatt tgcatattaa
     4921 aatttgattt ttcccagaga caagtattat atactgtatc tatatttaaa tcaaactgtg
     4981 gtaatatatt tctcagaaaa taatgttggg gactatagcc tgaacatgtg gacttgaagc
     5041 gacatggagg aggaggttga tcccattgtg tataagttaa tatgtgataa ctattgaatc
     5101 ttgtacaaaa acaaaaattg aaaaaaaaaa agaaaagcaa aaatacagtt tttattttga
     5161 aatacatttg ttctctggag aatgtacttt atcttttttt cctccagtct tttacagata
     5221 tttaaaagca tttaaatgat gacagcattt acttaaatct ttcaggtgct actggatttt
     5281 gcattagtgt gttatgttgt gaaatcctaa ctttgacata aaaggtttta taagtattcc
     5341 cctgcctgga aaattagttt ttgttctcct ctctctctct ttctcttttc cactttcttt
     5401 ctgcagacta aaacatgctc acgaagttgc atctctcctt gtctctatag aagatctcca
     5461 gcaccatcat agatttgatg ttctgctgtc attgaactgt tgggaagcag ttagaggaaa
     5521 agctcacttt ttttttcagg tggaaataaa aggaacactc aaaattaagc caacaccacc
     5581 actaccttta aaaactagtt tatttgccct gttaaaatta aatgtattct ttaacatgtg
     5641 ggctacagtc tcccatgttt ttatttaact gaagcatata cacttcggtc atttatctcc
     5701 ttgtggtcct gattttgtca gtactggaat gggaggcagg tcggggaaag tttgtttgat
     5761 ggcagtggat tcttattgtt gttttaacca ttgcattt
//
